ライフサイエンスコーパス: competitive inhibitor

1 ors against ACE, whereas PSSNK acts as a non-competitive inhibitor.

2 , given its status as a TBK1 substrate, as a competitive inhibitor.

3 Galactose was found to be the competitive inhibitor.

4 P binding pocket of the kinase and is an ATP competitive inhibitor.

5 CHK1 selective adenosine triphosphate (ATP) competitive inhibitor.

6 Kinetic assays revealed that BV is a non-competitive inhibitor.

7 A non-hydrolyzable ATP analog was a competitive inhibitor.

8 BoNT protein as a landscape for assembling a competitive inhibitor.

9 ATP and therefore leads to resistance to ATP competitive inhibitors.

10 hes biochemical potency and synergy with ATP-competitive inhibitors.

11 ifically target TdT and behave as nucleotide-competitive inhibitors.

12 lone or in combination with conventional ATP-competitive inhibitors.

13 y slowly and cannot be disrupted by strictly competitive inhibitors.

14 nct from that observed for kinase domain ATP-competitive inhibitors.

15 the ATP binding pocket by either ATP or ATP-competitive inhibitors.

16 r and that 1-thia-Trp and 1-oxa-Trp serve as competitive inhibitors.

17 We identified two classes of ATP-competitive inhibitors.

18 d screening strategy for Ras interfacial and competitive inhibitors.

19 efficiency, and increased resistance to SDH competitive inhibitors.

20 2 or Escherichia coli IDI-1 but instead were competitive inhibitors.

21 D-glucopyranoside and reduced sensitivity to competitive inhibitors.

22 AKAP79 also protects PKC from certain ATP-competitive inhibitors.

23 for Chagas disease, looking for reversible, competitive inhibitors.

24 t may not be apparent using conventional ATP-competitive inhibitors.

25 g site that has been effectively targeted by competitive inhibitors.

26 ructure-based design of dual JCV and BKV ATP-competitive inhibitors.

27 r the determination of costructures with ATP competitive inhibitors.

28 ower concentrations in comparison to the ATP-competitive inhibitors.

29 Hcy), D-Cys, thiosulfate, and azide bound as competitive inhibitors.

30 2N variant in the presence of pyruvate and a competitive inhibitor (2R,3R)-2,3,4-trihydroxy-N,N-dipro

31 es of ternary complexes of WT HMGCL with the competitive inhibitor 3-hydroxyglutaryl-CoA and of the c

32 An inhibitor screen identified the competitive inhibitor 3-pyridine carboxaldehyde with a K

33 f DHBPS from Vibrio cholerae (vDHBPS) with a competitive inhibitor 4-phospho-d-erythronohydroxamic ac

34 ading to the development of a very promising competitive inhibitor (8r, IC50 = 200 nM, K(i) = 82 nM).

35 cal" Akt hyperphosphorylation induced by ATP-competitive inhibitor, A-443654.

36 ricyanide), in the presence and absence of a competitive inhibitor, ADP-ribose.

37 ggest that Val-Glu-Leu-Tyr-Pro acts as a non-competitive inhibitor against ACE.

38 ies revealed that this compound behaves as a competitive inhibitor against the peptide substrate and

39 etics and docking studies suggested they are competitive inhibitors against a dimethylated H3K4 subst

40 plots suggested that AHEPVK and RIGLF act as competitive inhibitors against ACE, whereas PSSNK acts a

41 tructural basis for the design of nucleotide-competitive inhibitors against clinically relevant APH e

42 osine-containing tetrapeptides functioned as competitive inhibitors against mushroom tyrosinase by us

43 n exploited in the development of reversible competitive inhibitors against SK from Mycobacterium tub

44 ATP-competitive inhibitors against this complex have been re

45 estigated two IL-1 receptor antagonists, the competitive inhibitor anakinra (Kineret) and a potent no

46 ase-3 the resulting DEVD-T peptide acts as a competitive inhibitor and entraps the active site of cas

47 irst structure of CDK1 bound to a potent ATP-competitive inhibitor and identify aspects of CDK1 struc

48 ts indicates that octyl protocatechuate is a competitive inhibitor and the inhibition constant (Ki) w

49 insight into the activation of B-Raf by ATP-competitive inhibitors and can aid in the design of more

50 The development of efficient competitive inhibitors and chaperones to treat diseases

51 late G protein-coupled receptor signaling as competitive inhibitors and protein adaptors.

