ライフサイエンスコーパス: complementarity-determining region 3

1 ed clones (as confirmed by sequencing of the complementarity-determining region 3).

2 dominant germ line genes as well as dominant complementarity determining region 3.

3 acids, such as arginine, in the heavy chain complementarity-determining region 3.

4 use of a restricted set of sequences in the complementarity-determining region 3.

5 but they all had very different sequences in complementarity-determining region 3.

6 hybridomas, with mutations concentrating in complementarity-determining region 3.

7 d substantial sequence homology within their complementarity-determining region 3.

8 tirely determined by junctional diversity in complementarity-determining region-3.

9 maturation-associated changes in heavy-chain complementarity determining region 3, a key antigen-bind

10 t use, and in the length and features of the complementarity-determining region 3, a major determinan

11 re, increased palindromic nucleotides in the complementarity determining regions 3 and long stretches

12 y a single, conservative substitution in the complementarity-determining region 3 and the other conta

13 bnAbs, including a short CDRL3 (light-chain complementarity-determining region 3) and mutations that

14 ional protein antigens since the heavy chain complementarity-determining region 3 appears to play onl

15 ggests that cationic residues in the H chain complementarity-determining region 3 are important for t

16 Complementarity-determining region 3 averaged 10 amino a

17 Vgamma2Vdelta2 TCR has a basic region in the complementarity-determining region 3 binding groove that

18 nced to date possess a 10-amino acid L chain complementarity-determining region-3 (CDR-3) having an i

19 In the productive repertoire, the H chain complementarity determining region 3 (CDR3(H)) was signi

20 We found sequence identity for complementarity determining region 3 (CDR3) among a majo

21 5 shows that the tip of the CH65 heavy-chain complementarity determining region 3 (CDR3) inserts into

22 The complementarity determining region 3 (CDR3) length adjus

23 thin this population were documented by both complementarity determining region 3 (CDR3) length polym

24 vo quantitative TCR beta chain V segment and complementarity determining region 3 (CDR3) length reper

25 technique that displays the distribution of complementarity determining region 3 (CDR3) lengths for

26 conserved arginine-serine-serine sequence in complementarity determining region 3 (CDR3) of the V(bet

27 Also, the Vbeta complementarity determining region 3 (CDR3) regions from

28 h very similar and unusually long beta-chain complementarity determining region 3 (CDR3) regions in C

29 es of amino acids within the antigen binding complementarity determining region 3 (CDR3) repertoire o

30 These TCRs encoded a range of V, J, and complementarity determining region 3 (CDR3) sequences on

31 V5E1, by virtue of complementarity determining region 3 (CDR3), may also en

32 ough each of these Fabs contained a distinct complementarity determining region 3 (CDR3)-H sequence.

33 n dominated the interaction and, whereas the complementarity determining region-3 (CDR3) loops exclus

34 d that the somatically generated light chain complementarity-determining region 3 (CDR3) contributes

35 l in mice and humans, we wondered whether 1) complementarity-determining region 3 (CDR3) diversity wa

36 We measured the size distribution of the complementarity-determining region 3 (CDR3) for expanded

37 hape complementarity, and the TCR beta chain complementarity-determining region 3 (CDR3) has minimal

38 JH4 rather than JH1 and exhibit more diverse complementarity-determining region 3 (CDR3) junctions wi

39 We used complementarity-determining region 3 (CDR3) length analy

40 In 51p1-encoded immunoglobulin M (IgM), complementarity-determining region 3 (CDR3) length and f

41 study the diversity of Vbeta usage and beta complementarity-determining region 3 (CDR3) length of TC

42 Vbeta8.1 TCR repertoire directly ex vivo by complementarity-determining region 3 (CDR3) length spect

43 CR-based assay that permits determination of complementarity-determining region 3 (CDR3) length varia

44 tudy the diversities of Vbeta usage and beta complementarity-determining region 3 (CDR3) lengths of T

45 s were enriched for clones utilizing uniform complementarity-determining region 3 (CDR3) lengths.

