ライフサイエンスコーパス: complement factor H

1 most common mutation is in the gene encoding complement factor H.

2 02 protein polymorphism in the gene encoding complement factor H.

3 ed, i.e., TSG-6, chemokines IL-8 and KC, and complement factor H.

4 The purified protein was identified as human complement factor H.

5 and OPN form rapid and tight complexes with complement Factor H.

6 the complement cascade C1q, C6, and C8; and complement factor H.

7 ble proteins, such as C-reactive protein and complement factor H.

8 We have recently reported that complement factor H, a negative regulator of complement-

9 Indeed, the binding of human complement factor H, a negative regulator of the alterna

10 Genetic investigations have shown that complement factor H, a regulator of the alternative comp

11 Ten loci in 7 AMD genes [complement factor H, age-related maculopathy susceptibil

12 Deficiency of complement factor H and mutations in CFH associate with

13 In mice deficient in complement factor H and transgenic for human CR1, solubl

14 The association of variants in complement factors H and B with age-related macular dege

15 g two host-derived fluid-phase regulators of complement, factor H and factor H-like protein 1 (FHL-1)

16 d with genetic complement abnormalities/anti-complement factor H antibodies, which paved the way to t

17 convalescent B1b cell-derived IgM recognizes complement factor H-binding protein (FhbA), a B. hermsii

18 Genetic risk was based on Y402H in complement factor H (CFH) and A69S in age-related maculo

19 ants were genotyped for polymorphisms in the complement factor H (CFH) and age-related maculopathy su

20 Two biologically related factors, complement factor H (CFH) and C-reactive protein (CRP),

21 the relationship between local (ie, ocular) complement factor H (CFH) and choroidal neovascularizati

22 Association of variants in the complement factor H (CFH) and complement factor B (CFB)

23 tion cluster at chromosome 1q32 contains the complement factor H (CFH) and five complement factor H-r

24 s study, we investigated the associations of complement factor H (CFH) and hemicentin-1 (HMCN1) with

25 ctivation and genetic variants in inhibitory complement factor H (CFH) are also features of both ARMD

26 In addition, to determine the regulation of complement factor H (CFH) by oxidative stress, in vitro

27 Genetic variations in complement factor H (CFH) confer greater risk for age-re

28 f this disease, identifying mutations in the complement factor H (CFH) gene and a locus on chromosome

29 Rare variants in the complement factor H (CFH) gene and their association wit

30 anding puzzle why non-coding variants in the complement factor H (CFH) gene are more strongly associa

31 Variations in the complement factor H (CFH) gene are tightly associated wi

32 S, with a focus on genetic variations in the complement Factor H (CFH) gene cluster and CFH autoantib

33 us carriers of the Y402H risk variant in the complement factor H (CFH) gene developed neovascular AMD

34 ransition at amino acid position 402) in the complement factor H (CFH) gene have a pharmacogenetics e

35 ty variants and protective haplotypes in the complement factor H (CFH) gene modulate risk for AMD.

36 mparted by carrying the Y402H variant in the complement factor H (CFH) gene on chromosome 1, recent e

37 on of a rare, high-penetrance variant in the complement factor H (CFH) gene that is also causally ass

38 Polymorphisms in the complement factor H (CFH) gene that reduce activity of C

39 A Tyr402His variant in exon 9 in the complement factor H (CFH) gene was also significantly as

40 A locus on chromosome 1q31.1 containing the complement factor H (CFH) gene was strongly associated w

41 inly been attributed to a risk allele in the complement factor H (CFH) gene.

42 ted maculopathy susceptibility 2 (ARMS2) and complement factor H (CFH) genotypes, and other factors,

43 Complement factor H (CFH) has recently been identified a

44 gh interaction with an SNP (rs380390) in the complement factor H (CFH) intron reported to be highly a

45 Complement factor H (CFH) is a central regulator of the

46 Complement factor H (CFH) is a component of the mammalia

47 Complement factor H (Cfh) is a key plasma protein in hum

48 Complement factor H (CfH) is a key regulator of the alte

49 Complement factor H (Cfh) is a key regulator of the alte

50 Complement factor H (CFH) is a major susceptibility gene

51 Complement factor H (CFH) is a negative regulator of the

52 Plasma complement factor H (Cfh) is a potent complement regulat

53 Complement factor H (CFH) is an important regulatory pro

54 Y402H and I62V substitutions in the gene for complement factor H (CFH) is strongly associated with ri

55 associated loci and 6 additional SNPs at the complement factor H (CFH) locus.

