ライフサイエンスコーパス: concussion

1 enefits of early physical activity following concussion.

2 n suspected traumatic brain injury (TBI) and concussion.

3 ct, in the absence of a clinically diagnosed concussion.

4 return to play less than 24 hours after the concussion.

5 st enduring physiological deficits following concussion.

6 ld validity for predicting outcome following concussion.

7 ppears greater among those with a history of concussion.

8 and 6 control participants with MCI without concussion.

9 Mechanism and sport-specific activity of concussion.

10 nd related health care utilization rates for concussion.

11 f symptoms in student athletes who sustain a concussion.

12 ng about return to play after sports-related concussion.

13 ily structure and history of brain injury or concussion.

14 ge, 1-21 years) since the last self-reported concussion.

15 cussion symptoms (PCS) in children following concussion.

16 elationship is not explained by a history of concussion.

17 None of the players experienced a concussion.

18 orated demographic covariates and history of concussion.

19 for the treatment of patients diagnosed with concussion.

20 nitudes; and the biomechanical threshold for concussion.

21 e means of determining dysfunction following concussion.

22 prolonged symptoms and disability following concussion.

23 f multiple abnormal menstrual patterns after concussion.

24 ury currently arouses stronger interest than concussion.

25 l Modification diagnosis codes indicative of concussion.

26 the direct result of, or be exacerbated by, concussion.

27 urn to school and activities gradually after concussion.

28 urenine metabolites following sports-related concussion.

29 tom exacerbations (spikes) in children after concussion.

30 ate using both in vitro and murine models of concussion.

31 efforts to effectively reduce soccer-related concussions.

32 Test scores, and the number of grade 3 (G3) concussions.

33 .6% of boys' concussions and 25.3% of girls' concussions.

34 symptoms for both sexes was history of prior concussions.

35 Heading the ball accounted for 30.5% of concussions.

36 ental health of athletes who suffer multiple concussions.

37 heading in the prior 12 months and lifetime concussions.

38 d sex who are at risk of worse outcomes from concussions.

39 aging in the absence of clinically diagnosed concussions.

40 ith retired athletes without a history of G3 concussion (1 of 5) older than 63 years (P = .01).

41 Of the 68 patients who had a concussion, 16 (23.5%) experienced 2 or more abnormal me

42 athletes, 8 of whom had MCI and a history of concussion, 21 cognitively healthy control participants,

43 Concussion, a form of mild TBI, might be associated with

44 ugh most fully recover following an isolated concussion, a significant minority develop prolonged sym

45 nts were aged 11 to 18 years and sustained a concussion (according to the Centers for Disease Control

46 our knowledge, little research has examined concussion across the youth/adolescent spectrum and even

47 PURPOSE OF REVIEW: Sport-related concussion affects athletes at every level of participat

48 injury (mTBI), also commonly referred to as concussion, affects millions of Americans annually.

49 Patients who recovered from concussion also had lower HRQoL than norms at 4 weeks (m

50 However, concussions also occur in several other settings, such a

51 lear whether mild traumatic brain injury, or concussion, also confers risk.

52 in US high schools and is a leading cause of concussion among adolescents.

53 ommon mechanism of injury in heading-related concussions among boys (78.1%) and girls (61.9%).

54 s concussions, little research has evaluated concussions among middle-school athletes.

55 33 (1.35-4.04, p = 0.002) for 1 diagnosis of concussion and >1 diagnosis of concussion, respectively,

56 Among the athletes, 17 had a G3 concussion and 11 did not.

57 ed return to play at least 30 days after the concussion and 3.1% resulted in return to play less than

58 tion between HRQoL and PPCS at 4 weeks after concussion and assess the degree of impairment of HRQoL

59 Diagnoses of concussion and control diagnoses of broken limb bones we

60 on is optimised by battlefield assessment of concussion and follow-up screening of all personnel with

61 presenting to the emergency department with concussion and head injury within the previous 48 hours

62 e neurocognitive sequelae of a sport-related concussion and its management are poorly defined.

63 but no objective test reliably identifies a concussion and its severity.

64 ing and potentially disabling consequence of concussion and mild traumatic brain injury (mTBI).

65 Concussion and mild traumatic brain injury (TBI) are int

66 linked to conversations about sport-related concussion and mild traumatic brain injury.

67 l studies suggest that previous estimates of concussion and mTBI incidence are grossly underestimated

68 calable biological marker for sports-related concussion and other types of mild traumatic brain injur

69 The study of concussion and PCS has increased significantly over the

70 ing in mild traumatic brain injury (MTBI) or concussion and posttraumatic stress disorder (PTSD).

