ライフサイエンスコーパス: complement system

1 eceptors TLR-2 and TLR-4, FcgammaRs, and the complement system).

2 le (non-hemolytic, and poor activator of the complement system).

3 regulation of the alternative pathway of the complement system.

4 the activation and effector functions of the complement system.

5 o self versus non-self discrimination by the complement system.

6 hology by their capacity to overactivate the complement system.

7 ic circulation through the regulation of the complement system.

8 se, including the bactericidal effect of the complement system.

9 ve evolved multiple strategies to escape the complement system.

10 sist the antimicrobial activity of the human complement system.

11 Activated platelets can activate the complement system.

12 ble to malignancy through proteolysis of the complement system.

13 his was independent on the activation of the complement system.

14 PPARalpha and TNFalpha in the regulation of complement system.

15 several strategies to evade detection by the complement system.

16 e implicated an interaction of Trx1 with the complement system.

17 f the central regulatory component C3 of the complement system.

18 mers is critical to evade recognition by the complement system.

19 ere they may interact with components of the complement system.

20 . enterocolitica effectively evades the host complement system.

21 y proteins of the alternative pathway of the complement system.

22 Ps are activated, which in turn activate the complement system.

23 and protection was dependent upon an active complement system.

24 isticated array of proteins that inhibit the complement system.

25 ein (VCP), respectively, to subvert the host complement system.

26 ere, we report a novel role for CFHR4 in the complement system.

27 antibody-independent activation route of the complement system.

28 nd protects the pathogen from killing by the complement system.

29 well-established activation pathways of the complement system.

30 teases involved in blood coagulation and the complement system.

31 lular functions and include among others the complement system.

32 release of IL-17F and its regulation by the complement system.

33 as an opsonin and through activation of the complement system.

34 to the resultant renal injury, including the complement system.

35 plex relationship between merozoites and the complement system.

36 neurodegeneration, this study focused on the complement system.

37 influence recognition of C. albicans by the complement system.

38 at SV5 may have mechanisms to evade the host complement system.

39 eptors on effector cells, in addition to the complement system.

40 ss virulence factors that inhibit the host's complement system.

41 ein being responsible for homeostasis of the complement system.

42 e evasion proteins, many of which target the complement system.

43 oniae and subsequent activation of the mouse complement system.

44 h respect to regulators and receptors of the complement system.

45 ities in the alternative pathway (AP) of the complement system.

46 of the three main activation cascades of the complement system.

47 the classical and lectin pathways within the complement system.

48 concurrently activates both coagulation and complement systems.

49 ion of the inflammatory kallikrein-kinin and complement systems.

50 ay and triggers the kallikrein-kinin and the complement systems.

51 Evasion of killing by the complement system, a crucial part of innate immunity, is

52 ly the viral coat protein (CP), suppress the complement system, a fundamental component of the innate

53 -3) is a member of the lectin pathway of the complement system, a key component of human innate and a

54 Controlled activation of the complement system, a key component of innate immunity, e

55 dy provides mechanistic insight into how the complement system, a key component of innate immunity, r

56 Previous studies demonstrated that the complement system, a major component of innate immunity

57 The complement system, a part of the innate immune system, i

58 Components of the complement system act directly on T cells to alter conve

59 y antiphospholipid antibodies and subsequent complement system activation play a cardinal role in APS

60 tonomous neuroinflammatory response, classic complement system activation, and STAT3 activation throu

61 It has been recently demonstrated that the complement system activation, which is one of the first

62 constitutes a powerful fragment generated by complement system activation.

63 e outgrowth to human pulp fibroblast through complement system activation.

64 broblasts to the nerve sprouting through the complement system activation.

65 ammatory stimulus promoted activation of the complement system after incubation with serum.

66 Uncontrolled activation of the complement system against endothelial and blood cells is

67 ruption of the central component (C3) of the complement system ameliorated muscle pathology in dysfer

68 an serum because they successfully evade the complement system, an important arm of innate immunity.

