ライフサイエンスコーパス: complementarity

1 very different predictions, indicating their complementarity.

2 il that extends beyond general electrostatic complementarity.

3 packaging of molecular cargo through charge complementarity.

4 ty is achieved through position and momentum complementarity.

5 that is strictly dependent on their sequence complementarity.

6 ling belief that antibodies have lower shape complementarity.

7 l pathways requires host/endosymbiont genome complementarity.

8 d design new cocktails of MAbs with improved complementarity.

9 geted UPLC-MS methods showed high metabolite complementarity.

10 as the multifunctional equivalent of trophic complementarity.

11 to unintended targets with partial sequence complementarity.

12 inguish substrates from targets with similar complementarity.

13 argeting transcripts with varying degrees of complementarity.

14 otospacer adjacent motif (PAM) and crRNA-DNA complementarity.

15 mplexes to target RNAs based on miRNA-target complementarity.

16 sity and a need for physico-chemical binding complementarity.

17 NA interactions have perfect or partial seed complementarity.

18 t the expression of mRNAs that show sequence complementarity.

19 The two MS approaches exhibit a degree of complementarity.

20 conserved miR159-binding sites of analogous complementarity.

21 sion post-transcriptionally through sequence complementarity.

22 posable elements (TEs) through the base-pair complementarity.

23 volving DdrB-mediated proofreading of strand complementarity.

24 t" exons in several other genes through base complementarity across the entire SNORD27 sequence, not

25 is of protein-ligand electrostatic potential complementarity allowed us to significantly increase bin

26 of prey heterogeneity in driving functional complementarity among predators and enhanced top-down co

27 with nucleic acids by means of electrostatic complementarity), an essential energetic term to predict

28 trate-N load) were analyzed to determine the complementarities and trade-offs between environmental p

29 el named niche-efficiency to integrate niche complementarity and a heretofore-ignored mechanism of di

30 Relatively low surface complementarity and approximately 55% volume occupancy,

31 A wide proline pocket as well as molecular complementarity and capping at the S1 substrate site of

32 d their rationale for using mixed methods as complementarity and did not describe study priority or h

33 rials, and provide a framework to understand complementarity and directional interactions in DNA-medi

34 quantitatively testing their consistency and complementarity and for obtaining a comprehensive view o

35 domain within Cas9, REC3, recognizes target complementarity and governs the HNH nuclease to regulate

36 -31, seems to be due to better overall shape complementarity and hydrophobic interactions with S372 a

37 RNAs that recognize target sequences by base complementarity and play a role in the regulation of tar

38 As that bind to host mRNAs based on sequence complementarity and regulate protein expression.

39 y-ecosystem functioning relationships: niche complementarity and selection effects.

40 sessed the relationship between miRNA-target complementarity and silencing efficacy measured at both

41 s and adopted NoDGAT2s formulated functional complementarity and specific transcript abundance ratio

42 For two well-known mechanisms, 'complementarity' and 'selection', we detect only minor e

43 and health and human rights, identify their complementarities, and advocate for a combined approach.

44 e seed-sequence region to scout for sequence complementarity, and (2) further unwinding of the entire

45 of HCMV display MHC I allotype specificity, complementarity, and cooperativity.

46 lar mimicry, anti-idiotype theory, antigenic complementarity, and dual-affinity T cell receptors.

47 Their apparent affinity, epitope complementarity, and epitope accessibility helps explain

48 oducing two mutations that disrupt the miRNA complementarity around the cleavage site renders the tar

49 arly superior to full-length gRNAs (20 nt of complementarity), as truncated gRNAs are generally less

50 gaps during NHEJ partly depends on sequence complementarity at the break, with Pol lambda and Pol mi

51 is the notion of steric and physicochemical complementarity at the protein-protein interface.

52 6-nucleotide (nt) intervals in the region of complementarity, beginning 5 nt downstream from the crRN

53 The supramolecular chemical complementarities between the gamma-CD-based ditopic cat

54 a indicate that electrostatic and electronic complementarity between carbohydrates and aromatic resid

55 Cleavage requires not only complementarity between crRNA and target but also the pr

56 These findings illustrate the unique complementarity between cryo-EM and solution NMR for stu

57 ecificity can be driven by the electrostatic complementarity between DAN and NDI.

