ライフサイエンスコーパス: compromise

1 he value of identifying patients with visual compromise.

2 152T caused neurodegeneration and proteasome compromise.

3 ost from the CMs, and membrane integrity was compromised.

4 merase function or MMR activity is partially compromised.

5 efects, where ATM/p53-dependent apoptosis is compromised.

6 thematosus, can arise when TREX1 function is compromised.

7 n of structural proteins (GFAP and AQP4) was compromised.

8 drainage into mesenteric lymph nodes may be compromised.

9 unction of caveolae as membrane reservoir is compromised.

10 lopment was established, but maintenance was compromised.

11 under conditions in which the cytonemes were compromised.

12 MP, suggesting that the STING pathway may be compromised.

13 endodontically treated teeth (ETT) is often compromised.

14 he activity of regulatory T cells (Tregs) is compromised.

15 ne expression when ribosome integrity is not compromised.

16 r even when TH2 cell functions were severely compromised.

17 repair by homologous recombination (HR) was compromised.

18 o aged mice significantly enhances otherwise compromised Ab production to inactivated influenza vacci

19 These structures explain these proteins' compromised ability to assemble into catalytically activ

20 carboxylate, and R245E/L mutations severely compromise activity and heme content, although alkene pr

21 retention, abnormal morphology, and severely compromised activity, which can be functionally rescued

22 Regional sympathectomy compromises adipose tissue thermogenesis, and renders mi

23 we know it, straining limited resources and compromising advances in diagnostic and academic patholo

24 over MC3R and MC5R receptor subtypes without compromising agonist potency.

25 deprivation during these periods permanently compromises an organism's ability to perceive the outsid

26 nhance the selectivity of the method without compromising analysis speed.

27 f this model, mechanical force production is compromised and cell proliferation is reduced in Yap mut

28 eas where the intestinal epithelium had been compromised and demonstrated the potential use of this f

29 a/IL-13Ralpha1 (13R) heteroreceptor (HR), is compromised and determined whether the lack of signaling

30 In aged flies, respiratory activity is compromised and the production of peroxide radicals is i

31 nuclear decondensation followed by membrane compromise, and were accurately counted by applying filt

32 te immunity to a DeltaICP0 virus was largely compromised, and that permitted ICP0-deficient mutants t

33 ating myeloid cell (TIM) subsets that likely compromise anti-tumor T cell immunity.

34 sease, whereas defects in TH1 and TH17 cells compromise antiviral and antifungal immunity, respective

35 Compromised apoptotic signaling is a prerequisite for tu

36 Islet function and survival may be compromised as a consequence of an incomplete islet BM,

37 ilibrium with the host, but when the skin is compromised, bacteria can colonize the wound and impair

38 Type 2 diabetes is thought to involve a compromised beta cell differentiation state, but the mec

39 exhibited impaired glucose tolerance due to compromised beta-cell function and glucose-stimulated in

40 whose frequency of discharge results from a compromise between AIS and somatodendritic oscillators.

41 reviously, atomic interactions have forced a compromise between clock stability, which benefits from

42 tomyosin pathways must be optimally tuned to compromise between generation of motility forces and res

43 7CD45RA Regulatory T cell may offer the best compromise between susceptibility to loss of suppression

44 Then, four main compromises between the TE properties are elaborated fro

45 ) and CaM and is inhibited by mutations that compromise binding of phosphorylated Thr-348 to an allos

46 frequent production of protein variants with compromised biophysical properties.

47 found defects in NK-cell reconstitution that compromise both leukemia and pathogen-specific immunity.

48 ch a way that its anti-tumor efficacy is not compromised, but toxic effects are eliminated.

49 pregulation and cell survival functions were compromised by a pharmacological SGK1 inhibitor.

50 ntation of such a multimodal approach can be compromised by conflicting requirements to optimize each

51 -control protein modules (CCPs 1-20), may be compromised by disease-linked mutations.

