ライフサイエンスコーパス: computer model

1 1-dimensional transmural electrocardiography computer model.

2 tation deficits, as tested in a granule cell computer model.

3 st initiation, we developed a virtual-tissue computer model.

4 and we demonstrate one such circuit using a computer model.

5 model of the ryanodine receptor (RyR) in the computer model.

6 is hypothesis using clinical experiments and computer models.

7 five organ groups, and reconstructed as five computer models.

8 rm analyses on a variety of mathematical and computer models.

9 ne of the major deficiencies in contemporary computer models.

10 toire and was simulated using affinity-based computer models.

11 rs build a device layer by layer based on 3D computer models.

12 ) as well as regulatory T-lymphocytes and by computer modeling.

13 inding assay, site-directed mutagenesis, and computer modeling.

14 he known crystal structure of TLR4/MD-2 with computer modeling.

15 esults reported here are consistent with the computer modeling.

16 Wet-lab experiments validate estimates from computer modeling.

17 These results are supported by computer modeling.

18 ated region for a subset of miRNAs, based on computer modeling.

19 tionships (r2 > 0.97%) were observed for the computer modeling.

20 ched material, degradation, derivatives, and computer modeling.

21 expertise in biochemistry, spectroscopy and computer modelling.

22 These data are consistent with computer modelling.

23 Our computer model accurately mimics transverse array organi

24 The resulting computer models allow the first phylogenetic analysis of

25 The computer model also predicts powerful effects of perturb

26 Computer modeling analysis revealed that CQ was well doc

27 This was further supported by computer modeling analysis, which identified a surface-e

28 nucleosome distribution to a sequence-based computer model and in vitro-assembled nucleosomes.

29 roposal is illustrated by using a simplified computer model and placed within the context of a sequen

30 y and subsurface wavefront orientation using computer modeling and (2) test theoretical predictions e

31 Computer modeling and analysis of the NSP5 C terminus re

32 Computer modeling and biochemical data are consistent wi

33 binding sequence, GFPGEN, through the use of computer modeling and demonstrated that Scl2(GFPGEN) sho

34 es in binding assays, functional assays, and computer modeling and docking studies, we have identifie

35 Computer modeling and expression studies identified seve

36 Computer modeling and further mutational analysis reveal

37 These ultrastructural data support computer modeling and in vitro electrophysiological data

38 Here, we have used computer modeling and in vivo multisite recordings from

39 loading, which has been characterized using computer modeling and in vivo studies, is crucial for ma

40 Recent work using computer modeling and live imaging is helping to elucida

41 ting microchannel arrays is characterized by computer modeling and microscopic particle image velocim

42 Previously, computer modeling and mutational analysis predicted two

43 in autophosphorylation site of FAK, Y397, by computer modeling and screening of the National Cancer I

44 alyze the structure of botanical trees using computer modeling and show that many relevant measures o

45 We predict, from computer modeling and simulation in partnership with exp

46 Combining computer modeling and single-cell measurements, we exami

47 tes and five substrate analogues followed by computer modeling and site-directed mutagenesis.

48 tion of these hypotheses by a combination of computer modeling and stopped-flow pH-dependent kinetic

49 Using a combination of computer modeling and the knowledge that vicinal C-F and

50 We here focus on the contribution that computer modeling and theory make to this long-term effo

51 M2) near the C-terminal tail was proposed by computer modeling and verified by site-directed mutagene

52 ces in real, biological cells, bridging pure computer modelling and experimental electrophysiology.

53 provide critical input for the refinement of computer models and the elucidation of the structure and

54 rn biology by "building and breaking it" via computer models and their simulations.