58 We found biochemical complementarity between genomes of S. kawagutii and the

59 Our results imply sexual complementarity between host humoral toxicity and larval

60 Despite the need for complementarity between interacting partners, such pairw

61 ere is limited understanding about potential complementarity between management practices that promot

62 ne peptidic substrate, are favorable so that complementarity between phosphatase and coordinating lig

63 of DNA and has two key components: (i) shape complementarity between QMC partners, which is introduce

64 fact often attributed to increased resource complementarity between species in mixtures and negative

65 but is short-lived owing to lack of optimal complementarity between the active site cleft of proteas

66 Stereoelectronic complementarity between the active site of an enzyme and

67 The electrostatic complementarity between the CP(+) and CP(-) triple helic

68 nt complexes, variation in contacts and poor complementarity between the GPIbalpha beta-finger and th

69 e solid-state structures reveal a size/shape complementarity between the host and the dicarboxylate a

70 Regulation requires complementarity between the lower stem region of the pri

71 Although there are 18 nt of complementarity between the OrzO sRNA and the zorO mRNA,

72 epends on exquisite surface shape and charge complementarity between the proteins.

73 rous intrapeptide contacts that ensure shape complementarity between the substrate and the active sit

74 Complementarity between the template and non-template st

75 s between interacting RNAs and high level of complementarity between two RNA sequences is a powerful

76 possible base combinations and, through base-complementarity, between all sequence positions in a dup

77 versity on resource acquisition (i.e., niche complementarity), but a lack of study on resource utiliz

78 uences on the basis of 20-nucleotide RNA-DNA complementarity, but the mechanism of target searching i

79 off-target transcripts via partial sequence complementarity by a mechanism closely mirroring micro R

80 We tested this hypothesis of niche complementarity by measuring effects of substituting dif

81 parated the effect of selection from that of complementarity by varying community composition in high

82 Sites with extensive additional complementarity can appear as more potent, but only beca

83 nregulate gene expression guided by sequence complementarity, can be used therapeutically to block th

84 d the duplex region of the RNA through shape complementarity, cation-pi interactions, and multiple hy

85 complicated system where both size and shape complementarity change, and where one nanoparticle can p

86 nstraints including composition constraints, complementarity constraints, pattern prevention constrai

87 Here, we employed de novo complementarity determining region (CDR) design to engin

88 and (iii) de novo prediction of the elusive complementarity determining region (CDR) H3 loop.

89 Complementarity determining region (CDR) loop flexibilit

90 tagenic studies reveal a requirement of five complementarity determining region (CDR) loops for CD1c

91 ody trastuzumab at a crucial position in its complementarity determining region (CDR).

92 y high arginine (Arg) content in the H chain complementarity determining region (H3), suggesting that

93 gglutinin stem through conserved heavy-chain complementarity determining region (HCDR) residues.

94 The complementarity determining region 3 (CDR3) length adjus

95 es of amino acids within the antigen binding complementarity determining region 3 (CDR3) repertoire o

96 These TCRs encoded a range of V, J, and complementarity determining region 3 (CDR3) sequences on

97 V5E1, by virtue of complementarity determining region 3 (CDR3), may also en

98 global changes in T cell receptor beta chain complementarity determining region 3 (CDR3beta) sequence

99 The ultralong heavy chain complementarity determining region 3 (CDR3H) of bovine a

100 nique structure in its ultralong heavy chain complementarity determining region 3 (CDR3H) that folds

101 ese, the PG9 antibody has a long heavy chain complementarity determining region 3 (HCDR3) and possess

102 encoded and immunoglobulin (Ig) heavy-chain complementarity determining region 3 (HCDR3) residues, w

103 ult of stabilization of the long heavy chain complementarity determining region 3 (HCDR3).

