ライフサイエンスコーパス: compound

1 mL of RBC AChE inhibited with a soman model compound.

2 eact for 20 min before addition of the diazo compound.

3 berry is a major natural source of bioactive compounds.

4 luable assistance in designing new bioactive compounds.

5 ombination analysis of known XANES reference compounds.

6 are essential for learned responses to taste compounds.

7 sequester harmful reactions and store useful compounds.

8 es are an important target for antibacterial compounds.

9 ctabilities of flavanolic and total phenolic compounds.

10 initively assigned for all the corresponding compounds.

11 are yet unidentified) rather than by single compounds.

12 is presented to compare these two classes of compounds.

13 ters are found in many natural and unnatural compounds.

14 allow the development of novel antibacterial compounds.

15 affect the recovery of the newly identified compounds.

16 preparation of enantiomerically pure organic compounds.

17 and photophysical properties of these unique compounds.

18 ent biosynthetic pathways of floral volatile compounds.

19 gh price, toxicity, and scarcity of vanadium compounds.

20 f phospholipid and the OH groups of phenolic compounds.

21 ties of numerous natural biologically active compounds.

22 ric and ferulic acids were the most abundant compounds.

23 ntify DOM photochemical activity using probe compounds.

24 ned by decomposition reactions of esterified compounds.

25 dministration of pro- and antiquorum-sensing compounds.

26 of this pharmacologically important group of compounds.

27 a unique feature of the clathrate family of compounds.

28 TOF-MS) allows the detection of thousands of compounds.

29 obic, and more drug-like than non-allosteric compounds.

30 ) and then validated using an additional 519 compounds.

31 One approach is to develop radiosensitizing compounds.

32 qRT-PCR assay indicated that compound 1 and DBL exposure up-regulated the expression

33 Furthermore, the structure and bonding of compound 1 has been investigated by theoretical methods.

34 Compound 1 was tested in dose escalation studies in rats

35 presenting several modifications in the lead compounds 1 (HS665) and 2 (HS666).

36 ublimation of a low ionization energy matrix compound, 1,5-diaminonapthalene (1,5-DAN), minimizing th

37 ned X-ray structures of the most potent hit (compound 19, IC50 = 2.9 muM) in complex with the enzyme.

38 Four compounds (2-propanol, ethylene glycol, propargyl alcoho

39 The pharmacologic PKC-theta inhibitor (Compound 20) administered during allergen challenge redu

40 s at the 2-position led to identification of compound 25 as a potent and selective A2A adenosine rece

41 Compound 25 was advanced to first-in-man trials for the

42 Structural optimization led to compound 28, which was 4-fold more potent than its paren

43 The boron compounds 3 and 4 have shown low cytotoxicity activity i

44 SAR) analysis, we obtained an optimized lead compound (38u) that represses breast cancer invasion and

45 The target compound 4-(11)C-MBZA was prepared in 46% +/- 7% radioch

46 enotypes, including twenty-nine polyphenolic compounds (4 anthocyanins, 9 phenolic acids, 9 flavonols

47 nhibitor hydroxyl-ethyl-amine-based scaffold compound 49c.

48 ide, [Leu(3), Leu(7), Phe(8)]-gamma-MSH-NH2 (compound 5), which is 16-fold selective for the hMC1R (E

49 Azo-compounds 7 upon further reaction with NaTeC6H5 were red

50 dies on the mechanism of action suggest that compound 8 blocks translation.

51 ieno[2,3-c]pyrrol-3-ones (12)), and notably, compounds 8, 10, and 12 resemble the skeletons of 3-phen

52 For polar compounds, according to the theoretical discussion, the

53 molecular targets and efficiently screen new compounds aimed at those targets.

54 amino acids, including the sulfur-containing compounds and acetaldehyde, as well as lipid oxidation d

55 sitively affected peptides, soluble phenolic compounds and antioxidant activity whereas a negative im

56 significant covariation between the volatile compounds and bacterial assemblages in meerkat paste, pa

57 LOX-1 modulation by some naturally occurring compounds and efforts toward development of small molecu

58 nities to discover new or repurpose existing compounds and expedite treatment options.

