ライフサイエンスコーパス: compromised

1 thematosus, can arise when TREX1 function is compromised.

2 n of structural proteins (GFAP and AQP4) was compromised.

3 drainage into mesenteric lymph nodes may be compromised.

4 unction of caveolae as membrane reservoir is compromised.

5 lopment was established, but maintenance was compromised.

6 under conditions in which the cytonemes were compromised.

7 MP, suggesting that the STING pathway may be compromised.

8 endodontically treated teeth (ETT) is often compromised.

9 he activity of regulatory T cells (Tregs) is compromised.

10 oma (HCC) have been found to be functionally compromised.

11 er the cessation of cuprizone treatment were compromised.

12 n mesenchymal compartment, however, remained compromised.

13 f childhood seizures, cognitive outcomes are compromised.

14 ited, biotroph growth and/or development are compromised.

15 on to many vascular complications when it is compromised.

16 microglial-mediated clearance mechanisms are compromised.

17 ive diseases where the cholinergic system is compromised.

18 the cytoplasmic virus maturation was greatly compromised.

19 the cell to divide when ring constriction is compromised.

20 efects (NTDs) arose and dorsal extension was compromised.

21 propagating prion form that was functionally compromised.

22 s for organismal survival when DNA repair is compromised.

23 ne expression when ribosome integrity is not compromised.

24 r even when TH2 cell functions were severely compromised.

25 repair by homologous recombination (HR) was compromised.

26 merase function or MMR activity is partially compromised.

27 ost from the CMs, and membrane integrity was compromised.

28 efects, where ATM/p53-dependent apoptosis is compromised.

29 hough HRQoL improved over time, it was still compromised 24 months after primary diagnosis.

30 o aged mice significantly enhances otherwise compromised Ab production to inactivated influenza vacci

31 These structures explain these proteins' compromised ability to assemble into catalytically activ

32 ter decline in calcium release, suggesting a compromised ability to refill the SR.

33 retention, abnormal morphology, and severely compromised activity, which can be functionally rescued

34 duction of phosphorylated Stat3 and RelA was compromised after IMQ treatment in the knockout mice, ph

35 f this model, mechanical force production is compromised and cell proliferation is reduced in Yap mut

36 eas where the intestinal epithelium had been compromised and demonstrated the potential use of this f

37 a/IL-13Ralpha1 (13R) heteroreceptor (HR), is compromised and determined whether the lack of signaling

38 In aged flies, respiratory activity is compromised and the production of peroxide radicals is i

39 te immunity to a DeltaICP0 virus was largely compromised, and that permitted ICP0-deficient mutants t

40 studied alpha-galactosylsphingamides showed compromised antigenic properties.

41 Compromised apoptotic signaling is a prerequisite for tu

42 Islet function and survival may be compromised as a consequence of an incomplete islet BM,

43 s C and found that myo2-E1 is only partially compromised at 25 degrees C.

44 They were both precise, but trueness was compromised at the highest tested level with the EvaGree

45 ilibrium with the host, but when the skin is compromised, bacteria can colonize the wound and impair

46 rentiation capacity, which may contribute to compromised barrier function in normal-appearing uninvol

47 g reduced filaggrin mRNA and protein levels, compromised barrier function, marked ultrastructural cha

48 Antigen penetration through a compromised barrier likely leads to increased innate imm

49 Type 2 diabetes is thought to involve a compromised beta cell differentiation state, but the mec

50 exhibited impaired glucose tolerance due to compromised beta-cell function and glucose-stimulated in

51 , patients treated with lenalidomide develop compromised beta-cell function.

52 nslocation channel, whereas mutations in TM3 compromised binding of the import motor.

53 frequent production of protein variants with compromised biophysical properties.

54 dazole, presumably due to the combination of compromised bipolar attachment and premature spindle ass

55 is a metabolic bone disorder associated with compromised bone strength and an increased risk of fract

56 ity is accompanied by insulin resistance and compromised brain synaptic plasticity through the impair

57 ignaling with the IL4Ralpha antagonist IL4DM compromised breast cancer cell proliferation, invasion,

58 te long-term depression (LTD; L-LTD) was not compromised, but the positive associative interaction of

59 ch a way that its anti-tumor efficacy is not compromised, but toxic effects are eliminated.