52 We identified four promising PC1/3 competitive inhibitors and three PC2 inhibitors that exh

53 ne-derived antagonists, the newly identified competitive inhibitors are uncharged at physiological pH

54 EK1, a nucleotide, and an allosteric non-ATP competitive inhibitor: ATP-gammaS with compound 1 and AD

55 r crosslink promotes activity and how select competitive inhibitors bind.

56 Finally, the substrate-competitive inhibitor bisindolylmaleimide I displaces lo

57 The BTLA ectodomain acts as a competitive inhibitor blocking BTLA and CD160 from bindi

58 euT, in substrate-bound outward-occluded and competitive inhibitor-bound outward-facing states have a

59 , inward-open state, and competitive and non-competitive inhibitor-bound states, have revealed a mech

60 alytic activity in vitro, unlike typical ATP-competitive inhibitors, but acted in a mechanistically d

61 nti-apoptotic BCL-2 members that function as competitive inhibitors by binding to the hydrophobic cle

62 inhibitor PKC 20-28, but not the activation-competitive inhibitor calphostin C.

63 g site and that combining allosteric and ATP-competitive inhibitors can overcome resistance to either

64 ide derived from beta-neurexin is a powerful competitive inhibitor capable of efficiently blocking su

65 2,6-Dibromophenol is the strongest competitive inhibitor, consistent with PcpA's substrate

66 Inhibition of POX activity by a competitive inhibitor "dehydroproline" decreased ROS lev

67 oscillations are blocked by coinjection of a competitive inhibitor, derived from the WWI domain-bindi

68 activity using small interfering RNA or the competitive inhibitor difluoromethylornithine restored i

69 ling was inhibited by the small molecule ATP competitive inhibitors dorsomorphin and LDN-193189.

70 TopoIIalpha N-terminal ATP-competitive inhibitors, exemplified by the marine alkalo

71 ffinity for arginine, and arginine acts as a competitive inhibitor for glutamine transport.

72 Flouride is a competitive inhibitor for lpLSD but an apparent activato

73 ) 11-13 in Notch1, and therefore serves as a competitive inhibitor for Notch ligands to decrease expr

74 ibe an approach to accelerate the search for competitive inhibitors for carbohydrate-recognition doma

75 ies demonstrate that both TCAs and SSRIs are competitive inhibitors for eukaryotic BATs and bind to t

76 provide an alternative to rapidly search for competitive inhibitors for lectins.

77 food protein hydrolysates, are selective and competitive inhibitors for the C-domain with a selectivi

78 ilar di-oxygen compounds as a novel class of competitive inhibitors for the Prxs.

79 o determine accurate inhibitor constants for competitive inhibitors from measurements at a single inh

80 g pure proteins, treatment of cells with the competitive inhibitors Go 6983 or bisindolylmaleimide I,

81 less susceptible to inhibition from the ATP-competitive inhibitor Go6976 and the substrate-competiti

82 and pharmacological inhibition by the lipid-competitive inhibitor GW4869.

83 finity (Kd approximately 12-30 nM) selective competitive inhibitors (IC50 approximately 20-150 nM) fo

84 interleukin (IL)-1beta has co-evolved with a competitive inhibitor, IL-1 receptor antagonist (IL-1Ra)

85 rties, when used in combination with the ATP-competitive inhibitors imatinib or nilotinib, suppressed

86 ted form of cardiolipin could not serve as a competitive inhibitor in vitro.

87 a in favor of abundant and highly potent ATP-competitive inhibitors in screening libraries.

88 h the kinetic data, the affinity of peptidic competitive inhibitors is diminished at acidic pH.