104 use the biochemical features encoded by the complementarity determining region 3 of each B cell rece

105 maturation-associated changes in heavy-chain complementarity determining region 3, a key antigen-bind

106 produces an i-body library possessing a long complementarity determining region binding loop, and the

107 positively charged pocket formed within the complementarity determining region H2 loops that binds t

108 conewton force requires binding through both complementarity determining region loops and hydrophobic

109 affinity maturation by mutation outside the complementarity determining region surface of the antibo

110 n dominated the interaction and, whereas the complementarity determining region-3 (CDR3) loops exclus

111 ptide on their projecting, heavy-chain third complementarity determining region.

112 ouse Fvs, we grafted the combined KABAT/IMGT complementarity determining regions (CDR) into a human I

113 The recognition involves up to six complementarity determining regions (CDR) of the TCR.

114 The role of T cell receptor (TCR) germline complementarity determining regions (CDR1 and 2) in MHC

115 nd extensive coverage of the antigen-binding complementarity determining regions (CDRs) in a single L

116 Classification of the structures of the complementarity determining regions (CDRs) of antibodies

117 ification of the Xle site, especially in the complementarity determining regions (CDRs), can result i

118 We estimated the evolutionary rates of the complementarity determining regions (CDRs), which are mo

119 we turned to deep mutational scanning in the complementarity determining regions (CDRs).

120 eals a unique epitope, where the heavy-chain complementarity determining regions (HCDRs) 1 and 2 bind

121 evolved slowly and harbors highly conserved complementarity determining regions 1 and 2.

122 re, increased palindromic nucleotides in the complementarity determining regions 3 and long stretches

123 from the Waters antibody contains all three complementarity determining regions on the light chain.

124 coverage, with incomplete sequencing of the complementarity determining regions which are fundamenta

125 ues in variable domains, especially in CDRs (complementarity determining regions) of an antibody, may

126 mutation frequencies, long third heavy-chain complementarity determining regions, and/or autoreactivi

127 -associated antibody subset featured shorter complementarity-determining (CDR3) regions relative to t

128 e, ultrahumanized antibodies via single-step complementarity-determining region (CDR) germ-lining.

129 -cell receptors (TCRs) engage antigens using complementarity-determining region (CDR) loops that are

130 ovine antibody with a well-folded, ultralong complementarity-determining region (CDR), we have develo

131 hat carried the extended, 23- to 27-residue, complementarity-determining region (CDR)-H3 segments.

132 E10 was derived from the parental 3B4 using complementarity-determining region (CDR)-restricted muta

133 face area; and (iv) public heavy-chain third complementarity-determining region (CDR-H3) antibodies i

134 gnatures, including shared light-chain third complementarity-determining region (CDR-L3) amino acid s

135 ne-encoded residues in the second beta-chain complementarity-determining region (CDR2beta).

136 rnary complex revealed that germline-encoded complementarity-determining region 1beta residues presen

137 , VH4 family gene utilization, a heavy chain complementarity-determining region 2 (CDRH2) insertion,

138 ng paratope interactions; the variable light complementarity-determining region 2 plays a key role by

139 Moreover, the sequences of the complementarity-determining region 3 (CDR3) loop from to

140 Analysis of complementarity-determining region 3 (CDR3) regions cont

141 eveloped a computational method to infer the complementarity-determining region 3 (CDR3) sequences of

142 TCR transcripts, including complementarity-determining region 3 (CDR3) sequences, w

143 th conserved motifs and global similarity of complementarity-determining region 3 (CDR3) sequences.

144 igh-affinity antibodies with long human-like complementarity-determining region 3 (CDR3H), broad epit

145 The lineage Abs bore an anionic heavy chain complementarity-determining region 3 (CDRH3) of 25 amino

146 h unusual features, such as long heavy-chain complementarity-determining region 3 (HCDR3) loops.

