ライフサイエンスコーパス: concerted

1 fferent reaction pathways (i.e., stepwise vs concerted).

2 eps: C-H bond activation; C-C coupling via a concerted 1,2-aryl transfer; proto-demetalation; nucleop

3 isomer, perhaps hinting at the potential for concerted 2 e(-) /2 H(+) transfers.

4 ating that the oxaphosphetane is formed by a concerted [2 + 2] cycloaddition.

5 ent with an iron(III)-mediated asynchronous, concerted [2+2]-cycloaddition to form an intermediate ox

6 embered macrolactone, which may proceed as a concerted [4+2] Diels-Alder reaction or a stepwise [6+4]

7 highly coordinated process that requires the concerted action of a large, dynamic, ribonucleoprotein

8 n response to abiotic stress, which requires concerted action of both cis- and trans-regulatory featu

9 Concerted action of both regions sustains responses to d

10 ow that cueP expression is controlled by the concerted action of CueR, which detects the presence of

11 Taken together, we propose that the concerted action of DDK, Polo-like kinase, and CDK1 prom

12 yotic DNA replication fidelity relies on the concerted action of DNA polymerase nucleotide selectivit

13 intenance of genomic stability relies on the concerted action of DNA repair and DNA damage signaling

14 g embryonic morphogenesis is mediated by the concerted action of four proteins that delay the formati

15 Our results highlight that the concerted action of Isw1 and the nuclear exosome ensures

16 During homeostasis, the concerted action of local niche signals and epigenetic r

17 ial developmental response that involves the concerted action of many different cell types, is highly

18 iated fear-memory enhancement results from a concerted action of mechanisms that strengthen memory th

19 se entry in metazoans with open mitosis, the concerted action of mitotic kinases disassembles nuclei

20 proteins across cellular membranes with the concerted action of mostly three membrane proteins: TatA

21 gulation is a complex process, involving the concerted action of multiple physiologically relevant ef

22 ar matrix (ECM) remodeling, which requires a concerted action of multiple proteolytic enzymes and the

23 Strikingly, the concerted action of p53 and POLiota decelerates nascent

24 This can be achieved by a concerted action of peptidoglycan (PG) hydrolases and PG

25 Concerted action of priming and activating amino acids i

26 ating is a cooperative process involving the concerted action of residues from more than a single pro

27 associated siRNAs involves the noncanonical, concerted action of RNA POLYMERASE IV, RNA-DEPENDENT RNA

28 holesterol homeostasis is maintained through concerted action of the SREBPs and LXRs.

29 ensity of docked vesicles, suggesting that a concerted action of these mechanisms underlies the funct

30 Here we show that the concerted action of two enzymes commonly involved in nat

31 rrelations can be explained as a result of a concerted action of two mutation mechanisms, which we na

32 Fusion is orchestrated via the concerted action of two surface glycoproteins: an attach

33 d a complex polyferredoxin, each require the concerted action of two translocases for their assembly.

34 ases in health system resources will require concerted action.

35 Thus, our data show how the concerted actions of FGF13 and FGF14 regulate the polari

36 The concerted actions of PRR signaling, specific viral-restr

37 ular inflammation and thrombosis require the concerted actions of several different agonists, many of

38 alternative polyadenylation, and it is their concerted actions that define a gene's expression outcom

39 Their optimal function requires concerted actions with other regulatory cytokines, and t

40 r a complex signaling circuit leading to the concerted activation of specific metabolic pathways.

41 Infection is restrained by the concerted activation of tissue-resident and circulating

42 helial sheet, but which we now show involves concerted active cell movement.