69 Liposomes can, however, activate the complement system, an important branch of innate immunit

70 The complement system, an important element of both innate a

71 Complement system, an innate immunity, has been well doc

72 The complement system, an intricate network of proteins with

73 nt factor C3 is the central component of the complement system and a key inflammatory protein activat

74 However, the link between the complement system and adaptive immunity, which is formed

75 ell as the MASP SP inhibit the action of the complement system and also show a significant associatio

76 We recently revealed a link between the complement system and CC-induced inflammasome caspase-1

77 on represents a novel connection between the complement system and cell surface PDI-mediated thiol-di

78 actor H-related protein 2 (CFHR2, related to complement system and coagulant mechanism) were selected

79 nt, complement dominates when both an intact complement system and Dectin-1 are present.

80 acterized by intravascular activation of the complement system and deposition of complement fragments

81 immune insults, triggering activation of the complement system and further injury.

82 factor H (CFH) is a central regulator of the complement system and has been implicated in the etiolog

83 e data establish a critical link between the complement system and immunometabolic adaptations drivin

84 appears to be involved in activation of the complement system and in the production of chemotactic a

85 s and promote inflammatory responses via the complement system and inflammasome activation.

86 comprised the first element of the original complement system and initially functioned intracellular

87 mune response to self-antigens activates the complement system and initiates the inflammatory cascade

88 n activation pattern involving the classical complement system and its associated phagosome pathway.

89 ior research has established the role of the complement system and its effector proteins in the progr

90 ng events that connect the activation of the complement system and MC degranulation.

91 g another instance of cross-talk between the complement system and other host defense pathways.

92 f FDC function and suggest new ways that the complement system and persistent antigen presentation mi

93 ms are poorly understood, roles for both the complement system and reactive macrophages have been imp

94 les exhibited particular upregulation of the complement system and respective regulatory pathways, wi

95 Importantly, these mice have an intact complement system and showed no signs of graft-versus-ho

96 oteases, activates the lectin pathway of the complement system and subsequent inflammatory mechanisms

97 additional mechanism used by Nm to evade the complement system and survive in human blood.

98 indings explain the interactions between the complement system and T cells that are critical for the

99 mplex crosstalk between the endothelium, the complement system and the hemostasis in health and in di

100 ional connections between alterations in the complement system and the pathogenesis of MD remain to b

101 The complement system and TLRs provide important pattern rec

102 ry protein in the alternative pathway of the complement system, and CFH polymorphisms increase the ge

103 R signaling cross-talks extensively with the complement system, and combined CD14 and complement inhi

104 CRPs prevent attack on host cells by the complement system, and complement receptor 1-like protei

105 broad link between the kinin-kallikrein and complement systems, and suggest a role of CPN1 in the co

106 scripts sensitive to infection and implicate complement system, antigen processing and presentation,

107 These unexpected findings identify the complement system as a potential new target for anticanc

108 4 and Ptx3, in addition to activation of the complement system, as measured by immune cell infiltrati

109 in certain anti-proteases and in the immune complement system, both of which react with the ligand o

110 tion or development systemically inhibit the complement system, but since complement is important for

111 The activation of the complement system by canonical and non-canonical mechani

112 Modulation of the complement system by locally increasing CRP expression u

113 It evades the host complement system by upregulating expression of immune e

114 ing evidence suggests that components of the complement system, C1q and C3, can mediate elimination o

115 m the cleavage of the third component of the complement system (C3), is evidence for activation of co

116 s involved in bacterial killing, such as the complement system, can also exert cytolytic activity aga

117 injection, the intraocular activation of the complement system caused induction and progression of CN