89 Binding studies disclosed that the competitive inhibitor isoeugenol is predominantly in its

90 itionally, the dissociation constant for the competitive inhibitor isopropyl beta-d-1-thiogalactopyra

91 ystal structure of NDM-1 bound to the potent competitive inhibitor l-captopril, which reveals a uniqu

92 s by feeding leaves with the PEP carboxylase competitive inhibitors malate and diethyl oxalacetate (D

93 Development of competitive inhibitor molecules such as miRNA sponges ha

94 The competitive inhibitor N-(n-nonyl)deoxynojirimycin increa

95 The pK(i)-pH profiles for the competitive inhibitors N,N'-dibenzylbutane-1,4-diamine a

96 strate binding domain, we identified a novel competitive inhibitor, N-(3,5-dimethylphenyl)-2-[[5-(4-e

97 ibition of ferrochelatase using the specific competitive inhibitor, N-methylprotoporphyrin, produced

98 vitro in the presence and absence of a known competitive inhibitor (NaClO4).

99 As a test, we examined the effects of three competitive inhibitors (nimesulide, flurbiprofen, and di

100 Simvastatin (SMV) is a specific competitive inhibitor of 3-hydroxy-2-methyl-glutaryl coe

101 Atorvastatin (ATV) is a specific competitive inhibitor of 3-hydroxy-2-methyl-glutaryl coe

102 ng a mu-opioid receptor agonist, is a potent competitive inhibitor of 5-HT(3) receptors.

103 GTP binding and the first demonstration of a competitive inhibitor of a receptor guanylyl cyclase.

104 ions in the heart, attributed to its being a competitive inhibitor of ACE, leading to decreased AngII

105 intracellular conversion to CMP-3F-NeuAc, a competitive inhibitor of all sialyltransferases.

106 from 'Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent d

107 Unlike known inhibitors, JIB-04 is not a competitive inhibitor of alpha-ketoglutarate.

108 Titration of aspartate, a competitive inhibitor of Ans, revealed an increase in N(

109 migration through sequestration of Arpin, a competitive inhibitor of Arp2/3 complex.

110 We therefore conclude that A22 is a competitive inhibitor of ATP binding to MreB.

111 Compound 17k is a potent and selective ATP-competitive inhibitor of Aurora B and C with K(i)* value

112 ent, selective and cell active acetyl-lysine competitive inhibitor of BAZ2A and BAZ2B bromodomains as

113 Dasatinib is a novel, potent, ATP-competitive inhibitor of Bcr-Abl, cKIT, and Src family k

114 Cycloheximide is a non-competitive inhibitor of both eEF3 and ATP.

115 In contrast, compound 3 was a competitive inhibitor of both FS-3 and the phosphodieste

116 substrate demonstrated that alpha-PanAm is a competitive inhibitor of Cab1.

117 factor ATF4 and that this complex acted as a competitive inhibitor of cAMP response element-binding (

118 sphonate derivative of l-lysine was a potent competitive inhibitor of Cc2672 with a K(i) value of 120

119 pound was shown to be a highly specific, ATP-competitive inhibitor of CDK9/CycT1 with antiviral activ

120 ro kinetic studies revealed that FTY720 is a competitive inhibitor of ceramide synthase 2 toward dihy

121 alidated using AZD7762, a small-molecule ATP-competitive inhibitor of CHK1 activation.

122 s a potent and selective DAT inhibitor and a competitive inhibitor of cocaine binding to the DAT.

123 adenosine diphosphate ribose (8Br-cADPr), a competitive inhibitor of cyclic ADP-ribose (cADPr) signa

124 9, CYP2D6, CYP2E1 and CYP3A4, but also a non-competitive inhibitor of CYP1A2, with Ki values no more

125 y, the effects of tetrahydrouridine (THU), a competitive inhibitor of cytidine deaminase, on the phar

126 erization showed that this compound is a non-competitive inhibitor of cytochrome c When tested in cel

127 ocholesterol is a bioactive sterol, a potent competitive inhibitor of cytochrome P450 7A1, and toxic

128 on, we demonstrated that Phe-Ade is a strong competitive inhibitor of CYTOKININ OXIDASE/DEHYDROGENASE

129 A known competitive inhibitor of DES, C(8)-cyclopropenylceramide

130 was a non-competitive inhibitor of XO and a competitive inhibitor of DPP-IV.