52 Computers can be compromised by encoding malware in DNA sequences, and bi

53 s whose internalization properties have been compromised by genetic perturbations within the carboxyl

54 low rate; the utility of avibactam might be compromised by mutations that increase this deactivation

55 egation and genome stability, which are also compromised by p53 inactivation in cancer.

56 Stability was compromised by repulsive electrostatic forces originatin

57 mplexes, but their clinical utility has been compromised by resistance.

58 In cancer cells, PP2A function can be compromised by several mechanisms, including sporadic mu

59 ARgamma), but their therapeutic benefits are compromised by severe side effects.

60 aureus in these sites of replication is not compromised by the absence of transporter SbnD.

61 effectiveness of antibiotics has been widely compromised by the evolution of resistance among pathoge

62 erial adhesion to epithelial monolayers with compromised cell-cell junctions.

63 ffects of nocturnal light in humans, without compromising chromaticity.

64 vesicle in Gle1-depleted zebrafish revealed compromised ciliary beating and developmental defects.

65 eral days of turnaround time, which leads to compromised clinical outcome and promotes the spread of

66 Diabetes mellitus compromises CMSC function as consequence of metabolic al

67 Low birth weight predicts compromised cognitive ability.

68 lf-assembled quantum dots, albeit often with compromised coherence and optical quality.

69 role, enabling bulk trapping and leading to compromised contact properties.

70 e etiological agent, environmental stressors compromising coral condition might play a larger role in

71 Our results suggest that hypoxic stress compromises CPC function by inducing quiescence in part

72 ubstrate recognition or oligomerization both compromise CSR in splenic B cells.

73 day 5; large numbers of vesicles invaded the compromised cuticular plate.

74 In the absence of PLST-1, polarization was compromised, cytokinesis was delayed or failed, and 50%

75 ive to artifacts that may reduce resolution, compromise data and its interpretations, and drain resou

76 Children at elevated risk for compromised development due to stunting and poverty are

77 s result in complex syndromes that include a compromised DNA damage response (DDR) and prominent nerv

78 activity, defective catalytic activity, and compromised DNA processivity, even in the presence of th

79 conditions, Cu(II) activation produces >50% compromised DNA within 5 min.

80 Loss of both RECQL5 and WRN severely compromises DNA replication, accumulates genomic instabi

81 ich attenuated both NHEJ and HR and severely compromised DSB repair resulting in chromosomal instabil

82 f Parkinsonism, this nigro-vagal pathway was compromised during the early stages of motor deficit dev

83 with dementia experience increased risk for compromised eating performance due to intrapersonal, int

84 , could replace oral glucocorticoids without compromising efficacy.

85 function than standard TAC (TAC-C), without compromising efficacy.

86 ed in clinical trials and systematic reviews compromises efforts to compare and summarize results acr

87 Increasing DA sensitivity without compromising electrode kinetics is expected to significa

88 Deletion of CTCF sites compromises enhancer-promoter interactions.

89 ta-catenin abrogated its AJ localization and compromised epithelial barrier functions.

90 whether elimination of PLP1-expressing cells compromises epithelial maintenance or gastrointestinal m

91 isting enhances cofilin dissociation without compromising filament integrity.

92 costly for the utility, it also resulted in compromised filter performance, particularly for the dir

93 This pattern was accelerated in immune-compromised flies with higher bacterial load and gut cel

94 The T585P mutant was also compromised for forming stable subnuclear foci in living

95 associates with low gamete viability, which compromises fruit set and decreases fruit production.

96 this type of functional decline is linked to compromised GABAergic inhibition has not been fully conf

97 e the encoding of nose-up sensations without compromising gaze stabilization.

98 se and reproducible neuronal activity, while compromising general signal representation.

99 antling the machinery of DNA replication can compromise genome integrity and contribute to tumorigene

100 osed to nucleolytic degradation, potentially compromising genome stability.

101 undrum: a transcription fidelity factor that compromises genomic integrity.

102 ND was generally found in forest stands that compromised >50% eastern white pine by basal area.

103 ng P2Y14 R expression levels in functionally compromised hCPCs via lentiviral-mediated overexpression

104 Therefore, empowering functionally compromised hCPCs with proregenerative molecules ex vivo

105 promoted cardiomyocyte polyploidization and compromised heart regeneration.

