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1 n the bloodstream form of the parasite via a conditional knockout.
2 , all of which are upregulated in Hand2 limb conditional knockouts.
3 ither individually or in combinations, using conditional knockouts.
4 f Wnt proteins in this process, we created a conditional knockout allele of the Wnt cargo receptor Ev
5 or recombinases) or gene replacement (e.g., conditional knockout alleles containing exons flanked by
6 ribution to retinal development we generated conditional knockout alleles of DNA methyltransferase 1
10 n profiles of embryonic day 14.5 (E14.5) Yap conditional knockout and YAP transgenic mouse tooth germ
23 the subventricular zone of both FIP200hGFAP conditional knockout (cKO) and FIP200;p53hGFAP 2cKO mice
29 ced proliferation in naive T cells from Egr2 conditional knockout (CKO) mice and decreased production
31 e neuroligins, we analyzed single and triple conditional knockout (cKO) mice for all three major neur
32 ency contributes to ASD, we generated CTNNB1 conditional knockout (cKO) mice in parvalbumin interneur
33 ophysiological approach to analyze nicastrin conditional knockout (cKO) mice in the hippocampal Schaf
34 ms associated with Parkinson's disease using conditional knockout (cKO) mice in which Ndufs4 was sele
38 o address these questions, we generated Lgi1 conditional knockout (cKO) mice using a set of universal
39 functions and artificial decidualization in conditional knockout (cKO) mice, absence of uterine ALK5
45 role of BLIMP1 in innate immunity, we used a conditional knockout (CKO) of Blimp1 in myeloid cells an
46 metabolomic analysis in mice with inducible conditional knockout (cKO) of BMAL1, which is critically
49 is perinatal lethal in mice, we generated a conditional knockout (cKO) of Fst in the uterus using pr
50 g mice successfully generated progeny with a conditional knockout (CKO) of Notch1 in collagen I-expre
51 phenotypes of females with a Zp3-Cre-driven conditional knockout (cKO) of Smc5 demonstrated that mat
54 e, using tissue-specific dynamin-1 knockout [conditional knockout (cKO)] mice at a fast central synap
55 me (APC/C) ubiquitin ligase in neurons [Cdh1 conditional knockout (cKO)], disrupts dendrite arborizat
57 l TEC-defective (resulting from FoxN1-floxed conditional knockout [cKO]) and naturally aged mouse mod
58 ele, allowing for conditional gene ablation (conditional knockout [cKO]) when crossed with Cre recomb
60 defective in explants from the Bmp4/7 double conditional knockout (dCKO; Mef2c-Cre;Bmp4/7(f/f)) and m
66 educes the DNA manipulation needed to make a conditional knockout gene targeting vector to only two s
67 cations that have used tamoxifen to generate conditional knockouts have not reported even the minimum
68 ue to downregulation of TbIPMK expression by conditional knockout, have reduced levels of polyphospha
69 nt receptor, Ryk, in mice and rats by either conditional knockout in the motor cortex or monoclonal a
73 izes FVIII, we developed a Cre/lox-dependent conditional knockout (KO) model in which exons 17 and 18
74 an and colleagues characterize Shp1 and Shp2 conditional knockout (KO) murine models, underscoring th
76 V-Neu transgenic female mice with or without conditional knockout (KO) of Tcfap2c, the mouse homolog
79 ea, we used an Nkx2.1-Cre driver to generate conditional knockouts (KOs) in mice of leptin receptor (
80 ikewise, mice harboring liver-specific Lats2 conditional knockout (Lats2-CKO) displayed constitutive
81 inactivation of Tak1 in Trim33:Smad4 double conditional knockouts leads to the palatal phenotypes wh
86 , administration of Notch inhibitors in Fbw7 conditional knockout mice alleviated progressive bone re
88 n vitro organoid cultures derived from Snai1 conditional knockout mice also undergo apoptosis when Sn
89 ity alterations were normalized in GABA-CB1R conditional knockout mice and after subchronic treatment
91 or adipogenesis in culture and in vivo Using conditional knockout mice and derived white and brown pr
92 tasis using acute hippocampal slices from PS conditional knockout mice and primary cultured postnatal
95 ermore, RBCs from blood-cell-specific Piezo1 conditional knockout mice are overhydrated and exhibit i
97 lung contusion was significantly reduced in conditional knockout mice at all the time points, when c
98 cultured neural stem cells derived from Cic conditional knockout mice bypassed an EGF requirement fo
99 ent tissue- and developmental stage-specific conditional knockout mice carrying Smarcb1 and/or Nf2 de
100 mic populations are similar in CD4-cre HDAC3 conditional knockout mice compared with wild-type mice,
103 p(nestin) conditional knockout and Yap(GFAP) conditional knockout mice displayed fewer neocortical as
105 elial injury, we demonstrate that myeloid AC conditional knockout mice exhibit impairment of neutroph
106 ucture-related gene expression, whereas Tsc1 conditional knockout mice exhibited changes in genes reg
107 mice, whereas hepatocyte and macrophage Bmp6 conditional knockout mice exhibited no iron phenotype.