131 rious cellular stresses converts eIF2 into a competitive inhibitor of eIF2B, which triggers the integ

132 have previously reported a low nanomolar ATP-competitive inhibitor of EphB4 discovered in silico by f

133 sed if synthetic STR5 could serve as a novel competitive inhibitor of ERalpha and AR signaling by dis

134 m, where extracellular Na(+) should act as a competitive inhibitor of extracellular K(+) binding, whi

135 4 pockets, respectively, proved to be potent competitive inhibitor of factor Xa (fXa, Ki = 0.090 nM)

136 Finally, we demonstrate using Zn2+, a potent competitive inhibitor of Fe2+ binding and oxidation, tha

137 a secreted form, sFlt1, that functions as a competitive inhibitor of Flt1.

138 he resulting generation of UMP, a potent and competitive inhibitor of GnT-IX.

139 Hypoxanthine was a competitive inhibitor of guanine rescue, consistent with

140 % from d-lyxonolactone, is a potent specific competitive inhibitor of gut disaccharidases [K(i) 0.081

141 demonstrate that one of these fragments is a competitive inhibitor of HIV-1 RT with respect to deoxyr

142 s and in planta application of lovastatin, a competitive inhibitor of HMG1, we show that defects in H

143 nd characterized from Escherichia coli, is a competitive inhibitor of human ADAM9 catalytic/disintegr

144 ane protein (Omp) 19 from Brucella spp. is a competitive inhibitor of human cathepsin L.

145 5l, which is a potent (HeLa IC(50) = 19 nM) competitive inhibitor of IDO.

146 This molecule is a competitive inhibitor of K. pneumoniae OHCU decarboxylas

147 concept, we applied this approach to an ATP-competitive inhibitor of kinesin-5, a widely conserved m

148 rmine inhibition constants (K(i)) for a weak competitive inhibitor of Klenow fragment and two strong

149 ng studies with either a GRP78 antibody or a competitive inhibitor of ligand binding to LRP1.

150 aracterized the binding site of phosphate, a competitive inhibitor of LMW-PTPs, on MptpA and elucidat

151 ition to Hsp90 modulation, gedunin acts as a competitive inhibitor of LPS, blocking the formation of

152 r apparent stability, SSP IL-15 functions as competitive inhibitor of LSP IL-15.

153 AZD8055 is an ATP-competitive inhibitor of mammalian target of rapamycin (

154 dly reduced in the presence of gentamicin, a competitive inhibitor of megalin-dependent endocytosis.

155 The compound behaves as a selective and competitive inhibitor of mouse and human MAGL, which pot

156 s and was markedly inhibited by dicumarol, a competitive inhibitor of naphthoquinone oxidoreductases.

157 he thyroid (distinguished using ClO(4)(-), a competitive inhibitor of NIS), indicating that KCNQ1-KCN

158 The competitive inhibitor of NQO1 dicoumarol synergized with

159 GSK2656157 is an ATP-competitive inhibitor of PERK enzyme activity with an IC

160 showed that HG-829 is not a Pgp substrate or competitive inhibitor of Pgp-mediated drug efflux but ra

161 hat itself bears a Zalpha domain, a putative competitive inhibitor of PKZ.

162 ntified a potent, selective, reversible, ATP-competitive inhibitor of Plk1, GSK461364A, capable of in

163 We show that Dab2 acts as a competitive inhibitor of PP1 by binding to the same C-te

164 ed 2-aminoacetophenone as a pathway-inherent competitive inhibitor of PqsBC, whose fluorescence prope

165 The most promising competitive inhibitor of PvSUB1 (compound 2) was equally

166 l 2-methyl-2-hydroxypropyl-CoM (M-HPC) was a competitive inhibitor of R-HPCDH-catalyzed R-HPC oxidati

167 We found triacsin C to be a competitive inhibitor of RPE65 (IC50 = 500 nm).

168 P) substrate, whereas a second compound is a competitive inhibitor of RT polymerase activity with res

169 and autophagy impairments induced by the non-competitive inhibitor of sarco/ER Ca(2+)-ATPase, thapsig

170 iated IC(5)(0) values produced by glycine, a competitive inhibitor of serine racemase (SR).

171 report the discovery of the first substrate-competitive inhibitor of SETD8, UNC0379 (1).

