ライフサイエンスコーパス: complement

1 ochondrial peptidases to the total peptidase complement.

2 sight paving the way for novel modulators of complement.

3 elial cells, suggesting local involvement of complement.

4 d new layers of complexity to the biology of complement.

5 f ribonucleotide proteins, autoantibody, and complement.

6 hesion of monocytes in the presence of human complement.

7 antibacterial proteins such as lysozyme and complements.

8 The scaffold protein X-ray repair cross-complementing 1 (XRCC1) interacts with multiple enzymes

9 al detachments (PEDs) in a woman affected by Complement 3 (C3) glomerulopathy, which represents a spe

10 Response gene to complement 32 (RGC32) is a transcription factor that reg

11 TaVIT2 also complemented a manganese transporter mutant but not a va

12 Complement-activating anti-HLA donor-specific antibodies

13 tion of terminal complement complex on other complement-activating structures such as monosodium urat

14 tor receptor (EGFR) that effectively induces complement activation and CDC, are highly sought after.

15 Since complement activation and genetic variants in inhibitory

16 ariants have an impaired ability to regulate complement activation and may benefit more from compleme

17 RA101295 strongly inhibited E. coli-induced complement activation both in vitro and in vivo by block

18 Although complement activation by bacteria is well documented, wo

19 tional analyses indicate that FHR-1 enhances complement activation by competitive inhibition of FH bi

20 Complement activation end products and their receptors m

21 the classical pathway plays a major role in complement activation in patients with CRS.

22 nfusion did not produce measurable levels of complement activation in vivo.

23 Complement activation is a recognised mediator of myocar

24 ion and systemic angiopathy and suggest that complement activation may contribute to various human th

25 s provocative study suggests that inhibiting complement activation may heighten immunotherapeutic res

26 Marked local and systemic complement activation occurred in GCase-deficient mice o

27 tor and the resulting surface density of the complement activation product C3b, which autoamplifies v

28 our findings offer functional evidence that complement activation serves as a critical immunomodulat

29 te C1 and suggests a conserved mechanism for complement activation through the classical and the rela

30 Classical complement activation was inhibited by pretreatment of c

31 celerated antibody-mediated rejection (AMR), complement activation, and graft thrombosis.

32 assical, alternative, and lectin pathways of complement activation, and its cleavage products C3a and

33 ctive fragments C3a and C5a, produced during complement activation, can modulate both antigen present

34 athogenesis seems to be the vicious cycle of complement activation, endothelial cell damage, platelet

35 intramyelinic edema, interleukin-6 release, complement activation, inflammatory cell recruitment, an

36 splantation (HSCT) associated with excessive complement activation, likely triggered by endothelial i

37 rstanding of the mechanisms and locations of complement activation, which have added new layers of co

38 heir regulatory function for protection from complement activation.

39 iopulmonary distress in pigs irrespective of complement activation.

40 ify the severity of myocardial damage due to complement activation.

41 roteins have an important modulatory role in complement activation.

42 rombosis, acute phase response signaling and complement activation.

43 be explained by BCD-mediated attenuation of complement activation.

44 tic activity depended on the strength of the complement activator and the resulting surface density o

45 P) is an essential positive regulator of the complement alternative pathway (AP) providing stabilizat

46 Mutations in genes that encode the complement alternative pathway proteins or the molecules

47 MtBRI1 is able to complement an Arabidopsis BRI1 mutant, bri1-5.

48 of the posttraumatic immune response is the complement anaphylatoxin C5a, which acts via two recepto

49 ocardial dysfunction after generation of the complement anaphylatoxin, complement component 5a (C5a).

50 used for non-invasive detection of activated complement and in future could be exploited to quantify

51 ed the mechanism through which VWF modulates complement and its pathophysiological implications for h

52 previous findings that the interplay between complement and prions likely involves a complex balance

53 olely relying on transcriptomics data, which complements and improves the results of currently availa

54 online information on cell viability, which complements and supports other methods such as microscop

55 interwoven variations in sex, sex chromosome complement, and brain size.SIGNIFICANCE STATEMENT Cerebe

56 acute axonal degeneration in the presence of complement, and impair myelination.

