ライフサイエンスコーパス: completely abolish

1 which CaMKII's activity is specifically and completely abolished.

2 induced p38 phosphorylation by vitamin D was completely abolished.

3 impaired in IL-23p19(-/-) lungs, but was not completely abolished.

4 r the switch to late substrate secretion, is completely abolished.

5 ed effective if the corneal blink reflex was completely abolished.

6 teins 53bp1 and Brca1 to DNA damage foci was completely abolished.

7 dy formation, and the microtubule ribbon was completely abolished.

8 signal-regulated kinase (ERK) signaling was completely abolished.

9 what reduced, but PKCbetaI translocation was completely abolished.

10 (I/V)FF motif) resulted in the current being completely abolished.

11 ted, furrow formation in the early embryo is completely abolished.

12 nd ADP-glucose pyrophosphorylase, was almost completely abolished.

13 ptake in muscle and adipose cells was almost completely abolished.

14 acellular Ca(2+), whereas caspase inhibition completely abolished ABT737-induced PS exposure in both

15 Its replacement with leucine or valine completely abolished activation with paclitaxel while pr

16 ml ricin in DMEM at 121 degrees C for 30 min completely abolished activity; and (c) milk did not affe

17 gE and IgG to BGG was confirmed by ELISA and completely abolished after pre-incubation with alpha-gal

18 Monthly P-Dex injections completely abolished albuminuria in the (NZB x NZW)F1 mi

19 Our data show that conditional knock-out completely abolished all optically evoked glutamate rele

20 BM321, BM322, BM325, and BM326 showed almost completely abolished allergenic activity and induced sig

21 7, also found at the active site, to alanine completely abolished AMP production in our activity assa

22 In the patient's plasma, AP activity was completely abolished and could only be reconstituted wit

23 Silencing of both PYCR1 and PYCR2 completely abolished anti-oxidation activity of RRM2B, d

24 mal models in which oxidative metabolism are completely abolished are not always physiologically or p

25 n contrast, a MEK1/2 inhibitor (ERK pathway) completely abolished arginase II expression while actual

26 t pH 7.7 and by about 62% at pH 7.1 and were completely abolished at pH 6.5.

27 In transgenic plants, a G2A mutation completely abolished AtCPK5 membrane association, indica

28 n of carbenoxolone, a PANX1 channel blocker, completely abolished ATP release in Calhm1 knockout cult

29 d negatively charged side chain into site 2, completely abolishes ATP-induced openings of CFTR.

30 A missense change (S98R) in a case that completely abolished BAP1 deubiquitinase activity was id

31 cing of ATGL expression in adipocytes almost completely abolished basal and TNF-alpha-induced glycero

32 human alphavbeta3 monoclonal antibody LM609, completely abolished binding of ATX to tumor cells, demo

33 Protease treatment of the bacteria completely abolished binding of FH.

34 cluster reducing the positive-charge density completely abolished binding of R-LPS.

35 The mutation of arginine 68 to alanine completely abolished binding of the blocking antibody.

36 finity of IbpA for D-ribose by 10-fold while completely abolishing binding to myo-inositol.

37 topic activity, block of TGF-beta1 signaling completely abolished both arrhythmogenic conditions.

38 In contrast, spinal PKMzeta inhibition completely abolished both prolonged allodynia to hindpaw

39 one inputs linearly and without selectivity, completely abolished both the midget cell surround and a

40 lated uridine to the 3' end of RNA, which is completely abolished by 2'-O-methylation.

41 tion range (0.1-30 muM) and its effects were completely abolished by a mixture of alpha1- and beta-AR

42 re substantially reduced and, in some cases, completely abolished by administration of neutralizing m

43 Vascular oxidative stress was completely abolished by allopurinol.

44 subjects with MDD, the attentional bias was completely abolished by anodal tDCS.

