ライフサイエンスコーパス: complement protein

1 nhibited the binding of fH, a downregulatory complement protein.

2 receptor for multiple collectins and the C1q complement protein.

3 vascular endothelium, both produce C3 and C4 complement protein.

4 and C5a, potent anaphylatoxins derived from complement proteins.

5 ndependent of complement activation or other complement proteins.

6 re of receptors that directly bind activated complement proteins.

7 data derived from targeted gene deletions of complement proteins.

8 as animals that were deficient in individual complement proteins.

9 1r and C1s, the serine proteases that cleave complement proteins.

10 nching fibrils (12-24 nm) composed of Ig and complement proteins.

11 myloid (fAbeta) and other components such as complement proteins.

12 with thrombospondin, properdin, and several complement proteins.

13 at coagulation proteases can directly cleave complement proteins.

14 immune cell type capable of synthesizing all complement proteins.

15 l as on the local concentration of available complement proteins.

16 ent for binding to the excision repair cross-complementing protein 1 (ERCC1)/xeroderma pigmentosum co

17 se) polymerase 1 (PARP1), X-ray repair cross-complementing protein 1 (XRCC1) and tyrosyl-DNA phosphod

18 SSBR complex mediated by X-ray repair cross-complementing protein 1 (XRCC1) is assembled sequentiall

19 polymerase 1 (PARP1), and X-ray repair cross-complementing protein 1 (XRCC1), all essential component

20 edox factor-1 (Ref-1) and X-ray repair cross-complementing protein 1 (XRCC1), relevant to neurodegene

21 d the scaffolding protein X-ray repair cross-complementing protein 1 (XRCC1), which completes the fou

22 omplexes, in turn recruit X-ray repair cross-complementing protein 1 (XRCC1).

23 nuclear partner protein, X-ray repair cross-complementing protein 1 (XRCC1).

24 In contrast, cells deficient in x-ray cross-complementing protein 1, DNA polymerase beta, or poly (A

25 X-ray repair cross-complementing protein-1 (XRCC1)-deficient cells are sens

26 mologous to SP-A, mannose-binding lectin and complement protein 1q, did not.

27 hrough cross-linking the B-cell receptor via complement protein 3d and antigen to the complement rece

28 dditional factors, XRCC4 (X-ray repair cross-complementing protein 4), XLF (XRCC4-like factor/Cernuno

29 , a humanized monoclonal antibody that binds complement protein 5 (C5).

30 Complement protein 5 fragments or formylmethionyl-leucyl

31 culizumab, a monoclonal antibody against the complement protein 5, stops the intravascular hemolysis

32 After excluding complement proteins, a series of studies identified chon

33 with axons and myelin, it is unknown whether complement proteins affect axon growth or regeneration.

34 nd how polymorphisms in genes encoding human complement proteins affect susceptibility to this import

35 Complement proteins aid in the recognition and clearance

36 ring Western blots and immunoprecipitated C4 complement protein and alpha-2-macroglobulin.

37 d a novel way to coat themselves with the C3 complement protein and invade macrophages by interaction

38 available concerning the interaction between complement proteins and capsule type 5 and 8 Staphylococ

39 ecent papers reporting on the association of complement proteins and complement regulators with high

40 es were able to activate deposition of human complement proteins and passively protect against challe

41 Recent evidence indicates that complement proteins and receptors are synthesized on or

42 everal other proteins including the terminal complement proteins and the neural adhesion molecules F-

43 I discuss immune and nonimmune functions of complement proteins and the tumor-promoting effect of co

44 Using purified classical activation pathway complement proteins and the Western blot assay, we showe

45 gocytes, NK cells, NKT cells, cytokines, and complement proteins) and later by the adaptive immune sy

46 Sequence variations in complement proteins are associated with age-related macu

47 formation, structures, and interplay between Complement proteins are complex, and this has limited ou

48 Complement proteins are involved in early innate immune

49 Complement proteins are localized to developing CNS syna

50 Since complement proteins are produced in virtually any cell i

51 Complement proteins are profoundly upregulated in many C

52 Over 40 "Complement" proteins are produced in blood or on cell su

53 ehydrogenase and TM0449 thymidylate synthase-complementing protein are presented as examples of final

54 onclusion, this study documents functions of complement proteins as prosurvival factors that, through

55 The ways complement proteins assemble on nanoparticles have remai

56 Small molecule photoswitches could complement protein-based switches by mitigating potentia

57 e deposits were immunopositive for Abeta and complement proteins but did not stain for conventional a

58 kness or the interaction of the capsule with complement proteins, but the effects of small chemical m

59 n C3 allowed insight into the recognition of complement proteins by invading pathogens.