59 Fatty acids, volatile compounds and sensory attributes of beef from bulls fed

60 P with lesser destructive effect on volatile compounds and texture compared to thermal treatment.

61 Further, these compounds and their metabolites were investigated by LC/

62 lished for the first time the total phenolic compounds and total flavonoids contents in the pulp of m

63 he targeted screening based on more than 100 compounds, and a comparison of a nontargeted screening b

64 y identified peripherally active cannabinoid compounds, and could have clinical applications.

65 hods for tissue manufacture, accessing probe compounds, and generating new leads that yield manufactu

66 ed out at the level of scaffolds rather than compounds, and scaffold queries increasingly abstract fr

67 These compounds are able to inhibit GSK3beta and induce the Nr

68 The reactivity and magnetism of these compounds are discussed in the context of using a series

69 -metal bonds in experimentally characterized compounds are examined: a [Formula: see text]-[Formula:

70 Redox processes of molybdenum-sulfide (Mo-S) compounds are important in the function of materials for

71 tration (FDA) in late 2016 and several other compounds are in advanced clinical trials.

72 Under these conditions, the compounds are kinetically stable over long time periods

73 ysis because the concentrations of these two compounds are often well correlated.

74 emical guidelines for achieving the targeted compounds are presented, along with comprehensive struct

75 riments identified the primary target of the compounds as the T3SS needle pore protein EspD, which is

76 sulfide, ethanethiol), and ester and alcohol compounds associated with distinct 'sulfur-cabbage', 'fr

77 e enzyme activation rates by two most active compounds at 100 muM ( 150% and 130%) were comparable to

78 We assessed cerebral Abeta on Pittsburgh Compound B (PiB) positron emission tomography, gait spee

79 oid-positivity was defined as 11C-Pittsburgh compound B target-to-cerebellar ratio above 1.5 within a

80 Further medicinal chemistry on the compounds' basic scaffold could enhance the potency and

81 nto fundamental questions about how aromatic compounds behave.

82 lecular docking studies suggested that these compounds bind efficiently to beta-tubulin at the colchi

83 d rapamycin-pretreated wild-type mice, these compounds blocking alpha-amino-3-hydroxy-5-methyl-4-isox

84 also determined crystal structures of these compounds bound to PARP1 or PARP2.

85 GMS), artemisinin resistance is increasingly compounded by partner drug resistance, causing high fail

86 Moreover, our results were not compounded by whether the antagonism was between sympatr

87 systems inactivate endobiotic and xenobiotic compounds by linking them to a glucuronic acid sugar for

88 Thus, these compounds can be regarded as promising candidates for th

89 as a surfactant or stability agent on white compound chocolate sweetened with sucralose and Stevia w

90 etermine changes in the low-molecular-weight compound composition of peanuts due to dry-roasting.

91 al structures of CARM1 in complex with these compounds confirm a mode of binding that is indeed refle

92 Products of chemical degradation and compounds contained within the vesicular bodies of the p

93 es, showed major 1,2-eliminations of neutral compounds containing one, two, or three aromatic rings.

94 Two of the identified compounds correspond to a new fungal metabolite (29) and

95 d transcription antitermination, while other compounds could suppress it, both in vitro and in vivo.

96 absent from inland natural systems and these compounds could therefore play an important role as envi

97 These compounds crystallize to form robust open hydrogen-bonde

98 y in income, the article reviews evidence on compounded deprivation, racial cleavages, civic engageme

99 a-lyase (BlMGL) produced the sulfur volatile compound dimethyl sulfide (DMS).

100 was characterised by a high level of sulfur compounds (dimethyl sulfide, ethanethiol), and ester and

101 rected in vitro by treatment with NKH-477, a compound discovered as protective in our previous studie

102 These N-oxide compounds display promising performance properties as en

103 ffects of autophagy-activating digitalislike compounds (DLCs) on redifferentiation and concomitant re

104 2-based iron pnictides are quite interesting compounds, due to the two magnetic sublattices in them a

105 Assessing how endocrine disrupting compounds (EDCs) affect population dynamics requires tra

106 ts that provide information about the target compound ee and the synchronous release of the indicator

107 This compound efficiently protects cells against various toxi

108 tudy aims to measure and analyze unregulated compound emissions for two Euro 6 diesel and gasoline ve

109 rticular on hydrated perfluoro-sulfonic acid compounds employed as electrolytes in fuel cells.