71 Concussion and subconcussive impacts have been associate

72 prospective evidence of reduced CBF in human concussion and subsequent recovery.

73 lationship between long-term consequences of concussion and the function of the hypothalamic-pituitar

74 d patient populations (ie, those affected by concussion and those affected by various degrees of trau

75 History of clinician-diagnosed concussion and years of football experience.

76 re was a significant inverse relationship of concussion and years of football played with hippocampal

77 fic activity, responsible for 30.6% of boys' concussions and 25.3% of girls' concussions.

78 nts included sprains and strains, fractures, concussions and bleeding.

79 compared with less severe injuries, such as concussions and cranial fractures, more severe injuries,

80 GROUND AND The relationship between repeated concussions and neurodegenerative disease has received s

81 o significant associations between number of concussions and performance on cognitive tests.

82 Until now, the interacting effects of concussions and the normal ageing process on white matte

83 ed by sex, age at death, severity (including concussion), and different follow-up times after diagnos

84 protein B were measured immediately after a concussion, and they decreased during rehabilitation.

85 l injuries regardless of severity, including concussions, and athlete exposure information were docum

86 The effects of TBI and concussion are not restricted to cognition and balance.

87 While concussions are recognized etiological factors for a spe

88 ld likely be a more effective way to prevent concussions as well as other injuries.

89 l neurocognitive testing with Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT).

90 urocognitive testing with the Immediate Post-Concussion Assessment and Cognitive Testing evaluation w

91 on symptom scale), cognition (Immediate Post-Concussion Assessment and Cognitive Testing), and balanc

92 s has a potential clinical utility of proper concussion assessment and management.

93 linical preseason baseline testing regarding concussion assessment measures.

94 The Child Sport Concussion Assessment Tool (SCAT3) is a postconcussion s

95 Football practices were a major source of concussion at all 3 levels of competition.

96 l volume compared with athletes without a G3 concussion at the 40th percentile (P = .03), 60th percen

97 tic brain injury (mTBI), also referred to as concussion, can result in chronic post-concussive syndro

98 with more Medicaid patients using the ED for concussion care (478/1290 Medicaid patients [37%] used t

99 he importance of the primary care setting in concussion care management, and demonstrate the potentia

100 Concussions carry devastating potential for cognitive, n

101 cessing of sound correctly identifies 90% of concussion cases and clears 95% of control cases, sugges

102 I; eg, sports concussions), whether repeated concussions cause long-term cognitive deficits remains c

103 erity, cognition (Standardized Assessment of Concussion-child version [SAC-C]), and balance (modified

104 d to patient populations presenting to sport concussion clinics or to emergency departments (EDs) and

105 e first study to show an association between concussion, cognition, and anatomical structural brain c

106 Concussions comprised 9.6%, 4.0%, and 8.0% of all injuri

107 All eligible patients had concussions consistent with the Zurich consensus diagnos

108 Concussion cumulative incidence, incidence rate, and des

109 o improve care for the epidemic of pediatric concussion depends on early identification of those most

110 ll players has prompted studies for sideline concussion diagnosis and testing for neurological defici

111 Specifically, we hypothesize that concussions disrupt the processing of the fundamental fr

112 We hypothesize that concussions disrupt these auditory processes, and that t

113 Concussions during practice might be mitigated and shoul

114 PURPOSE OF REVIEW: Millions of youth sustain concussion each year; although most fully recover follow

115 n Symptoms Questionnaire scores and lifetime concussion events (rho = 0.58, P = .02 and rho = 0.52, P

116 Here we show that children who sustained a concussion exhibit a signature neural profile.

117 es without concussions, former athletes with concussions exhibited widespread white matter anomalies

118 ely one-third of children experiencing acute concussion experience ongoing somatic, cognitive, and ps

119 and psychosocial functioning in relation to concussion exposure and apolipoprotein epsilon4 status.

120 rmance on these measures was associated with concussion exposure.

121 Even in the absence of concussion, football players may experience repeated BBB

122 control group of 15 retired athletes without concussions, former athletes with concussions exhibited

123 age in 15 retired athletes with a history of concussions, free of comorbid medical conditions.