60 The complement protein C1q binds to apoptotic cells, facilit

61 Complement protein C1q is induced in the brain in respon

62 Complement protein C1q is required to maintain immune to

63 Mice deficient in complement protein C1q or the downstream complement prot

64 time, to our knowledge, a unique function of complement protein C1q, as a molecular bridge between pn

65 croglia also express C1qR(P), a receptor for complement protein C1q, ligation of which in vitro enhan

66 The complement protein C1q, mannose-binding lectin (MBL), an

67 interaction, whereby pneumococci use a host complement protein C1q, primarily involved in the host-d

68 ACRP30 is a close homologue of the complement protein C1q, which is involved in the recogni

69 orrelates strongly with synaptic markers and complement protein C1q.

70 Immune molecules, including complement proteins C1q and C3, have emerged as critical

71 sue, we subjected mice deficient in selected complement proteins (C1q, C3, C5) to transient focal cer

72 ization of fAbeta microaggregates to that of complement protein, C1q-coated fAbeta microaggregates, a

73 was shown to bind to collagen type V and the complement protein, C1q.

74 lyses identified a gene signature, including complement protein C1qB and eukaryotic translation initi

75 scube1 (signal peptide-CUB (complement protein C1r/C1s, Uegf, and Bmp1)-EGF domain-c

76 NT003, a mouse monoclonal antibody targeting complement protein C1s, prevents induction of in vitro h

77 ammalian and insect cell-derived NS1 bind to complement proteins C1s, C4, and C4-binding protein, as

78 Type II complement protein C2 deficiency is characterized by a s

79 We identify complement protein C3 as an astroglial target of NFkappa

80 rprisingly, the functional deficiency of the complement protein C3 did not rescue the abnormal reprod

81 in complement protein C1q or the downstream complement protein C3 exhibit large sustained defects in

82 tor B (FB) and factor D (FD) and the central complement protein C3 in genotyped human postmortem dono

83 sults suggest a novel and prominent role for complement protein C3 in mediating aged-related and regi

84 Complement protein C3 is a 187-kDa (1641-aa) protein tha

85 Complement protein C3 is the converging point for activa

86 Importantly, deletion of the complement protein C3 or the receptor for the anaphylato

87 nd that the opsonic fragments of the central complement protein C3, C3b and iC3b, were present on the

88 Plasminogen binds the central complement protein C3, the C3 cleavage products C3b and

89 tein produced by S. aureus that binds to the complement protein C3.

90 ens from the body is the covalent binding of complement proteins C3 and C4 to their surfaces.

91 m earlier studies by Prodeus et al. in which complement proteins C3 and C4 were shown to be required

92 is known about other neisserial targets for complement proteins C3 and C4, which covalently attach t

93 Modeling of homologous domains from complement proteins C3 and C4, which do not participate

94 r, as well as the synthesis and secretion of complement proteins C3 and C5.

95 th their identical functions in cleaving the complement proteins C3 and C5.

96 Prominent deposition of complement proteins C3 and C9 in brains of MRL/lpr mice

97 ation of the antimicrobial peptide LL-37 and complement proteins C3, C4, and C5.

98 CD27 ligand and 4-1BB ligand, and the third complement protein (C3), which positions LIGHT within th

99 tivation products (C3bc and C4bc) and native complement proteins (C3 and C4).

100 in two flavors: (i) proteolytic fragments of complement proteins (C3, C4, C5) generated during activa

101 , a serine protease that cleaves the central complement protein, C3.

102 Using complement protein C3a as a marker of complement activat

103 asmin(ogen) bound to PGK cleaved the central complement protein C3b thereby further modifying the com

104 minogen activator, generated plasmin cleaved complement protein C3b thus assisting in complement cont

105 asles virus for binding to CD46 but not with complement protein C3b.

106 ound plasmin was able to degrade the central complement proteins C3b and C5 and inhibited the bacteri

107 1b/CD18, Mac-1) mediates the phagocytosis of complement protein (C3bi)-coated particles.

108 35 or transferred into mice deficient in the complement protein C4 are not anergized by soluble self-

109 The complement protein C4, encoded by two genes (C4A and C4B

110 ease and they also displayed lower levels of complement proteins C4 and C3 in blood.