110 n tests with radio or stable isotope labeled compounds enable the detection of the formation of nonex

111 s uncovered that the number of multigranular compound events (i.e. granule-to-granule homotypic fusio

112 On heating, this compound exhibits a spin transition between a LS ground

113 functional units, at a cellular level, of a compound eye from the base of the Cambrian, more than ha

114 ernal structures or anything about how those compound eyes may have functioned.

115 indicating that the neurotransmitter of the compound eyes participates in both entrainment pathways.

116 ods showed the external lattices of enormous compound eyes, but not the internal structures or anythi

117 s has had a long and difficult course with 3 compounds failing in phase III clinical trials.

118 two-electron bonds in the context of related compounds featuring multiply and singly bonded boron spi

119 During cooling, the compound first transits into a magnetically distinguisha

120 he results showed the presence of seven compounds: fluorene, phenanthrene, anthracene, fluoranth

121 -74.22mg/L) as the most abundant anthocyanin compound, followed by cyanidin-3-xyloside-galactoside (C

122 lic acid is the most appropriate OH(*) probe compound for the characterization of electrochemical and

123 inhibitor represents a highly promising lead compound for the development of novel anticancer therape

124 hods with regard to classification of active compounds for cancers.

125 epresent a potential source of antimicrobial compounds for food and health benefits.

126 0000-member library of natural and synthetic compounds for sensitizers of RCC cells to TRAIL-mediated

127 ized the yield of five different anthocyanin compounds from black carrot pomace with cyanidin-3-xylos

128 ification and clearance of drugs and foreign compounds from the liver.

129 nulate, they release a plethora of bioactive compounds from their secretory granules, including mast

130 t waves affect emissions of volatile organic compounds from urban/suburban vegetation and correspondi

131 computational characterization to literature compounds gave valuable insights about the aromaticity o

132 (TMS)3}3](-) yield the novel neutral cluster compounds [Ge9{Si(TMS)3}3PR2] (R: Cy (1), (i)Pr (2)) wit

133 However, the majority of compounds had no systematic change in concentrations dur

134 However, resistance to these compounds has begun to emerge often months to years afte

135 the 5-HT6 receptor, new benzimidazole-based compounds have been designed and synthesized.

136 enty-five to ninety percent of patients have compound heterozygous loss-of-function mutations in the

137 Rare homozygous and compound-heterozygous nonsense (c.1213C > T, rs139309795

138 ain and the TX430 bran had the levels of all compounds higher than the flour.

139 cellular target of several antimycobacterial compounds; however, evidence for direct inhibition of Mm

140 been proposed to increase the reactivity of compound I with respect to C-H bond activation.

141 Phenolic compounds, i.e. Gallic acid, catechin, chlorogenic acid,

142 Compound III, a selective MMP7 inhibitor, decreased deve

143 ral effects of these two key principal amine compounds imposed by hydrogen bonding to water, where a

144 Both the compounds improved the gut epithelium by promoting goble

145 west field observed so far for a diamagnetic compound in agreement with quantum chemical predictions.

146 0% of the (+)-ephedrine enantiomer as target compound in only 4 min.

147 can be used for determination of classes of compounds in cases where deuterated counterparts are eit

148 xtraction and determination of organosulphur compounds in different matrices.

149 nuous flow leads to isolation of the desired compounds in enhanced yields relative to standard batch

150 ation may facilitate the triage of candidate compounds in hit-to-lead campaigns.

151 y to develop methodologies to evaluate these compounds in samples related to the food chain.