112 retinal ganglion cell death, similar to Nf1 conditional knockout mice harboring a neomycin insertion
114 nses to TLR stimulation in vitro, and alphav-conditional knockout mice have elevated antibody respons
116 , spatial memory, and metabolic functions of conditional knockout mice in which the inactivation of t
120 sence of NF186, they fail to do so in double conditional knockout mice lacking both NF186 and the par
121 induced SNS injury, while NPY injection into conditional knockout mice lacking the Y1 receptor in mac
122 Both whole-body (Lgr4(-/-)) and monocyte conditional knockout mice of Lgr4 (Lgr4 CKO) exhibit ost
125 iciency in CMFs in fibroblast-specific MyD88 conditional knockout mice resulted in a strong increase
129 stomorphometric analysis revealed that STAT5 conditional knockout mice showed reduced bone mass, with
131 dedicated to controlling the forelimb in Ryk conditional knockout mice than in controls (wild-type or
132 ifferentiation less effectively in the STAT5 conditional knockout mice than in the wild-type mice aft
133 proprioception to twitching in newborn ErbB2 conditional knockout mice that lack muscle spindles and
139 lls from the hypoxia-inducible factor-1alpha conditional knockout mice were isolated and evaluated fo
141 n2 expression, surgical transplant and novel conditional knockout mice were super-ovulated and analyz
142 Pten in hematopoietic cells by crossing Pten conditional knockout mice with a knock-in mouse expressi
143 In our current study, we crossed our Lpd conditional knockout mice with a mouse line expressing C
144 ramatically reduced in the absence of EpCAM, conditional knockout mice with EpCAM-deficient LCs and c
146 s to externally applied proteins, we studied conditional knockout mice with EpCAM-deficient LCs.
149 ignificantly reduced in both Raptor and Tsc1 conditional knockout mice, albeit with variations in sev
151 glion neuronal cultures are absent in Piezo2 conditional knockout mice, and ex vivo skin nerve prepar
152 circumvent this problem, we generated RIPK1 conditional knockout mice, and show that mice lacking RI
183 velopmental role, Dbx1 hypothalamic-specific conditional-knockout mice display attenuated responses t
186 dress this question, we produced triple cKO (conditional knockout) mice that allow ablating all neure
187 address this, the authors generated a unique conditional knockout model involving the major CLP gene,
192 Here we demonstrate using isogenic pairs of conditional knockout mouse ESCs, that Snail1 exerts Wnt-
193 re, we address this question by generating a conditional knockout mouse for Dpy30, which is a common
195 ferentiation and development by generating a conditional knockout mouse in which the protein is deple
198 development, we generated and analyzed three conditional knockout mouse lines, in which the essential
200 le of inducing inflammaging, we used a Foxn1 conditional knockout mouse model that induces accelerate
201 of Rbfox1 in muscle function, we developed a conditional knockout mouse model to specifically delete
202 could suppress EAC development, we created a conditional knockout mouse model using progesterone rece
208 ity, we generated tissue-specific Ugt1 locus conditional knockout mouse models and examined the role
214 lusively in GC B cells by crossing the Gna13 conditional knockout mouse strain with the GC-specific A
216 formed normally after depletion of OCT2 in a conditional knockout mouse, but their proliferation is r
217 ur studies using an N-cadherin lens-specific conditional knockout mouse, N-cad(Deltalens), show that
218 Using fibroblast lines derived from an Arpc2 conditional knockout mouse, we established matched-pair
222 e model of pancreatic adenocarcinoma-whereas conditional knockout of another RCP cargo, alpha5 integr
223 generated a mouse model with kidney-specific conditional knockout of Arl13b Deletion of Arl13b in the
224 lized Atg5(f/f);Aqp5-Cre mice which harbor a conditional knockout of Atg5, in salivary acinar cells.