106 Dramatically compromised hematopoietic recovery and increased lethali

107 nconsistencies correlated with the volume of compromised hippocampal tissue.

108 sulted in aberrant TNT cell-to-cell contact, compromising HIV spread and replication.

109 Rather than compromising host defenses, pathogen-mediated inhibition

110 ine of antiviral defense in the lung without compromising host fitness.

111 esection at sites of DNA damage, resulted in compromised HR and misrejoining of S-phase DSBs, and inc

112 utant with slow recovery from N deprivation, compromised hydrolysis of triacylglycerols7 (cht7), was

113 Likewise, compromised hypothalamic function and subsequent defects

114 es to maintenance of murine B-ALL cells with compromised Ikaros function.

115 ant morbidity and mortality in patients with compromised immunity, underscoring the urgent need for n

116 cking is not sufficiently specific and hence compromises immunity, leading to severe side effects.

117 pc, and to determine whether this pathway is compromised in a rat model of Parkinsonism.

118 ystems, the NRF2-mediated stress response is compromised in aging and neurodegenerative diseases.

119 dac8-deficient hematopoietic progenitors are compromised in colony-forming cell serial replating in v

120 d for the repair of oxidative DNA damage, is compromised in Foxo3(-/-) primitive hematopoietic cells.

121 irAGO8 plants were significantly compromised in herbivore-induced levels of defense metab

122 The P2X7R-Gln460Arg variant per se is not compromised in its function.

123 s because of evidence that their function is compromised in MDD.

124 is higher and the immunity to B. cinerea is compromised in pmei10, pmei11, and pmei12 mutants with r

125 er hand, cardiac structure and function were compromised in response to aortocaval shunt in both WT a

126 glycolysis in activated CD4(+) T cells were compromised in the absence of the INSR, which was associ

127 lysosome flux and mitochondrial function are compromised in the Drosophila nervous system and SRS pat

128 hat although H3S10 phosphorylation is indeed compromised in the H2Av null mutant, chromatin decondens

129 12 weeks of an HFD, blood flow recovery was compromised in WT mice, whereas it was fully recovered i

130 the health of upwardly mobile minorities is compromised in young adulthood.

131 To facilitate the diagnosis of compromised individuals, we developed and independently

132 This may compromise information coding capacity and thereby motor

133 and the presence of irregularities that may compromise integrity.

134 hallenged by manufacturing problems, such as compromised integrity of coated pellets and poor content

135 gi apparatus, interfering with secretion and compromising intestinal antimicrobial defense.

136 lix-(pi-sheet)-coil assemblies occur without compromising intrinsic helicity, while both parallel and

137 finishes applied and irregularities that may compromise its performance and value.

138 nd IL-35-independent functions of EBI3 could compromise its therapeutic uses.

139 e conformation of the helical hairpin and/or compromised its pairwise arrangement with the companion

140 the lack of the para-methoxy group in SPA70 compromises its interaction with the AF-2, thus explaini

141 gic phenotype culminating in a significantly compromised life expectancy and transformation to aggres

142 the gestational uterus but rather is due to compromised local innate cellular immune responses.

143 n sites in the MAD1(CTD), including Thr-716, compromised MAD2 binding and the checkpoint responses.

144 yielding high recovery values (98%) without compromising maltene integrity.

145 does not impede mammary gland induction, but compromises mammary bud growth, as well as TEB formation

146 red resistance to both FIP and AS-48 without compromising membrane fusion.

147 to address this issue is in situ healing of compromised membranes via healing agents that are added

148 Whereas immune-compromised mice developed persistent infection, immune-

149 P1R1, injected into the tail veins of immune-compromised mice, and followed by noninvasive biolumines

150 ined bacterial consortia to individuals with compromised microbiota composition may reduce inter-pati

151 ifers can occur from unlined or structurally compromised mine tailings storage facilities.