60 protection network is likely to be severely compromised by a changing climate.

61 pregulation and cell survival functions were compromised by a pharmacological SGK1 inhibitor.

62 hildren provide improvement in BCVA when not compromised by amblyopia.

63 ntation of such a multimodal approach can be compromised by conflicting requirements to optimize each

64 13-HER2 co-localization could be effectively compromised by depleting MUC13 and mediated by the first

65 -control protein modules (CCPs 1-20), may be compromised by disease-linked mutations.

66 Computers can be compromised by encoding malware in DNA sequences, and bi

67 s whose internalization properties have been compromised by genetic perturbations within the carboxyl

68 However, this is compromised by insufficient information about the effect

69 r speckle contrast imaging (LSCI) systems is compromised by motion artefacts.

70 low rate; the utility of avibactam might be compromised by mutations that increase this deactivation

71 However, their therapeutic efficacy can be compromised by NA changes that emerge naturally and/or f

72 egation and genome stability, which are also compromised by p53 inactivation in cancer.

73 when Cdk1-cyclin B activation at the SPB is compromised by reduction of Cut12 function.

74 Stability was compromised by repulsive electrostatic forces originatin

75 mplexes, but their clinical utility has been compromised by resistance.

76 In cancer cells, PP2A function can be compromised by several mechanisms, including sporadic mu

77 ARgamma), but their therapeutic benefits are compromised by severe side effects.

78 therapeutic peptides for diabetes therapy is compromised by short half-lives of drugs with the conseq

79 in air, and provides information that is not compromised by surface contamination by ensuring that th

80 aureus in these sites of replication is not compromised by the absence of transporter SbnD.

81 he AASK-N repository urine samples have been compromised by the acetic acid preservative.

82 ts, and their helpfulness is being seriously compromised by the drug resistance problem.

83 effectiveness of antibiotics has been widely compromised by the evolution of resistance among pathoge

84 dification of natural enzymes is potentially compromised by their intrinsic complexity, which often o

85 llular matrix deposition that contributes to compromised cardiac function and potentially heart failu

86 cits, pups born to CB-treated dams exhibited compromised CCK-INT-mediated feedforward and feedback in

87 other pCF10-encoded proteins, have severely compromised cell envelopes and strong growth defects.

88 we found that accumulation of autophagosomes compromised cell viability, and this effect was alleviat

89 erial adhesion to epithelial monolayers with compromised cell-cell junctions.

90 etry showed about 70% population of dead and compromised cells after 24 h of exposure of both bacteri

91 vesicle in Gle1-depleted zebrafish revealed compromised ciliary beating and developmental defects.

92 eral days of turnaround time, which leads to compromised clinical outcome and promotes the spread of

93 Low birth weight predicts compromised cognitive ability.

94 lf-assembled quantum dots, albeit often with compromised coherence and optical quality.

95 as assumed that their antitumor immunity was compromised compared with immunocompetent patients.

96 d improved basal renal function but markedly compromised compensatory hemodynamic responses to hemorr

97 role, enabling bulk trapping and leading to compromised contact properties.

98 day 5; large numbers of vesicles invaded the compromised cuticular plate.

99 In the absence of PLST-1, polarization was compromised, cytokinesis was delayed or failed, and 50%

100 Compromised development can also lead to degeneration be

101 Children at elevated risk for compromised development due to stunting and poverty are

102 lacking functional acid-sensing TRCs showed compromised discrimination between water and nonaqueous

103 s result in complex syndromes that include a compromised DNA damage response (DDR) and prominent nerv

104 activity, defective catalytic activity, and compromised DNA processivity, even in the presence of th

105 conditions, Cu(II) activation produces >50% compromised DNA within 5 min.

106 y for viability of embryos from mothers with compromised dorsal levels.

107 ich attenuated both NHEJ and HR and severely compromised DSB repair resulting in chromosomal instabil

108 however, vaccine effectiveness is frequently compromised due to antigenic drift arising from amino ac

109 at communication between conspecifics may be compromised during critical biological periods.