43 ature of VIB assembly/disassembly, and these concerted activities may be relevant to the assembly and

44 The concerted activities of mutation and recombination are k

45 drug-induced cross-link repair requires the concerted activities of translesion synthesis (TLS), Fan

46 which likely discharge in response to either concerted activity among a large proportion of inputs or

47 ddition-elimination (TEWT) to a lower energy concerted acyl substitution (TES148C), accounting for th

48 ons indicate that the cycloaddition involves concerted addition of the diene onto the oxidopyridinium

49 ms, Fahey, and others, alkenes can undergo a concerted AdE3-type reaction via nucleophile participati

50 The many concerted and conserved changes in the RNA targets of Pu

51 clusion with bound ATP and calcium is highly concerted and cooperative, the phosphorylation of Asp351

52 a mood-related circuit believed to provide a concerted and distributed regulation of the excitability

53 on is re-established after DSB repair by the concerted and interdependent action of replication-indep

54 nces illustrate that the competition between concerted and interrupted pericyclic pathways can be fin

55 calculations for two reaction pathways, one concerted and one stepwise, for the production of each e

56 that this architecture is suitable to ensure concerted and protected transfer of potentially toxic ir

57 oss-tissues variability that is functionally concerted and reproducible across different datasets, su

58 Both concerted and stepwise cycloadditions are predicted, dep

59 The concerted and stepwise mechanisms of the hexadehydro-Die

60 Only a sustained, concerted, and coordinated international effort will pro

61 imately 22 cm(-1) (H) and 49 cm(-1) (D)) and concerted, and it exhibits an unexpected inverse KIE = 0

62 pectrum of halocyclizations from stepwise to concerted, and suggest strategies for design of new reac

63 he reactivity of C horizontal lineC bonds, a concerted anti-addition pathway was favored due to the t

64 Herein, according to a concerted approach based on in vitro and in silico metho

65 utational and experimental results support a concerted asynchronous [3 + 2] cycloaddition involving a

66 ed-state triple proton transfer (ESTPT) in a concerted, asynchronous manner.

67 may not be a single state, which implies non-concerted atomic motions on a multidimensional energy la

68 mer length, primer transfer to Polalpha, and concerted autoregulation of alternate activation/inhibit

69 This concerted biophysical and functional analysis demonstrat

70 could be associated with a different mode of concerted bond cleavage rather than two different reacti

71 ter clusters, the geared motion involves the concerted breaking of two hydrogen bonds.

72 ion, intramolecular 1,6 proton transfer, and concerted but asynchronous bicyclization events.

73 Duplication is concerted by replisomes.

74 moted by halo-sequestering Ag salts enabling concerted C3-palladation-deprotonation, as explored by r

75 KIEs, suggest that this process occurs via a concerted carbo-palladation across the thiophene double

76 electrochemistry (including stepwise versus concerted carbon-halogen bond cleavage, identification o

77 e moieties on linear polymers facilitate the concerted catalysis, thus leading to superior catalytic

78 ngs and genealogical placements of events of concerted change from the signals left in contemporary d

79 xample of a one-electron redox event causing concerted change in multiple iron centers.

80 Such concerted changes are a way to identify helical regions

81 Transitions between modes are said to spark concerted changes in the morphology, physiology, behavio

82 (CW) and kinase-off (CCW A) states differ by concerted changes in the positions of spin-label sites a

83 sole carbon source requires more robust and concerted chitinase activity.

84 ytic domains (HNH and RuvC), responsible for concerted cleavage of the two DNA strands.

85 AF) have had disappointing outcomes, despite concerted clinical and research efforts, which could ref

86 This can only be achieved through a concerted collaborative approach from physicians, indust

87 t, demonstrating that cooperative binding or concerted conformational changes are not required for mo

88 ses on the four domains of Scap that undergo concerted conformational changes in response to choleste

89 site, which confers substrate specificity by concerted conformational changes of the central beta hai

90 molecular simulations to accurately describe concerted conformational transitions identifying the ove

91 evidence that internal friction arises from concerted, crankshaft-like dihedral rearrangements.

92 cyclization and supporting rate-determining concerted cyclization.

93 through a two-step mechanism involving (i) a concerted cycloaddition between one monomer and the carb

94 ta obtained were in agreement with the polar concerted cycloaddition mechanism via the energetically

95 We apply a comparative framework to test for concerted demographic changes in response to climate shi

96 OH oxidation does not necessarily induce its concerted deprotonation.

97 a free energy barrier of 22 kcal/mol for the concerted Diels-Alder process and provide no evidence of

98 tigations revealed two competing pathways, a concerted Diels-Alder reaction and a stepwise Michael ad

99 Ifh1p and recruitment of Crf1p, followed by concerted dissociation of Hmo1p and Tor1p.

100 onent hydrocarbon systems to investigate how concerted-distinct conformational changes of hydrocarbon

101 This type of concerted divergence is a previously unreported fate of

102 Here, we provide an example of concerted divergence of simultaneously duplicated genes

103 leavage site in a conformation essential for concerted DNA cutting.

