ライフサイエンスコーパス: complementarity-determining region

1 ic residues in its CDR H3 (third heavy-chain complementarity-determining region).

2 ptide on their projecting, heavy-chain third complementarity determining region.

3 tional regions showed diversity in the third complementarity-determining region.

4 st, the hybridomas expressed a diverse third complementarity-determining region.

5 neation of IG V domain framework regions and complementarity determining regions.

6 g suggested a putative binding site near the complementarity-determining regions.

7 three loops that are equivalent to antibody complementarity-determining regions.

8 parent in the six hypervariable loops of the complementarity-determining regions.

9 y between two IL-18 loops and all six 125-2H complementarity-determining regions.

10 cement mutations and mutational targeting in complementarity-determining regions.

11 ns of immunoglobulin molecules outside their complementarity-determining regions.

12 by five atoms contributed from four antibody complementarity-determining regions.

13 tified asparagine deamidation in light chain complementarity determining region 1 (CDR1) of a humaniz

14 ns containing a succinimidyl intermediate in complementarity determining region 1 (CDR1) on zero, one

15 evolved slowly and harbors highly conserved complementarity determining regions 1 and 2.

16 3 loop, with minor contacts from heavy-chain complementarity-determining region 1, and is sufficient

17 H) gene segments at conserved sites flanking complementarity-determining regions 1 and 2.

18 iffering interactions between the respective complementarity-determining region 1alpha loops and the

19 termining region 3alpha and germline-encoded complementarity determining region 1beta loops of the SB

20 rnary complex revealed that germline-encoded complementarity-determining region 1beta residues presen

21 jawed vertebrates share amino acids in their complementarity determining region 2 (CDR2).

22 ctivated an N-linked glycosylation sequon in complementarity-determining region 2 (CDR2).

23 dextran V(H) that contains a carbohydrate in complementarity-determining region 2 (CDR2).

24 , VH4 family gene utilization, a heavy chain complementarity-determining region 2 (CDRH2) insertion,

25 stinct alleles that use either a heavy-chain complementarity-determining region 2 (HCDR2) aspartic ac

26 ng paratope interactions; the variable light complementarity-determining region 2 plays a key role by

27 In the productive repertoire, the H chain complementarity determining region 3 (CDR3(H)) was signi

28 5 shows that the tip of the CH65 heavy-chain complementarity determining region 3 (CDR3) inserts into

29 The complementarity determining region 3 (CDR3) length adjus

30 h very similar and unusually long beta-chain complementarity determining region 3 (CDR3) regions in C

31 es of amino acids within the antigen binding complementarity determining region 3 (CDR3) repertoire o

32 These TCRs encoded a range of V, J, and complementarity determining region 3 (CDR3) sequences on

33 V5E1, by virtue of complementarity determining region 3 (CDR3), may also en

34 ough each of these Fabs contained a distinct complementarity determining region 3 (CDR3)-H sequence.

35 global changes in T cell receptor beta chain complementarity determining region 3 (CDR3beta) sequence

36 The ultralong heavy chain complementarity determining region 3 (CDR3H) of bovine a

37 nique structure in its ultralong heavy chain complementarity determining region 3 (CDR3H) that folds

38 r unusual traits, such as a long heavy chain complementarity determining region 3 (CDRH3) and autorea

39 (BLV1H12) which has an ultralong heavy chain complementarity determining region 3 (CDRH3) provides a

40 ese, the PG9 antibody has a long heavy chain complementarity determining region 3 (HCDR3) and possess

41 encoded and immunoglobulin (Ig) heavy-chain complementarity determining region 3 (HCDR3) residues, w

42 ult of stabilization of the long heavy chain complementarity determining region 3 (HCDR3).

43 e characterized by a substantial decrease in complementarity determining region 3 diversity.

44 unique and thus far not reported heavy-chain complementarity determining region 3 motifs, of which 4

45 use the biochemical features encoded by the complementarity determining region 3 of each B cell rece

46 Tyrosine and glycine constitute 40% of complementarity determining region 3 of the immunoglobul

47 maturation-associated changes in heavy-chain complementarity determining region 3, a key antigen-bind

48 dominant germ line genes as well as dominant complementarity determining region 3.