147 unusual traits, including a long heavy chain complementarity-determining region 3 (HCDR3), polyreacti

148 ve N-region additions, Vh usage, and charged complementarity-determining region 3 consistent with aut

149 ealed an extended VH binding interface, with complementarity-determining region 3 deeply penetrating

150 h-throughput sequencing of the TCRbeta chain complementarity-determining region 3 of liver-infiltrati

151 through interactions with the unusually long complementarity-determining region 3 of the HC33.1 heavy

152 dentical T-cell receptor variable beta-chain complementarity-determining region 3 sequences were iden

153 bnAbs, including a short CDRL3 (light-chain complementarity-determining region 3) and mutations that

154 t use, and in the length and features of the complementarity-determining region 3, a major determinan

155 TCRs feature identical, or nearly identical, complementarity-determining region 3alpha (CDR3alpha) an

156 lthy donors, that patients have shorter TCRB complementarity-determining region 3s (CDR3), in all cel

157 Six mutations (three in the complementarity-determining region and three in the fram

158 y of amino acids at positions 6 and 7 of the complementarity-determining region CDR3beta robustly pro

159 a common epitopic focus by utilizing various complementarity-determining region H3 (CDRH3) lengths.

160 Insertion of any of these motifs into the complementarity-determining region H3 of a "clean" antib

161 led the major contribution made by the first complementarity-determining region in each of sifalimuma

162 at generally found in more flexible antibody complementarity-determining region loops but resembles t

163 Surprisingly, crenezumab's complementarity-determining region loops can effectively

164 The peptide design was based on complementarity-determining region loops of human broadl

165 The loop is analogous to the third complementarity-determining region of immunoglobulin var

166 ic residues in its CDR H3 (third heavy-chain complementarity-determining region).

167 he buried monomeric peptide in solanezumab's complementarity-determining region, crenezumab binds the

168 Perturbations within complementarity-determining regions (CDR) induce rich be

169 ntibodies between the framework and loops of complementarity-determining regions (CDRs) 1 and 2.

170 Modifications in the complementarity-determining regions (CDRs) are especiall

171 mmonly accumulate charged mutations in their complementarity-determining regions (CDRs) during affini

172 e backbone entropy change for immunoglobulin complementarity-determining regions (CDRs) from the crys

173 ting amyloidogenic peptide segments into the complementarity-determining regions (CDRs) of single-dom

174 In addition to conformational changes in complementarity-determining regions (CDRs) of the TCR se

175 fic, high-affinity binding of quinine to the complementarity-determining regions (CDRs) of these anti

176 ne whether they recognize SAEs through their complementarity-determining regions (CDRs) or framework

177 mulate affinity-enhancing mutations in their complementarity-determining regions (CDRs) without compr

178 ble region contains three antigen-contacting complementarity-determining regions (CDRs), with CDR1 an

179 ding site, located within the loops known as complementarity-determining regions (CDRs).

180 then annotated with key information such as complementarity-determining regions and potential post-t

181 that the beta-subunit binds pMHC using Vbeta complementarity-determining regions as well as an expose

182 verlap of the IgG-Fc binding site in FcRn by complementarity-determining regions in DX-2507.

183 surface consists of residues located in four complementarity-determining regions including a major co

184 rate separation-of-function mutations in the complementarity-determining regions of 3E10 revealing th

185 It is mostly light chain complementarity-determining regions that are driving par

186 or yeast display libraries of mutants within complementarity-determining regions to affinity mature a

187 The antibody uses all six complementarity-determining regions to bind to a quatern

188 individual amino acids and motifs within the complementarity-determining regions which contribute to

189 Alanine scanning of their complementarity-determining regions, coupled with epitop

190 ere, we show that exome reads mapping to the complementarity-determining-region 3 (CDR3) of mature T-

191 on of numerous interactions with heavy chain complementarity domain regions (CDRs) of HM14c10, while

192 Complementarity downstream of the gap promotes deletion

193 ighlight the importance of ancillary protein complementarity during Rubisco biogenesis in plastids, t

194 effect in nonnative communities and positive complementarity effect in native communities.

195 ve overyielding suggests that positive niche complementarity effects are driving some of the response

196 Specifically: (i) complementarity effects at low and intermediate position

197 Using Linear Mixed Models we show that, complementarity effects depend on tree size along an ene

198 species mixtures have revealed selection and complementarity effects driving these responses.