104 uced in an intricate process that includes a concerted down-regulation of genes encoding rRNA and rib

105 nd next-generation zirconias, representing a concerted drive toward greater translucency while preser

106 repair system, the DNA damage is removed by concerted dual incisions bracketing the damage and at a

107 to take place via two competing pathways, a concerted E2 elimination and a SN2 nucleophilic substitu

108 adjacent sites in the ribosome and that this concerted effect needs to be considered in predicting th

109 d very large depolarization depending on the concerted effects of extreme lifetime enhancement and re

110 Their remarkable properties originate from concerted effects of the crystal field, magnetic interac

111 argue that the future use of MRTs requires a concerted effort among the global research and clinical

112 he final step, called maturation, involves a concerted effort between Csm3, a ruler protein in Cas10-

113 and implementation science), we can drive a concerted effort focused on cancer vaccines to reprogram

114 m mental health stigma and discrimination, a concerted effort is needed to fund methodologically stro

115 ing burden of patients with cirrhosis, and a concerted effort is required to determine the mechanisms

116 Although this ability relies upon the concerted effort of multiple brain regions, the dorsal m

117 In this Perspective, we propose a national concerted effort to create a Precancer Atlas (PCA), inte

118 h mortality countries, countries that made a concerted effort to reduce maternal mortality between 20

119 iders delivering HCV care, contributing to a concerted effort to reduce the overall burden of HCV inf

120 e urge scientific communities to make a more concerted effort to tackle this problem and propose pote

121 Further concerted efforts are necessary to effectively exploit a

122 Concerted efforts are needed to increase the evidence ba

123 Concerted efforts by all stakeholders are highly needed.

124 Concerted efforts in genomic studies examining RNA trans

125 Despite the concerted efforts of molecular and structural biologists

126 The concerted efforts of two membrane-integral viral protein

127 Although there have been concerted efforts to develop tools for non-contact manip

128 Despite major, concerted efforts to find new treatments, a new GB thera

129 s in health systems should be accompanied by concerted efforts to improve quality of care in faciliti

130 echnology-driven collaboration is happening, concerted efforts to incorporate other key elements are

131 alized in terms of a novel mechanism called "concerted electrophilic ipso-substitution" (CEIS) in whi

132 and an electron from an amide substrate in a concerted elementary step.

133 In concordance with concerted elevation of circulating adiponectin and FGF15

134 Direct observation of concerted equilibrium fluctuations would therefore be an

135 two subgenera, suggesting different rates of concerted evolution in two subgenera which could be attr

136 GC plays in various genetic diseases and the concerted evolution of gene families, the parameters tha

137 h recombination and breakpoint repair, while concerted evolution of IR1 is driven by gene conversion

138 Still, support for this idea of concerted evolution of the morphology of the lizard sens

139 sequence variation resulting from imperfect concerted evolution of the ribosomal DNA region follows

140 se members possess a single dsRBM that shows concerted evolution with the most C-terminal dsRBM domai

141 sovers lead to repeat homogenization through concerted evolution, although the degree of unequal cros

142 ed" via a combination of endoproteolysis and concerted exoproteolysis in a manner, and at sites, inde

143 Our results demonstrate that the concerted expression of AtIRT1, AtNAS1 and PvFERRITIN sy

144 against pathogens and is orchestrated by the concerted expression of genes induced by microbial stimu

145 the studies failed to achieve regulated and concerted expression of pro-angiogenic and angiostatic f

146 Pericyclic reactions-which proceed in a concerted fashion through a cyclic transition state-are

147 g inflammation, proteins and lipids act in a concerted fashion, calling for combined analyses.

148 hanism of activation by directly probing the concerted fluctuations of retinal ligand and transmembra

149 the oxygen abstracts the leaving H-atom in a concerted, four-center (H3C...*...H...O*)() transition s

150 monas palustris BisB18 and demonstrate their concerted function in vitro.