49 re, increased palindromic nucleotides in the complementarity determining regions 3 and long stretches

50 Mutagenesis of M88 showed that the complementarity determining regions 3 of both gammadelta

51 We measured the size distribution of the complementarity-determining region 3 (CDR3) for expanded

52 We used complementarity-determining region 3 (CDR3) length analy

53 s were enriched for clones utilizing uniform complementarity-determining region 3 (CDR3) lengths.

54 Moreover, the sequences of the complementarity-determining region 3 (CDR3) loop from to

55 ue regions" of VpreB and lambda5 replace the complementarity-determining region 3 (CDR3) loop of an a

56 germline-encoded residues of its delta chain complementarity-determining region 3 (CDR3) loop to bind

57 result of a conformational change in the TCR complementarity-determining region 3 (CDR3) loop.

58 de centric, dominated by two residues of the complementarity-determining region 3 (CDR3) loops that a

59 ongly with a somatically recombined TCRdelta complementarity-determining region 3 (CDR3) motif derive

60 structure and key amino acid residues on the complementarity-determining region 3 (CDR3) of FLCs are

61 Complementarity-determining region 3 (CDR3) of the TCR i

62 Analysis of complementarity-determining region 3 (CDR3) regions cont

63 We performed deep sequencing of TCRbeta complementarity-determining region 3 (CDR3) regions in s

64 ng of rearranged T-cell receptor (TCR) Vbeta complementarity-determining region 3 (CDR3) regions, a p

65 eveloped a computational method to infer the complementarity-determining region 3 (CDR3) sequences of

66 TCR transcripts, including complementarity-determining region 3 (CDR3) sequences, w

67 th conserved motifs and global similarity of complementarity-determining region 3 (CDR3) sequences.

68 We have used complementarity-determining region 3 (CDR3) size distrib

69 receptor (TCR), the variable beta (VB)-chain complementarity-determining region 3 (CDR3), can serve a

70 re including antibodies with quasi-identical complementarity-determining region 3 (CDR3), which sugge

71 variable major antigen-binding determinant, complementarity-determining region 3 (CDR3), with specif

72 igh-affinity antibodies with long human-like complementarity-determining region 3 (CDR3H), broad epit

73 that a four-residue insertion in heavy chain complementarity-determining region 3 (CDRH3) contributed

74 The lineage Abs bore an anionic heavy chain complementarity-determining region 3 (CDRH3) of 25 amino

75 However, the heavy chain complementarity-determining region 3 (H-CDR3) of most pa

76 idues (H97-H100A) in the apex of heavy chain complementarity-determining region 3 (HCDR3) are disorde

77 h unusual features, such as long heavy-chain complementarity-determining region 3 (HCDR3) loops.

78 unusual traits, including a long heavy chain complementarity-determining region 3 (HCDR3), polyreacti

79 ve N-region additions, Vh usage, and charged complementarity-determining region 3 consistent with aut

80 ealed an extended VH binding interface, with complementarity-determining region 3 deeply penetrating

81 ct human scFv from a library with randomized complementarity-determining region 3 domains.

82 er, neutralizing antibodies possessed longer complementarity-determining region 3 for both heavy and

83 Complementarity-determining region 3 length and amino ac

84 ng site is dominated by a single heavy-chain complementarity-determining region 3 loop, with minor co

85 teraction was dominated by the hypervariable complementarity-determining region 3 loops, indicating t

86 in the T-cell receptor Vbeta gene usage and complementarity-determining region 3 loops.

87 ere used to replace the extended heavy chain complementarity-determining region 3 of an IgG antibody

88 h-throughput sequencing of the TCRbeta chain complementarity-determining region 3 of liver-infiltrati

89 through interactions with the unusually long complementarity-determining region 3 of the HC33.1 heavy

90 and identified an A to S substitution in the complementarity-determining region 3 of the variable reg

91 We found that T-cell receptor beta (TCRbeta) complementarity-determining region 3 repertoire sequenci

92 opologies are possible because of the unique complementarity-determining region 3 sequences created d

93 In addition, complementarity-determining region 3 sequences formed in

94 dentical T-cell receptor variable beta-chain complementarity-determining region 3 sequences were iden

95 with nearly identical heavy and light chain complementarity-determining region 3 sequences.