124 adolescents aged 5.00-17.99 years with acute concussion from 9 Pediatric Emergency Research Canada ne

125 Thirty-five players had a concussion from September 13, 2012, to January 31, 2013;

126 Clearly differentiating concussion from traumatic brain injury is essential to a

127 RECENT FINDINGS: Although concussion generally does not produce any structural dam

128 Importance: Recovery from concussion generally follows a trajectory of gradual imp

129 Older retired athletes with at least 1 G3 concussion had significantly smaller bilateral hippocamp

130 Players with and without a history of concussion had smaller hippocampal volumes relative to h

131 Players with a history of concussion had smaller hippocampal volumes than players

132 former college players with more than three concussions had lower FA in a broadly distributed area o

133 erved: Nonspeed players with more than three concussions had lower FA in frontal white matter compare

134 Over the past decade, concussion has become the most widely discussed injury i

135 Previous epidemiologic research on concussions has primarily been limited to patient popula

136 rial changes in regional CBF following human concussion have yet to be performed.

137 Sports-related concussions have been shown to lead to persistent subcli

138 Lifetime concussion history and demographic features were not sig

139 .5 [8] vs 60.24 [7]; P = .002); those with a concussion history and MCI performed worse (mean [SD], 3

140 D PSC revealed a similar interaction between concussion history and position (all adjusted P < .004).

141 A separate interaction between concussion history and position was observed: Nonspeed p

142 Retired athletes with concussion history but without cognitive impairment had

143 ferences between athletes with and without a concussion history on 5 cognitive measures but did show

144 aying position seem to modify the effects of concussion history on white matter structure and neural

145 cant interaction between career duration and concussion history was observed; former college players

146 ross three crossed factors: career duration, concussion history, and primary playing position.

147 edical care of children and adolescents with concussion (ie, the Lystedt Law), with all other states

148 Concussion in adolescence was associated with a raised r

149 There is continuing concern about effects of concussion in athletes, including risk of the neurodegen

150 Child SCAT3 scores for young athletes with a concussion in athletic and clinical settings.

151 To assess whether concussion in childhood or adolescence is associated wit

152 notable association with MS was observed for concussion in childhood, or broken limb bones in childho

153 Sports-related concussion in professional ice hockey players is associa

154 differences across states, rates of treated concussion in states without legislation were 7% higher

155 had 1 or more in-person clinical visits for concussion in the CHOP unified electronic health record

156 958 high school athletes from Maine with no concussion in the past 6 months who completed a preseaso

157 Understanding the pathophysiology of concussion in the pediatric population can potentially o

158 h care utilization rates among children with concussion in the United States are both directly and in

159 Concussion in youth athletes is a growing problem worldw

160 American football has the highest number of concussions in high school with girls' soccer having the

161 The estimated number of concussions in RIRP averaged 14 (median=7; IQR 5-40).

162 Despite a high number of concussions in RIRP, differences in mental health, socia

163 The findings suggest estimates of concussion incidence based solely on ED visits underesti

164 Medicine called for comprehensive nationwide concussion incidence data across the spectrum of athlete

165 Cumulative concussion incidence was 13.0% per season, and the incid

166 Concussion is a particular problem, as are injuries to t

167 The magnitude of impact that results in concussion is also the same at both levels of play, alth

168 Concussion is frequently undiagnosed as a cause of psych

169 s on traumatic brain injury and assumes that concussion is merely a mild form of traumatic brain inju

170 jor impediment to improving the treatment of concussion is our current inability to identify patients

171 sulted in a lack of understanding about what concussion is, and how to diagnose, monitor, and treat i

172 presenting with a history of sports-related concussions is linked to diffuse white matter abnormalit

173 athletes being diagnosed with sport-related concussions is rising.

174 Mild traumatic brain injury (mTBI, cerebral concussion) is a risk factor for the development of psyc

175 Mild traumatic brain injury, or concussion, is associated with a range of neural changes

176 During the same period, states with concussion laws demonstrated a 10% higher concussion-rel

177 ion legislation, and (3) the effect of state concussion laws on trends in states with concussion legi

178 Concussion legislation has had a seemingly positive effe

179 ate concussion laws on trends in states with concussion legislation in effect by means of negative bi

180 (2) postlegislation trends in states without concussion legislation, and (3) the effect of state conc

181 are both directly and indirectly related to concussion legislation.

182 pite recent increased awareness about sports concussions, little research has evaluated concussions a

183 tes has passed legislation for sport-related concussion, making this health issue important for physi

184 cations, monitoring menstrual patterns after concussion may be warranted in this population.

185 tact with another player was the most common concussion mechanism.

186 lso increased in players with sports-related concussion(median, 0.075 mug/L; range, 0.037-0.24 mug/L)

187 ential confounders including age, sex, prior concussions, migraine, anxiety, learning disability, dep

188 of Defense Clinical Practice Guidelines for Concussion/Mild TBI.

189 kynurenine levels would correlate with post-concussion mood symptoms.