152 autophagy or the proteasome, in addition to compromising mitochondrial quality, enhances the product

153 ering with quercetin detoxification, thereby compromising mitochondrial regeneration and ATP producti

154 SET ablation compromised mitotic fidelity as evidenced by unresolved

155 an respond flexibly to serious challenges of compromised MT-dependent MT nucleation to complete mitos

156 er injury similarly hinders regeneration and compromises muscle strength.

157 guish between well vascularized (n = 32) and compromised (n = 27) parathyroid glands during thyroid s

158 tion and elevated intracellular Na(+), which compromised Na(+)-dependent nutrient transport, were doc

159 When p53-compromised NCCs were transformed with N-Myc, we generat

160 Mutation of the SUMOylation site compromised neither ErbB4-induced phosphorylation of the

161 ened noradrenergic responsivity in line with compromised neural gain.

162 olescent intermittent ethanol (AIE) exposure compromises neural function into adulthood.

163 sed gray matter volumes are not explained by compromised neuronal integrity.

164 ify defects in SMN-deficient astrocytes that compromise normal function.

165 f the methylation pathway mediated by folate compromises normal neural tube closure (NTC) and cilioge

166 Despite the high risk of compromised nutrition, evidence of the effect of refugee

167 ural and functional connectivity and, hence, compromise of functional networks within the brain.

168 d insulin resistance is due, in part, to the compromise of hepatic autophagy, a process that leads to

169 patients, especially those with respiratory compromise, of this risk.

170 rocesses, may affect PNS regulation, thereby compromising older adults' capacity for adaptation, and

171 ctron microscopy with higher current without compromising on spatial resolution.

172 dministered could lower toxicities while not compromising on the effectiveness of the drugs.

173 ted macrophages slightly, but significantly, compromised optic nerve regeneration.

174 ogression or unacceptable toxicity (severely compromises organ function, quality of life, or both).

175 ibrosis that affects a multitude of tissues, compromising organ function.

176 using engineering design modifications that compromise other performance attributes, such as acceler

177 ities as a lifesaving procedure and does not compromise outcomes of retransplantation.

178 he potential for larynx preservation without compromising overall survival.

179 poventilation may decrease hypoxemia without compromising patient tolerance.

180 in protective immunity, especially in immune-compromised patients.

181 Heart failure (HF) is a chronic disease that compromises patients' quality of life (QoL).

182 n 1 with N-cadherin and VE-cadherin, thereby compromising pericyte-endothelial cell interactions and

183 e; ie, soluble MER), a critical biomarker of compromised phagocytosis by innate macrophages.

184 ns originate from individuals with partially compromised piRNA defense.

185 The iput1 mutants show severe dwarfism, compromised pollen tube guidance, and constitutive activ

186 gnitive performance when SCN timing has been compromised, possibly by coordinating activity in the SC

187 s by overexpression of PPIP5K1, and a kinase-compromised PPIP5K1 mutant had no effect.

188 es dopamine release and inhibits IM neurons, compromises prefrontal control of the amygdala, and sets

189 s to action automaticity, something that can compromise procedural learning in ageing.

190 resent potential safety risks to patients or compromise product stability.

191 tive pathways, and the mechanistic basis for compromised production is rarely elucidated since rate-l

192 opoietic stem and progenitor cells displayed compromised proliferation, and replication stress that c

193 f ZEB2 protein induces ribosomal pausing and compromises protein synthesis.

194 xcretion mechanism ensures rapid disposal of compromised proteins.

195 quimod (IMQ), Trim32 knockout mice displayed compromised psoriasiform phenotypes and defective T help

196 t represents a particular inter-generational compromise: quick development benefits parental fecundit

197 rt of nonadherence to immunosuppression that compromised recovery.

198 Detected mutations compromise recruitment of MAPKBP1 to the MSP and/or its

199 Anthropogenic climate change compromises reef growth as a result of increasing temper

200 allenging, as optimising the latter requires compromises regarding the first two properties.