118 In contrast, components of the complement system, chemokines, chemokine receptors, and

119 P. ovis infestation, including roles for the complement system, clotting cascade and fibrinolysis.

120 In particular, it is unclear how the complement system communicates with nociceptors and whic

121 Several genes encoding complement system components and fragments are associate

122 The complement system, consisting of soluble and cell membra

123 The vertebrate complement system consists of sequentially interacting p

124 The complement system contributes to autoimmune injury, but

125 In addition to chemokines, the complement system contributes to the attraction and acti

126 The complement system contributes to the protection of the h

127 The complement system contributes to various immune and infl

128 Thus, the complement system could be used as one of the 'staging p

129 les, such as Toll-like receptors (TLRs), the complement system, cytokines, chemokines, inflammatory r

130 n C3 (C3(-/-)), an upstream component of the complement system, did not affect mouse susceptibility t

131 atients with HIV infection and influence the complement system during acute illness.

132 and compelling insight into the role of the complement system during mammalian embryonic development

133 this study, we have examined the role of the complement system during the priming phase of liver rege

134 The complement system, especially the alternative pathway, p

135 As the complement system forms a key immune pathway that may al

136 data was performed to analyze variants in 32 complement system genes for positive association with CA

137 nly associated with rare genetic variants in complement system genes, unique to each patient/family.

138 e were also observed in oxidative stress and complement system genes.

139 In recent years, the complement system has been associated with a growing num

140 ation in genes involved in regulation of the complement system has been implicated as a major cause o

141 Abnormal regulation of the complement system has been implicated in its pathogenesi

142 Activation of the complement system has been implicated in the development

143 nce between activation and inhibition of the complement system has been implicated in the etiologies

144 ng identified, the basic architecture of the complement system has been known for decades.

145 For decades, the complement system has been recognized as an effector arm

146 The complement system has been shown to facilitate periphera

147 mmunological and inflammatory processes, the complement system has emerged as an attractive target fo

148 The complement system has evolved to annul pathogens, but it

149 n many types of human cells, our view of the complement system has expanded.

150 Activation of the complement system has long been known to be regulated by

151 The impact that viral hijacking of the complement system has on iDC function could be an import

152 Our understanding of the biology of the complement system has undergone a drastic metamorphosis

153 Inhibitors of the complement system have been described in the saliva of h

154 lar degeneration (AMD), rare variants in the complement system have been described, but their functio

155 An intracellular complement system (ICS) has recently been described in i

156 trate the regulation of BBB integrity by the complement system in a neuroinflammatory setting.

157 regulates the terminal pathway of the human complement system in addition to being a component of th

158 ce supports a link between microglia and the complement system in Alzheimer's disease (AD).

159 The role of the complement system in antibody-mediated rejection has bee

160 ment activation, the functional roles of the complement system in atherogenesis are not yet fully res

161 Cumulative evidence indicates a role for the complement system in both pathology and recovery after i

162 The involvement of the complement system in brain injury has been scarcely inve

163 mportance of C5a and other components of the complement system in inflammatory and neuropathic pain,

164 A role for the complement system in MDs was suggested by genetic associ

165 The role of the complement system in mediating human renal disease has l

166 ient mice, confirming the involvement of the complement system in neurodegeneration.

167 etermined the impact of HIV infection on the complement system in patients with asymptomatic HIV infe

168 rated the pathophysiologic importance of the complement system in several rare diseases.

169 dy, we address the involvement of NA and the complement system in the activation of innate immunity t

170 rticle highlights recent publications on the complement system in the atherosclerosis field.

171 t epithelial cells before they encounter the complement system in the mosquito hemolymph.

172 identify a central role for the inflammatory complement system in the pathogenesis of osteoarthritis.