96 ow cytometry, Vbeta repertoire analysis, and complementarity-determining region 3 sequencing) were us

97 bnAbs, including a short CDRL3 (light-chain complementarity-determining region 3) and mutations that

98 variable region beta) gene usage and a CDR3 (complementarity-determining region 3) sequence to assess

99 t use, and in the length and features of the complementarity-determining region 3, a major determinan

100 alphabeta TCR after grafting of a G8 or KN6 complementarity-determining region 3-delta (CDR3delta) l

101 but they all had very different sequences in complementarity-determining region 3.

102 hybridomas, with mutations concentrating in complementarity-determining region 3.

103 d substantial sequence homology within their complementarity-determining region 3.

104 ere, we show that exome reads mapping to the complementarity-determining-region 3 (CDR3) of mature T-

105 n dominated the interaction and, whereas the complementarity determining region-3 (CDR3) loops exclus

106 o peptide-mediated interactions in which the complementarity determining region 3alpha and germline-e

107 TCRs feature identical, or nearly identical, complementarity-determining region 3alpha (CDR3alpha) an

108 4 complex is recognized by the TCR through a complementarity-determining region 3alpha (CDR3alpha)-me

109 hot-spot' of germline-encoded amino acids in complementarity-determining regions 3alpha, 1alpha and 2

110 harged residue in the first segment of their complementarity determining region 3beta.

111 lthy donors, that patients have shorter TCRB complementarity-determining region 3s (CDR3), in all cel

112 t could be susceptible to degradation in the complementarity determining region and Fc region.

113 elates with high hydrophobicities of certain complementarity determining regions and with high positi

114 Six mutations (three in the complementarity-determining region and three in the fram

115 tructurally-tolerated diversity in the three complementarity-determining regions and a fourth loop wi

116 then annotated with key information such as complementarity-determining regions and potential post-t

117 mutation frequencies, long third heavy-chain complementarity determining regions, and/or autoreactivi

118 The complementarity-determining regions are spatially orient

119 that the beta-subunit binds pMHC using Vbeta complementarity-determining regions as well as an expose

120 es at the tip of the m66.6 heavy-chain third complementarity-determining region, as in the case of 2F

121 produces an i-body library possessing a long complementarity determining region binding loop, and the

122 differ by small sequence alterations in the complementarity-determining region but show very large d

123 igidified the initially flexible heavy-chain complementarity determining region by two nearly indepen

124 Its crystal structure revealed a long complementarity determining region (CD3) folding over pa

125 ha TRAV5D-4 alpha-chains with many different complementarity determining region (CDR) 3 sequences, ev

126 tion with single cell analysis to define the complementarity determining region (CDR) 3alpha and CDR3

127 profile Hidden Markov Models, and translated complementarity determining region (CDR) capture-recaptu

128 Here, we employed de novo complementarity determining region (CDR) design to engin

129 using a phage-displayed framework to support complementarity determining region (CDR) diversity restr

130 on a precise distribution within one or more complementarity determining region (CDR) domains and exp

131 ion revealed its unusually long, 28-residue, complementarity determining region (CDR) H3 forms a uniq

132 and (iii) de novo prediction of the elusive complementarity determining region (CDR) H3 loop.

133 Light chain complementarity determining region (CDR) isoelectric poi

134 Complementarity determining region (CDR) loop flexibilit

135 tagenic studies reveal a requirement of five complementarity determining region (CDR) loops for CD1c

136 protein-protein interface, including the TCR complementarity determining region (CDR) loops, Valpha/V

137 bodies typically accumulate mutations in the complementarity determining region (CDR) loops, which us

138 and heavy framework regions and each of the complementarity determining region (CDR) loops.

139 The Fab fragment exhibits novel complementarity determining region (CDR) structures with

140 ody trastuzumab at a crucial position in its complementarity determining region (CDR).

141 ohydrate recognition maps to a cleft between complementarity determining region (CDR)H2 and CDRH3.

142 s codons prone to amino acid change in their complementarity determining regions (CDR) compared with

143 ouse Fvs, we grafted the combined KABAT/IMGT complementarity determining regions (CDR) into a human I

144 The recognition involves up to six complementarity determining regions (CDR) of the TCR.

145 ructure was dominated by a heavy-chain third-complementarity-determining region (CDR H3) of 21 residu

146 affinity maturation, and a heavy chain-third complementarity-determining region (CDR H3) that is one

147 s, individual mutation of amino acids in the complementarity-determining region (CDR) 2beta to Ala re

148 ls showing a very strong preference for N(+) complementarity-determining region (CDR) 3 compared with

149 ibodies has been developed using heavy chain complementarity-determining region (CDR) 3 grafting comb

150 also prevents peptide contacts by the short complementarity-determining region (CDR) 3beta loop, and

151 nition via conformational changes within the complementarity-determining region (CDR) 3beta loop.