45 ogical defects in er-ant1 plants were nearly completely abolished by application of high environmenta

46 onstraint was present in 15 patients and was completely abolished by both biventricular and left vent

47 erature on the thermal tolerance of PSII was completely abolished by chloramphenicol, indicating that

48 ally, the EC activation by both bacteria was completely abolished by combined inhibition of TNF and I

49 cular relaxation to acetylcholine, which was completely abolished by endothelial nitric oxide synthas

50 e IFN-gamma-mediated induction of Trim21 was completely abolished by inhibiting protein synthesis wit

51 ments in the AD mice and this protection was completely abolished by inhibiting the dNGIs survival.

52 maltose and maltotriose and the response was completely abolished by introduction of a single point m

53 nticancer/cytotoxic effects of ascorbate are completely abolished by iron at physiological concentrat

54 These changes were completely abolished by L-histidine, supporting a key ro

55 Reporter expression is completely abolished by loss of PTHrP signaling and ecto

56 The activity of UXNAcS is completely abolished by NADH but unaffected by UDP-xylos

57 1R-Abs-induced contraction, which was almost completely abolished by neutralizing peptides targeting

58 These events were completely abolished by pepstatin A, a pharmacological i

59 pendent growth of MCF-10A(arom) cells can be completely abolished by pre-treatment with the aromatase

60 IgE binding to bromelain (r = 0.68) and was completely abolished by serum preincubation with the CCD

61 sensitive to CysLT1R or EP3 antagonists but completely abolished by simultaneous treatment both in v

62 by substitution of either Asn51 or Cys47 and completely abolished by substitution of both residues.

63 f spontaneous and miniature IPSCs, an effect completely abolished by the GABAA receptor antagonist ga

64 Fucoidan-induced platelet activation was completely abolished by the pan-Src family kinase (SFK)

65 omyosin regulatory properties of sMyBP-C are completely abolished by the presence of the DA-1 mutatio

66 The CTL response was completely abolished by the substitution of E138G/A/K in

67 nt mechanical hyperalgesia which were almost completely abolished by TRPA1 inhibitors.

68 abrogates CFTR-mediated Cl(-) secretion and completely abolishes cAMP-activated whole cell currents.

69 ignals or in the linker peptide attenuate or completely abolish capsid-specific inhibition of nuclear

70 ell growth on cellulose while loss of cel48F completely abolished cellulolytic activity.

71 rutinib, a Tec family kinase inhibitor, also completely abolished CLEC-2-mediated aggregation and Syk

72 (CLEC18A) --> Arg(339) (CLEC18A-1) mutation completely abolishes CLEC18A-1 binding to GLPS-F3, and a

73 Mutating both sites completely abolished Cx43-AP-2/Dab2/clathrin interaction

74 Mutations within and near this interface completely abolish dimerization, whereas mutations consi

75 the N-terminal dimer swapped helix (aa 1-20) completely abolishes dimerization and severely reduces p

76 Mutagenesis of the tmm gene in R. pomeroyi completely abolished DMS oxidation and subsequent DMSO f

77 s mutation of Arg36 (R36W) or Arg35 (R35H/L) completely abolished DNA binding, mutation of Arg60 (R60

78 shift in the steady-state inactivation curve completely abolished EADs in myocytes while maintaining

79 -NCs) for 3 wk to hairless mouse skin almost completely abolishes EGFR expression, suppresses downstr

80 mutation to alanine significantly reduced or completely abolished enzymatic activity.

81 th in xenografts, attenuation of lipogenesis completely abolished establishment of hepatic metastasis

82 and EGF, because withdrawal of such factors completely abolishes estradiol-induced proliferation.