111 Deposition of the complement protein C4d in renal allograft biopsies obtai

112 complement by blocking the activation of the complement protein C5 and shows remarkable clinical bene

113 The complement protein C5 initiates assembly of the membrane

114 Although proteolytic activation of the complement protein C5 initiates important defensive and

115 e of the innate immune system along with the complement protein C5 on exosomes' rate of clearance.

116 This antibody against terminal complement protein C5 reduces intravascular hemolysis, h

117 mab, a humanized monoclonal antibody against complement protein C5 that inhibits terminal complement

118 ymph tissue of mice immunized with the human complement protein C5, fused with a limited repertoire o

119 rapeutic monoclonal IgG that neutralises the complement protein C5--in neuromyelitis optica spectrum

120 PSA was able to cleave iC3b and the related complement protein C5.

121 , immunoglobulin light chains, Factor X, and complement proteins (C5 and C5b-9 complex) were identifi

122 Using purified distal complement proteins (C5-9) to assemble functional MAC on

123 Complement protein C5a, acting via C5aR, is shown in thi

124 activation of eosinophils with TNF-alpha and complement protein C5a, respectively.

125 scpA, encoding a peptidase that inactivates complement protein C5a.

126 Activated terminal complement proteins C5b to C9 form the membrane attack c

127 bstrate-binding domain, was found to bind to complement proteins C8 and C9 and to inhibit zinc-induce

128 ently by blocking the hCD59-binding site for complement proteins C8alpha and C9.

129 As part of the membrane attack complex complement protein C9 is responsible for direct killing

130 ever, a very recent study has indicated that complement proteins can also promote tumor growth.

131 Previous studies have suggested that complement proteins can contribute to the immune surveil

132 mplement protein, falling at the base of the complement protein clade.

133 t the liver, which produces large amounts of complement proteins, clears activators of complement and

134 mined for immunoreactivity (IR) of classical complement proteins (Clq and C3), markers indicating act

135 Experiments using human serum as a source of complement proteins confirmed Pic proteolytic activity o

136 arious inactive mutant permease proteins can complement proteins containing mutations at position 257

137 A fragment of this protein spanning the two complement protein (CP)-modules (residues 126 to 243) wh

138 external factors including immunoglobulins, complement proteins, cytokines, chemokines, integrins, a

139 es are intravenously injected into the body, complement proteins deposit on the surface of nanopartic

140 The detection of complement proteins deposited within transplanted tissue

141 t information is available about the role of complement proteins during enteric infections.

142 h complete deficiencies of one of the plasma complement proteins enabled the field to move beyond the

143 We have complemented protein-encoded defects in HCV by construct

144 Several complement proteins exacerbate prion disease, including

145 source of C4 and raise the possibility that complement protein expression by the cells plays a role

146 Reestablishment of complement protein expression was found to be mediated b

147 he ability of NK cells to positively mediate complement protein expression.

148 To investigate the role of complement protein factor B (Bf) and alternative pathway

149 ulin, shows that SpC3 is the first divergent complement protein, falling at the base of the complemen

150 We investigated deposition of the complement protein fragment C3b and its breakdown produc

151 w variants of the streptococcal inhibitor of complement protein has been implicated in the perpetuati

152 C1q signature domain, also found in many non-complement proteins, has a compact jelly-roll beta-sandw

153 The multiple interconnections among complement proteins, immune cells, and mediators provide

154 luding the major histocompatibility complex, complement proteins, immunoglobulin receptors, cytokines

155 In vitro, C1q, in the absence of other complement proteins, improves neuronal viability and neu

156 plement activation in vitreous, but not with complement proteins in BM/C protein extracts.

157 ceptor C3aR, revealing an unexpected role of complement proteins in early vertebrate development.

158 The distinct expression profile of complement proteins in regenerative tissues of the urode

159 that rs800292 was associated with levels of complement proteins in serum.

160 ic lupus erythematosus (SLE) but the role of complement proteins in SLE is not yet clear.

161 s, because rodent models indicate a role for complement proteins in synaptic pruning and neurodevelop

162 The function of complement proteins in the brain appears analogous to th

163 To determine possible sources of complement proteins in the brain, we investigated by in

164 mplement pathway that leads to deposition of complement proteins in the renal glomerulus.