57 given the existing clinical availability of complement antagonists.

58 substrate, and this activity was not able to complement APTX deficiency in mitochondrial extracts fro

59 of these, three were capable of functionally complementing Arabidopsis T-DNA insertion mutants in thi

60 For example, although natural Abs (NA) and complement are key components of the innate immune syste

61 deletion mutant lacking D14L, and with D14L complemented as well as their respective wild-type culti

62 otype by AAV-CRRY gene therapy suggests that complement attack on the RPE is an important etiologic f

63 This new approach complements available prodrugs/donors that directly deli

64 Solid-phase assays to distinguish complement binding from noncomplement binding HLA-specif

65 These discoveries have been complemented by a substantial suite of experimental stud

66 ainties is impossible, LCA results should be complemented by an uncertainty analysis.

67 Our data are complemented by cell division profiles and expression pa

68 A metagenomic approach was taken complemented by detection of N2 O released and nitrogen

69 icrosecond MD simulations in explicit water, complemented by hydrogen exchange mass spectrometry (HDX

70 Observations are complemented by intensification of absorbance peaks in F

71 This is complemented by outlining important knowledge gaps regar

72 In addition, bglc1 bglc3 was complemented by overexpression of either BGLC1 or BGLC3

73 These results were further complemented by pathway analysis (Molecular Mechanisms o

74 on mass spectrometry imaging (MALDI-MSI) and complemented by quantitative measurement of drug concent

75 Complemented by several alternative analytical approache

76 These results are complemented by showing that under basic forms of active

77 IgE-western blot and IgE-ELISA were complemented by Skin Prick Testing (SPT) and mediator re

78 13, using a genome-wide association approach complemented by targeted resequencing.

79 found that some of these phenotypes could be complemented by wild-type (WT) hematopoietic cells or ad

80 Genetic deficiency of complement C3 and factor D prevented both the systemic t

81 Complement C3 is important for the classical, alternativ

82 Genetic ablation of complement C3 or its inactivation with Cobra Venom Facto

83 lysis or fibrinogen, C-reactive protein, and complement C3) confirmed that denser clots are independe

84 ibrinolysis (plasmin-antiplasmin [PAP]), and complement (C3b, C5a, C5b-9) in baboons infused with fac

85 Complement C5A anaphylatoxin (C5A), lipopolysaccharide b

86 agulation proteases in vivo can activate the complement cascade in 2 highly coagulopathic models.

87 Triggering of the complement cascade induces tumor cell lysis via compleme

88 ight the importance of immune responses, the complement cascade pathway and the involvement of exosom

89 apies that target specific components of the complement cascade, rather than global inhibition, may b

90 , and MASP2, the activating proteases of the complement cascade.

91 a UL21-null virus was made and propagated on complementing cells to discourage selection of compensat

92 ovel technique for hypothesis generation and complements classic GWAS interpretation.

93 Here we characterize the complement, cluster, and expression of Hox genes in two

94 f anaphylatoxins (C3a, C5a) and the terminal complement complex (TCC) that together contribute to org

95 the PD parietal arterioles, C1q and terminal complement complex abundance correlated with the level o

96 ion independent of formation of the terminal complement complex and provide in vivo evidence for cont

97 Formation of terminal complement complex on other complement-activating struct

98 l and parietal arteriolar C1q, C3d, terminal complement complex, and phosphorylated SMAD2/3, a downst

99 Complement component 3 (C3) was upregulated in four lept

100 generation of the complement anaphylatoxin, complement component 5a (C5a).

