ライフサイエンスコーパス: concept

1 or the years 2016-2030 is used as a proof-of-concept.

2 important evidence and present a generalized concept.

3 by the identification of a suitable prodrug concept.

4 anatomy and demonstrated feasibility of the concept.

5 tion of alternatives to the negated expected concept.

6 scales and the focus on apathy as a unitary concept.

7 d the top 2 candidates in vivo as a proof-of-concept.

8 urious signals inherent to this multiplexing concept.

9 en expanding in terms of both number and the concept.

10 al health system, which has been a neglected concept.

11 d on a three-compartment phantom as proof-of-concept.

12 dren's spontaneous, nonsymbolic mathematical concepts.

13 wing for novel activation modes and reaction concepts.

14 functions and applications, and novel device concepts.

15 the design of new graphene functionalization concepts.

16 d the change of geographic focus for various concepts.

17 example to illustrate many of the discussed concepts.

18 This study proposes and proves (in concept) a novel approach of combining electrokinetic (E

19 As a proof of concept, a reversible label-free glutathione-S-transfera

20 nd analyzed if they are to produce models or concepts about physiological function or mechanisms of p

21 ss between picture language and mathematical concepts: abstraction and simulation.

22 This concept allows quantitative assessments of the shape-mem

23 We describe the concept and the algorithm, test it on known benchmarks,

24 Novel concepts and paradigms are described here that have emer

25 Herein we summarize and review evolving concepts and provide a personal perspective on clinical

26 ogress in GLP biology, highlighting emerging concepts and scientific insights with translational rele

27 n and exemplification of protein degradation concepts and their resulting applications to medicine di

28 cular magnetic resonance imaging techniques, concepts, and applications.

29 terms were indirectly evaluated through the concept annotations on a gold standard corpus and also b

30 In a proof-of-concept application in organocatalysis, the diastereomer

31 articular case of the more general ambimodal concept applied to a transition state that connects reac

32 ess mechanisms in TBI and provide a proof-of-concept approach to improve acute TBI management that ma

33 These concepts are dignity and respect, information sharing, p

34 These concepts are relevant to videos that contain evidence fo

35 We refer to this concept as chemistry at a point and illustrate it by tra

36 To summarize key concepts, as well as early safety and efficacy signals f

37 sipative self-assembled material, the unique concepts at the basis of these supramolecular materials

38 the development of a novel lysozyme sensing concept based on the use of Micrococcus lysodeikticus wh

39 MnO2 could be recovered, enabling a proof-of-concept biobattery/supercapacitor hybrid device.

40 phene opens up new paradigms to realize this concept, but so far this has been elusive experimentally

41 We verified the superiority of our design concept by achieving an unprecedented photocurrent densi

42 Finally, we developed this concept by performing the reductive alkylation reaction

43 We apply this concept by using a nanoelectromechanical platform to dem

44 The concepts called STED/RESOLFT superresolve features by a

45 The medial temporal lobe (MTL) contains "concept cells" that respond invariantly to specific indi

46 ve fibres However, the data supporting these concepts come from vibratory measurements at cochlear lo

47 As proof of concept, cultured renal epithelial cells were exposed to

48 We demonstrate that statistical concepts developed for discovery proteomics based on spe

49 treated simultaneously according to the same concept except STC.

50 treated simultaneously according to the same concept except STC.

51 se findings unravel an unexpected regulatory concept executed by coiled-coil MDs to tightly control A

52 rived xenografts (zPDX) and provide proof-of-concept experiments that compare response to chemotherap

53 This work provides a proof of concept for a general strategy to use nanohoops and thei

54 Therefore, DPM-1001 represents a proof of concept for a new approach to therapeutic intervention i

55 Our studies offer a preclinical proof of concept for a strategy of cotargeting the EGFR and PYK2/

56 As proof of concept for anti-TRBC immunotherapy, we developed anti-T

57 ionally designed DNA molecules are proofs of concept for embedding control within complex molecular e

58 f principle experiments of an optical gating concept for free electrons via direct time-domain visual

59 er resection of murine PDAC, suggesting this concept for future clinical trials.

60 rall, our results offer preclinical proof of concept for H3B-6527 as a candidate therapeutic agent fo

61 gn considerations are explored, and proof-of-concept for highly pathogen-specific cargo release from

62 microbial and plant hosts provided proof of concept for metabolic engineering of pseudolaratriene.