199 nd responsible mechanisms (i.e. selection or complementarity effects).

200 itive effects on aboveground biomass through complementarity effects, whereas weed species diversity

201 ugh additive partitioning into selection and complementarity effects.

202 The complementarity ends at the 18th base, A58, which in tRN

203 Hydrophobic interactions and shape complementarity enhance peptide affinity beyond the cata

204 We demonstrate, however, skill complementarity enhances heterophily in the formation of

205 s of the evolved affinity was improved shape complementarity established by interloop (AB-CD) and int

206 Yet, whether a complementarity exists between roots and mycorrhizal fun

207 agates into a stable association when target complementarity extends to nucleotides 2-8.

208 Unexpectedly, this complementarity extends to these proteins' synaptic func

209 ociation (ETD) shows their great utility and complementarity for the identification and characterizat

210 We discuss how this sexual complementarity guarantees adaptive advantages for both

211 In plants, microRNA (miRNA)-target complementarity has long been considered the predominant

212 cular recognition, such as self-assembly and complementarity, have inspired the development of biomim

213 sic PRD domain grooves through electrosteric complementarity in a widely applicable mechanism.

214 protein complexes suggested that lower shape complementarity in antibody-antigen interfaces is relate

215 encompassing both protein and small-molecule complementarity in terms of shape and chemistry via grap

216 Although there is a clear complementarity in these behaviours, no dynamic evidence

217 The Biosynthetic Support Score and Metabolic Complementarity Index provide insight into host-microbe

218 ic or a commensal species, and the Metabolic Complementarity Index which quantifies the complementari

219 the more global beta-sheet/beta-sheet facial complementarity is a critical determinant for amyloid nu

220 BCR crosslinking in the absence of complementarity is a superantigen effect induced by some

221 Here we show evidence that complementarity is contingent on tree size across large-

222 Niche complementarity is expected to result in significant gro

223 upper end of the gradient (warmer regions), complementarity is more widespread in larger than smalle

224 Furthermore, the degree of skill complementarity is positively correlated with their prod

225 Surface complementarity is relatively low due to the nonspecific

226 mixtures of oligomers with various degree of complementarity, liquid crystal microdomains are formed

227 ncated gRNAs, with shorter regions of target complementarity <20 nucleotides in length, can decrease

228 amp recognizes substrates by a general shape-complementarity mechanism.

229 This complementarity must be optimized both for functional in

230 Neither the free energy of miR159-target complementarity, nor miRNA binding site accessibility, a

231 y, we examined the structural and electronic complementarities of convex 1-Zn(II), comprising functio

232 c Complementarity Index which quantifies the complementarity of a pair of microbial organisms' niches

233 In contrast to previous findings, the shape complementarity of antibody-antigen interfaces resembles

234 c acid detection of microorganisms, based on complementarity of base-pairing between probe and target

235 With this setup the complementarity of data obtained from both APPI and APLI

236 The complementarity of fast, specific proteolytic degradatio

237 The complementarity of historical and contemporary processes

238 The described differences underline the complementarity of NISs and RCTs.

239 Utilizing the complementarity of oppositely charged domains in short c

240 These differences highlight the complementarity of organic synthons and boron clusters,

241 tween these two species and demonstrates the complementarity of population genetics and ecological ni

242 In addition, previous work of shape complementarity of protein complexes suggested that lowe

243 This demonstrates the complementarity of RNA-Seq and NanoString.

244 "off-target" effects resulting from partial complementarity of siRNAs to multiple mRNAs via the "see

245 ular docking programs to assess the chemical complementarity of small molecules with the target; such

246 inical competencies in China, especially the complementarity of specialist training and general pract

247 The complementarity of SWAXS and MD is illustrated using thr

248 ended "on-target" mechanism, defined by full complementarity of the 21-nt siRNA sequence to a target

249 drogen bonds to the hydantoin moiety and the complementarity of the 5-substituent for a hydrophobic p

250 es thus provide a way of optimally using the complementarity of the available methods for a quantitat

251 Given the complementarity of the energy-dependent component of NPQ

252 Specificity is driven by the complementarity of the enzyme active site cleft and the

253 nds on the chemical, physical and structural complementarity of the interacting components.