152 ion on a heavy chain lysine located within a complementarity-determining region (CDR) did not signifi

153 om phage-displayed libraries with restricted complementarity-determining region (CDR) diversity.

154 e, ultrahumanized antibodies via single-step complementarity-determining region (CDR) germ-lining.

155 R6261 required only seven amino acids in the complementarity-determining region (CDR) H1 and framewor

156 ine-sulphated, anionic antigen-binding loop (complementarity-determining region (CDR) H3) characteris

157 nvolve interaction of its long, hydrophobic, complementarity-determining region (CDR) H3, with adjace

158 bic pockets on IL-13 that accommodate Phe32 [complementarity-determining region (CDR) L2] and Trp100a

159 -cell receptors (TCRs) engage antigens using complementarity-determining region (CDR) loops that are

160 1d by germline Vdelta1 residues spanning all complementarity-determining region (CDR) loops, as well

161 attributed in part to the flexibility of TCR complementarity-determining region (CDR) loops, yet ther

162 bility complex (MHC) proteins using multiple complementarity-determining region (CDR) loops.

163 Complementarity-determining region (CDR) mutagenesis is

164 ecific RNA binding on a shallow surface with complementarity-determining region (CDR) sequence divers

165 Unusual complementarity-determining region (CDR) structural feat

166 ovine antibody with a well-folded, ultralong complementarity-determining region (CDR), we have develo

167 hat carried the extended, 23- to 27-residue, complementarity-determining region (CDR)-H3 segments.

168 Moreover, B7-H6 contacts NKp30 through the complementarity-determining region (CDR)-like loops of i

169 E10 was derived from the parental 3B4 using complementarity-determining region (CDR)-restricted muta

170 n interactions between the germ-line-encoded complementarity-determining region (CDR)1 and CDR2 loops

171 face area; and (iv) public heavy-chain third complementarity-determining region (CDR-H3) antibodies i

172 gnatures, including shared light-chain third complementarity-determining region (CDR-L3) amino acid s

173 Relatively conserved amino acids in the TCR complementarity-determining regions (CDR) 1 and CDR2 are

174 Perturbations within complementarity-determining regions (CDR) induce rich be

175 ring is composed of two antibodies with the complementarity-determining regions (CDR) of the two Fab

176 hape, and surface electrostatic potential of complementarity-determining regions (CDR), despite <20%

177 Abs have long (21-residue) heavy-chain third complementarity-determining regions (CDR-H3s), and m66.6

178 The role of T cell receptor (TCR) germline complementarity determining regions (CDR1 and 2) in MHC

179 49, which is located adjacent to the second complementarity-determining region (CDR2) in the light c

180 ne-encoded residues in the second beta-chain complementarity-determining region (CDR2beta).

181 e former light chain interface and the third complementarity determining region (CDR3).

182 b MK2-23 Fab' and shown that its heavy chain complementarity-determining region (CDR3) (H3) and its l

183 Whether critical amino acids in the third complementarity-determining region (CDR3) of the ANA ori

184 ptor diversity is contained within the third complementarity-determining region (CDR3) of the T-cell

185 y of amino acids at positions 6 and 7 of the complementarity-determining region CDR3beta robustly pro

186 restriction in the structure of the Ig third complementarity determining regions (CDR3s), which were

187 The third complementarity-determining regions (CDR3s) of antibodie

188 Despite a disulfide bond linking complementarity determining regions (CDRs) 1 and 3, both

189 d previously by site-directed mutagenesis of complementarity determining regions (CDRs) 1beta, 2alpha

190 typical antigen-binding cavity formed by the complementarity determining regions (CDRs) and another c

191 nd extensive coverage of the antigen-binding complementarity determining regions (CDRs) in a single L

192 Classification of the structures of the complementarity determining regions (CDRs) of antibodies

193 V-gene sequences are characterized by short complementarity determining regions (CDRs) of high diver

194 comprehensive mutagenesis of the light chain complementarity determining regions (CDRs) of HIV-1 anti

195 selective analysis of diagnostic heavy-chain complementarity determining regions (CDRs) of single-cha

196 imensional convex hull was formed around the complementarity determining regions (CDRs) of the antibo

197 ification of the Xle site, especially in the complementarity determining regions (CDRs), can result i

198 We estimated the evolutionary rates of the complementarity determining regions (CDRs), which are mo

199 arily by the sequence and structure of their complementarity determining regions (CDRs).