172 otent, selective, and cell-active, substrate-competitive inhibitor of SMYD2, which is the first repor

173 but denaturation converted BSA into a strong competitive inhibitor of such proteolysis.

174 f 3MG uptake with Ki(app) = 0.3 mum but is a competitive inhibitor of sugar exit indicating that WZB1

175 ggest that the C terminus of SPI-1 acts as a competitive inhibitor of target proteases as it remains

176 nation, we found that chenodeoxycholate is a competitive inhibitor of taurocholate-mediated germinati

177 inobenzohydrazide was determined to be a non-competitive inhibitor of TBR-POD and Turnip-POD.

178 Furthermore, the S22 peptide is a competitive inhibitor of the 17b HIV-1 neutralizing anti

179 It is a competitive inhibitor of the acceptor glycyl-glycine, wh

180 f double-stranded DNA and a highly effective competitive inhibitor of the bacterial type I restrictio

181 o the BH4 domain of Bcl-2 and functions as a competitive inhibitor of the Bcl-2-IP(3)R interaction.

182 erwent apoptosis after treatment with an ATP-competitive inhibitor of the BCR-associated spleen tyros

183 Our study revealed that this compound is a competitive inhibitor of the binding of ATP and inhibits

184 nds has led to discovery of the first purely competitive inhibitor of the CTP.

185 at beta-aminoproprionitrile, an irreversible competitive inhibitor of the enzymatic activity of all l

186 One of these molecules acts as a competitive inhibitor of the enzyme and cures mice of th

187 4-Methyltryptophan is a competitive inhibitor of the enzyme that has been used i

188 ehyde and yield tagatose 1,6-bisphosphate, a competitive inhibitor of the enzyme.

189 as enhanced in cells treated with lactose, a competitive inhibitor of the galectin lattice, suggestin

190 e and following treatment with brodalumab, a competitive inhibitor of the IL-17 Receptor A subunit.

191 ommodating pyridine-2,6-dicarboxylic acid, a competitive inhibitor of the native enzyme, suggesting t

192 led that BMS-791325 is a time-dependent, non-competitive inhibitor of the polymerase.

193 Atovaquone, a 2-hydroxynaphthoquinone, is a competitive inhibitor of the quinol oxidation (Q(o)) sit

194 Bromide ion is a competitive inhibitor of the reaction indicating that it

195 Methenyl-dH(4)MPT is shown to be a competitive inhibitor of the reduction of methenyl-H(4)F

196 that UDP-(5F)-GlcNAc acts as a slow-binding, competitive inhibitor of the retaining glycosyltransfera

197 e kinetic studies showed that Crescent was a competitive inhibitor of Tolloid activity, which bound t

198 This is the first competitive inhibitor of UDG that is incorporated into D

199 AKB-9778 is a small-molecule competitive inhibitor of vascular endothelial-protein ty

200 Sunitinib is an orally available, ATP-competitive inhibitor of VEGF and PDGF receptors used cl

201 Tetrabenazine (TBZ) is a non-competitive inhibitor of VMAT2 that is used in the treat

202 Adamantyl Gb(3) is an amphipathic competitive inhibitor of VT1/VT2 Gb(3) binding.

203 more tightly, suggesting that Nan KLF1 is a competitive inhibitor of wild-type KLF1.

204 nalog Ubc5BC85S-ubiquitin oxyester acts as a competitive inhibitor of wild-type Ubc5B approximately (

205 and Burk analysis showed that Trp was a non-competitive inhibitor of XO and a competitive inhibitor

206 inetic analysis revealed that flavonoids are competitive inhibitors of ACE.

207 administration of "classical" antiandrogens, competitive inhibitors of androgen receptor (AR) ligands

208 on and may guide the rational drug design of competitive inhibitors of Arno enzymatic activity.

209 Competitive inhibitors of ATP binding to Hsp90 prevent c

210 aging chemotherapy is through the use of ATP-competitive inhibitors of ATR or Chk1.