101 , enable completely selective binding to the complement component C1q and activation of complement vi

102 atively regulates beta2 integrin adhesion to complement component iC3b and ICAM-1 in shear-free, but

103 R4, and TLR9 induces murine DC production of complement components and local production of the anaphy

104 ound proteins accelerate the assembly of the complement components of the alternative pathway on the

105 Our atomic overlap distance complements computed partial charges by measuring the si

106 nt or prevention of allograft rejection that complement contemporary immunosuppression and could lead

107 vity of CFH, a soluble protein containing 20 complement-control protein modules (CCPs 1-20), may be c

108 /MS-based quantification with DIA data, thus complementing conventional MS1-based quantification.

109 nsport, its heterologous expression in yeast complemented copper-specific defects observed upon delet

110 owth -mediated declines in Vcmax(25) on An , complementing current photosynthetic thermal acclimation

111 debris is a new therapeutic target that may complement cytotoxic cancer therapies.

112 By using various serum sources with defined complement deficiencies, we demonstrate that, under phys

113 Data on total resident complement, demographic information, and annual attritio

114 plement cascade induces tumor cell lysis via complement-dependent cytotoxicity (CDC) and attracts and

115 ral blood mononuclear cells, and had minimal complement-dependent cytotoxicity activity similar to th

116 It was shown that complement-dependent cytotoxicity and Ab-dependent cellu

117 mechanisms to delete target cells, including complement-dependent cytotoxicity, Ab-dependent cellular

118 ental approach for delineating the effect of complement-dependent effector-cell engagement in various

119 de novo donor-specific antibody (DSA) causes complement-dependent endothelial cell injury in kidney t

120 e cell surface can also lead to disseminated complement-dependent macrovascular thrombosis.

121 rovide in vivo evidence for contributions of complement-dependent membrane perturbations to prothromb

122 de-based drug leads, identified as clues for Complement-directed therapeutic development, are assembl

123 ound that the disulfide bond stabilizes self-complemented DraE (DraE-sc) by approximately 50 kJ mol(-

124 e multifaceted and contextual involvement of complement-driven networks in a wide range of inflammato

125 ts demonstrate a causal relationship between complement dysregulation and systemic angiopathy and sug

126 Complement dysregulation underlies several inflammatory

127 by which gonadal hormones and sex chromosome complement each contribute to lipid metabolism and assoc

128 d how these RecQ helicases co-operate and/or complement each other in response to cellular stress.

129 We state that these two landscapes complement each other with one crucial for stabilities o

130 ch hits from orthogonal screening approaches complemented each other for lead identification.

131 fects were mediated by caspase-11, TLR4, and complement, each of which trigger eicosanoid production

132 ymerase (pol) gamma and pol beta as possible complementing enzymes in the case of APTX deficiency.

133 impairment and Alzheimer's disease that can complement existing dimensional approaches for staging A

134 tive care teams is optimal, and services may complement existing programs.

135 r mimicking human lung cell exposure to NPs, complementing existing ALI systems.

136 measurement by LC-MS/MS holds the promise of complementing existing laboratory tests as a means of as

137 study reports a ddHRMS/MS method capable of complementing existing quantitative methodologies and su

138 nzymes with known or modeled structures, and complements existing experimental methods for specificit

139 gy and describing the theoretical tools that complement experimental research in this field, we will

140 Our prediction method complements experimental efforts, and demonstrates that

141 Variants were assigned to the complement, extracellular matrix (ECM), lipid, cell surv

142 human-inflamed tissue and allows binding of complement factor 1q (C1q) and activation of the classic

143 Complement factor 3 (C3) deficiency causes prolonged ble

144 crosis factor alpha (TNF-alpha) induction of complement factor B (CFB) in RPE cells.

145 ctivation and genetic variants in inhibitory complement factor H (CFH) are also features of both ARMD

146 Rare variants in the complement factor H (CFH) gene and their association wit

147 und in locus 1q31.3, containing the gene for complement factor H (lead single nucleotide polymorphism

148 ibiting drusen proteins and inflammatory and complement factors while upregulating nucleosome, riboso

149 contribute to age-related memory impairment, complementing findings in the rodent and human postmorte

150 The sensitivity of complement fixation (62 cases) was 66.1%, but the specif

151 zed after elimination of prozone effect, and complement-fixation was determined using C1q, C4d, or C3

152 In contrast, complement-fixing antibodies to merozoites did not decli

153 s of CP activation, such as capillary C4d or complement-fixing donor-specific antibodies (DSA).