55 bance, photoluminescence-excitation mapping, computer modeling, and electron microscopic imaging to c

56 he as-prepared material, as revealed here by computer modeling, and involve distinct zigzag paths bet

57 ylated SWNTs with HRP was further studied by computer modeling, and the products of the enzymatic deg

58 high-resolution two-dimensional (2D) NMR and computer modeling approach was carried out to study the

59 We utilized mutagenesis, kinetic, and computer modeling approaches to better understand differ

60 this, we used stopped-flow spectroscopy and computer modeling approaches to determine how the phosph

61 Kinetic isotope effects (KIEs) and computer modeling are used to approximate the transition

62 g animals are isotropic, since sophisticated computer models are required to estimate the 3D scatteri

63 llectively these findings demonstrate that a computer model based analysis of routine clinical EEG pr

64 uided by a delayed eligibility trace rule, a computer model based on the anatomy and dynamics of the

65 We present a computer model based on translational murine data for in

66 Computer modeling based on the PRLR crystal structure sh

67 Computer modelling based on the Runx1/CBFbeta/DNA crysta

68 Computer models based on the detailed biology of the bra

69 In particular, data driven computer model calibration is the basis for inference of

70 A computer model can be helpful in understanding septal de

71 , developments in machine learning show that computer models can also make valid judgments.

72 Computer models can make transcranial electric stimulati

73 Mathematical and computer models can provide guidance to public health of

74 The cascade computer model (CCM) was designed as a machine-learning

75 967, and deeper insight is being obtained by computer modelling combined with empirical work.

76 present study, we use anatomically accurate computer models constructed from digitized images of bon

77 Computer models constructed from these images are used t

78 designed protein confirms that the minimized computer model contains a haem/non-haem Fe(B) centre tha

79 al inversion of diffraction data-producing a computer model correctly representing the material explo

80 Computer modeling corroborated these experimental findin

81 For dedicated breast imagers, the computer model could increase the specificity from 34% t

82 For residents, the computer model could potentially improve the specificity

83 Developments in proteomics and computer modeling could expand our view of proteins medi

84 Computer modelling coupled with classical biochemical te

85 hermal profiles were determined by using the computer modeling data and correlated by using linear re

86 Computer modeling data suggested that residue 96 resides

87 A three-dimensional computer model depicts the physical interactions between

88 By use of empirically well-constrained computer models describing the coupled function of the b

89 uccessful application of QSPR models for the computer-model-driven design of liposomal drugs.

90 The employed cellular automaton-based computer model examines the life history of the subject

91 Variability in the recommendations of the computer model for different observers was also calculat

92 We develop a computer model for how two different chemical catalysts

93 tissue property modulation, and the role of computer modeling for treatment optimization.

94 which can significantly hamper the skill of computer models for climate change.

95 To address extreme crowding, various computer models for crowd movement have been developed i

96 expense of in vitro experimentation by using computer models for in silico predictions.

97 convection is a central challenge in current computer models for long-range ensemble forecasting of w

98 Computer modelling, gel mobility shift and footprint ana

99 In the computer model, gray zones were assigned slower conducti

100 Computer modelling has emerged as a particularly useful

101 increasing I K1 density in a two-dimensional computer model having realistic mouse ionic and action p

102 pically derived from: (i) global circulation computer models; (ii) interpolated weather station data;

103 Computer modeling implicated TMH3-4-5-6 for activation b

104 Computer modeling implied that this motif might function

105 Here, the advantage of applying computer modeling in optimizing the therapeutic efficacy

106 d design using PKA mutants as surrogates and computer modeling in the discovery of selective inhibito

107 ed, our study also showed the limitations of computer modelling in extending the data from the X-ray

108 The collective experimental data and computer modeling indicate that the deacylation-deficien

109 t measurements of calyx I(NaP) together with computer modeling indicate that the fast deactivation ti

110 In addition, computer models indicated that early depletion of memory

111 Computer modeling indicates that the optimal spacing of

112 The extended computer model is corroborated by simulating an independ

113 Molecular dynamic computer modelling is a new powerful tool to predict or

114 of imperfect Atmosphere Ocean Science (AOS) computer models is a central issue in climate change sci

115 mics, was selected for further studies using computer modeling methods and site-directed mutagenesis.