211 , reveals that bile salts act as partial non-competitive inhibitors of ATX, thereby attenuating LPA r

212 Compounds 1 and 2 were competitive inhibitors of ATX-mediated hydrolysis of the

213 OPP, 4-SPP/SPP, and 5-SPP/SPP were excellent competitive inhibitors of avian farnesyl diphosphate syn

214 The final compounds behave as selective competitive inhibitors of beta-glucosidase and are promi

215 e discovered, as well as the first substrate-competitive inhibitors of c-Src with activity in both bi

216 trast, a subset of steroid hormones acted as competitive inhibitors of C. difficile spore germination

217 GNF-2 (1) and GNF-5 (2) as selective non-ATP competitive inhibitors of cellular Bcr-Abl kinase activi

218 l molecules and identified 13 small molecule competitive inhibitors of ctRAGE interaction with DIAPH1

219 etic compounds (CD4mc) bind gp120 and act as competitive inhibitors of gp120-CD4 engagement.

220 Competitive inhibitors of IDO are currently being tested

221 lly identified miRNA targets may actually be competitive inhibitors of miRNA function, preventing miR

222 Fortunately, non-ATP-competitive inhibitors of MK2 have been already discover

223 We suggest that dimers might be competitive inhibitors of monomer binding to iterons and

224 de phosphonates (ANPs) have been shown to be competitive inhibitors of MtHGPRT with Ki values as low

225 dy was to investigate adenosine triphosphate-competitive inhibitors of mTOR kinase previously unrepor

226 Kinetic studies showed that P3 and P4 are competitive inhibitors of mushroom tyrosinase.

227 ngs should allow for the rationale design of competitive inhibitors of mycolactone binding to N-WASP,

228 e more potent than any previously documented competitive inhibitors of NQO2 and represent the first m

229 ion in a program to identify pan-isoform ATP-competitive inhibitors of PDHK.

230 Competitive inhibitors of PLB reduced the ability of spe

231 onic acid (6a), were recognized as nanomolar competitive inhibitors of PNP isolated from cell lines w

232 phenylboronic acid (PBA) function as potent competitive inhibitors of PtNHase.

233 Nalpha-bis(carboxymethyl)-L-lysine (BCML) as competitive inhibitors of quinine-activated T2R4 with an

234 cked signaling activity while functioning as competitive inhibitors of RIG-I binding and IFN-beta exp

235 difications that convert activator RNAs into competitive inhibitors of RIG-I signaling may be useful

236 cluding benzoquinone and phenylquinone, were competitive inhibitors of sepiapterin reduction but nonc

237 amidine-based sphingosine analogues that are competitive inhibitors of sphingosine kinases exhibiting

238 We have developed ATP competitive inhibitors of TgCDPK1 that block invasion of

239 be broadly grouped into four categories: (1) competitive inhibitors of the accessory gene regulator (

240 contains the ATPase active site, but are not competitive inhibitors of the ATPase reaction.

241 ATP competitive inhibitors of the BRAF(V600E) oncogene parad

242 with TdT, explaining why these compounds are competitive inhibitors of the deoxynucleotide triphospha

243 phenols to generate potent and selective ATP-competitive inhibitors of the DNA damage response signal

244 Clinical use of ATP-competitive inhibitors of the epidermal growth factor re

245 hly selective non-metal chelating, substrate-competitive inhibitors of the JmjC KDMs.

246 hat combine the activities of allosteric and competitive inhibitors of the type-I insulin-like growth

247 Is), gefitinib and erlotinib, are reversible competitive inhibitors of the tyrosine kinase domain of

248 n and therefore have the potential to act as competitive inhibitors of this interaction.

249 starting point for a new class of substrate-competitive inhibitors of TNKS with potential for suppre

250 Interestingly, non-ATP-competitive inhibitors of TopoIIalpha, etoposide and mer

251 tracellular vestibule of LeuT and act as non-competitive inhibitors of transport.

252 eretin and (2S)-naringenin were validated as competitive inhibitors of UGM against NADPH with Ki valu

253 sed core scaffold and were identified as ATP-competitive inhibitors of wild-type EGFR.