46 Moreover, the sequences of the complementarity-determining region 3 (CDR3) loop from to

47 ue regions" of VpreB and lambda5 replace the complementarity-determining region 3 (CDR3) loop of an a

48 d always be identified at position 98 of the complementarity-determining region 3 (CDR3) loop of TCR

49 germline-encoded residues of its delta chain complementarity-determining region 3 (CDR3) loop to bind

50 result of a conformational change in the TCR complementarity-determining region 3 (CDR3) loop.

51 de centric, dominated by two residues of the complementarity-determining region 3 (CDR3) loops that a

52 essed TCR beta-chains with highly homologous complementarity-determining region 3 (CDR3) loops.

53 ongly with a somatically recombined TCRdelta complementarity-determining region 3 (CDR3) motif derive

54 d several phylogenetically conserved Vgamma2 complementarity-determining region 3 (CDR3) motifs betwe

55 ients with skewed repertoires, cDNA from the complementarity-determining region 3 (CDR3) of 4 TCR-Vbe

56 structure and key amino acid residues on the complementarity-determining region 3 (CDR3) of FLCs are

57 We used complementarity-determining region 3 (CDR3) of the immun

58 Complementarity-determining region 3 (CDR3) of the TCR i

59 fected macaques by assessing T-cell receptor complementarity-determining region 3 (CDR3) profiles and

60 Analysis of complementarity-determining region 3 (CDR3) regions cont

61 We performed deep sequencing of TCRbeta complementarity-determining region 3 (CDR3) regions in s

62 ng of rearranged T-cell receptor (TCR) Vbeta complementarity-determining region 3 (CDR3) regions, a p

63 ha11(+)Vbeta3(+) Th (70%) express a critical complementarity-determining region 3 (CDR3) residue (glu

64 ed selected usage of TCR V beta families and complementarity-determining region 3 (CDR3) segments.

65 eveloped a computational method to infer the complementarity-determining region 3 (CDR3) sequences of

66 TCR transcripts, including complementarity-determining region 3 (CDR3) sequences, w

67 th conserved motifs and global similarity of complementarity-determining region 3 (CDR3) sequences.

68 ing anchored RT-PCR of all the TCRbeta locus complementarity-determining region 3 (CDR3) sequences.

69 peripheral blood lymphocytes was assessed by complementarity-determining region 3 (CDR3) size distrib

70 We have used complementarity-determining region 3 (CDR3) size distrib

71 as been studied by examining the profiles of complementarity-determining region 3 (CDR3) sizes expres

72 We examined the heterogeneity of complementarity-determining region 3 (CDR3) sizes of Ig

73 atients, multiple monoclonal and oligoclonal complementarity-determining region 3 (CDR3) spectratype

74 receptor (TCR), the variable beta (VB)-chain complementarity-determining region 3 (CDR3), can serve a

75 oding an even number of Cys (two or four) in complementarity-determining region 3 (CDR3), which is an

76 re including antibodies with quasi-identical complementarity-determining region 3 (CDR3), which sugge

77 variable major antigen-binding determinant, complementarity-determining region 3 (CDR3), with specif

78 major components of junctional diversity in complementarity-determining region 3 (CDR3).

79 ymocytes that express shorter TCR beta-chain complementarity-determining region 3 (CDR3).

80 o acid residue in the second position of the complementarity-determining region 3 (CDR3).

81 ements and display considerable diversity in complementarity-determining region 3 (CDR3).

82 ing a high-resolution analysis of the TCR VB complementarity-determining region 3 (CDR3).

83 lthy donors, that patients have shorter TCRB complementarity-determining region 3s (CDR3), in all cel

84 pparent bias for histidine at position 95 of complementarity-determining region-3 (CDR3).