63 Here we report a concept for monolayer MoS2 optoelectronic memory devices

64 Our findings offer a preclinical proof of concept for small-molecule therapies to target the CBP/p

65 Our results introduce a concept for the domain wall electronic property, the wal

66 Here, we provide proof-of-concept for the TFT, by showing that introduction of a m

67 ly, our results offer a preclinical proof of concept for the use of anti-Jagged1/2 to reprogram MDSC-

68 migration and provide a preclinical proof of concept for their candidacy as targets to treat metastat

69 Our results constitute a proof-of-concept for, to our knowledge, a new design principle fo

70 n important clinical implications, including concepts for drug delivery and new classifications and t

71 Concepts for information storage and logical processing

72 Novel concepts for on-chip vortexing of the magnetic beads and

73 cle, as well as their coupling, as important concepts for understanding the changes that occur in pul

74 ducing CH4 emissions is an entirely distinct concept from biological C sequestration projects to enha

75 This article outlines how a core concept from theories of homeostasis and cybernetics, th

76 of interactive particles, and uses tools and concepts from density functional theory.

77 Inspired by concepts from landscape ecology and Markowitz's portfoli

78 ights from recent microbial experiments with concepts from lattice-field theory and non-equilibrium s

79 A proof-of-concept gas sensor equipped with the resulting porous go

80 Proof-of-concept has been established in nonhuman primates.

81 This concept has been reinforced by recognition of the comple

82 nt from human cornea, where limbal stem cell concept has been well established and accepted.

83 This concept has led to efforts to map both virus and antibod

84 Social values and concepts have played a central role in the history of me

85 yed on novel experimental data as a proof of concept, illustrating the recruitment of LAT to the T-ce

86 This concept implies the importance of a three-dimensional (3

87 A new concept in anionic 10 pi aromaticity is described by the

88 early to mid-20th century, reductionism as a concept in biology was challenged by key thinkers, inclu

89 Darwinian fitness is a central concept in evolutionary biology.

90 s of this work provide an important physical concept in fundamental understanding of atomistic pathwa

91 nges in microbiota immune targeting as a new concept in IBD diagnotics.

92 Scaffolds are a core concept in medicinal chemistry, and they can be the focu

93 In a proof-of-concept in vivo experiment, blockade of C1q and C3a tran

94 ACI Position Paper aims to harmonize current concepts in AECs and to project unmet needs with the int

95 omatically infers missed connections between concepts in literature.

96 as and the limitations of precision-medicine concepts in MDS.

97 and diagnostics, is among the most promising concepts in nuclear medicine for optimizing and individu

98 nostructures holds promise for future device concepts in optoelectronic and spin-based technologies.

99 early pathogenic events and prove molecular concepts in patients with psoriasis.

100 xample of routine utilization of the current concepts in pediatric CT optimization.

101 We review key principles and evolving concepts in the care of MPM patients with a focus on the

102 provide an overview of how well-established concepts in the fields of quantum chemistry and material

103 e open-source movement to best practices and concepts in this area and to survey the state of open-so

104 To test this concept, in this-proof-of-principle study, we screened f

105 of this Perspective is to highlight emerging concepts, including mathematical modelling and the molec

106 Here we translate this concept into an operational definition at the network le

107 Moreover, to move beyond proof-of-concept into translational applications, we discuss futu

108 We will also examine how to craft these concepts into tools such as financial incentives and soc

109 The concept is applicable to any track geometry, including t

110 This concept is at the core of initiatives for merging cost e

111 The main idea of this concept is based on an automated curve fitting of most r

112 This concept is being used clinically to harvest hematopoieti

113 The feasibility of this new concept is demonstrated in the direct functionalization

114 Our concept is generally applicable and could significantly

115 Clarifying this central concept is necessary for assessing Burkart et al.'s prop

116 fect clearer, the recent development of this concept is reviewed here and a novel principle for the d

117 A prospective trial to validate this concept is warranted.

118 we envisage that this lattice misfit design concept may be applied to many other metallic alloys.