190 s, pathophysiology, and diagnostic workup of concussion, mTBI, and PTH, there is a paucity of evidenc

191 epidemiology, evaluation, and management of concussion, mTBI, and PTH.

192 The longer-term impact of combat-related concussion/MTBI and comorbid PTSD on troops' health and

193 Self-reports of concussion/MTBI and PTSD were assessed at times 1 and 2.

194 The rate of self-reported concussion/MTBI during deployment was 9.2% at time 1 and

195 ld increase in reports of deployment-related concussion/MTBI history have important implications for

196 e evidence of a long-term negative impact of concussion/MTBI history on these outcomes after accounti

197 Based on time 1 concussion/MTBI status (defined as an injury during depl

198 However, after adjusting for PTSD symptoms, concussion/MTBI was not associated with postdeployment s

199 Soldiers with a history of concussion/MTBI were more likely than those without to r

200 egiate football players without a history of concussion (n = 25), and non-football-playing, age-, sex

201 layers with a history of clinician-diagnosed concussion (n = 25), collegiate football players without

202 lescent and young women with a sport-related concussion (n = 68) or a nonhead sport-related orthopedi

203 at 1-week (N=14; 9.29 days) and 1-month post-concussion (N=14, 30.93 days).

204 t that, across all sports, approximately 2.5 concussions occur for every 10 000 athletic exposures, i

205 t the frequency-following response indicates concussion occurrence and severity.

206 impacts in a season, and the level at which concussion occurs is approximately 100 g and 5500 rad/s/

207 ntional research should target the effect of concussion on HRQoL.

208 Sport-related concussion or nonhead sport-related orthopedic injury.

209 in 30 days after a sport-related injury to a concussion or sports medicine clinic at a single academi

210 Multiple concussions or even a single moderate to severe TBI can

211 e development of AD pathology after repeated concussions or TBI.

212 rovided an independent measure of real-world concussion outcome (ie, number of days withheld from com

213 Finally, concussed athletes with worse concussion outcome, defined as number of days until retu

214 were more common if reporting more than nine concussions (p=0.028), although these symptoms were not

215 53 athlete exposures (AEs) among girls (4.50 concussions per 10,000 AEs), and 442 concussions were su

216 tained during 1,592,238 AEs among boys (2.78 concussions per 10,000 AEs).

217 g participants aged 5 to 18 years with acute concussion, physical activity within 7 days of acute inj

218 head injuries with loss of consciousness or concussion prior to Parkinson's disease (PD) diagnosis.

219 Concussion produces a brief disruption in mental status

220 main outcome measure was the Rivermead Post-Concussion Questionnaire-16 (RPQ-16) collected before co

221 concussion rate was higher than the practice concussion rate across all 3 competitive levels.

222 The game concussion rate for college athletes (3.74 per 1000 athl

223 The practice concussion rate in college (0.53 per 1000 athlete exposu

224 The game concussion rate was higher than the practice concussion

225 Concussion rates in young female soccer players are grea

226 air with his or her head) given the rise in concussion rates, with some calling for a ban on heading

227 er NFL players with and without a history of concussion recruited from the North Texas region and age

228 from youth soccer would likely prevent some concussions, reducing athlete-athlete contact across all

229 Baseline scores on a computerized concussion-related cognitive battery were used for cogni

230 ut legislation had a 75% overall increase in concussion-related health care utilization during the sa

231 the following: (1) prelegislation trends in concussion-related health care utilization from January

232 th concussion laws demonstrated a 10% higher concussion-related health care utilization rate compared

233 th legislation experienced a 92% increase in concussion-related health care utilization, while states

234 olescent spectrum and even less has examined concussion-related outcomes (ie, symptoms and return to

235 Differences in concussion-related outcomes existed by level of competit

236 differences or level-specific variations in concussion-related policies and protocols, athlete train

237 The initial concussion-related visit was selected and variation in t

238 Safely returning athletes to sport after concussion relies on accurately determining when their s

239 rkers are more efficient at deciphering post-concussion residual neurocognitive deficits and thus has

240 diagnosis of concussion and >1 diagnosis of concussion, respectively, compared with none.

241 Concussion results in profound metabolic derangements du

242 Mild traumatic brain injury (cerebral concussion) results in cognitive and emotional dysfuncti

243 The 1-season concussion risk was highest in high school (9.98%) and c

244 Youth football had the lowest 1-season concussion risks in 2012 (3.53%) and 2013 (3.13%).

245 nsitive approach for sideline or post-injury concussion screening.