173 The identification of involvement of the complement system in the pathophysiology of AAA provides

174 though studies have suggested a role for the complement system in the pathophysiology of spinal cord

175 study we established the involvement of the complement system in the recognition and the phagocytosi

176 P plays in modulating the blood clotting and complement systems in health and disease.

177 a potent modulator of the blood clotting and complement systems in hemostasis, thrombosis, and inflam

178 ical matter for this pivotal protease of the complement system: in silico active site mapping for hot

179 lation, has led to the appreciation that the complement system includes membrane inhibitors that are

180 n to possess several mechanisms to evade the complement system, including binding to complement inhib

181 ease model in which genetic variation in the complement system increases the risk of AMD by a combina

182 The complement system is a critical component of the innate

183 The complement system is a crucial component of the innate i

184 Abnormal activation of the complement system is a feature of these blinding disease

185 The complement system is a front-line defense system that op

186 The complement system is a fundamental component of innate i

187 ing inflammation including activation of the complement system is a hallmark of systemic lupus erythe

188 The complement system is a key component of the host immune

189 The complement system is a key component regulation influenc

190 Activation of the complement system is a key event in the pathogenesis of

191 The activation of the complement system is a key initiating step in the protec

192 asome caspase-1 activation, showing that the complement system is a key trigger in CC-induced inflamm

193 is that recognition of tubular injury by the complement system is a major mechanism by which the syst

194 The complement system is a major target of immune evasion by

195 The complement system is a potent component of the innate im

196 The complement system is activated in a wide spectrum of CNS

197 Complement system is activated in patients with trauma.

198 The complement system is activated in response to tissue inj

199 The complement system is an ancient innate immune defense pa

200 The complement system is an efficient plasma immune surveill

201 The complement system is an elegantly regulated biochemical

202 The complement system is an essential component of the innat

203 The complement system is an essential element of the innate

204 The complement system is an evolutionarily ancient component

205 The complement system is an important antimicrobial and infl

206 The complement system is an important first line of defense

207 The complement system is an important innate defense mechani

208 The complement system is an important part of the innate imm

209 The complement system is an important part of the innate imm

210 An overactive complement system is associated with AMD pathogenesis, a

211 The membrane attack complex (MAC) of the complement system is detected in the traumatized brain e

212 Excessive activation of the complement system is detrimental in acute inflammatory d

213 The complement system is important for host resistance to he

214 The human complement system is important in the immunological cont

215 The human complement system is increasingly perceived as an intric

216 Dysregulation of the complement system is increasingly recognized as a contri

217 The complement system is involved in a range of diverse deve

218 The complement system is involved in mediation of joint dama

219 The complement system is part of our first line of defense a

220 The complement system is part of the innate immune response

221 Activation of the complement system is primarily initiated by pathogen- an

222 The human complement system is the frontline defense mechanism aga

223 Inadequate control of the complement system is the underlying or aggravating facto

224 The activity of the complement system is tightly controlled by many fluid-ph

225 The complement system is tightly regulated to safeguard agai

226 regulator of the alternative pathway of the complement system, is only expressed in the eye and on t

227 ng substances and subsequently activates the complement system, it has been proposed that the antipne

228 In this review, we discuss the complement system, its importance in retinal development

229 Components of the complement system, known to produce a local inflammatory

230 by genetic and acquired abnormalities of the complement system leading to alternative pathway (AP) ov

231 nal proposal by Fearon and Locksley that the complement system linked innate and adaptive immunity, t

232 empt to evade annihilation by the vertebrate complement system, many microbes capture factor H (FH),

233 by anti-BP180 antibodies and depends on the complement system, mast cell (MC) degranulation, and neu

234 nt studies have shown that activation of the complement system may be associated with long-term graft

235 regeneration, and suggest that manipulating complement system may produce therapeutic benefit in mus

236 the protection of digestive tissues against complement system-mediated damage.

237 sferlinopathy and suggest that targeting the complement system might serve as a therapeutic approach

238 hesis of C1q, a recognition component of the complement system, occurs in brain during ischemia/reper

239 The complement system of innate immunity is important in reg

240 n through opsonization and activation of the complement system on surfaces with an appropriate presen

241 in cancer is mirrored by the effects of the complement system on this disease process.