154 CSDE1 as a somatically mutated driver gene, complementing four known drivers (HRAS, RET, EPAS1, and

155 Phosphor-inactive mutations of ICE1 complement freezing sensitivity in the ice1-2 mutant.

156 In vitro assays of complement function identified a single complement inhib

157 Abnormalities in complement functions occur in many infectious and autoim

158 Complementing genome sequence with deep transcriptome an

159 TMDs) have emerged as promising materials to complement graphene for advanced optoelectronics.

160 otein biomarkers in stool that outperform or complement hemoglobin in detecting CRC and advanced aden

161 resulting detailed conformational landscapes complement in an integrative manner the available experi

162 Given the role of complement in disease, there is a requirement for inhibi

163 ts, activation of the alternative pathway of complement in the carriers of rs800292 minor allele (Ile

164 f IgG-immune complexes and the activation of complement in the kidney have long been thought to promo

165 cell infiltrates, or the deposits of IgG and complement in the kidney.

166 n alleles found in cancer patients failed to complement in these assays.

167 nduction of increased titers of high-quality complement-independent antibodies with greater pre-F sit

168 In this context, CD55 functions in a complement-independent manner and required lipid raft lo

169 Our results complement information theoretic studies of granule laye

170 riant carriers may be important for upcoming complement-inhibiting therapies.

171 plement activation and may benefit more from complement-inhibiting therapy than patients with AMD in

172 several inflammatory disorders, and terminal complement inhibition has thus far afforded significant

173 of acute humoral injury is not reduced with complement inhibition in this chronic setting.

174 rticipants, but ENDATs were not reduced with complement inhibition.

175 pts (ENDATs), that may be attenuated through complement inhibition.

176 tion, which was partially reduced by genetic complement inhibition.

177 study suggested that eculizumab, a terminal complement inhibitor, produced clinically meaningful imp

178 s of complement function identified a single complement inhibitory compound, termed cmp-5, and mechan

179 by denatured HLA on SAB, antibody titre, and complement interference that causes a misleading low ass

180 s pigs to either serve as an alternative, or complement investigations from the mouse.

181 nt result; further research into the role of complement is needed.

182 ng whereby the IAV nuclear export uses it to complement its own nuclear export proteins (a site not t

183 n sequence identity between these two steps, complement known structural data, and suggest that PCSK9

184 for monitoring demographics may effectively complement labor-intensive approaches, with the potentia

185 t high dose (100 microg/ml) induced elevated complement, leukocyte CD11b and inflammatory mediators,

186 t and protecting ookinetes from the mosquito complement-like response, respectively.

187 Upstream inhibition of classical complement may be therapeutic to dampen mononuclear cell

188 Complement may play a key role in antibody-mediated reje

189 ty against M. catarrhalis through increasing complement-mediated attack, improving phagocytic killing

190 r polysaccharide was also protective against complement-mediated bactericidal activity in human ascit

191 E. coli-challenged baboons, implying reduced complement-mediated bacteriolysis, whereas treated anima

192 mplement proteins that could protect against complement-mediated damage.

193 0 mg/kg) of the anti-C1s antibody BIVV009 in complement-mediated disorders.

194 t increased resistance to antibody-dependent complement-mediated killing secondary to genetic deletio

195 ection E. coli strain to become sensitive to complement-mediated killing.

196 production compared to wild type and esat-6 complemented Mtb strains.