246 conflicts, mTBI patients with even a single concussion showed a significant slow-down in all respons

247 PURPOSE OF REVIEW: Sport-related concussion (SRC) is common in children and adolescents.

248 e assessment and management of sport-related concussions sustained by United States high school athle

249 Concussions sustained during high school-sanctioned socc

250 re persistent symptoms on the validated Post-Concussion Symptom Inventory at 4 weeks.

251 (>/=3 new or worsening symptoms on the Post-Concussion Symptom Inventory) was assessed at 28 days po

252 There were few differences in concussion symptom patterns by injury mechanism.

253 a significant correlation between high total concussion symptom score and reduced FA at the gray matt

254 keletonized FA values in white matter, total concussion symptom score, and findings of sleep and wake

255 Total concussion symptom scores varied from 2 to 97 (mean +/-

256 In the absence of a recent concussion, symptom reporting is related to sex and pree

257 To identify predictors of persistent concussion symptoms (PCS) in children following concussi

258 uency partially recover to control levels as concussion symptoms abate, suggesting a gain in biologic

259 We inquired weekly about concussion symptoms and, if present, the symptom type an

260 ayers were also assessed with Rivermead Post Concussion Symptoms Questionnaire and magnetic resonance

261 oncentrations correlated with Rivermead Post Concussion Symptoms Questionnaire scores and lifetime co

262 Compared with youth, a higher number of concussion symptoms were reported in high school athlete

263 n subscale, PTSD Checklist-Military Version, concussion symptoms, and Suicide Behaviors Questionnaire

264 ury, general and mental health, life stress, concussion symptoms, cognitive function, disability and

265 d function that occur independently of overt concussion symptoms.

266 ic amnesia) do not correlate with persistent concussion symptoms.

267 Significantly, Post-Concussion Syndrome is resistant to existing therapeutic

268 matter compared with those with zero to one concussion (t25 = 3.861; adjusted P = .002).

269 matter compared with those with zero to one concussion (t29 = 2.774; adjusted P = .037), and the opp

270 ler hippocampal volumes than players without concussion (t48 = 3.15; P < .001; mean difference, 761 m

271 ce, 1788 muL; 95% CI, 1317-2258 muL; without concussion: t48 = 4.35; P < .001, mean difference, 1027

272 lative to healthy control participants (with concussion: t48 = 7.58; P < .001; mean difference, 1788

273 was significantly higher among patients with concussion than among those with an orthopedic injury (o

274 Prior concussion that results in loss of consciousness is a ri

275 symptom, and the proportion of patients with concussions that had long return-to-play time (ie, requi

276 The short and long-term effects of concussions that occur during childhood and adolescence

277 ighlights problems in defining and measuring concussion, the mildest form of traumatic brain injury (

278 is the most common activity associated with concussions, the most frequent mechanism was athlete-ath

279 e of traumatic brain injury (TBI), from mild concussion to severe, penetrating injury.

280 Importance: Although concussion treatment guidelines advocate rest in the imm

281 By examining concussion visits across an entire pediatric health care

282 Frequency of initial concussion visits at each type of health care location.

283 Concussion visits in the EHR were defined based on Inter

284 y prognosticators of PCS following pediatric concussion was conducted.

285 mpal volume in retired athletes with MCI and concussion was significantly smaller compared with contr

286 injury and were considered to have an acute concussion were enrolled across 9 pediatric emergency de

287 In RIRP, persisting symptoms attributed to concussion were more common if reporting more than nine

288 Athletes with a history of G3 concussion were more likely to have MCI (7 of 7) compare

289 Overall, 1429 sports-related concussions were reported among youth, high school, and

290 Overall, 627 concussions were sustained during 1,393,753 athlete expo

291 s (4.50 concussions per 10,000 AEs), and 442 concussions were sustained during 1,592,238 AEs among bo

292 hological patterns consistent with models of concussion wherein brainstem white matter tracts undergo

293 ld traumatic brain injury (rmTBI; eg, sports concussions), whether repeated concussions cause long-te

294 gh school athletes who sustain sport-related concussions will be cared for by athletic trainers and p

295 tors have yet to evaluate the association of concussion with menstrual patterns in young women.

296 physician-diagnosed migraine history, prior concussion with symptoms lasting longer than 1 week, hea

297 escent and young women after a sport-related concussion with those after sport-related orthopedic inj

298 Among the 351 soccer players, there were 59 concussions with 43 742 athletic exposure hours.

299 wer leg injury within the past 2 months or a concussion within the past month.

300 compared with those who have recovered from concussion, yet deficits in HRQoL are pervasive across a