152 The composition of condensed-phase organic compounds in SOA is measured using several complementary

153 ectively annotating all approximately 20,000 compounds in the LINCS database as either having publish

154 The fraction of target compounds in the particulate phase relative to the disso

155 nescence (PL) data for any corannulene-based compounds in the solid state.

156 Varietal thiols are key aroma compounds in wine issued from multiple and complex origi

157 ducts (containing the above-mentioned active compounds) in a greenhouse study plant material was cryo

158 n of unlabeled and [(13)C] isotopologs of 43 compounds, including amino acids, amino acid derivatives

159 ery and development of improved or novel new compounds, including D1 agonists with better pharmacokin

160 consistently inactive and frequently active compounds, indicating that the structural context in whi

161 In vitro, the compounds induce misfolding of chromatin fibre and block

162 from Sedum sarmentosum, was a very effective compound induced SSCs proliferation.

163 Besides, all compounds inhibit the trophozoite proliferation in amoeb

164 In mice, the compound inhibited cytokine production induced by inject

165 emperature, ultrasound or light to introduce compounds into cells, to release molecular species from

166 and allowed tentative identification of the compounds involved.

167 Additionally, the compound is a noncompetitive inhibitor of daunorubicin (

168 This compound is a promising lead for further development of

169 e parent pentabenzo[a,d,g,j,m]coronene (PBC) compound is shown to exhibit a shifted and rotated type

170 he QS inhibition activity of the synthesized compounds is encouraging for further exploration of nove

171 eric equilibria of this new class of quinoid compounds is strongly required in order to explain their

172 Optimizing a compound known to block the H3K27me3 site in EED discove

173 ry fermented sausage) or moderate boar taint compound levels (dry-cured ham) occurred.

174 The initial screen of small molecule compound libraries identified more than thirty hits that

175 of lipophilic groups play important roles in compound-lipid interactions.

176 as characterized by chemotypes rich in cymyl-compounds, mainly carvacrol, thymol and gamma-terpinene.

177 been previously recognised; and contaminated compounded medications.

178 riven by synergistic mechanisms of a complex compound mixture (of which many are yet unidentified) ra

179 used for the concomitant quantitation of 18 compounds (mixture of anabolics, beta-2 agonists, diuret

180 rch community by providing new hypotheses on compound MoA and potential insights for drug repurposing

181 ement with former studies of similar silicon compounds, molecules 1 and 4 prefer to adopt the Pheq co

182 Motor function scores (MFS) and compound muscle action potential (CMAP) decreased rapidl

183 tin, nucleotides, and the pyrazolopyrimidine compound myoVin-1.

184 employed for rapid sensing of nitroaromatic compounds (NACs) where picric acid (PA, as a model explo

185 The most potent compound of the present series, sodium 1-amino-4-[4-(2,4

186 Phenolic compounds of berries and leaves of thirteen various plan

187 r of possible molecular formulas for organic compounds of relative high molecular mass (e.g., between

188 reactions of [60]fullerene/phosphine borane compounds offer a promising new strategy for the reversi

189 e fraction of chromatographically unresolved compounds, often referred to as humic-like substances (H

190 mical analyses assessed the effects of these compounds on retinal neurovascular injury induced by hyp

191 cal for allosteric modulatory effects of SRI-compounds on the interaction of cocaine with hDAT.

192 effects induced by these fermentative aroma compounds on the secondary structure and stability of VV

193 hs and can be used as a carrier of an active compound or as a filler in bioplastics.

194 arch allow precise identification of desired compounds or functional groups.

195 In certain cases, however, compounds other than Schiff bases have been reported to

196 nt correlations between PM10 and heavy metal compounds (other heavy metals (r = 0.43, p = <0.001)), P

197 gh stability and low release of encapsulated compounds over time.

198 The identified halogenated organic compounds, particularly iodinated organic molecules, are

199 izumab was prepared in insulin syringes by a compounding pharmacy.

200 The resultant lead compounds possess potent activity against a multidrug re

201 tic for the construction of diverse bicyclic compounds possessing highly functionalized cyclopentane

202 rug Administration-approved chemotherapeutic compounds possessing synergistic activity with leucovori

203 olecular formulae and ion intensities of the compounds present.