197 y and interpretability must be recognized as complements, not substitutes, when evaluating explanatio

198 on leaf curl Kokhran virus that lacks a full complement of a gene encoding a transcription activator

199 Gains and losses shape the gene complement of animal lineages and are a fundamental aspe

200 gence depends on the development of a proper complement of dendritic tips and transduction proteins i

201 ther studies are needed to fully explore the complement of diversity and resistance determinants with

202 id droplet (LD) functions are regulated by a complement of integral and peripheral proteins that asso

203 aphy (mCT) to trace the profiles of the full complement of large ocellar L-neurons in the male orchid

204 The complement of paramagnetic Cu(II) ions in the Mnx protei

205 rates for degradation from among the diverse complement of proteins present in mitochondria, yet the

206 In the present work we assessed the lncRNAs complement of Schistosoma mansoni, the blood fluke that

207 viruses and that all clones possessed a full complement of the TrAP gene.

208 e subclusters are present, each with its own complement of transcription factors and neurotransmitter

209 ell-bound lysibodies induced the fixation of complement on the bacterial surface, promoted phagocytos

210 n predict HF severity and prognosis that may complement or even outperform traditional markers, such

211 hanced in the presence of intact human serum complement or purified C3a or C5a.

212 GS-9620 may effectively complement orthogonal therapies designed to stimulate an

213 Its bandgap complements other widely studied two-dimensional materia

214 sed in ON-OFF direction-selective (DS) RGCs, complementing our previous work demonstrating that RGCs

215 This study complements our previous investigation on the transforma

216 ed CFH genetic variants had more alternative complement pathway deposits than controls.

217 sen formation, COL4 accumulation in ECM, and complement pathway gene alteration, it impacted the comp

218 The complement pathway mediates innate and acquired immunity

219 Variants in the complement pathway modify the clinical course of AMD and

220 Specific inhibition of the classical complement pathway using TNT003 or C1q-depleted serum si

221 ssion of hCD59, which regulates the terminal complement pathway, provides further protection.

222 tor 1q (C1q) and activation of the classical complement pathway.

223 the dominant Ig and proteins of the classic complement pathway.

224 ericidal activity of NHS via the alternative complement pathway.

225 in both diseases, including inflammasome and complement pathways.

226 nts lacked the ability to stimulate, and the complemented PF-positive T. denticola strain restored th

227 Complement plays a key role in host defense, but its dys

228 n of heritable mutations in human embryos by complementing preimplantation genetic diagnosis.

229 These results complement previous demonstrations of on-demand single-p

230 of hyperammonemia; these preclinical studies complement previous studies on ammonia-induced skeletal

231 d in the geometric morphometric toolkit that complements previous approaches to quantifying the facia

232 These results based on causal brain lesions complement prior neuroimaging studies in Parkinson disea

233 ether, our data position immune cell-derived complement production and autocrine/paracrine C3ar1/C5ar

234 Several complement proteins exacerbate prion disease, including

235 s, because rodent models indicate a role for complement proteins in synaptic pruning and neurodevelop

236 RI) and cardiomyocytes are a known source of complement proteins including the central component C3,

237 ophism, but also through modulation of local complement proteins that could protect against complemen

238 kness or the interaction of the capsule with complement proteins, but the effects of small chemical m

239 at coagulation proteases can directly cleave complement proteins.

240 d continued access to forest canopy may have complemented, rather than opposed, adaptations that faci

241 These results complement recent experimental evidence for immiscible m

242 However, the distinct roles of the two complement receptors C5aR1 and C5aR2 in bone has to date

243 5 orthologs have also been shown to bind the complement regulator protein factor H.

244 e this, many pathogens recruit soluble human complement regulators to their surfaces and hijack their

245 tion-optimized factor H showed full in vitro complement regulatory activity similar to that of plasma

246 g that VEGF inhibition could reduce cellular complement regulatory capacity.

247 A key effector of the complement response is the activation fragment C5a, whic

248 ve, microbes exposed to serum must evade the complement response.

249 lines was the time absent from a fluid-phase complement source; therefore, we hypothesized that loadi

250 Complement studies showed low C3 level in 22/50 (43%) an

251 ansduction in mice lacking IgM antibodies or complement, suggesting that alternative transduction pat

252 ell as the MASP SP inhibit the action of the complement system and also show a significant associatio

253 s and promote inflammatory responses via the complement system and inflammasome activation.