254 NA-like approach, the requirement of perfect complementarity of the microRNA seed region to a given t

255 the GC content, length, sequence and strand complementarity of the product, HRM analysis is highly s

256 Studying the size complementarity of the stoppers at the ends of the threa

257 g to 3Q fibrils requires a precise molecular complementarity of the sulfate moieties on the GAG and c

258 A possible application of the observed complementarity of the two methods, namely assessment of

259 The complementarity of these contrasts is experimentally val

260 Thus, we were able to highlight the complementarity of top-down and bottom-up approaches, wh

261 dination cage achieved through the geometric complementarity of two carefully designed ligands, L(A)

262 e the effects of nanoparticle size and shape complementarity on the resultant crystal symmetry, micro

263 e correlations with Deltabiomass, indicating complementarity or positive selection effects.

264 ole in quantum physics by demonstrating that complementarity or wave-particle duality can be enforced

265 Complementarity patterns that are functional in animals

266 toimmune disease?" The theory of autoantigen complementarity posits that the initiating immunogen cau

267 ents delineated in the theory of autoantigen complementarity potentially promote the acquisition of m

268 ognizes the lasso peptide substrate by shape complementarity rather than through sequence specificity

269 PCR products with different location of the complementarity region.

270 analog of TM4(88-100) retains the structural complementarity required to disrupt the Hsmr TM4-TM4 loc

271 the models' binding sites for protein-ligand complementarity reveals new putative pockets that can be

272 hydrophobic groups, which assemble via shape complementarity (shape synthons), reliably form low ener

273 olecules of DnaK are large with good surface complementarity, suggesting functional importance of thi

274 mechanism constraints and required chaperone complementarity that hinder Rubisco biogenesis in altern

275 cleavage events, the tandem repeat provides complementarity that promotes realignment to a nick and

276 CENP-N uses charge and space complementarity to decode the L1 loop that is unique to

277 rmline repertoire could be triggered by both complementarity to influenza HA and a separate mode of s

278 ulting from short regions of oligonucleotide complementarity to many different messenger RNAs.

279 t Ago2 initially scans for target sites with complementarity to nucleotides 2-4 of the miRNA.

280 A and RP11-462G22.1, each entailing sequence complementarity to numerous microRNAs.

281 nkov telescope array, will provide important complementarity to other search techniques.

282 cals at the middle-up level of analysis, its complementarity to reversed phase liquid chromatography,

283 with a protospacer adjacent motif (PAM) and complementarity to the guide RNA.

284 s a viral microRNA bearing complete sequence complementarity to the mRNA for the important viral gene

285 whether there is continuous or discontinuous complementarity to the target mRNA.

286 the specificity of truncated gRNAs (18 nt of complementarity to the target) is not clearly superior t

287 ans-encoded small RNA with 16 nucleotides of complementarity to the toxin mRNA.

288 Our results show that molecular complementarity underlies the higher frequency and signi

289 eletion formation more effectively than does complementarity upstream of the gap, consistent with con

290 To assess possible functional complementarity, we established P4ha1(+/-);P4ha2(-/-) mi

291 ndicate that considerations of electrostatic complementarity, whether through a polar-pi or substitue

292 ween host and guest confirmed the high shape complementarity with fully enveloping dispersive interac

293 iciencies, suggesting the need for metabolic complementarity with other microbes.

294 Its complementarity with other online resources is facilitat

295 We also demonstrate its complementarity with other variant calling tools.

296 translational repression depending on their complementarity with targets.

297 r an extended surface exhibiting close shape complementarity with the protein.

298 cribing RNAP and through regions of sequence-complementarity with the target.

299 are evolutionarily deep-rooted, and sequence complementarity with their targets is maintained through

300 their different levels of specialization and complementarity within long-term stable-state systems.