56 eptor 1 (CR1) on human erythrocytes (Es) and complement factor H (CFH) on rodent platelets perform im

57 This activation is efficiently suppressed by complement factor H (CFH) on self-surfaces but not on fo

58 smoking, and presence of risk alleles of the complement factor H (CFH) or age-related maculopathy sus

59 plicated in the disease pathology, including complement factor H (CFH) precursor and alpha-2-macroglo

60 Complement factor H (CFH) regulates complement activatio

61 erage of 10.1 years, individuals with 1 or 2 complement factor H (CFH) risk alleles derived maximum b

62 hyperopia, and AMD-susceptibility genotypes Complement Factor H (CFH) RS1061170 and Age Related Macu

63 Two loci in complement factor H (CFH) were included in a risk score

64 have associated a common variant (Y402H) of complement factor H (CFH) with a highly significant incr

65 tomegalovirus (CMV) immunoglobulin (Ig)G and complement factor H (CFH) Y402H genotype.

66 These include complement factor H (CFH), a negative regulator of C3 ac

67 t form of HUS maps to chromosome 1q and that complement factor H (CFH), a regulatory component of the

68 Ten genetic loci in 7 genes [complement factor H (CFH), age-related maculopathy susce

69 mplementary to the 3'-untranslated region of complement factor H (CFH), an important repressor of the

70 y complement fluid-phase regulatory protein, complement factor H (CFH), are strongly associated with

71 Genetic variants of complement factor H (CFH), C3, C2, and FB associated wit

72 ilies were filtered for rare variants in the complement factor H (CFH), complement factor I (CFI), co

73 Genetic variation across the genes encoding complement factor H (CFH), factor B (CFB) and component

74 with the physiological complement inhibitor, complement factor H (CFH), for ligand binding.

75 sm, encoding the sequence variation Y402H in complement factor H (CFH), has been strongly associated

76 Variants of the CFH gene, encoding complement factor H (CFH), show strong association with

77 Two common variants in the gene encoding complement factor H (CFH), the Y402H substitution (rs106

78 that binds the negative complement regulator complement factor H (CFH), thereby inhibiting the altern

79 ponses by hijacking a host-immune regulator, complement factor H (CFH), to the bacterial surface.

80 ly it to a comparison of hemopexin (HPX) and complement factor H (CFH), two liver-secreted glycoprote

81 Complement factor H (CFH), which inhibits complement act

82 ificant peak was found on chromosome 1, near complement factor H (CFH), with P= 6.20 x 10(-4).

83 th age, sex, smoking status, presence of the complement factor H (CFH)-rs1061170 and age-related macu

84 oth common and rare, in the coding region of complement factor H (CFH).

85 omplement proteins or autoantibodies against complement factor H (CFH).

86 ted maculopathy susceptibility 2 (ARMS2) and complement factor H (CFH).

87 ANGPT1) and four retinal genes interact with Complement Factor H (CFH).

88 her [age-related macular degeneration (AMD); complement factor H (CFH)], or even three disease charac

89 Genetic risk factors such as variations in complement factors H (CFH) and B (CFB) have been implica

90 Human complement factor H, consisting of 20 complement control

91 Human complement factor H controls spontaneous activation of c

92 model of MPGN that develops spontaneously in complement factor H-deficient mice (Cfh(-/-)).

93 ns extend freely into solution when the five complement factor H domains are bound within C3b.

94 Further, we show that complement factor H (FH) binds mCRP to dampen its proinf

95 The ability to recruit complement factor H (FH) by S. pneumoniae has been impli

96 PspC was found to bind human complement factor H (FH) by Western blot analysis of D39

97 plement control protein (CCP) modules within complement factor H (fH) encompass binding sites for C3b

98 iC3b, and C3dg and enhanced competition with complement factor H (FH) in surface plasmon resonance (S

99 Complement factor H (FH) inhibits complement activation

100 Complement factor H (fH) is a plasma protein that regula

101 The complement factor H (FH) mutation R1210C, which was desc

102 Numerous complement factor H (FH) mutations predispose patients t

103 The Tyr402His polymorphism of complement factor H (FH) with 20 short complement regula

104 soluble plasma-regulatory proteins including complement factor H (fH), a 155 kDa protein composed of

105 ement-mediated innate immunity by recruiting complement factor H (FH), a complement alternative pathw

106 Complement factor H (fH), a molecule that downregulates

107 human secretory immunoglobulin A (sIgA) and complement factor H (FH).

108 ve regulator of the AP is the plasma protein complement factor H (FH).

109 Alternative pathway activity is inhibited by complement factor H (FH).

110 MD (P = .03); between rs2669845 and Y402H in complement factor H for AMD (P = .04); and between rs266

111 Polymorphisms in the complement factor H gene (CFH) are associated with a sig

112 typed, an intronic and common variant in the complement factor H gene (CFH) is strongly associated wi

113 actors--smoking and the Y402H variant of the complement factor H gene (CFH)--we used logistic regress

114 a contiguous 358 kb region that contains the Complement Factor H gene cluster.