151 formation is a complex process that requires concerted function of multiple growth factors.

152 Despite concerted functional genomic efforts to understand the c

153 d elucidate their mechanisms of action using concerted genetics, protein interaction analyses, and ce

154 wth mechanism and unequivocal evidence for a concerted growth-organization process.

155 uence of proton and electron transfer steps, concerted H atom transfer steps, or some combination the

156 These isotope effects support concerted hydride and proton transfer for both light and

157 Upon virus infection, host cells mount a concerted innate immune response involving type I interf

158 d carboxy-terminal domains essential for the concerted integration reaction.

159 he stiffness and its gradients emerge from a concerted interaction across multiple length-scales: pac

160 pening of its periplasmic aperture through a concerted interaction with MexA.

161 The assembly of coronavirus virions entails concerted interactions among the viral structural protei

162 ull potential as monomers but rather undergo concerted interactions as either homo-oligomers or with

163 Concerted internal combustion engine improvements result

164 missions by less (42 +/- 10% reduction) than concerted internal combustion engines improvements.

165 production is tightly regulated through the concerted interplay of sequential Lgl1-dependent global

166 the studied cycloadditions were found to be concerted involving small free activation energies and a

167 lucidate that the low energy barriers of the concerted ionic diffusion are a result of unique mobile

168 r heterolysis of the boronate competing with concerted ipso protonation/C-B cleavage.

169 o- and antiferro-elastic interactions) drive concerted lattice distortions.

170 acellular volume control and is regulated by concerted liver, muscle, and renal actions.

171 corrinoid-based methyl donors proceeds in a concerted manner through a single transition state by tr

172 per into membranes when FP1 and FP2 act in a concerted manner, suggesting that they form an extended

173 euron character proposing the existence of a concerted maturation process, which seems to endow this

174 In the concerted mechanism a single electron broke two C-I bond

175 carbation process does not proceed through a concerted mechanism as in alkyne syn-hydroboration, or t

176 eriments and computational studies support a concerted mechanism for the migratory insertion of the a

177 These results suggest a concerted mechanism for the recruitment and activation o

178 cycloaddition reaction takes place through a concerted mechanism in gas phase and in apolar solvents

179 activates the GAP activity of DLC1 through a concerted mechanism involving DLC1 phosphorylation by ME

180 which regulates cilia disassembly through a concerted mechanism involving Kif24-mediated microtubule

181 Furthermore, our data support the idea of a concerted mechanism involving TFIIIB and RNA polymerase

182 ing probability is reduced in heavy LDH, the concerted mechanism of the hydride-proton transfer react

183 een these three regions, which may suggest a concerted mechanism of toxicity.

184 ism, whereas (2)TSs are found to react via a concerted mechanism that is lower in energy compared to

185 namics simulations supported an asynchronous concerted mechanism with a relatively short-lived polar

186 These results imply a synchronous concerted mechanism, in which the proton and electron tr

187 r both 2N and 3N, which is consistent with a concerted mechanism.

188 sylation is shown to occur by an effectively concerted mechanism.

189 ecies, similar to loci that evolve under non-concerted mechanisms but arising through rather differen

190 imilar barriers, whereas the barriers of the concerted mechanisms differ significantly.

191 tion outcomes between the successive and the concerted mechanisms in terms of the time required for t

192 iphilic metal-ligand assistance" (AMLA) and "concerted metalation deprotonation" (CMD) concepts.

193 While the C-H cleavage occurs via the concerted metalation-deprotonation (CMD) mechanism in al

194 Deuterium isotope effects, typical of a concerted metalation-deprotonation (CMD) mechanism, were

195 Computational studies support a concerted metalation-deprotonation (CMD)-type ruthenatio

196 arylsilver(I) species, presumably through a concerted metalation-deprotonation pathway.

197 by means of an external carboxylate-assisted concerted metalation/deprotonation mechanism.

198 ical in solids, but instead proceeds through concerted migrations of multiple ions with low energy ba

199 tions between crystal structures involve the concerted motion of a few atoms, without diffusion.