200 -47) are located in the loops comprising the complementarity determining regions (CDRs).

201 to design libraries of synthetic heavy chain complementarity determining regions (CDRs).

202 we turned to deep mutational scanning in the complementarity determining regions (CDRs).

203 ntibodies between the framework and loops of complementarity-determining regions (CDRs) 1 and 2.

204 reveals unique conformations of heavy chain complementarity-determining regions (CDRs) 2 and 3 (H2 a

205 V(H) library by grafting naturally occurring complementarity-determining regions (CDRs) 2 and 3 of he

206 erate significant diversity within all three complementarity-determining regions (CDRs) and also with

207 Modifications in the complementarity-determining regions (CDRs) are especiall

208 mmonly accumulate charged mutations in their complementarity-determining regions (CDRs) during affini

209 Complementarity-determining regions (CDRs) from monoclon

210 e backbone entropy change for immunoglobulin complementarity-determining regions (CDRs) from the crys

211 humanized anti-CD20 monoclonal antibody with complementarity-determining regions (CDRs) identical to

212 All complementarity-determining regions (CDRs) in the Fab co

213 Previous analyses of the complementarity-determining regions (CDRs) of antibodies

214 oth containing Asp-Asp motifs and located in complementarity-determining regions (CDRs) of light chai

215 matic mutations and arginine residues in the complementarity-determining regions (CDRs) of pathogenic

216 ting amyloidogenic peptide segments into the complementarity-determining regions (CDRs) of single-dom

217 aspartic acid residues (Asp) present in the complementarity-determining regions (CDRs) of the light

218 In addition to conformational changes in complementarity-determining regions (CDRs) of the TCR se

219 fic, high-affinity binding of quinine to the complementarity-determining regions (CDRs) of these anti

220 y and optimised via mutagenesis of the third complementarity-determining regions (CDRs) of variable h

221 ne whether they recognize SAEs through their complementarity-determining regions (CDRs) or framework

222 in a single LC-MS run; (ii) connectivity of complementarity-determining regions (CDRs) via Sap9-prod

223 mulate affinity-enhancing mutations in their complementarity-determining regions (CDRs) without compr

224 ble region contains three antigen-contacting complementarity-determining regions (CDRs), with CDR1 an

225 k with a template containing human consensus complementarity-determining regions (CDRs).

226 ent-exposed positions within the heavy chain complementarity-determining regions (CDRs).

227 ding site, located within the loops known as complementarity-determining regions (CDRs).

228 Alanine scanning of their complementarity-determining regions, coupled with epitop

229 he buried monomeric peptide in solanezumab's complementarity-determining region, crenezumab binds the

230 The three light-chain complementarity-determining regions do not adopt canonic

231 s were influenced most by the VHH CDR3 (CDR, complementarity-determining region) elements, with the m

232 In both complexes of the unit, all the complementarity-determining regions except for L3 intera

233 utation and long, variable heavy-chain third complementarity-determining regions, factors that may li

234 Two metal ions bridge complementarity determining regions from the antibody li

235 ency of charged amino acids localized to the complementarity-determining regions, further suggesting

236 ibrary with synthetic diversity in the three complementarity determining regions (H1, H2, and H3) of

237 positively charged pocket formed within the complementarity determining region H2 loops that binds t

238 a common epitopic focus by utilizing various complementarity-determining region H3 (CDRH3) lengths.

239 17-mer peptide of VP1 was inserted into the complementarity-determining region H3 loop of MFE-23, a

240 Insertion of any of these motifs into the complementarity-determining region H3 of a "clean" antib

241 y high arginine (Arg) content in the H chain complementarity determining region (H3), suggesting that

242 espite heritable segment use, the rearranged complementarity-determining region-H3 repertoires remain

243 gglutinin stem through conserved heavy-chain complementarity determining region (HCDR) residues.