85 ere, we show that exome reads mapping to the complementarity-determining-region 3 (CDR3) of mature T-

86 global changes in T cell receptor beta chain complementarity determining region 3 (CDR3beta) sequence

87 The ultralong heavy chain complementarity determining region 3 (CDR3H) of bovine a

88 nique structure in its ultralong heavy chain complementarity determining region 3 (CDR3H) that folds

89 igh-affinity antibodies with long human-like complementarity-determining region 3 (CDR3H), broad epit

90 and sequenced to identify utilized V genes, complementarity-determining regions 3 (CDR3s), and joini

91 he relative roles of VH FR1, heavy (H) chain complementarity determining region 3 (CDRH 3) and the li

92 r unusual traits, such as a long heavy chain complementarity determining region 3 (CDRH3) and autorea

93 (BLV1H12) which has an ultralong heavy chain complementarity determining region 3 (CDRH3) provides a

94 that a four-residue insertion in heavy chain complementarity-determining region 3 (CDRH3) contributed

95 The lineage Abs bore an anionic heavy chain complementarity-determining region 3 (CDRH3) of 25 amino

96 s CD8 independent but correlated with longer complementarity-determining regions 3 characteristic of

97 ve N-region additions, Vh usage, and charged complementarity-determining region 3 consistent with aut

98 MRL/lpr mice still revealed the presence of complementarity-determining region 3 containing apparent

99 ealed an extended VH binding interface, with complementarity-determining region 3 deeply penetrating

100 alphabeta TCR after grafting of a G8 or KN6 complementarity-determining region 3-delta (CDR3delta) l

101 e characterized by a substantial decrease in complementarity determining region 3 diversity.

102 clones reveals a marked heterogeneity in the complementarity-determining region 3 domain and differen

103 ct human scFv from a library with randomized complementarity-determining region 3 domains.

104 mAbs against both Valpha24 and the invariant complementarity-determining region 3 epitope of the huma

105 er, neutralizing antibodies possessed longer complementarity-determining region 3 for both heavy and

106 mmunoglobulin heavy-chain gene coding in the complementarity-determining region 3 for three repeats o

107 However, the heavy chain complementarity-determining region 3 (H-CDR3) of most pa

108 ese, the PG9 antibody has a long heavy chain complementarity determining region 3 (HCDR3) and possess

109 nt anti-ssDNA Fab, DNA-1, and 16 heavy chain complementarity determining region 3 (HCDR3) mutant vari

110 encoded and immunoglobulin (Ig) heavy-chain complementarity determining region 3 (HCDR3) residues, w

111 ult of stabilization of the long heavy chain complementarity determining region 3 (HCDR3).

112 idues (H97-H100A) in the apex of heavy chain complementarity-determining region 3 (HCDR3) are disorde

113 ults from a short and inflexible heavy chain complementarity-determining region 3 (HCDR3) loop and a

114 h unusual features, such as long heavy-chain complementarity-determining region 3 (HCDR3) loops.

115 The heavy chain complementarity-determining region 3 (HCDR3) of the anti

116 unusual traits, including a long heavy chain complementarity-determining region 3 (HCDR3), polyreacti

117 .03 except for amino acid differences in the complementarity-determining region 3 in both heavy and l

118 a higher than average frequency of atypical complementarity-determining regions 3, including those m

119 ells were expressing identical TCR Vbeta13.6/complementarity-determining region 3/J region sequences.

120 llowed the characteristic public clone using complementarity determining region 3 length T cell reper

121 nt of junctional diversity, and mean H chain complementarity determining region 3 length.

122 nvestigated the CD8 TCR V beta repertoire by complementarity-determining region 3 length analysis usi

123 Complementarity-determining region 3 length and amino ac

124 Complementarity-determining region 3 length displays sug

125 little evidence for changes in Vss usage or complementarity-determining region 3 length distribution

126 mers and a panel of anti-Vss Abs, as well as complementarity-determining region 3 length distribution

127 D8+ T cells by TCRV beta surface expression, complementarity-determining region 3 length distribution

128 r an absolute deletion of a single preferred complementarity-determining region 3 length polymorphism

129 Analysis of complementarity determining region 3 lengths of 24 TCR-b

130 ntly evolved clones, and a narrower range of complementarity-determining region 3 lengths at day 15.