201 with multiple risk factors, TFS was severely compromised, regardless of the timing of S2P and most se

202 ergent starved L1 larvae that correlate with compromised reproductive fitness of the generation that

203 Transmitted drug resistance (TDR) may compromise response to antiretroviral therapy (ART).

204 progression but also to prevent circulatory compromise resulting from the mass effect on the mediast

205 DEL-tagged luminal resident, implying that a compromised retention mechanism causes saturation of the

206 ned normally and neuronal differentiation is compromised: rx3-derived ff1b+ neurons, implicated in an

207 terminus away from the filament axis, which compromises S3D cofilin's ability to weaken longitudinal

208 nhances their access to these agents without compromising safety or development strategies.

209 ndings highlight insular disintegration (ie, compromised salience network membership) as a neurobiolo

210 Channel regulation is also compromised since cAMP-dependent PKA activity is enhance

211 hape, alloying or strain effects and without compromising stability.

212 under the catalytic relay conditions without compromising stereoselectivity.

213 ed global gene expression profiles, and have compromised stress responses.

214 ive damage from normal muscle use due to the compromised structural integrity of the dystrophin assoc

215 nder catalytic operating conditions, without compromising structural integrity of the catalyst framew

216 fatty liver disease (NAFLD) as controls can compromise study validity and subject safety.

217 arising through further gene deletion could compromise such a strategy.

218 on of NdbC leads, directly or indirectly, to compromised sugar catabolism, to glycogen accumulation,

219 gers the loss of synaptic vesicles (SVs) and compromises synaptic integrity.

220 n rhythmicity and preferred sleep timing and compromises synchronisation to the solar day when wake-t

221 known to facilitate intracyst communication, compromise synchronous spermatogonial death and reduces

222 This observation was paralleled by a compromised TDG (thymine DNA glycosylase) and TET1 (ten-

223 cus on the current practical limitations and compromises that must be made when designing an SRM expe

224 etramer; however, they did not significantly compromise the ability of M-TTR to inhibit CsgA amyloido

225 y to investigate whether lack of SPARC would compromise the ability to repair muscle.

226 hat OD Cu can reoxidize rapidly, which could compromise the accuracy of ex situ methods for determini

227 residing in the central nervous system (CNS) compromise the blood-brain barrier (BBB) via increased v

228 This may seriously compromise the conservation of biodiversity and ecosyste

229 K-12, despite the fact that pressure cannot compromise the covalent integrity of DNA.

230 single and double stabilizing substitutions compromise the full inhibition of contraction in the rel

231 sibility that pathological aggregation could compromise the function of LSD1 in AD and FTD."LSD1 is a

232 ven approaches to HIV eradication that could compromise the health status of HIV-infected individuals

233 some and additional downstream pathways that compromise the integrity and function of the RPE.

234 eased maternal hepcidin during pregnancy can compromise the iron availability for placental transfer

235 g polymerizing microtubules and yet does not compromise the kinetochore's ability to grip depolymeriz

236 nctionalities or electronic factors does not compromise the potential of the method.

237 t the 30% larval export rule are unlikely to compromise the protection of resident adults.

238 that regulate the actin cytoskeleton, would compromise the structural stability of spines, leading t

239 uced prostate tumorigenesis in mice but also compromised the inhibitory effect of the anticancer drug

240 king mitochondrial Ca(2+) uniporter activity compromises the ability of mitochondria to maintain dist

241 iling, we show that, in BL, HSP90 inhibition compromises the activity of the pivotal B-cell antigen r

242 sal dendrites of CA1 neurons, which severely compromises the animals' consolidation of both memory an

243 and skilled personnel to provide the service compromises the availability of such dialysis in parts o

244 al delivery of miR-327 to WATs significantly compromises the beige phenotype and thermogenesis.

245 Acquired resistance compromises the clinical efficacy of EGFR inhibitors dur

246 to demonstrate that malignant transformation compromises the DNA-nuclear matrix interface.

247 RKA)-mediated phosphorylation, which largely compromises the LKB1/AMPK signaling axis, in turn leadin

248 While exposure to fog strongly compromises the water-repellency of hydrophobic structur

249 mild conditions and can be scaled up without compromising the asymmetric induction.