119 This first proof of concept may ultimately be applicable to geofencing other

120 ists who introduced the seminal terminology, concepts, methodological approaches, and initial data pe

121 Limited proof-of-concept monotherapy studies to evaluate safety and antiv

122 We fabricated and tested a proof-of-concept NanoThermoMechanical device that has shown a max

123 As proof of concept, Nd/Sm and Nd/Dy are used as binary models to de

124 Gervais & Fessler dissect the folk concept of "contempt" to argue for a functionally integr

125 The concept of a glucose-responsive insulin (GRI) has been a

126 rust was removed by exhumation, supports the concept of a lower crustal channel flow beneath Eastern

127 We suggest a concept of absorptive fine root foraging strategies invo

128 Here we miniaturize the concept of affinity pulldown, a gold-standard in vitro P

129 By using the concept of an effective excitation energy, depth-depende

130 nked tools-epidemiological modelling and the concept of an investment case-are being developed to exp

131 o current arguments or data suggest that the concept of art can be meaningfully circumscribed.

132 This concept of bending strain engineering of spins via topol

133 lic health responses: (1) operationalise the concept of centrality of protection; (2) integrate affec

134 These findings broaden the concept of cognitive aging to include evidence of Alzhei

135 Conclusion Many radiologists support the concept of communicating more directly with patients but

136 The concept of community is often used in environmental poli

137 In addition, the concept of complementary modulation of normally antagoni

138 To clarify the concept of de-escalation of violence and aggression as d

139 published genome-wide data set supports the concept of delayed paternal genome activation in plant e

140 Furthermore, the concept of dysregulated inflammation resolution in ather

141 suggest that microflow sensors based on the concept of elastic deformation could be designed for in

142 The concept of electrical energy generation based on asymmet

143 DCP3 defines a model concept of essential universal health coverage (EUHC) wi

144 E2 Collectively, we will need to modify the concept of estrogen's positive feedback mechanism.

145 The concept of forcing covalent and reversible bonds to mix

146 The concept of freedom from infection, routinely used in vet

147 Here, we outline a novel concept of functional connectome-wide alterations that a

148 We provide proof-of-concept of Homo-PROTACs using diverse molecules composed

149 Inspired by the concept of hydrogen bond, herein we focus on the Li bond

150 ith greater LV trabeculation, supporting the concept of hypertrabeculation being an epiphenomenon of

151 (nodes or brain regions) over time using the concept of intrinsic ignition, which are naturally occur

152 s, a concept that overlaps with the emerging concept of live biotherapeutic products.

153 nding would constitute a major change in our concept of malaria parasite invasion, suggesting it is,

154 This new concept of metabolic disease modeling by somatic genome

155 op an algorithm named dpath that applies the concept of metagene entropy and allows the ranking of ce

156 lity that is consistent with the generalized concept of mobility proposed by Giddings.

157 The concept of motifs provides a fresh perspective for study

158 Inspired by the concept of multilayer thermionic devices, we propose and

159 The concept of natriuretic peptide guidance has been extensi

160 The concept of neutrophil plasticity is new and, to our know

161 Together, these results support the concept of NFI-A as a master molecular transcriptome swi

162 ent and contribute to the development of the concept of number.

163 and single-domain Abs have reinvigorated the concept of passive immunization.

164 Here we introduce the concept of phasor representation to qMRI to disentangle

165 Exact disease recognition, an element of the concept of precision in medicine, requires new infrastru

166 These data support the concept of progranulin-boosting therapies for frontotemp

167 To illustrate the concept of rapid digital antimicrobial susceptibility as

168 In this Review, we introduce the concept of resonant SEIRA and discuss the underlying phy

169 This emergent model supports the concept of SCZ as an 'associative' disorder-a breakdown

170 wishes for the treatment of DR confirmed the concept of SDM, which was favored by three quarters.

171 ernational task force recently redefined the concept of sepsis.

172 and history of SERS and TERS, including the concept of SERS hot spots and the plasmonic nanostructur

173 l delocalization, obviating the need for the concept of superaromaticity.

174 This new concept of switching of excited-state configuration shou

175 These results provide a proof of concept of systemic antitumor activity after intratumora

176 Although the concept of the atopic march has been refined and strengt

177 These findings represent proof-of-concept of the efficacy and tolerability of antiangiogen

178 In this review we will introduce the concept of the environmental epigenome in asthmatic pati

179 hylogenetic tree reconstruction based on the concept of the generalized ACS approach.

180 g of allostery and suggests that the general concept of the native state be expanded to allow for mor

181 The mathematical concept of topology has brought about significant advant

182 The concept of upper airway remodelling has only recently be

183 The manuscript describes a concept of using off surface matrix modified with captur

184 A brief discription of the concept of vacancies, the way to create and control them

185 Here, we propose a concept of valley photonic crystals with electromagnetic

186 ibes various synthetic methods and modifying concepts of 1D-photoanodes (nanotubes, nanorods, nanofib

187 rived empirical laws by applying methods and concepts of aggregation dynamics of aerosol physics.