110 f Parkinsonism, this nigro-vagal pathway was compromised during the early stages of motor deficit dev

111 animals whose visual-auditory experience is compromised early in life by noise-rearing can develop v

112 with dementia experience increased risk for compromised eating performance due to intrapersonal, int

113 the production of an antibody with severely compromised efficacy.

114 ism, as mesoderm invagination fails in Rab35 compromised embryos and Rab35 localizes to constricting

115 brains, the increased apoE4 aggregation and compromised endosomal function further exacerbate the in

116 in vivo experiments from mice showed that L5 compromised endothelium-dependent vascular relaxation th

117 ient metabolism of this phytochemical may be compromised energy production.

118 ta-catenin abrogated its AJ localization and compromised epithelial barrier functions.

119 We conclude that compromised feedforward inhibition within the local circ

120 costly for the utility, it also resulted in compromised filter performance, particularly for the dir

121 This pattern was accelerated in immune-compromised flies with higher bacterial load and gut cel

122 l challenge to body fluid homeostasis may be compromised following RDN.

123 The T585P mutant was also compromised for forming stable subnuclear foci in living

124 mortality in a mouse model and were severely compromised for neuroinvasion.

125 n, was significantly reduced in both strains compromised for Opi1p-Scs2p interaction, indicating that

126 guanine adenine synthase (cGAS) was severely compromised for the pUL25 mutant.

127 Severely injured patients frequently suffer compromised fracture healing because of systemic post-tr

128 riate expression of protective genes through compromised function of the chromatin remodeler Chd1/CHD

129 this type of functional decline is linked to compromised GABAergic inhibition has not been fully conf

130 ose DI in IGT versus NGT is in line with the compromised glucose metabolism reflected in impaired bet

131 ND was generally found in forest stands that compromised >50% eastern white pine by basal area.

132 ng P2Y14 R expression levels in functionally compromised hCPCs via lentiviral-mediated overexpression

133 Therefore, empowering functionally compromised hCPCs with proregenerative molecules ex vivo

134 promoted cardiomyocyte polyploidization and compromised heart regeneration.

135 Dramatically compromised hematopoietic recovery and increased lethali

136 ERT-RPE1 cells displayed several features of compromised heterochromatin maintenance, including decre

137 nconsistencies correlated with the volume of compromised hippocampal tissue.

138 esection at sites of DNA damage, resulted in compromised HR and misrejoining of S-phase DSBs, and inc

139 utant with slow recovery from N deprivation, compromised hydrolysis of triacylglycerols7 (cht7), was

140 Likewise, compromised hypothalamic function and subsequent defects

141 es to maintenance of murine B-ALL cells with compromised Ikaros function.

142 ant morbidity and mortality in patients with compromised immunity, underscoring the urgent need for n

143 pc, and to determine whether this pathway is compromised in a rat model of Parkinsonism.

144 R-LTD, a form of synaptic plasticity that is compromised in a severe monogenic form of autism, Fragil

145 However, coumarin exudation was compromised in abcg37 mutants only with respect to certa

146 ves damaged mitochondria (mitophagy) is also compromised in AD, resulting in the accumulation of dysf

147 s of high regenerative pressure and is often compromised in aged animals.

148 ystems, the NRF2-mediated stress response is compromised in aging and neurodegenerative diseases.

149 y and alphaM/beta2 integrin localization are compromised in Arpc2(-/-) cells.

150 all resistance adipose arteries, and this is compromised in arteries from diabetic patients.

151 TNT-active GSTs AtGST-U24 and AtGST-U25 were compromised in biomass production when grown in the abse

152 dac8-deficient hematopoietic progenitors are compromised in colony-forming cell serial replating in v

153 d dramatically reduced CA on ES but was less compromised in DAA.

154 al process of learning and memory and may be compromised in degenerative diseases, such as Alzheimer'

155 t HR repair of conventional DSBs is severely compromised in DEK-deficient cells.