242 Natural killer (NK) cells and the complement system play critical roles in the first line

243 The complement system plays a central part in both innate an

244 The complement system plays a central role in promoting the

245 Because the complement system plays a critical role in orchestrating

246 The complement system plays a crucial role in the progressio

247 The complement system plays a pivotal protective role in the

248 We recently reported that the complement system plays a pivotal role in innate immune

249 The complement system plays an essential protective role in

250 The human complement system plays an essential role in innate and

251 Here, we show that the complement system plays an important role in muscle path

252 The human complement system plays an important role in the control

253 matory autoimmune joint disease in which the complement system plays an important role.

254 HIV activates the complement system, predominantly via the classical pathw

255 The complement system present in circulating blood is an eff

256 proinflammatory cytokines, activation of the complement system, production of autoantibodies, overexp

257 The complement system protects against extracellular pathoge

258 nalysis revealed the presence of Igs and the complement system proteins C3, factor B, and clusterin.

259 eriments with human and mouse phagocytes and complement systems provide additional evidence to suppor

260 The complement system rapidly detects and kills Gram-negativ

261 uctural and mechanistic understanding of the complement system rationalizes the genetic defects confe

262 versely, only E coli challenge activated the complement system, reaching a maximum at 2 hours postcha

263 its ligand C3d provides insight into how the complement system regulates access of antigen by B cells

264 The complement system represents an evolutionary old and cri

265 ts show that therapeutic manipulation of the complement system requires rigorous disease-specific tar

266 hare the common theme of overactivity of the complement system's alternative pathway.

267 mplement component C4 upon activation of the complement system's classical and lectin pathways, which

268 This result demonstrates that the complement system senses intravenously injected Ad prima

269 Ad interactions with the complement system significantly contribute to innate imm

270 activation of the alternative pathway of the complement system strongly contributes to serum MMP-8 co

271 ociated with an inadequate regulation of the complement system, supporting current evidence on the ro

272 C1q, the initiating component of the classic complement system that is the protein-based arm of the i

273 onal gene networks, including members of the complement system, that appeared to be related to cIOPx,

274 The four cascades are: the complement system, the blood clotting cascade, the fibri

275 ding antigen-specific IA interferes with the complement system; this effect may be partially responsi

276 ovel mechanism by which NiV evades the human complement system through a unique factor I-like activit

277 subjected to repeated exposures to the host complement system through cyclic infections of mammalian

278 study we hypothesized whether CC employ the complement system to activate inflammasome/caspase-1, le

279 ost cells that mimics that used by the human complement system to eliminate pathogens.

280 We conclude that CC employ the complement system to induce cytokines and activate the i

281 Spontaneous activation enables the complement system to respond very rapidly to diverse thr

282 the last year highlight the relevance of the complement system to the atherosclerosis field.

283 d brain disorders.SIGNIFICANCE STATEMENT The complement system, traditionally known as a controller o

284 The complement system, typically associated with innate immu

285 h to examine the interaction of NPs with the complement system using in vitro assays and correlating

286 ogrammer of cell metabolism suggest that the complement system utilizes C3 to guard not only extracel

287 Activation of the complement system via classical, lectin, or alternative

288 century after the significance of the human complement system was recognized, we have come to realiz

289 tubular epithelial cells (TECs) control the complement system, we examined the expression of complem

290 ta-fibrils in Alzheimer disease activate the complement system, we have here investigated specific in

291 including acute-phase response signaling and complement system) were overexpressed in the follicular

292 CRPs, which protect cells from attack by the complement system, were lower in abca4(-/-) versus wild-

293 A number of these proteins inhibit the complement system, which labels bacteria for phagocytosi

294 HIV-1 activates the host complement system, which results in opsonization of viru

295 indings provide initial evidence linking the complement system with cortical thinning in humans, a pr

296 During sepsis, excessive activation of the complement system with generation of the anaphylatoxin C

297 ial sepsis triggers robust activation of the complement system with subsequent generation of anaphyla

298 study, we demonstrated the importance of the complement system within the CNS in the development of b

299 lly, we investigated activation of the local complement system within the dental pulp and its role in

300 these results suggest that IgM activates the complement system within the glomerulus in an animal mod