188 veloped method allowed implementation of the concepts of human biomonitoring at the community scale,

189 The combination of the supramolecular concepts of mechanical motion and guest binding with the

190 erature search was performed on the two main concepts of MR imaging (MR imaging, and direct and indir

191 have both transformed and expanded classical concepts of receptor pharmacology and have begun to illu

192 aling have provided insight into the general concepts of receptor signaling, receptor internalization

193 In this perspective, the fundamental concepts of single cell-SERS analysis including origin o

194 in deciphering the mechanisms underlying the concepts of tumor immunosurveillance and immunoevasion h

195 In this review, we present current concepts on the role of clonal evolution in lymphoid and

196 fields struggle with grasping bioinformatic concepts only from classroom lectures.

197 cent years, and games that convey scientific concepts or themes are increasingly popular.

198 We performed a proof-of-concept phase Ib study of ibrutinib monotherapy followed

199 In this proof-of-concept pilot study, patients wore wristband pedometers

200 To demonstrate this concept, planar and 3D-structured sheets are preprogramm

201 Finally, concepts proposed to improve the efficiency of reactors

202 Additionally, a proof-of-concept prototype system, which integrates an on-line sa

203 at represents structured relationships among concepts, providing a substrate for expectations and a c

204 The current concept regarding endochondral bone formation postulates

205 The authors discuss fundamental concepts regarding the design and interpretation of noni

206 This concept remains controversial and lacks direct experimen

207 confirmed in numerous studies, and its basic concept remains valid.

208 In a proof-of-concept setting systemic treatment with ustekinumab dimi

209 cent experimental data, we propose that this concept should also include metabolic pressure secondary

210 ubjects, using virtual and real mathematical concepts simulated by pictures.

211 As a preclinical proof of concept, specific tumor uptake, pharmacokinetics, and fe

212 ur recent article, we elaborate our proof-of-concept studies of a mouse/human chimeric IgE antibody (

213 Proof of concept studies of tissue phantoms yielded a mean error

214 Proof of concept studies were performed to detect salivary cortis

215 This proof of concept study demonstrates that bacterial flora within t

216 This proof of concept study demonstrates that pericardial resection th

217 of gammadelta T cells >30 y ago, a proof-of-concept study has not been done to prove the principle t

218 Conclusion This proof-of-concept study indicates that TA of nonenhanced cine MR i

219 Collectively, this proof-of-concept study links urine peptidomics to molecular chang

220 In this proof-of-concept study, Raman microspectroscopy was utilized for

221 In this proof-of-concept study, stable isotope probing (SIP) was used to

222 In a proof-of-concept study, we defined two groups (1) an acute STEMI

223 eous nephrolithotomy (PCNL) in this proof-of-concept study.

224 ing for the initiation of a Phase-2 proof of concept study.

225 allow testing some of the recently proposed concepts such as OAM-induced dichroism, magnetic switchi

226 other emerging schools of thought, that is, concepts such as the exposome, social determinants of he

227 involve a process of self-assembly [2], this concept suffers from a number of logistical issues when

228 al discussion of QD materials along with key concepts surrounding their preparation and bioconjugatio

229 sive and in-depth description of fundamental concepts, technical implementations, and current technol

230 arify the relationship between the different concepts, technologies, and descriptions of biofabricati

231 In this study, we present a proof-of-concept technology comprising an on-chip planar Goubau l

232 mpulsive disorder (OCD) and tic disorders, a concept termed pediatric autoimmune neuropsychiatric dis

233 olymerization in vitro As a further proof-of-concept test for cellular effects of these compounds, we

234 ndings of this study are consistent with the concept that abnormal AAT protein conformation and intra

235 These findings support the concept that an amplification process occurs along the p

236 We have also provided proof of concept that blocking 12-HETE production is a promising

237 This is a decisive proof of concept that cancer cells' malignant behaviour can be do

238 ning the vision of precision medicine is the concept that causative mutations in a patient's cancer d

239 ient gynoecial primordium and strengthen the concept that cytokinin regulates auxin homeostasis durin

240 n responders to antidepressants supports the concept that dysregulation of brain arousal is a possibl