115 tion studies have found variation within the complement factor H gene family links to host susceptibi

116 Inherited variation in the complement factor H gene is a major risk factor for drus

117 kely caused by the Y402H polymorphism in the complement factor H gene is a recognized risk factor for

118 T-->C substitution in exon 9 (Y402H) of the complement factor H gene is strongly associated with sus

119 age, sex, and the Y402H polymorphism in the complement factor H gene on chromosome 1q) and mortality

120 DNA resequencing of the complement factor H gene within this haplotype revealed

121 Complement factor H genotype had no effect on the respon

122 Deficiency of complement factor H has long been associated with MPGN.

123 ain, antithrombin III, Fas ligand, factor V, complement factor H, IgK, and Fas.

124 work presented here demonstrates that human complement factor H is an adhesion ligand for human neut

125 und in locus 1q31.3, containing the gene for complement factor H (lead single nucleotide polymorphism

126 n up to 50% of cases, caused by mutations in complement factor H, membrane cofactor protein, factor I

127 etic mutation causing aHUS, including 4 with complement factor H mutations.

128 fluid-phase CRP to six immobilized proteins: complement factor H, oxidized low-density lipoprotein, c

129 serine peptidase 1) (P =2.7 x 10(-72)), CFH (complement factor H) (P =2.3 x 10(-47)), C2 (complement

130 The complement factor H R1210C rare variant confers the stro

131 The typical phenotype of the complement factor H R1210C rare variant is associated wi

132 is revealed a novel heterozygous mutation in complement factor H (R83S) in addition to known risk pol

133 tients carrying a genetic abnormality in the complement factor H related 1 gene (CFHR1) that originat

134 We demonstrate that complement factor-H related 3 (CFHR3) promotes immune ac

135 Copy number variations in the complement factor H-related (CFHR) gene cluster on chrom

136 and identified a chromosomal deletion in the complement factor H-related (CFHR) gene cluster.

137 The autoimmune renal disease deficient for complement factor H-related (CFHR) genes and autoantibod

138 tains the complement factor H (CFH) and five complement factor H-related (CFHR) genes.

139 n includes genomic rearrangements within the complement factor H-related (CFHR) locus.

140 The role of the complement factor H-related (FHR) proteins in homeostasi

141 C3G-associated genomic mutation in the gene complement factor H-related 1 (CFHR1), which encodes FHR

142 onstrates that a duplication within the gene complement factor H-related 1 (CFHR1; encoding FHR1) lea

143 ociation studies have shown that deletion of complement factor H-related genes 1 and 3 (CFHR3,1Delta)

144 e association studies identified deletion of complement factor H-related genes 1 and 3 as protective

145 Human complement factor H-related protein (CFHR) 4 belongs to

146 ing the association of rs7517126 with plasma complement factor H-related protein 1 (CFHR1) level at p

147 , Factor H, Factor H-like protein-1 (FHL-1), complement Factor H-related protein 1 (CFHR1), and plasm

148 and endogenous nitric oxide production) and complement factor H-related protein 2 (CFHR2, related to

149 e cosegregated with the same mutation in the complement factor H-related protein 5 gene (CFHR5).

150 Complement factor H-related proteins (FHRs) are strongly

151 riants suggest decreased inhibition of C3 by complement factor H, resulting in increased activation o

152 Interactions with complement factor H (rs1061170), age-related maculopathy

153 The role of complement factor H still needs to be better defined, bu

154 d, followed by the first five SCR domains of complement factor H that bind to complement C3b.

155 noncoding variant in CFH, the gene encoding complement factor H, that substantially increases the in

156 with these diseases affect the glycoprotein complement factor H, the main regulator of the alternati

157 first to a cell surface receptor and then to complement Factor H thereby blocking the lytic activity

158 are disrupted by the abundant serum protein, complement Factor H, thereby probably limiting SIBLING-m

159 characteristic of sub-RPE deposits, such as complement factor H, vitronectin, and amyloid beta, reve

160 a-2-glycoprotein and positively with afamin, complement factor H, VLDL-associated apolipoproteins, an

161 leukin-6 (IL-6), interleukin-10 (IL-10), and complement factor H was unaffected.

162 venger receptors, IgM natural antibodies and complement factor H, which bind, neutralize and/or facil

163 association of ARM with the Y402H allele of complement factor H, which has previously been reported

164 e mutant also had decreased binding of human complement Factor H, which in previous studies increased

165 Maculopathy Susceptibility 2 rs10490924 and Complement Factor H Y402H (P for trend = 4.2x10(-7)).