83 The maternal deletion also completely abolished expression of downstream maternally

84 , which selectively cleaves heparan sulfate, completely abolished extracellular TG2 in normal and dis

85 nzyme's N-terminal RING-finger domain almost completely abolishes fiber formation but not cellulose b

86 siRNA-mediated knockdown of both PCs almost completely abolished FLAG-pro-GX sPLA2 processing in Y1

87 In addition, loss of Stx1 completely abolished fusion-competent vesicles and sever

88 inhibition, but mutating both sites together completely abolished Gem inhibition without affecting Ge

89 alpha4F71L, in alpha4beta1(delta)-receptors completely abolished GHB but not GABA function, indicati

90 Preinhibition of 11beta-HSD1 completely abolished GIP-induced effects on FFA release.

91 Mutating the Glu-binding site completely abolished Glu signaling while leaving its Ca(

92 Phloretin completely abolished gut peptide secretion stimulated by

93 loop of phosphorylation site mutants nearly completely abolished HAC1 splicing, induction of KAR2, P

94 athway and amelioration of ER stress in mice completely abolishes high fat diet-induced upregulation

95 r, selective manipulations of the MEC do not completely abolish hippocampal spatial firing.

96 results demonstrated that MW thermal heating completely abolished honey antibacterial activity wherea

97 s, we revealed that PIGG activity was almost completely abolished; however, the GPI-APs had normal su

98 expression of single phosphomimic mutations completely abolished HTTex1 aggregation in human cells.

99 Additionally, deletion of TTP completely abolishes IFN-gamma-mediated p19 mRNA degrada

100 Importantly, Treg depletion completely abolished IGF-I-mediated protection confirmin

101 Importantly, PHB2 knockdown completely abolished IGFBP-6-mediated RMS cell migration

102 Furthermore, DC depletion completely abolished IL-12 production in response to inf

103 ur findings, we verified that a Bim knockout completely abolished immunotoxin-mediated apoptosis.

104 ional activity in response to kynurenine was completely abolished in a kynR mutant, further indicatin

105 The antinociceptive effects of 3a were completely abolished in A(1)AR knockout mice, revealing

106 Moreover, ethanol-induced NREM sleep was completely abolished in A2AR knockout mice compared with

107 -biased D(2)R agonist, in wild-type mice was completely abolished in beta-arrestin-2 knockout mice.

108 This enhancement was completely abolished in carbonic anhydrase (CA)-deficien

109 cyte and monocyte-derived DC recruitment was completely abolished in CCR2 knockout mice.

110 Both of these effects were almost completely abolished in cells from SNI-operated rats.

111 e effects of AICAR on Na(+),K(+)-ATPase were completely abolished in cultured primary mouse muscle ce

112 s significantly reduced, however, it was not completely abolished in diabetic PKC-alpha/beta(-/-) mic

113 1) foci are largely reduced, and synapsis is completely abolished in dsy2 meiocytes.

114 mouse models in which ERK/MAPK signaling was completely abolished in each of the two distinct classes

115 , protein production, and Ca(2+) influx were completely abolished in EBV-transformed B cell lines fro

116 kingly, AICAR-induced glycogen synthesis was completely abolished in G6P-insensitive GS knock-in mice

117 L-selectin-dependent leukocyte rolling was completely abolished in Galnt1(-/-) mice compared with w

118 42% in the single alphaNOS1-null mutants and completely abolished in GluR1/alphaNOS1 double-knock-out

119 the adipogenic effect of ibm-infused UAG was completely abolished in GOAT-KO mice.

120 I(h) was completely abolished in hair cells of Hcn1(-)/(-) mice a

121 ivation of place cells during SWR events was completely abolished in KO.

122 unted and signal from [(13)C]bicarbonate was completely abolished in livers from PEPCK KO mice, indic

123 ABT-089-evoked transients were completely abolished in mice lacking beta2* nAChRs.

124 ons are independent of Tp53 status, they are completely abolished in mice with germline Fbxw7 haploin

125 kinsonian effects of tropicamide were almost completely abolished in mutant lesioned mice that lack M

126 ons, but responses to beta-NAD and ADPR were completely abolished in P2ry1(-/-) mice.

127 e oocyst stage and sporozoite formation were completely abolished in pat(-) parasites.

128 siglitazone treatment during HFD feeding was completely abolished in Pparg-BKO mice, an effect associ

129 th the specific activity of the enzyme being completely abolished in several TsdA-Cys(96) variants.

130 und that severing at CMT crossover sites was completely abolished in the Arabidopsis katanin mutant.