165 RI) and cardiomyocytes are a known source of complement proteins including the central component C3,

166 Several complement proteins interact with hemostatic factors.

167 ectrometry was used to specifically quantify complement proteins interacting with the cartilage expla

168 Our results demonstrate that the complementing protein interacts directly with apobec-1 i

169 ntigen presentation and protein degradation, complement proteins, interferon-regulated proteins, and

170 in this superfamily, a unique feature of the complement proteins is a 150-residue-long C-terminal ext

171 Opsonization of bacteria by complement proteins is an important component of the imm

172 e to proteins provided in trans, even if the complementing protein is translated from a different cis

173 ent peripheral T cells were bound by IgM and complement proteins, leading to the elimination of these

174 Complement protein levels were found elevated in the cer

175 ral definition and biological activity, thus complementing protein ligation and recombinant protein e

176 0) is a member of the Ixodes scapularis anti-complement protein-like family of tick salivary proteins

177 he alternative pathway and absence of the LP complement protein mannan-binding lectin abrogates elast

178 Similarly, synapses tagged with complement proteins may be eliminated by microglial cell

179 Whole-blood transcriptome findings complement protein measurement from the site of disease,

180 Recent studies have indicated that complement proteins might exert novel functions that are

181 r on cell surfaces through activation of the Complement protein network mainly by infection or injury

182 With the availability of new structures for Complement proteins, new knowledge of how they function,

183 , we demonstrate that C1q, but neither other complement proteins nor FcRgamma, is required for early

184 Deposition of complement proteins on the bacteria was monitored by Wes

185 Plasma complement protein or activation product levels were sim

186 Opsonization with either complement proteins or antibody is not required for upta

187 ttack against host cells due to mutations in complement proteins or autoantibodies against complement

188 These include complement proteins, other bactericidal peptides, cytoki

189 ion, but increasing evidence also implicates complement proteins produced locally within the graft, i

190 C to PMN-synthesized concentrations of these complement proteins promoted astrogliogenesis and cell m

191 first time, to our knowledge, that the human complement protein properdin binds to early apoptotic T

192 The complement protein properdin, traditionally viewed as a

193 Cytoskeletal and complement proteins, proteases, and their inhibitors wer

194 the protein to the plasma membrane, thereby complementing protein-protein interactions, located in f

195 The intricate system of serum complement proteins provides resistance to infection.

196 cell response more strongly than circulating complement protein, raising the possibility that there i

197 ts cDNA-derived amino acid sequence contains complement protein-repeating modules (CP) 1-6, 28, 29, a

198 Complement proteins resulting from activation of the cla

199 Serum depleted of individual complement proteins revealed that C3 and factors B and D

200 eletion strains expressing either one of the complementing proteins revealed that in addition to a cy

201 omplement factor B (Cfb), in detail, because complement proteins secreted by cells other than cardiom

202 the hypervariable streptococcal inhibitor of complement protein (Sic).

203 e TED (thioester-containing domain) and CUB (complement protein subcomponents C1r/C1s, urchin embryon

204 The occurrence of APOBEC-1-complementing proteins suggested a naturally occurring m

205 he liver constitutes the primary circulating complement protein synthesis site, extrahepatic synthesi

206 (W54011) demonstrated that the activation of complement proteins synthesized by pulp fibroblasts and

207 Recent work suggests that genes encoding complement proteins that are active in the innate immune

208 C8 is one of five complement proteins that assemble on bacterial membranes

209 ophism, but also through modulation of local complement proteins that could protect against complemen

210 ack complex generated from the five terminal complement proteins that directly binds to and penetrate

211 role for function-altering mutations in the complement proteins that form or regulate the alternativ

212 AMD is associated with genetic variation in complement proteins that results in enhanced activation

213 sess the structures of these segments of the complement proteins, their relationships with other doma

214 e Fabs shows how Biacore T100 can be used to complement protein therapeutic discovery programs from b

215 the contribution of individual inflammatory complement proteins to spinal cord injury (SCI) patholog

216 nionic lipids in the binding of the terminal complement proteins to the membrane and the efficiency o

217 mined the contribution of activated terminal complement proteins to the pathogenesis of the lupus-lik

218 e lack of CRP and the exposure of activating complement proteins to tubular cells, alternative comple

219 to quantify the attachment of HUVEC-released complement proteins to ULVWF strings secreted by, and an

220 as ascertained by measuring levels of plasma complement proteins using an enzyme-linked immunosorbent

221 The association of terminal complement proteins was investigated by analytical ultra

222 was specific in that synthesis of two other complement proteins was normal.

223 The production of other complement proteins was normal.

224 , 80 kDa), with actively assembling terminal complement proteins were characterized.

225 The xeroderma pigmentosum group A complementing protein (XPA) and eukaryotic replication p

226 The xeroderma pigmentosum group A complementing protein (XPA) is believed to be involved i

227 interact with Xeroderma pigmentosum group A complementing protein (XPA), a key protein involved in n