116 We developed a computer model of "virtual pea seeds," that uses Monte C

117 To understand how CobA and FldA interact, a computer model of a CobA.FldA complex was generated.

118 rocess of development of a complex multibody computer model of a primate skull (Macaca fascicularis),

119 We have built a computer model of apicobasal polarity that suggests that

120 address this issue by using a coarse-grained computer model of arrays of 101 nucleosomes considering

121 s of the dinC and recA operators we docked a computer model of B.subtilis LexA on the preferred opera

122 We developed a simple computer model of clonal expansion in an epithelium in w

123 died theta-modulated gamma oscillations in a computer model of hippocampal CA3 in vivo with and witho

124 We linked data from recent trials to a computer model of HIV acquisition, screening, and care t

125 pothesized that a patient-specific in silico computer model of intracranial pressure (ICP) dynamics m

126 experimental data to develop a comprehensive computer model of Kv1.4 channels to determine the intera

127 wo models into a two-dimensional, stochastic computer model of lamellipodial protrusion, and studied

128 ated guinea pig cardiac mitochondria using a computer model of mitochondrial bioenergetics and cation

129 e first developed a realistic finite element computer model of rat lumbosacral segments to identify t

130 A multicompartment, history-independent computer model of rat skeletal muscle was developed to d

131 d by representing clinical imaging data as a computer model of the anatomical defect and translating

132 A computer model of the auxin redistribution shows agreeme

133 A computer model of the axon showed that the changes in ma

134 A similar protocol was used in a simplified computer model of the cardiac tachycardia circuit in a 2

135 Using a computer model of the hippocampal Schaffer collateral pa

136 hrough the analysis of unfolding times for a computer model of the homogeneous and heterogeneous tand

137 sceptibility in a biophysically detailed, 3D computer model of the human atria representing electrica

138 l deformation pattern, we used the CircAdapt computer model of the human heart and circulation.

139 We developed an individual cell-based computer model of the interaction of cancer stem cells a

140 as been deleted, and apply a newly developed computer model of the metabolism of these cells to predi

141 ing structure-based virtual screening with a computer model of the Stat3 SH2 domain bound to its Stat

142 This setup was replicated using a computer model of the thalamocortical system, which cons

143 As a specific example, we constructed a computer model of the visual system of cephalopods (octo

144 In silico analysis using a computer model of ventricular tissue incorporating these

145 NOS association with Cav-1 (Kd = 49 nM), and computer modeling of CAV(90-99) docking to eNOS provides

146 work represents an important development in computer modeling of chromosomes, and suggests new expla

147 Computer modeling of cytoplasmic domains indicated that

148 Computer modeling of interactions of Lp-PLA(2) with diff

149 t an investigation of this possibility using computer modeling of quasi-transition states and pH-depe

150 We present a new approach to computer modeling of solvation free energies of oil in w

151 Computer modeling of the CDK7 structure was used to desi

152 Computer modeling of the complexity data suggests that m

153 other recombinant monoclonal antibodies and computer modeling of the Fab part of rhuMAb suggest that

154 Computer modeling of the GS52 apyrase structure identifi

155 Finally, computer modeling of the kinase domain suggests a phosph

156 Based on computer modeling of the Kir6.2 structure, we infer that

157 These data combined with computer modeling of the putative three-dimensional orga

158 Computer modeling of the RecBCD-DNA complexes suggests t

159 Computer modeling of the spatial distribution of resonan

160 e hepcidin-binding region of ferroportin and computer modeling of their docking.

161 Computer modeling of urotoxin's three-dimensional struct

162 Computer modeling of WT and mutant STAT1 molecules showe

163 Computer modelling of the CR2 SCR1-2 solution structure

164 Accuracy of results from mathematical and computer models of biological systems is often complicat

165 uch, GPs are well suited for the analysis of computer models of biological systems, which have been t

166 odeling and Cx43 distribution in subcellular computer models of cells of the outer pathway (IZo) and

167 Computer models of disease take a systems biology approa

168 ed GD1a in a solid phase assay, we generated computer models of GD1a based on binding patterns of dif

169 Computer models of increasing sophistication have predic

170 ferent activity and for generating realistic computer models of neuronal networks of striatal and mid

171 mented subcellular monodomain and two-domain computer models of normal epicardium (NZ) to understand

172 We construct personalized three-dimensional computer models of post-infarction hearts from patients'

173 through the analysis of unfolding times for computer models of protein tandems.