244 (motif-2) in the Ig heavy-chain (IgH) third complementarity-determining region (HCDR3) of IgH, respe

245 gments with unique, shared heavy chain third complementarity-determining region [HCDR3] and light cha

246 eals a unique epitope, where the heavy-chain complementarity determining regions (HCDRs) 1 and 2 bind

247 led the major contribution made by the first complementarity-determining region in each of sifalimuma

248 verlap of the IgG-Fc binding site in FcRn by complementarity-determining regions in DX-2507.

249 surface consists of residues located in four complementarity-determining regions including a major co

250 Their heavy-chain complementarity determining region inserts into the cons

251 Ag receptors of lymphocytes rather than the complementarity-determining region involved in the bindi

252 ned oligonucleotide libraries encoding three complementarity-determining regions (L3 from the light c

253 rmining region [HCDR3] and light chain third complementarity-determining region [LCDR3] motifs).

254 libraries generated by randomizing all three complementarity-determining region -like loops of the (1

255 tes as well as structural properties such as complementarity determining region loop conformation and

256 conewton force requires binding through both complementarity determining region loops and hydrophobic

257 a preference for coding substitutions in the complementarity determining region loops of many of the

258 The complex structure shows that the complementarity determining region loops of the 10C12 an

259 at generally found in more flexible antibody complementarity-determining region loops but resembles t

260 Surprisingly, crenezumab's complementarity-determining region loops can effectively

261 The peptide design was based on complementarity-determining region loops of human broadl

262 The variable CDR (complementarity-determining region) loops at the antigen

263 nstrained loop of the peptides and the third complementarity determining region of the antibody heavy

264 me conformations capable of fitting into the complementarity determining region of the ELDKWA-binding

265 use and only modest differences in the third complementarity determining region of the immunoglobulin

266 associated with Alzheimer's disease into the complementarity determining regions of a domain (V(H)) a

267 t of ligand mimicry by the third heavy-chain complementarity-determining region of 1C1.

268 The loop is analogous to the third complementarity-determining region of immunoglobulin var

269 nally alter a hydrophobic patch on the third complementarity-determining region of the heavy chain (C

270 ase of the unusually long (22-residue) third complementarity-determining region of the heavy chain (C

271 motif of the natural ligand within the third complementarity-determining region of the heavy chain.

272 rate separation-of-function mutations in the complementarity-determining regions of 3E10 revealing th

273 inding capability was grafted into different complementarity-determining regions of a fully human Fab

274 loidogenic peptides (6-10 residues) into the complementarity-determining regions of a single-domain (

275 ficient distance for contact by two separate complementarity-determining regions of antibody.

276 O receptor-activating peptides inserted into complementarity-determining regions of Fab (Fab 59), att

277 through a series of hydrogen bonds from the complementarity-determining regions of Gipg013 Fab to th

278 Contacts are made with five complementarity-determining regions of the antibody as w

279 a cleft formed by residues from five of the complementarity-determining regions of the scFv.

280 ues in variable domains, especially in CDRs (complementarity determining regions) of an antibody, may

281 from the Waters antibody contains all three complementarity determining regions on the light chain.

282 as carried out by converting over 60% of non-complementarity-determining region residues to those of

283 Our unique complementarity-determining region sequence design optim

284 ha/beta-chain usage and restricted TCR third complementarity-determining region spectra.

285 es show clustered mutational patterns in the complementarity determining region, suggesting that vari

286 affinity maturation by mutation outside the complementarity determining region surface of the antibo

287 io of replacement to silent mutations in the complementarity determining regions than in the framewor

288 It is mostly light chain complementarity-determining regions that are driving par

289 extensive framework contacts in addition to complementarity-determining regions that has not been se

290 H91VL, and an aromatic residue in the third complementarity-determining region to recognize thymine-

291 or yeast display libraries of mutants within complementarity-determining regions to affinity mature a

292 The antibody uses all six complementarity-determining regions to bind to a quatern

293 ing was used to identify key residues in the complementarity-determining regions to guide mutagenesis

294 strong bias for replacement mutations in the complementarity determining regions was found, indicatin

295 of intrinsic ligand bias, the germ-line TCR complementarity determining regions were extensively div

296 coverage, with incomplete sequencing of the complementarity determining regions which are fundamenta

297 individual amino acids and motifs within the complementarity-determining regions which contribute to

298 rid TCR containing TCR-gamma chain germ-line complementarity determining regions, which engaged effic

299 atic mutations and amino acid replacement in complementarity-determining regions with a high replacem

300 tching the distribution observed in antibody complementarity-determining regions without incurring th