131 a recurrent amino acid sequence motif in the complementarity-determining region 3 loop and a prevalen

132 ng site is dominated by a single heavy-chain complementarity-determining region 3 loop, with minor co

133 These results demonstrate that the complementarity-determining region 3 loops contribute to

134 Our results highlight the role of the TCR complementarity-determining region 3 loops for controlli

135 the V beta elements and the sequences of the complementarity-determining region 3 loops of their TCRs

136 teraction was dominated by the hypervariable complementarity-determining region 3 loops, indicating t

137 in the T-cell receptor Vbeta gene usage and complementarity-determining region 3 loops.

138 y body demonstrated the presence of the same complementarity determining region 3 motifs found in MBP

139 unique and thus far not reported heavy-chain complementarity determining region 3 motifs, of which 4

140 demonstrated sets of related, but different, complementarity-determining region 3 nucleotide sequence

141 use the biochemical features encoded by the complementarity determining region 3 of each B cell rece

142 Tyrosine and glycine constitute 40% of complementarity determining region 3 of the immunoglobul

143 Mutagenesis of M88 showed that the complementarity determining regions 3 of both gammadelta

144 ere used to replace the extended heavy chain complementarity-determining region 3 of an IgG antibody

145 h-throughput sequencing of the TCRbeta chain complementarity-determining region 3 of liver-infiltrati

146 we altered single amino acid residues of the complementarity-determining region 3 of the beta-chain o

147 through interactions with the unusually long complementarity-determining region 3 of the HC33.1 heavy

148 and identified an A to S substitution in the complementarity-determining region 3 of the variable reg

149 ponse was the generation of arginines in the complementarity-determining region-3 of DNA-binding hybr

150 n with sequencing of the highly variable TCR complementarity-determining region 3, permitting a quant

151 Spectratyping of the complementarity-determining region 3 regions reveals tha

152 We found that T-cell receptor beta (TCRbeta) complementarity-determining region 3 repertoire sequenci

153 exhibited the dominant responses of TCR-beta complementarity-determining region 3-restricted T cell s

154 it has always been tempting to assume that a complementarity-determining region 3 sequence has been a

155 a 20-mer TCR peptide incorporating a common complementarity-determining region 3 sequence of the imm

156 novial compartment; (3) some T-cell receptor complementarity-determining region 3 sequence similariti

157 In six of seven specimens, the same complementarity-determining region 3 sequence was repeat

158 variable region beta) gene usage and a CDR3 (complementarity-determining region 3) sequence to assess

159 opologies are possible because of the unique complementarity-determining region 3 sequences created d

160 In addition, complementarity-determining region 3 sequences formed in

161 However, the complementarity-determining region 3 sequences of the V

162 Analysis of expressed TCRB complementarity-determining region 3 sequences showed th

163 dentical T-cell receptor variable beta-chain complementarity-determining region 3 sequences were iden

164 e whether these differences in V beta usage, complementarity-determining region 3 sequences, and the

165 cell responses that preferentially recognize complementarity-determining region 3 sequences, contribu

166 with nearly identical heavy and light chain complementarity-determining region 3 sequences.

167 etermining region 3 length distribution, and complementarity-determining region 3 sequencing analysis

168 ow cytometry, Vbeta repertoire analysis, and complementarity-determining region 3 sequencing) were us

169 However, PCR-based complementarity-determining region 3 size spectratyping

170 ells in Jak3(-/-) and CTLA-4(-/-) mice using complementarity-determining region 3 spectratype analysi

171 The complementarity-determining region 3 spectratypes of thy

172 IV disease, using a sensitive beta-variable complementarity-determining region 3 spectratyping appro

173 of T cell receptor (TCR) alpha or beta chain complementarity-determining region 3 transcripts by real

174 sequenced and the amino acid sequence of the complementarity-determining region 3 was deduced.