226 d at much lower levels than alpha-neurexins, conditional knockout of beta-neurexins with continued ex
230 l striatum- or D1 dopamine receptor-specific conditional knockout of Cdk5, or ventral striatum infusi
233 Moreover, behavioral studies in mice with a conditional knockout of Deaf1 in the brain showed memory
238 e we report that mice with a T-cell-specific conditional knockout of HGK (T-HGK cKO) develop systemic
240 s starvation-induced autophagy in larvae and conditional knockout of HTT in the mouse CNS causes char
242 o this end, we generated a mouse strain with conditional knockout of IKKalpha in CD4 cells (Ikkalpha(
243 ocyte (MK)-specific Pf4 promoter permits the conditional knockout of Itga2 in the MK/platelet lineage
247 roduced a marked synaptic phenotype, whereas conditional knockout of neuroligin-3 during early develo
250 trate that smooth muscle cell (SMC)-specific conditional knockout of Oct4 in Apoe(-/-) mice resulted
255 rom female mice with dendritic cell-specific conditional knockout of Prdm1 (CKO mice) altered the pre
257 phenotype is independently recapitulated by conditional knockout of Rbpj, a core Notch pathway compo
264 Here, we report that in vivo knockdown or conditional knockout of the autism-linked ubiquitin liga
265 ts production, and created a muscle-specific conditional knockout of the class III phosphatidylinosit
266 ping granule neurons (Sync-TRAP) showed that conditional knockout of the core NuRD subunit Chd4 impai
267 tion of the NuRD complex by in vivo RNAi and conditional knockout of the core NuRD subunit Chd4 profo
272 sr3 conditional knockouts, we found that the conditional knockout of Vangl2 in the hippocampus 1 week
274 sed the mechanism of TRF1 action using mouse conditional knockouts of BLM, TRF1, TPP1, and Rap1 in co
276 Using novel cell-type- and region-specific conditional knockouts of the GABAA receptor alpha2 subun
277 dy, we used reporters, lineage analysis, and conditional knockout or activation of the Wnt/beta-caten
279 Ldlr knockout mice transplanted with XBP1-conditional knockout (or wild-type control littermate) b
280 macological Cdk5 inhibition, brain-wide Cdk5 conditional knockout, or viral-mediated dorsolateral str
281 ed by Cre-mediated recombination, yielding a conditional knockout/reporter strategy suitable for mosa
286 all interfering RNA-treated DCs, or DCs from conditional knockout (Sirt1(f/f)-CD11c-Cre(+)) mice show
291 ed constitutive KOR knockouts (KOR(-/-)) and conditional knockouts that lack KORs in DA-containing ne
294 on of ccRCC, we generated a novel mouse Vhlh conditional knockout, using Hoxb7-driven Cre that is spe
295 ody VDR(-/-) mice, intestinal epithelial VDR conditional knockout (VDR(DeltaIEC)) mice, and cultured
300 (X-box binding protein-1) floxed mice (XBP1-conditional knockout), with antibody-mediated depletion
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