250 cells during the primary infection, thereby compromising the cellular immune response.

251 ease of swallowing and b) divisible without compromising the drug release characteristics of the ind

252 alloy fibres without serum present while not compromising the fibres' mechanical integrity.

253 esis in the liver slows tumor growth without compromising the health of normal hepatocytes.

254 -tunable transport gap without significantly compromising the on-current.

255 peptides onto the surface of RBCNPs without compromising the peptide's brain targeting ability.

256 stored for extended periods of time without compromising the quality of the final NPs.

257 o apply the microcapsules in yogurt, without compromising the rheological properties and physicochemi

258 al lipid species could be determined without compromising the scope, accuracy, and dynamic range of f

259 kness could be adopted up to 60days, without compromising the standard commercial life of industrial

260 us nerve, and then travel to higher centers, compromising the substantia nigra pars compacta (SNpc) a

261 active species to a downstream point without compromising the underpinning species generation mechani

262 V in Aruba has increased to alarming levels, compromising the WHO-recommended first-line regimen.

263 lasma wave can be locally overloaded without compromising the witness bunch normalized emittance.

264 When ATL function is compromised, the morphology of the endoplasmic reticulum

265 hown to incorporate into HIV-1 particles and compromise their ability to fuse with target cells, an e

266 ression results in irreversible changes that compromise their developmental potential.

267 ndent and method-specific uncertainties that compromise their ecophysiological interpretation as well

268 en introduced, but technical limitations may compromise their interpretation.

269 e a negatively ionizable function that might compromise their pharmacokinetic distribution and behavi

270 aracatinib in these CTL clones also severely compromised their functional activities toward autologou

271 ore DARPins in predefined geometries without compromising their binding affinities and specificities.

272 oung's modulus of the bio-elastomers without compromising their elongation ability.

273 at products, enabling salt reduction without compromising their microbial stability.

274 er strains are comparatively acid sensitive, compromising their persistence in low pH soils.

275 esulting in the HSA binding capacity without compromising therapeutic activities.

276 mentarity-determining regions (CDRs) without compromising thermodynamic stability is critical to thei

277 r, their utility in biological fluids can be compromised through denaturation induced by physiologica

278 ing, wound breakdown, fistula formation, and compromised tissue reconstruction.

279 ype 1 capsid template can evade NAbs without compromising titer, transduction efficiency, or tissue t

280 with increased bioactive properties without compromising total yield.

281 Sensitivity was not compromised: true bacteremia was noted in 65/904 (7.2%)

282 etative and reproductive growth was severely compromised under chilling conditions.

283 t protein pp150 and the formation of vAC was compromised upon endocytic inhibition.

284 In this model, barrier function is compromised upon exposure to inflammatory factors such a

285 ion in Kindlin-2 levels in endothelial cells compromises vascular barrier function.

286 ease to reduce VEGF165-induced edema without compromising vessel growth.

287 fined as essential when loss of its function compromises viability of the individual (for example, em

288 ion machinery that function together without compromising viability or clashing with endogenous pathw

289 death at both 24 weeks and 48 weeks without compromising viral suppression or increasing toxic effec

290 Abnormalities in this cycle can compromise vision because of the diminished supply of 11

291 due to genetic and/or environmental factors, compromising visual acuity and often resulting in blindn

292 Features consistent with immune compromise were also detected, notably elevated numbers

293 to survive under warmer temperatures is less compromised when anthropogenic sedimentation is maintain

294 cademic labs, persistence of the software is compromised when developers graduate, funding ceases, or

295 nt blockade immunotherapy for metastases was compromised when NK cells lacked heparanase.

296 A major pathway that was compromised, when TCR signaling was suboptimal, was link

297 synapses and (2) AP propagation was severely compromised with >40% of axonal branches no longer respo

298 eir ability to help B cell responses, become compromised with aging.

299 an fine tune the basepair geometries without compromising with their stability.

300 ximal and distal interphalangeal joints were compromised, without interphalangeal instability.