156 role in stability of mushroom spines and is compromised in different mice models of Alzheimer's dise

157 KD proteins polycystin-1 and polycystin-2 is compromised in DZIP1L-mutant cells.

158 rated stress response genes in liver was not compromised in Fgf21(-/-) mice.

159 d for the repair of oxidative DNA damage, is compromised in Foxo3(-/-) primitive hematopoietic cells.

160 irAGO8 plants were significantly compromised in herbivore-induced levels of defense metab

161 The P2X7R-Gln460Arg variant per se is not compromised in its function.

162 s because of evidence that their function is compromised in MDD.

163 Instead, GC treatment was compromised in mice expressing a defective GR in the non

164 target, and female-specific Sxl splicing is compromised in multiple m(6)A pathway mutants.

165 nd ventromedial prefrontal cortex (vmPFC) is compromised in multiple psychiatric disorders, many of w

166 ssociated DNA repair pathway was extensively compromised in mutant cells due to decreased NAD(+) avai

167 al question remains: Why is airway tolerance compromised in patients with allergic airway diseases?

168 ogenin (ANG) is a human ribonuclease that is compromised in patients with amyotrophic lateral scleros

169 is higher and the immunity to B. cinerea is compromised in pmei10, pmei11, and pmei12 mutants with r

170 er hand, cardiac structure and function were compromised in response to aortocaval shunt in both WT a

171 glycolysis in activated CD4(+) T cells were compromised in the absence of the INSR, which was associ

172 lysosome flux and mitochondrial function are compromised in the Drosophila nervous system and SRS pat

173 rnification-associated DNA breakdown was not compromised in the epidermis.

174 hat although H3S10 phosphorylation is indeed compromised in the H2Av null mutant, chromatin decondens

175 in perturbations, the blood-nerve barrier is compromised in the presence of ectopic OPCs.

176 n striking contrast to conventional T cells, compromised in their ability to secrete cytokines.

177 ported that ischemia-induced angiogenesis is compromised in type 2 diabetic mice.

178 Likewise, nMSCs presented compromised in vitro chondrogenesis, and Meckel's cartil

179 Mechanistically, IL-2 production was compromised in weakly stimulated T cells, affecting the

180 12 weeks of an HFD, blood flow recovery was compromised in WT mice, whereas it was fully recovered i

181 the health of upwardly mobile minorities is compromised in young adulthood.

182 To facilitate the diagnosis of compromised individuals, we developed and independently

183 iated knockdown or pharmacological inhibitor compromised inflammasome activation and subsequent produ

184 hallenged by manufacturing problems, such as compromised integrity of coated pellets and poor content

185 the cerebral vasculature is associated with compromised integrity of the blood-brain barrier.

186 Wells with compromised integrity typically exhibit pressure in thei

187 e conformation of the helical hairpin and/or compromised its pairwise arrangement with the companion

188 Mutant animals displayed highly compromised jump and flight ability, disrupted muscle pr

189 gic phenotype culminating in a significantly compromised life expectancy and transformation to aggres

190 the gestational uterus but rather is due to compromised local innate cellular immune responses.

191 cause increased autophagosome biogenesis and compromised lysosomal activity.

192 n sites in the MAD1(CTD), including Thr-716, compromised MAD2 binding and the checkpoint responses.

193 cells show increased germ cell apoptosis and compromised male fertility.

194 , the consumption of an obesogenic HFHS diet compromised maternal glucose tolerance and insulin sensi

195 ccl3(-/-) deletion compromised ME bacterial clearance and prolonged mucosal

196 moting factor (MPF) activation, and severely compromised meiotic resumption.

197 echnique recovered the particle rejection of compromised membranes to 99.1% of the original membrane'

198 to address this issue is in situ healing of compromised membranes via healing agents that are added

199 Immuno-compromised mice bearing A375Pbeta6 experimental metasta

200 Whereas immune-compromised mice developed persistent infection, immune-

201 P1R1, injected into the tail veins of immune-compromised mice, and followed by noninvasive biolumines

202 ined bacterial consortia to individuals with compromised microbiota composition may reduce inter-pati

203 These mutants display compromised microtubule tracking activity in vitro and r

204 ifers can occur from unlined or structurally compromised mine tailings storage facilities.