241 Overall, this study supports the concept that early assessment of urinary antimicrobial p

242 Proof-of-concept that FFLUX's architecture is suitable for geomet

243 and proliferation increase; this led to the concept that glia are required for maintenance of the ga

244 uced TNF-alpha synthesis, which supports the concept that glycerophosphoinositol inhibits the de novo

245 Support for the concept that herpes simplex virus type 1 (HSV1), when pr

246 These data support the concept that immunisation of devils with DFTD cancer cel

247 Our data support a novel concept that immunogenic DCs can be engineered for myeli

248 The concept that individuals with the same disease and a sim

249 These findings provide a proof of concept that introducing gut bacteria to a herbivore may

250 This study shows proof of concept that LAIVs boost preexisting, cross-reactive T c

251 minal region of the protein, and support the concept that modulating mutant HTT conformation might pr

252 Finally, these data confirm the concept that normal stroma function is essential for nor

253 referred to as next-generation probiotics, a concept that overlaps with the emerging concept of live

254 results provide an empirical example for the concept that population-based linkage analysis is a usef

255 tanding of prion replication and support the concept that prion replication can be separated from tox

256 These results further support the concept that SM proteins in general are part of the core

257 Proof of concept that such proteins can be detected with antibody

258 This study is the first proof of concept that targeting a lncRNA to transcriptionally act

259 Collectively, these data provide proof of concept that targeting thrombin or fibrin(ogen) may limi

260 findings provide additional support for the concept that the anatomic and genetic etiological bases

261 Our results are consistent with the concept that the beneficial action of PI3Kgamma ablation

262 We also found evidence supporting the concept that the effects on microphthalmia-associated tr

263 Our data provide proof-of-concept that this technology can be used to treat diseas

264 l classes, we outline key cross-disciplinary concepts that emerge in this challenging field.

265 ves an overview of ongoing studies and trial concepts that will lead to a more refined therapy for th

266 As a proof-of-concept, the ability of niosomes to prevent physical and

267 As a proof of concept, the biodistribution of (89)Zr-Df-pembrolizumab

268 Based on these emerging concepts, the prognosis, quality of life, and survival o

269 As a proof-of-concept, these materials were fabricated into thin films

270 As a proof-of-concept, this study demonstrates the successful use of s

271 Here, we adapt this raster/vector concept to a 2D colloidal system and realize 'vector ass

272 This work provides a concept to achieve enhanced forward scattering with weak

273 To reduce this concept to practice, we fabricated two flow cells such t

274 physics and has rapidly grown from proof-of-concept to robust demonstrations and deployment of comme

275 Applying the species pool concept to symbiotic fungi facilitated a better understa

276 Here, we develop concepts to coat surfaces with quorum-sensing-manipulati

277 To prove this concept, trans-/intramucosal and lymph-node delivery of

278 blind, randomised, sham-controlled, proof-of-concept trial.

279 Guide is to introduce readers to fundamental concepts underlying adjustment as a way of dealing with

280 Emerging treatment concepts use drugs directed against KIT and other releva

281 Fracture mechanics concepts using double cantilever beam configuration were

282 ve demonstrated compelling clinical proof-of-concept, validating the biology and drug discovery appro

283 The molecular torsion balance concept was applied to a new conformationally controlled

284 While its theoretical concept was established already in the 1950s and its con

285 This concept was extended to live rats with an induced bloods

286 This concept was further explored by screening 42 targets fro

287 This concept was further supported by the observation that de

288 As a proof of concept we exposed growing colonies of Escherichia coli

289 As proof-of-concept we investigated proteome-wide protein interactio

290 As proof of concept, we apply the theory for the investigation of th

291 As a proof-of-concept, we delivered short guide RNAs targeting 3 genes

292 To exploit this dual concept, we developed agents exerting partial FXR agonis

293 To prove the concept, we employed free energy perturbation (FEP) coup

294 As a proof of concept, we performed a biochemical characterization of

295 As a proof-of-concept, we used these advances to rapidly mutate 10 hig

296 Using these concepts, we present ultra-thin diffusers where the geom

297 c results are consistent with spatiotemporal concepts where embedding the amide group between two car

298 rmaceutical ingredient-ionic liquid (API-IL) concept, which suggests using traditional drugs in the f

299 1) in excess of that expected from the Zintl concept, while its structure offers interstitial spaces

300 As a proof of concept, wild-type (ATCC 29212) and vancomycin-resistant