131 S. platensis; iso-migrastatin production was completely abolished in the DeltamgsF mutant SB11012 str

132 of the persistent tatCN21 effect was almost completely abolished in the GluN2B mutant mouse.

133 dramatic stenotic response, which is nearly completely abolished in the immunodeficient SCID/beige (

134 though lignin deposition in roots is almost completely abolished in the lac11 lac4 lac17 triple muta

135 SKO mouse in which de novo GSH synthesis was completely abolished in the lens.

136 on-mediated enhancement of transcription was completely abolished in the looping defective sua7-1 str

137 DSI is completely abolished in the presence of a cannabinoid re

138 The response was completely abolished in the presence of the GLUT2 inhibi

139 ly affected in the site-1 mutant, and almost completely abolished in the site-4 mutant.

140 eptor agonists in lateral septal neurons was completely abolished in TRPC1/4 double-knockout mice, an

141 Cs; mutation of both conserved CArG elements completely abolished in vivo promoter activity.

142 ficiency of LC infection is reduced, but not completely abolished, in the absence of the pentameric c

143 Treg depletion during iNKT infusions completely abolished iNKT efficacy in treating cGVHD.

144 Blocking both pathways completely abolishes integrin affinity and avidity regul

145 Two substitutions, L48F and Y63W, almost completely abolished intracellular virulence gene induct

146 Synthetically deleting this appendage also completely abolishes ion channel and antifungal activiti

147 ion of the right tonsil, we found (1) nearly completely abolished ipsilateral smooth pursuit and impa

148 ependent remodeling, cholinergic stimulation completely abolished isoproterenol-induced triggered act

149 whereas combined knockdown of TAp73 and p21 completely abolishes it.

150 eraction, and ATP binding by the transporter completely abolishes it.

151 ith a nonacidic amino acid glutamine (E211Q) completely abolished its ATPase activity and ATP-depende

152 the two predicted PKGI phosphorylation sites completely abolished its basal phosphorylation by PKGI.

153 on in the region preceding its VQ motif that completely abolishes its binding to WRKY proteins.

154 d eukaryotic K(v)1.6 channels, can reduce or completely abolish K(+) selectivity and in some cases ma

155 henotype, but the Hs2st;Hs6st double mutants completely abolished lacrimal gland development, suggest

156 Disruption of the NRPS lpmC gene completely abolished laspartomycin production in the cor

157 the 4-residue CTV from Escherichia coli FtsZ completely abolished lateral interactions between chimer

158 impair PCSK9 self-cleavage or secretion but completely abolished LDLR-degrading activity.

159 ed depletion of IL-7-producing stromal cells completely abolished LN reconstruction.

160 rtantly, autophagy inhibitor 3-methyladenine completely abolishes LPS-induced muscle proteolysis, whi

161 te) of the cardiac ryanodine receptor (RyR2) completely abolishes luminal, but not cytosolic, Ca(2+)

162 1 to M-CSF dramatically reduces but does not completely abolish M-CSF binding and signaling through i

163 Anti-TLR2 antibody completely abolished M. pneumoniae-induced AA release an

164 ssion of ERalpha in the preoptic area almost completely abolished maternal care, significantly increa

165 ogic inhibition and genetic knockout of TLR4 completely abolished ML exosome-induced cytokine product

166 eletion of myomaker in adult satellite cells completely abolishes muscle regeneration, resulting in s

167 Lack of dystrophin protein completely abolishes muscular nitric-oxide synthase (NOS

168 omyelinase by NB-19 before addition of POVPC completely abolished nanoplatform disintegration by oxPL

169 The NPY Y1 receptor antagonist BIBO3304 completely abolished NPY effects on fear extinction retr

170 spectrum TRPC antagonist, or La(3+) (50 mum) completely abolished OA-NO2 currents.

171 educing agent DTT (50 mm) or La(3+) (50 mum) completely abolished OA-NO2 responses.