204 esults showed the importance of the volatile compounds produced from amino acids, including the sulfu

205 Since quaternary ammonium compounds (QACs) are exuded by germinating seeds, we ass

206 lude protein microarray, metabolic pathways, compounds, quantitative proteomics, copy number variatio

207 Active methylene compounds react with in situ generated nonstabilized azo

208 atment with NitroSynapsin, a new dual-action compound related to the FDA-approved drug memantine, rep

209 On the other hand, higher content of some compounds related with the geranyl-diphosphate pathway (

210 f mass spectral libraries, a majority of the compounds remains unidentified because of the lack of pa

211 entanone were isolated and identified as the compounds responsible for the characteristic odor of lio

212 Detailed analysis of these vanadate compounds reveals the key role of VO4 structural motifs

213 itro and in vivo characterization of 3 novel compounds-RO6958948, RO6931643, and RO6924963-that bind

214 Dibenzo-7-phosphanorbornadiene compounds, RPA (A = C14H10 or anthracene), are investiga

215 rediction could be used to deduce not only a compound's possible active ingredients but also its ther

216 After conducting a compound screening contest in 2014, we report results ac

217 Phytochemical compound screening of all Fagioli di Sarconi beans perfo

218 idin-5-yloxy)picolinamide (27, VU0424238), a compound selected for clinical evaluation.

219 nclude time-consuming sample preparation and compound separation by liquid chromatography (LC).

220 These novel compounds shed light on the role of functional selectivi

221 The purified compound showed similar properties compared with TsSPs a

222 ves are excellent source of health promoting compounds, since hydroxytyrosol and tyrosol are almost 8

223 ociception therapeutic window in a series of compounds spanning a wide range of signaling bias.

224 Between the new compounds stands out 12b for its high affinity value (Ki

225 These compounds stimulate cAMP levels and raise mature let-7 l

226 Compounds substituted with an equatorial hydroxyl or ami

227 Compounds such as 20 were prepared using a palladium-cat

228 liking is influenced by perception of bitter compounds such as glucosinolates (GSLs) and isothiocyana

229 proteins and minerals, as well as bioactive compounds such as glucosinolates and phenolics.

230 ting otherwise bioavailable, reduced organic compounds such as lipids and waxes from decomposition.

231 Major dicarbonyl compounds such as methylglyoxal or glyoxal are found to

232 ules such as ICOS, regulatory T cells and by compounds such as nicotine.

233 m/z values, was helpful to annotate specific compounds, such as alkaloids, saponins, flavonoids, and

234 in vitro and is inhibited by small molecule compounds, such as the drug tafamidis.

235 Those studies have found that allosteric compounds tend to be smaller, more rigid, more hydrophob

236 As one of the latter class of compounds tetrahydropyrans (THPs) constitute a core stru

237 ins provides a much richer feature set for a compound than a spectral signature based on peak positio

238 We propose that a pharmacological compound that abates TGF-beta signalling and enhances ER

239 have identified JNJ0966, a highly selective compound that inhibited activation of MMP-9 zymogen and

240 ing, Novartis scientists have now produced a compound that shows durable tumor regression in a lympho

241 model was first trained with 1037 individual compounds that adopt the most populated ternary 1:1:1 st

242 agnetic data storage and spintronic devices, compounds that allow a tailoring of magnetic domain shap

243 Discovery of molecular targets or compounds that alter neuronal function can lead to thera

244 To discover compounds that have anti-eIF2α-P activity suitable

245 We identified compounds that match the pharmacophore of the key actin

246 le agonists of TFEB and discover three novel compounds that promote autophagolysosomal activity.

247 ulted in the serendipitous discovery of nine compounds that were MC3R agonists (EC50 < 1000 nM) and M

248 amounts of two well-characterized defensive compounds, the volatile (E)-alpha-bergamotene and trypsi

249 quencher of emission of many phosphorescent compounds, thus oxygen concentration could in many cases

250 in such cases would cause us to expect these compounds to be present in the gas state, whereas measur

251 somers 4, 5, 9 and 12 of diferulic acids key compounds to explain the observed AC.