174 Executable computer models of signaling pathways can accurately rep

175 orial review we show how the construction of computer models of such natural supramolecular systems n

176 Well-tested computer models offer new insight in the control of the

177 scribe an R package, mlegp, that fits GPs to computer model outputs and performs sensitivity analysis

178 the packed tissues using disease, genetic or computer model perturbations, we show that as long as pa

179 muli (S(2)S(3)S(4)S(5)=CL(VF)) for which the computer model predicted maximal spatial dispersion of r

180 In addition, computer modeling predicted a docking site for OSU-03012

181 Computer modeling predicted that 81% of AD-HIES mutation

182 Computer modeling predicted that IpaD binds the bile sal

183 Computer modelling predicted (and experiments verified)

184 Computer modelling predicted that this reduces spike lat

185 Computer models predicted a conserved miR-103/107 target

186 Computer modeling predicts that a delay in the onset of

187 Computer modeling predicts that N(1575)Y allosterically

188 Computer modeling predicts that these unique residues in

189 Computer modelling predicts that enzyme active sites are

190 Together, our computer model provides new mechanistic insights into ho

191 Computer modeling provides a structural explanation for

192 A computer model representation of the system allows furth

193 Computer modeling reproduced an enhanced effectiveness o

194 e of this study was to determine whether the computer model results pertained to the initiation of VF

195 Computer models reveal that slow IPSCs in bushy cells ca

196 Computer modeling revealed that EAD generation by hypoka

197 Computer modeling reveals that these arginine residues r

198 ther with mutagenesis, kinetic analysis, and computer modeling shed light on the cofactor binding and

199 a personality questionnaire (r = 0.49); (ii) computer models show higher interjudge agreement; and (i

200 Computer modeling showed prolongation of cardiomyocyte a

201 Computer modeling showed that the R6.58A mutant has addi

202 The computer model simulated the observed changes in the ES

203 Computer model simulations support the hypothesis that D

204 Computer modeling, structure probing, and/or compensator

205 Computer model studies based on density functional theor

206 In computer model studies, we investigated calcium dynamics

207 Despite its potential importance, computer modeling studies focused on arrhythmia mechanis

208 We performed a series of computer modeling studies on the skull of Uromastyx hard

209 Earlier computer modeling studies predicted that glycolysis woul

210 Computer modeling studies show that the more open active

211 lphosphocholine (DPC) was also observed, and computer modeling studies showed that it may likely orig

212 erstand the differential SAR, we carried out computer modeling studies to gain insight into the effec

213 PXRD patterns and computer modeling study, together with pore size distrib

214 In a computer modeling study, we demonstrated that specific s

215 The computer model successfully reproduced both qualitative

216 Theory and computer modeling suggest that the rate of emergence of

217 For both polymerases, computer models suggest that bypass occurs only when O(6

218 The computer models suggest that the spatial positions and o

219 Computer modeling suggested that the first resembles the

220 Computer modeling suggested that the rWTX loop II protru

221 Because computer modelling suggested significant structural simi

222 son of these data to simulations produced by computer models suggested that multiple factors were inv

223 Computer modeling suggests that Arg-593 may cross-bridge

224 Computer modeling suggests that both P558G and P558A mut

225 Computer modeling suggests that GABAergic quenching of l

226 Computer modeling suggests that oxygenase(DIC) has stron

227 Computer modeling suggests that the KITD816V mutation de

228 Combining these experimental results with computer modelling suggests that PE formation involves b

229 e the dynamics of a genomic invasion using a computer model, supported by in vitro and in vivo experi

230 Computer modeling supports these findings by showing tha

231 alization was guided by the Plaque Simulator computer modeling system using preoperative imaging stud

232 Among the various computer modeling techniques, the application of molecul

233 ymmetric distribution that can be fit with a computer model that assumes two rupture rates, a slow on

234 owing dynamic mechanisms to be revealed in a computer model that can then be tested in biological sys

235 elationships were compared with results of a computer model that simulates IMS operation based on a f

236 DESIGN, SETTING, AND PATIENTS: A computer model that simulates the life histories of indi

237 Computer models that capture key features of the heterog

238 experiments, as well as biophysically based computer models that have been used to integrate and int

239 We conclude that structure-based, multiscale computer models that incorporate accurate information ab

240 r BRCA1/2 mutations, it is not known whether computer models that predict mutations work accurately i