172 il extravasation elicited by CCL3 was almost completely abolished on inhibition of G protein-receptor

173 he assembly domain, when changed to alanine, completely abolish or reduce capsid assembly.

174 Pharmacological block of endocytosis completely abolishes p38-mediated Na(v)1.6 current reduc

175 neutrophils toward C. neoformans but almost completely abolished phagocytosis and killing of the org

176 Inclusion of 1-5% serum completely abolished phagocytosis of non-opsonized YG be

177 signal peptides simultaneously was found to completely abolish physiological tetrathionate reductase

178 r targeted to the ER surface (termed p4PKIg) completely abolished PKA-mediated augmentation of HERG i

179 y loop, and deletion of the regulatory loop, completely abolished processing capacity of the mutants.

180 mals were strongly reduced along with almost completely abolished production of IL-17A, IFN-gamma, an

181 RORbeta, and point mutations in these sites completely abolish promoter activity in living retinas.

182 Pharmacological block of IA completely abolished rebound delays and, importantly, sh

183 Mutations D52A(2.50) and N284A(7.49) completely abolished receptor signaling, whereas mutatio

184 nated with CyaA-E7, rapamycin administration completely abolished recruitment of CD8+ T cells into TC

185 ibition of alpha-glucosidase activity almost completely abolished residual glucose production by G6pc

186 defense genes and the establishment of SAR, completely abolishes resistance to two different ETI-ind

187 p120ctn/Rac1 double knockdown completely abolished Smk-induced cell migration, whereas

188 ccordingly, siRNA knockdown of Rac1 or Cdc42 completely abolished Smk-induced cell migration, whereas

189 This Acr completely abolishes SpCas9-mediated immunity in our ass

190 In vivo, WIN 18,446 treatment completely abolished spermatogenesis after 4 weeks of tr

191 n the activation loop decreased, but did not completely abolish, splicing of HAC1 mRNA, induction of

192 tor, 17-allylamino-17-demethoxygeldanamycin, completely abolished SSTK catalytic activity.

193 t four residues of the ETON region or beyond completely abolished STIM1-dependent Orai1 function.

194 h a homozygous R429C point mutation in STIM1 completely abolishing store-operated calcium entry in T

195 tutions of serine by aspartate or asparagine completely abolished substrate transport.

196 ed the interaction between Cx50 and Skp2 and completely abolished such effects.

197 EB1, the metabolic activity was increased or completely abolished, suggesting that GREB1 may function

198 oordination site of the endopeptidase domain completely abolished SXN101742 inhibitory actions on GH

199 GS7 does not reconfigure the GAP complex and completely abolishes synaptic transmission, resulting in

200 talytically important core and CR4/5 domains completely abolish telomerase activity, unveiling mechan

201 dor-SN protein (MEF-KO) affects but does not completely abolish the association of PPARgamma and aP2-

202 2 weeks of detraining is not long enough to completely abolish the beneficial effects of regular exe

203 contrast, syt(-/-); cpx(-/-) double mutants completely abolish the enhanced spontaneous release obse

204 weakening of activity was powerful enough to completely abolish the hyperactivity induced by intense

205 in plant hormone signaling pathways did not completely abolish the transcript response but hinted at

206 roduction by donor T cells was sufficient to completely abolish the Treg suppressive effect in GVHD.

207 on using a lentivirus harboring shRNA almost completely abolished the ability of Klotho to rescue neu

208 btlest mutations either severely impaired or completely abolished the ability of the replicon to repl

209 namic injection of cytokine-encoding plasmid completely abolished the accumulation of promonocytes in

210 Knockdown of sns or duf completely abolished the accumulation of the fluorescent

211 ogenous side chain within an aromatic system completely abolished the antibacterial character.

212 f resting SG Ca(2+) by approximately 75% and completely abolished the ATP-mediated release of Ca(2+)

213 paired dorsal roots distal to the transplant completely abolished the behavioral improvement.