200 Here we analyse the concerted motion of G-protein-coupled receptors and G pr

201 duced by ATP hydrolysis is harnessed via the concerted motion of the protein-protein interfaces in th

202 ion conserves functional dynamics, i.e., the concerted motion or displacement of large protein region

203 a few side-chain dihedral angles or involve concerted motions in larger portions of the three-dimens

204 pecifically, low-frequency motions involving concerted motions of the crown scaffold and the H3O(+) i

205 This could be explained by assuming that the concerted motions of two preceding or following coils re

206 electric field pulses strong enough to drive concerted motions on the sub-microsecond timescale.

207 states provide an atomic description of the concerted motions that illuminate potential path(s) for

208 We propose that a concerted movement involving the NTD, C-terminal NADH, a

209 specificity determining loop 1 (SDL1) causes concerted movement of SDL2 and thereby tightens the bind

210 closing of the MacB periplasmic domains via concerted movements of the second transmembrane segment

211 up was formed to facilitate the first large, concerted, multiancestry study to systematically evaluat

212 naccurate label of PenA as well as propose a concerted multidisciplinary approach to address this imp

213 Success in this research will require a concerted, multidisciplinary effort on the part of tuber

214 nvironment, promoting ecological changes and concerted multispecies efforts that are conducive to aci

215 at binds very tightly to chromatin through a concerted multivalent binding mode.

216 icate control, the reaction regime where the concerted nature of the AdE3 mechanism is of greatest im

217 Here we present an unusual concerted nucleophilic aromatic substitution reaction (C

218 dissociation and DFT calculations indicate a concerted nucleophilic attack mechanism.

219 reveals how this reaction can change from a concerted, one-step mechanism in gas phase to a stepwise

220 the hydrodynamic mechanisms underlying this concerted optimization.

221 t a model with no prior knowledge of complex concerted or regular changes can nevertheless infer the

222 ws that varying sulfidation protocols (e.g., concerted or sequential) and key operational variables (

223 er, whether their catalytic cycles involve a concerted or stepwise cyclization mechanism has not been

224 loaddition is not well described as either a concerted or stepwise process, and dynamical effects inf

225 and thermodynamic data are provided for the concerted path and the stepwise path over a neutral tetr

226 nstead, it is theoretically predicted that a concerted pathway can never compete with the stepwise el

227 which also show that the reaction follows a concerted pathway without formation of an intermediate.

228 h water as a proton acceptor can occur via a concerted pathway, provided that the oxidant has weak en

229 A computational search has revealed concerted pathways for [2 + 2] cycloaddition of ethylene

230 Four different concerted pathways have been found, three of them pseudo

231 energetically favorable by both stepwise and concerted pathways.

232 steps, the resulting photoproduct decays via concerted PCET (tau = 4.7 mus) with an H/D kinetic isoto

233 In the latter case, concerted PCET is likely a consequence of significantly

234 ave been shown to undergo either stepwise or concerted PCET, where the latter process is defined by s

235 of a representative lactone occurs through a concerted PCET.

236 results are incongruent with expectations of concerted population expansion in response to increased

237 The intricate mechanism of concerted primer synthesis by two catalytic centers was

238 reaction revealed a rapid, multi-phase, non-concerted process involving up to 8-10 NO molecules per

239 This method allowed us to dissect the concerted process of E1-E2-catalyzed Ub conjugation in o

240 nate immune response to infection requires a concerted process of gene expression that is regulated a

241 igh resolution structural description of the concerted process of synthesis and ligand-induced restru

242 Inflammation is an extensively concerted process that confers protection to the host en

243 ncoupling these two processes and converting concerted processes into their "interrupted" versions by

244 iSF, and find that they primarily decay via concerted processes.

245 The concerted production of neurons and glia by neural stem

246 onses against invading pathogens require the concerted production of three key cytokines: TNF-alpha,

247 her vibronic transitions, that contribute to concerted proton coupled electron transfer must also be

248 )) = 0), which thermodynamically disfavors a concerted proton transfer to H2O.

249 Mechanistic experiments implicate a concerted proton-coupled electron transfer (PCET) pathwa

250 The distance dependence of concerted proton-coupled electron transfer (PCET) reacti

251 Moreover, this study demonstrates that concerted proton-coupled electron transfer can enable ho

252 ge-recombination reaction seems to involve a concerted proton-coupled two-electron oxidation of AQH2.