241 Computer modeling the peptides NRLLLTG and ELPPVKI in bo

242 In our computer model, the tip link tension and fast adaptation

243 In computer models, these findings were best explained by r

244 Using computer modeling, this increase in Ito resulted in loss

245 s characterized by X-ray crystallography and computer modeling, this study shows that a new conformat

246 Through computer modelling, this study investigated mechanisms b

247 Through biophysically detailed computer modelling, this study investigated mechanisms b

248 Using biophysically-detailed human atria computer models, this study investigated the mechanistic

249 ical expressions and created a corresponding computer model to describe the consequences of independe

250 -directed mutagenesis data, we established a computer model to explain the specific A27-A17 binding m

251 rotubule behaviour rules is sufficient for a computer model to mimic the observed responses to change

252 We used a computer model to simulate a cohort of HIV-infected, pre

253 We used Zimbabwean data in a validated computer model to simulate a cohort of pregnant, HIV-inf

254 e have incorporated it into a 2D, stochastic computer model to study lamellipodia via the self-organi

255 Computer modeling to a minimal mechanism was consistent

256 tural studies, we carried out homology-based computer modeling to aid analysis.

257 We used computer modeling to characterize the effect of STAT3 mu

258 Finally, we used computer modeling to depict how the A125V amino acid cha

259 d DARPins at 1.95-A resolution, we could use computer modeling to design a link to a trimeric protein

260 We used computer modeling to dock INS2 onto the known three-dime

261 We used computer modeling to examine the function of these dista

262 and voltage imaging from the same neuron and computer modeling to investigate signal processing in th

263 ues, using quantitative spatial analysis and computer modeling to investigate the topology of astrocy

264 e then aligned along the peptide template by computer modeling to predict the possible monomer sequen

265 r AP explain TWA and predict VT/VF, and used computer modeling to suggest potential cellular mechanis

266 his new understanding may help expand use of computer modelling to explore adhesive wear processes an

267 cies in the United States use activity-based computer models to estimate mobile source emissions for

268 nments depend increasingly on predictions by computer models to justify their decisions.

269 This study compared computer-modeled triamcinolone acetonide diffusion after

270 Computer modeling under the framework of a local-enhance

271 A computer model used to simulate the network washout curv

272 We developed a conductance-based computer model using the simulation tool NEURON.

273 Kinetic isotope effects (KIEs) and computer modeling using density functional theory were u

274 Animal models such as the neonatal pig and computer models using finite element analysis are promis

275 y detailed rabbit ventricular slice bidomain computer model was constructed from 25-mum magnetic reso

276 In this study, a 3D computer model was constructed to calculate local Ca flu

277 epen our understanding of these processes, a computer model was developed to integrate the biophysica

278 by quantifying these anatomical parameters a computer model was generated that accurately predicted a

279 A multi-compartment computer model was used to estimate the amplitude and ti

280 A computer model was used to simulate decentration of a 6-

281 Contrast CT and computer modeling was used to determine the vena cava re

282 Computer modeling was utilized to determine and compare

283 From this computer model we designed a slice preparation that cont

284 Using a computer model we investigated whether top-down induced

285 In laboratory experiments and computer modelling we uncovered patterns of the foraging

286 Using a computer model, we investigate the phase behavior and th

287 Using a computer model, we reproduced the observed spatio-tempor

288 Based on behavioral studies and computer modeling, we develop a 2D model of face evaluat

289 -directed mutagenesis, NMR spectroscopy, and computer modeling, we investigated the recombinant mutan

290 Using computer modeling, we reproduced voltage-clamp experimen

291 amiliar and new examples of mathematical and computer models, we provide a complete methodology for p

292 Agent-based computer models were built to explore how a polarized re

293 atients (0-16 years old), for whom full-body computer models were recently created from clinical CT d

294 Petri net computer models were shown to be an effective method for

295 calculated cost-effectiveness ratios with a computer model which projected results to 10 years.

296 exchanges; its reports relied especially on computer modeling, which became a center of fully integr

297 urons was reconstructed and used to generate computer models, which were adjusted to fit the somatic

298 Computer modeling with Orbit 1.8 (Eidactics, San Francis

299 in these three model organisms has combined computer modelling with experimental analysis to reveal

300 ems has often been performed using classical computer models with continuous properties.