205 SET ablation compromised mitotic fidelity as evidenced by unresolved

206 in vivo, and the activity of Pol epsilon is compromised more than lagging-strand polymerase Pol delt

207 an respond flexibly to serious challenges of compromised MT-dependent MT nucleation to complete mitos

208 s variant causes impaired AKT activation via compromised mTORC2 complex function.

209 he paracrine signaling events activated by a compromised mucosal barrier and provide a novel in vivo

210 guish between well vascularized (n = 32) and compromised (n = 27) parathyroid glands during thyroid s

211 tion and elevated intracellular Na(+), which compromised Na(+)-dependent nutrient transport, were doc

212 When p53-compromised NCCs were transformed with N-Myc, we generat

213 ilar to that observed in solution and is not compromised neither by either the surface confinement or

214 Mutation of the SUMOylation site compromised neither ErbB4-induced phosphorylation of the

215 ophage recruitment in zebrafish and observed compromised neovascularization, neutrophil clearance, ca

216 The results provide evidence for compromised neural function in these patients and provid

217 ened noradrenergic responsivity in line with compromised neural gain.

218 ocampus Glu excess, together with indices of compromised neuron integrity.

219 7 mice display decreased amyloid deposition, compromised neuronal integrity, and robust brain inflamm

220 sed gray matter volumes are not explained by compromised neuronal integrity.

221 o degrade internalized bacteria also exhibit compromised NF-kappaB activation.

222 The partially compromised nodule functioning induces two striking phen

223 Virus-induced gene silencing of NOG1 compromised nonhost resistance in N. benthamiana and tom

224 Hallmarks of aged cells include compromised nuclear envelope integrity, impaired nucleoc

225 Despite the high risk of compromised nutrition, evidence of the effect of refugee

226 ted macrophages slightly, but significantly, compromised optic nerve regeneration.

227 ay result in physiological shifts leading to compromised organismal capacity to respond to additional

228 gs lacking Lkb1 have defective mitochondria, compromised OXPHOS, depleted cellular ATP, and altered c

229 We conclude that compromised PASMC HIF-1alpha expression may contribute t

230 sympathetic activity known in metabolically compromised patients and animal models.

231 re increasingly common, especially in immune compromised patients.

232 in protective immunity, especially in immune-compromised patients.

233 Compromised Pdx1 mRNA and protein levels in weaned male

234 and because intrinsically aged skin displays compromised permeability barrier homeostasis and reduced

235 e; ie, soluble MER), a critical biomarker of compromised phagocytosis by innate macrophages.

236 ns originate from individuals with partially compromised piRNA defense.

237 When fetal growth is compromised, placental insufficiency must be distinguish

238 The iput1 mutants show severe dwarfism, compromised pollen tube guidance, and constitutive activ

239 tality in the paediatric, elderly and immune-compromised populations(1,2).

240 gnitive performance when SCN timing has been compromised, possibly by coordinating activity in the SC

241 s by overexpression of PPIP5K1, and a kinase-compromised PPIP5K1 mutant had no effect.

242 tive pathways, and the mechanistic basis for compromised production is rarely elucidated since rate-l

243 opoietic stem and progenitor cells displayed compromised proliferation, and replication stress that c

244 xcretion mechanism ensures rapid disposal of compromised proteins.

245 g an increase of 1-2 centimetres per allele) compromised proteolytic inhibition of PAPP-A and increas

246 quimod (IMQ), Trim32 knockout mice displayed compromised psoriasiform phenotypes and defective T help

247 impairment of oxidative phosphorylation and compromised recovery of the affected organ.

248 rt of nonadherence to immunosuppression that compromised recovery.