253 proton donor on the kinetics of interfacial concerted proton-electron transfer (CPET) to polycrystal

254 Multiple-site concerted proton-electron transfer (MS-CPET) reactions w

255 basic with a pKa of 24.3.2 is competent for concerted proton-electron transfer from TEMPOH, but is a

256 inetic and thermodynamic analyses evidence a concerted proton-electron transfer pathway for these pro

257 OER mechanism on metal oxides involves four concerted proton-electron transfer steps on metal-ion ce

258 gger lattice-oxygen oxidation and enable non-concerted proton-electron transfers during OER.

259 ble hydrogen electrode scale, indicating non-concerted proton-electron transfers in the OER mechanism

260 ymatic biosynthesis, which features a highly concerted pyrrole formation and necessary O2-mediated ox

261 honon scattering mechanism that involves the concerted rattling of a group of Ag ions that strongly r

262 The final step of biogenesis is a concerted reaction involving coordinated Tyr ring deprot

263 DFT calculations of stepwise and concerted reaction pathways are used to rationalize the

264 events allowed the IPh to rotate, whereas in concerted reaction the computed delay between excitation

265 or lower than the activation barrier of the concerted reaction.

266 They differ from other concerted reactions, such as S(N)2, E2, or pericyclic re

267 e residue interaction networks revealed that concerted rearrangements of local interacting modules at

268 An unprecedented concerted reductive elimination mechanism for benzoxazol

269 ning a retrograde response that involves the concerted regulation of distinct groups of nuclear genes

270 ave had little effect on disease burden, and concerted regulatory and fiscal action by the UK Governm

271 complex biological mechanisms occur through concerted relationships of multiple genes working in net

272 hat such duplications might arise due to the concerted repair of adjacent single-strand breaks (SSBs)

273 is retained, highlighting the importance of concerted repression by splicing and NMD.

274 posttranscriptional regulator RsmA imposes a concerted repression on all three T6SS clusters.

275 g, suggesting that this system can mediate a concerted response to most of the established host-relat

276 irs post-ischemic cardiac remodeling through concerted roles on vascular cells, monocytes and T lymph

277 stems can control the reactivity and how the concerted scission of the central sigma bond is prevente

278 ered sequence and an original Mitsunobu-type concerted sequence for the synthesis of tetracyclic syst

279 nerve repair through integration of multiple concerted signals.

280 plex by restricting coupled fast motions and concerted slower motions.

281 part of the Michael acceptor, a high energy concerted SN2' reaction occurs.

282 the reaction mechanism reveal an unexpected, concerted SNAr mechanism, with the organocatalyst playin

283 those of transition-state calculations for a concerted SNAr reaction with a bromine nucleofug, gives

284 limitations have revealed a clear need for a concerted software engineering effort to support emergin

285 -localization, and the B' subunit stimulates concerted strand transfer activity of delta-retroviral I

286 In other words, channel opening is a highly concerted, switch-like process.

287 Concerted tandem and traveling wave ion mobility mass sp

288 MD simulations reveal that productive concerted trajectories display a strong angle bending os

289 ether, our study reveals novel principles of concerted transcriptional regulation by multiple TRs at

290 sibility to distinguish between stepwise and concerted transfer of the electron and proton, and how P

291 The concerted transition model for multimeric proteins is a

292 ar isoboles of additivity are predicted by a concerted transition model where the binding of each GAB

293 and basal activity was well described by the concerted transition model.

294 tely 43 kcal/mol) is required to achieve the concerted transition state geometry.

295 arbon-fluorine bond formation proceeds via a concerted transition state rather than a discrete Meisen

296 deletions (NYVAC-C-DeltaB8RB19R) revealed a concerted upregulation of innate immune pathways (IFN-st

297 Our results show the delicate nature of the concerted versus stepwise mechanism of inverse electron-

298 ernative reaction mechanisms, successive and concerted, were observed giving different product distri

299 dissociative OS-SET (SET to a sigma* orbital concerted with C-Cl breakage) in alkanes compared to ste

300 erein alkyne activation by neutral ClBcat is concerted with cyclative attack by nucleophilic sulfur.