254 the functional domain of BAI1 was used as a competitive inhibitor or BAI1 expression was inhibited b

255 ATP-competitive inhibitors OSI-027 and OXA-01 targeted both

256 and mTORC1 were completely inhibited by ATP competitive inhibitors PI103 and BEZ235 and partially in

257 mpetitive inhibitor Go6976 and the substrate-competitive inhibitor PKC 20-28, but not the activation-

258 We show that the ATP-competitive inhibitor PP242, but not rapamycin, signific

259 We found that 2 structurally distinct competitive inhibitors (PP242 and AZD8055), both of whic

260 These competitive inhibitors presumably act as KpnI binding si

261 Glutathione-competitive inhibitors produced dose-dependent thermal s

262 VMAT transport is inhibited by the competitive inhibitor reserpine, a second-line agent to

263 binary complexes with ADP and K252a, an ATP-competitive inhibitor (see Table 1), at 1.9 and 2.7 A re

264 ol-open model could identify a pseudopeptide competitive inhibitor showing >100-fold higher affinity

265 While many dications act as purely competitive inhibitors, some fail to displace protein ef

266 .7 cell lines expressing an inducible miR-29 competitive inhibitor (sponge construct), miR-29 knockdo

267 n together, our data lead us to suggest that competitive inhibitors stabilize hSERT in a state that i

268 depends on autophosphorylation, and that ATP-competitive inhibitors staurosporin and sunitinib, which

269 brief overview of results obtained with ATP-competitive inhibitors such as palbociclib and dinacicli

270 These results suggest that non-ATP-competitive inhibitors, such as GNF-2, can serve as chem

271 f various psychoactive substances, including competitive inhibitors, such as tricyclic antidepressant

272 We show that IP6 is a non-competitive inhibitor that acts by blocking the stimulat

273 Lysine is a competitive inhibitor that binds to the active site of T

274 We demonstrate activin A functions as a competitive inhibitor that blocks the ligand binding epi

275 erization of Torin2, a second-generation ATP-competitive inhibitor that is potent and selective for m

276 distal carboxy tail that resembles an enzyme competitive inhibitor that retunes channel affinity for

277 h N(G)-nitro-L-arginine, a slowly reversible competitive inhibitor that stabilizes nNOS, decreases bo

278 e drug discovery has been the finding of ATP-competitive inhibitors that behave as agonists, rather t

279 The compounds are substrate competitive inhibitors that bind to the docking site of

280 Ire1alpha as a target for development of ATP-competitive inhibitors that will modulate the UPR in hum

281 single agents, but when combined with an ATP-competitive inhibitor, they completely suppress the acti

282 that interacts with the ITK SH3 domain as a competitive inhibitor to disrupt the association between

283 Binding of a competitive inhibitor to the transporter leads to reduct

284 We apply these tools as competitive inhibitors to dissect the polyubiquitin-link

285 rted CpIMPDH inhibitors, these compounds are competitive inhibitors versus NAD(+).

286 showing that d-2-HGA, but not l-2-HGA, is a competitive inhibitor vs 4PE and a noncompetitive inhibi

287 the receptors TLR2, TLR4, RAGE, and P2Y1 as competitive inhibitors, we demonstrate that polyP amplif

288 irus-expressed short hairpin RNA (shRNA) and competitive inhibitors, we show that Ad-induced IL-1beta

289 Interestingly, ATP-/substrate-competitive inhibitors were found to be highly selective

290 rent K(i) values of a small set of LRRK2 ATP-competitive inhibitors were within 5-fold between Mg(2+)

291 studies, we propose that these compounds are competitive inhibitors, which mimics the oligonucleotide

292 avathrin." Avathrin is a fast, tight binding competitive inhibitor with an affinity of 545 pM for thr

293 mGluR1 and mGluR2, combining the same mGluR1 competitive inhibitor with an mGluR1 or mGluR2 NAM yield

294 We identified (-)-fenchone as a competitive inhibitor with different potencies at the tw

295 In the presence of 3-PGA, ADP-Glc is a competitive inhibitor with respect to ATP.

296 s been conducted showing that triclosan is a competitive inhibitor with respect to NADH and an uncomp

297 NADP(+) is a competitive inhibitor with respect to NADPH, demonstrati

298 -ethoxy-5,6-dibromosalicylaldehyde, is a non-competitive inhibitor with respect to the XBP-1 RNA subs

299 at interact with ClpA N-domains and is a non-competitive inhibitor with substrates that depend on int

300 TP binding pocket making it sensitive to ATP-competitive inhibitors with bulky substituents that comp