252 models and identified interesting groups of compounds to investigate further.

253 In this study, we deliver therapeutic compounds to neutrophils using biocompatible, nanometer-

254 (DNAN), are replacing traditional explosive compounds to protect soldiers and simplify transport log

255 Our results suggest that designing compounds to target specific receptor states, rather tha

256 rancidity indices of fried oil (total polar compounds (TPC), and triglyceride dimers-polymers (TGDP)

257 Ox, CO2, CO and non methane volatile organic compound tracers in a city that might be considered repr

258 harmaceutical metabolites back to the parent compound, treatment systems should be designed based on

259 phy mass spectrometry (GC-MS), we identified compounds typically associated with plant products, incl

260 ses of natural products with findings of the compounds' unique abilities to regulate stem cell fate p

261 However, unlike SBAs, BA compounds uniquely induced the formation of empty capsid

262 itions of allylmagnesium halides to carbonyl compounds, unlike additions of other organomagnesium rea

263 Encapsulation of lipophilic bioactive compounds using plant-derived proteins as delivery syste

264 products further transformed into tricyclic compounds via intramolecular Michael addition.

265 ngerprints generated by the volatile organic compounds (VOCs) emitted.

266 ssume that the transport of volatile organic compounds (VOCs) from a source toward a building is limi

267 tching properties for polar volatile organic compounds (VOCs).

268 The antihyperalgesic activity of such compounds was assessed by means of the paw-pressure and

269 that the organ-specific processing of these compounds was consistent with clinical data, and discove

270 is for the construction of novel tetracyclic compounds was described.

271 ery low concentrations of these carcinogenic compounds was developed and compared by applying two dif

272 entification of light-absorbance interfering compounds was performed by spectrophotometry and HPLC an

273 The compounds were able to reduce QS-regulated virulence fac

274 Odorous volatile compounds were analysed by solid-phase microextraction/g

275 The CIELAB parameters and volatile compounds were analysed using spectrophotometry-UV and G

276 specifically higher concentrations of these compounds were associated with lower concentrations of t

277 MenA inhibiting, long chain-based compounds were designed, synthesized and evaluated again

278 None of the analyzed compounds were detected in fruits, leaves, stems and roo

279 namic signatures of the EED aminopyrrolidine compounds were found to be mainly enthalpy driven with i

280 of polar metabolites also revealed that many compounds were highly sequestered among the various seed

281 Phenolic compounds were identified by a combination of HPLC-PDA,

282 Fourty-eight bioactive compounds were identified in Saskatoon berry genotypes,

283 lation, indicating that no sources of target compounds were introduced or, that source introduction w

284 The TXRF spectra of the compounds were measured using variable X-ray energies in

285 sing, the release was lower and the released compounds were not degraded.

286 luoroalkyl sulfonamide-based polyfluorinated compounds were transformed to perfluorinated carboxylic

287 their tissue burden differentiates these two compounds while other mammals contain PFOS from both dir

288 Further study into this interesting set of compounds will continue to provide insights into fundame

289 "stackable" (i.e., they can be combined and compounded with little increase in complexity), and "hac

290 rocesses mediated by heme proteins and model compounds with a focus on recent progress in the charact

291 Interaction of the compounds with ABCG2 was investigated by a colorimetric

292 ziridination of aldehydes, amines, and diazo compounds with BOROX catalysts is developed.

293 Antimalarial compounds with dual therapeutic and transmission-blockin

294 For compounds with in vivo target activity data (e.g. animal

295 tivity relationship studies have resulted in compounds with moderate to potent antitubercular activit

296 n at therapeutic indices similar to previous compounds with more agonist activity.

297 ossibilities for discovering BACE-1-targeted compounds with more complex mechanisms of actions and im

298 Deprotonated compounds with only beta-O-4 linkages, or both 5-5 and b

299 m starting from amicarbalide that led to two compounds with optimized pharmacological and antiparasit

300 , hydroxy-PLTX and, at least, two additional compounds with PLTX-like profile in the Palythoa canarie