249 with multiple risk factors, TFS was severely compromised, regardless of the timing of S2P and most se

250 with C-terminal truncated TnI showed similar compromised relaxation effects, indicating the importanc

251 dectomy (n = 39), including 17 patients with compromised renal function and 22 patients with known (n

252 ergent starved L1 larvae that correlate with compromised reproductive fitness of the generation that

253 DEL-tagged luminal resident, implying that a compromised retention mechanism causes saturation of the

254 series of nine nonconsecutive patients with compromised right heart function, pulmonary hypertension

255 ned normally and neuronal differentiation is compromised: rx3-derived ff1b+ neurons, implicated in an

256 ndings highlight insular disintegration (ie, compromised salience network membership) as a neurobiolo

257 ockdown of Rngtt in cultured mammalian cells compromised Shh pathway activity, suggesting that RNGTT

258 Channel regulation is also compromised since cAMP-dependent PKA activity is enhance

259 njury given the distended and/or potentially compromised small bowel.

260 Moreover, mutation of the CUE1 domain compromised SMARCAD1 binding to KAP1 target genes.

261 ce of the sextuple haplotype associated with compromised SP effectiveness.

262 indle formation as deleting or mutating TOG5 compromised spindle architecture and increased the mitot

263 s is often considered to result in an immune-compromised state, the impact of chronic hyperglycemia o

264 he programmed destruction of the mitotically compromised stem cell niche that triggers its regenerati

265 ctive shift in mycothiol redox potential and compromised stress response.

266 ed global gene expression profiles, and have compromised stress responses.

267 ive damage from normal muscle use due to the compromised structural integrity of the dystrophin assoc

268 on of NdbC leads, directly or indirectly, to compromised sugar catabolism, to glycogen accumulation,

269 These findings suggest that compromised SUMOylation of LRH-1 promotes the developmen

270 n Leishmania Finally, we noted significantly compromised survival of LdSar1:T34N-GFP-overexpressing t

271 Armc5 knockout mice have compromised T-cell proliferation and differentiation int

272 ited reduced expression of V-type ATPase and compromised targeting of this proton pump to the plasma

273 This observation was paralleled by a compromised TDG (thymine DNA glycosylase) and TET1 (ten-

274 Mertk deficiency compromised the accumulation of MHCII(LO) phagocytes, an

275 GSH deficiency compromised the activation of mammalian target of rapamy

276 ation of GLI-mediated transcription activity compromised the aggressive phenotype of Merlin-deficient

277 n Mavs(-/-) dendritic cells and subsequently compromised the antigen-presenting capacity for CD4(+) T

278 ration of the electrolytes has significantly compromised the benefits of Mg/S chemistry and hindered

279 We found that MLL4 deficiency compromised the development of regulatory T cells (Treg

280 uced prostate tumorigenesis in mice but also compromised the inhibitory effect of the anticancer drug

281 , or expression of VEGF-C/D trap, which also compromised the lymphatic drainage function.

282 When ATL function is compromised, the morphology of the endoplasmic reticulum

283 ilibrium of red blood cells (RBCs) and, when compromised, the RBCs are more susceptible to haemolysis

284 aracatinib in these CTL clones also severely compromised their functional activities toward autologou

285 r, their utility in biological fluids can be compromised through denaturation induced by physiologica

286 ing, wound breakdown, fistula formation, and compromised tissue reconstruction.

287 Sensitivity was not compromised: true bacteremia was noted in 65/904 (7.2%)

288 etative and reproductive growth was severely compromised under chilling conditions.

289 t protein pp150 and the formation of vAC was compromised upon endocytic inhibition.

290 In this model, barrier function is compromised upon exposure to inflammatory factors such a

291 uently observed in diseases characterized by compromised vascular integrity such as diabetic retinopa

292 to survive under warmer temperatures is less compromised when anthropogenic sedimentation is maintain

293 cademic labs, persistence of the software is compromised when developers graduate, funding ceases, or

294 nt blockade immunotherapy for metastases was compromised when NK cells lacked heparanase.

295 insights into protective mechanisms that are compromised when nonhibernating species, such as humans,

296 pendent of known nucleophagy pathways but is compromised when nuclear protein export is blocked.

297 A major pathway that was compromised, when TCR signaling was suboptimal, was link

298 synapses and (2) AP propagation was severely compromised with >40% of axonal branches no longer respo

299 eir ability to help B cell responses, become compromised with aging.

300 ximal and distal interphalangeal joints were compromised, without interphalangeal instability.