214 Blocking of IFN-gamma with specific mAb completely abolished the beneficial effect of donor Treg

215 change of valine to alanine at position 135 completely abolished the binding of LPS to the hMD-2 mut

216 mediated CCL2 knockdown in endothelial cells completely abolished the blood-brain barrier protective

217 ivity, selective inhibition of alpha3 almost completely abolished the capacity to restore [Na(+)](i)

218 reas blockade of IL-7Ralpha signaling almost completely abolished the development of primary SS, base

219 A C46A mutation completely abolished the E3 ligase activity and the abil

220 s or CD8alpha+ cells from tumor-bearing mice completely abolished the effect of imiquimod.

221 necrosis factor alpha in the hippocampus and completely abolished the effect of peripheral inflammati

222 rticularly, deletion of subunit COX5a almost completely abolished the electrochemical signal.

223 eover, mutations in residue NqrB-G140 almost completely abolished the electron transfer to ubiquinone

224 e significantly increased basal activity and completely abolished the ethanol-induced activity of the

225 esion prevented intralesion angiogenesis and completely abolished the fibrotic scar.

226 morphine treatment of slice cultures almost completely abolished the firing of LC neurons, whereas c

227 Importantly, knockdown of NDR1/2 almost completely abolished the function of cyclin D1 K112E in

228 RNA-mediated suppression of CD146 expression completely abolished the galectin-3-induced secretion of

229 e selection eliminated Runx3d expression and completely abolished the generation of CD8(+) single-pos

230 We further showed that this mutation completely abolished the GPAT activity of the recombinan

231 EPI64B almost completely abolished the GTP-bound form of Rab27B, witho

232 uperoxide dismutase/catalase mimetic EUK-134 completely abolished the H(2)O(2)-mediated RIRR response

233 WT-20 disordered the L(alpha) phase and completely abolished the HII phase in DOPE-Me/WT-20 50:1

234 hereas a combination of these two inhibitors completely abolished the IL-1beta-induced expression of

235 eed, mutation of Pro(830) to leucine (P830L) completely abolished the kinase and RNase activities, si

236 Hippocampal suppression of HDAC4 in vivo completely abolished the long-lasting AChE-related and b

237 the lysosomal association of mTOR and almost completely abolished the lysosomal association of TSC2.

238 SRC kinase inhibitor, saracatinib (AZD0530), completely abolished the MEK inhibitor-induced invasion.

239 (+) cells from reprogramming cultures almost completely abolished the NANOG and OCT4 positive sub-pop

240 Surprisingly, cyclophilin D ablation completely abolished the phenotypic advantage of G93A fe

241 ver, transient inhibition of mTORC2 by PP242 completely abolished the phosphorylation of 4EBP1 and de

242 acologic inhibition of glycolytic metabolism completely abolished the protection afforded the heart b

243 the murine TLR4 K367E/S386K/R434Q mutations completely abolished the response to lipid IV(A), effect

244 two RAREs, DE-RARE and ENE-RARE, in the BAC completely abolished the rostral expansion of the 5 Hoxb

245 SCN ablation completely abolished the sleep-promoting and hypothermic

246 nce mutation of the catalytic serine residue completely abolished the stimulatory activity.

247 ing RNA-mediated knockdown of Lyn expression completely abolished the synergistic effects of IL-3 pri

248 studies demonstrated that regulatory T cells completely abolished the tPA-induced elevation of MMP9 a

249 of the promoter activity, but neither mutant completely abolished the TX-induced GLT-1 promoter activ

250 Specifically, while deletion of fimP completely abolished the type 1 fimbrial structures, sur

251 rival at the intercellular bridge but almost completely abolishes the abscission failure phenotype.

252 s (Glu(200) and Glu(414)) of the active site completely abolishes the beta-glucosidase activity.

253 er glycine residue in the two Axin segments, completely abolishes the binding of the corresponding Ax

254 utation of Trp(233) to phenylalanine (W233F) completely abolishes the Cc-dependent peroxidase activit

255 XP3(+) Treg cells during tolerance induction completely abolishes the development of LZT, resulting i

256 blocking Notch signaling in late RPCs almost completely abolishes the generation of terminal asymmetr

257 ecause the systemic depletion of neutrophils completely abolishes the nanoparticle tumor deposition.