254 ms are poorly understood, roles for both the complement system and reactive macrophages have been imp

255 les exhibited particular upregulation of the complement system and respective regulatory pathways, wi

256 lar degeneration (AMD), rare variants in the complement system have been described, but their functio

257 study we established the involvement of the complement system in the recognition and the phagocytosi

258 The complement system is a front-line defense system that op

259 Activation of the complement system via classical, lectin, or alternative

260 ial sepsis triggers robust activation of the complement system with subsequent generation of anaphyla

261 ical matter for this pivotal protease of the complement system: in silico active site mapping for hot

262 broad link between the kinin-kallikrein and complement systems, and suggest a role of CPN1 in the co

263 in influenza A virus assembly were found to complement the lethal M2Y76A mutation.

264 Protein profiling of CTCs would complement the recent advances in enumeration, transcrip

265 , TbSTT3B, and TbSTT3C that can functionally complement the Saccharomyces cerevisiae OST, making it a

266 ional study by molecular docking was made to complement the structural study.

267 elieve that these data-driven approaches can complement the traditional method of close reading in de

268 sensitive phenotype of yeast strain G19, and complemented the low-K(+) -sensitive phenotype of Arabid

269 l versus noncanonical functions of DGCR8, we complemented the mutant mESCs with a phosphomutant DGCR8

270 the band gap, a promising strategy involves complementing the conventional PEC setup with additional

271 usual insulating behavior of such materials, complementing the physical picture previously presented

272 tive chemical inhibitor or short hairpin RNA complements the effects of idelalisib, as a single agent

273 As suspected, MoGlo3 partially complements the function of yeast Glo3p.

274 s a defense mechanism against pathogens that complements the mucous and secretory IgA Ab-mediated sys

275 of structure in temporal state dynamics that complements the well-described static spatial organizati

276 ion of various electrodeposited compounds to complement their ex situ characterization.

277 viduals and how this changes over time would complement these findings by enhancing understanding of

278 suppressor mutations in the M1 protein which complement this lethal M2 mutation by increasing the eff

279 t elevated CO2 Exogenous expression of BASS6 complemented this photorespiration mutant phenotype.

280 present three {P8W48}-based frameworks which complement those frameworks which have previously been d

281 Activation of complement through the alternative pathway has a key rol

282 sitivity and specificity, making it a useful complement to any NGS pipeline dealing with the analysis

283 o assess whether obtaining these images as a complement to bone reconstructions alters sensitivity, s

284 S treatment of epilepsy either alone or as a complement to drug treatments.

285 As a complement to the chemistry surrounding the loading, ext

286 lt tolerant and efficient, which is a useful complement to the current mainstream image registration

287 ies, but were not always perceived as useful complements to practice.

288 al approaches are important alternatives and complements to standard approaches that use segmented sp

289 fields of gastroenterology and hepatology to complement traditional means of diagnostic and therapeut

290 such as photosynthetic energy transfer, and complements traditional global and target analysis techn

291 ccess to polycyclic pyridine derivatives and complements transition-metal-catalyzed [2 + 2 + 2] strat

292 e moderately neutralizing in the presence of complement, VACV-138 and VACV-304 also fully blocked D8

293 e complement component C1q and activation of complement via the classical pathway without any concomi

294 ctate lyase, but not for the pectinesterase, complement water soaking when delivered by XgDeltaavrHah

295 activation was inhibited by pretreatment of complement with an anti-C1s antibody (TNT003).

296 actions to construct a focused HTB1 library, complemented with an experimental platform based on yeas

297 These maps, complemented with genetic perturbations, allowed us to u

298 on, especially when measures of TSPO are not complemented with other markers of inflammation.

299 to separate proteins that only fluoresce on complementing with one another.

300 ntified putative de novo mutations failed to complement yeast strains lacking the EEF1A ortholog show