258 domain with a (GGS)(10) unstructured linker completely abolishes the phosphorylation of all tyrosine

259 Inactivating both piki-1 and vps-34 completely abolishes the production of phagosomal PtdIns

260 ish, whereas restricting TyrRS nuclear entry completely abolishes the protection.

261 encing or eliminating the remodelled circuit completely abolishes the recovered proprioceptive functi

262 segment in the protein tag to 18 amino acids completely abolishes the RNA binding function of dsRBD.

263 Consequently, neutralization of IFN-gamma completely abolishes the suppressive capacity of this po

264 diversity and joining [V(D)J] recombination completely abolishes the Tcralpha/delta-c-myc translocat

265 g domains of the human beta3 subunit) almost completely abolishes the very small amount of function s

266 onatal amygdala damage retarded, but did not completely abolish, the acquisition of a learned fear.

267 Abrogation of dectin-1 in DCs completely abolishes their Th9-polarizing capability in

268 Genetic disruption of gp96-CNPY3 interaction completely abolishes their TLR chaperone function.

269 tory cortex during the priming period almost completely abolished these improvements, suggesting that

270 ing the O. formigenes CM with heat or pepsin completely abolished this bioactivity, and selective ult

271 However, AT lesions completely abolished this contextual learning advantage,

272 Remarkably, severe-stress exposure completely abolished this effect without recovery for at

273 transducer and activator of transcription 3 completely abolished this effect.

274 es, whereas blockade of VIP receptors almost completely abolished this form of epileptiform activity.

275 of IL-17A in CD4 T cells in Apc(Min/+) mice completely abolished this pathogenic potential in vivo.

276 Breathing air completely abolished this phenomenon.

277 tly contribute to the dimerization interface completely abolishes this coupling.

278 oR-Hdac3 interaction alone was sufficient to completely abolish TLR4 tolerance and to render mice vul

279 However, ER stress preconditioning almost completely abolished TNF-alpha-elicited NF-kappaB activa

280 Knockdown of PPARgamma via siRNA strategy completely abolished TNF-alpha-mediated p65 binding to k

281 totoxins such as alpha-sarcin and ricin that completely abolish translation.

282 mutational inactivation of spyB translation completely abolishes translation of spyA.

283 oline substitutions on the PC1-proximal side completely abolished transport and reduced backbone flex

284 t rather significantly reduces, although not completely abolishes, transporter activity.

285 Such protection was completely abolished upon the chronic protocol.

286 Moreover, rapamycin completely abolished vaccine-induced cytotoxic T-cell re

287 Interestingly, ORF7 deletion completely abolishes viral spread in human nervous tissu

288 hown that deletion of either nrdHEKF or nrdI completely abolishes virulence in an animal model of end

289 pSmad2 (but not Smad7) foci were completely abolished when ATM was depleted or inactivate

290 for the homomeric form of the channel and is completely abolished when coexpressed with Kir5.1.

291 ated GIP, GLP-1 and PYY secretion, which was completely abolished when extracellular Ca2+ was absent.

292 uction of IFN-alpha in human PBMC was nearly completely abolished when IL-32 was silenced.

293 Callus formation was completely abolished when macrophage depletion was initi

294 ux (100 nm) in cultured DRG neurons that was completely abolished when TRPA1 was deleted or inhibited

295 oter region, and the repressive function was completely abolished when WT1 binding sites were mutated

296 -AG were significantly decreased and DSI was completely abolished, whereas DAGLbeta deficiency did no

297 Subsequently, GnRH receptor activation was completely abolished with a selective Galphaq inhibitor,

298 ne, with anti-MPO antibody treatment and was completely abolished with monocyte depletion.

299 establishment of CRC metastasis in vivo was completely abolished with targeted inhibition of mTORC1

300 ndent on alpha-catenin; the rescue effect is completely abolished with the depletion of alpha-catenin