ライフサイエンスコーパス: conditional knockout mice

1 fibroblasts from dynamin 1, dynamin 2 double conditional knockout mice).

2 dynamin (derived from dynamin 1 and 2 double conditional knockout mice).

3 pment, we generated forebrain-specific Foxp1 conditional knockout mice.

4 there is no requirement for the breeding of conditional knockout mice.

5 2 in adult hematopoiesis was investigated in conditional knockout mice.

6 e RAL GTPases in vivo, we generated null and conditional knockout mice.

7 y eyeblink conditioning was performed in the conditional knockout mice.

8 tic deletion using floxed c-jun (c-jun(f/f)) conditional knockout mice.

9 pment, hemostasis, and thrombosis using TFPI conditional knockout mice.

10 ent morphogenesis proceeded normally in Rac1 conditional knockout mice.

11 -Cre to generate mammary-gland specific Elf5 conditional knockout mice.

12 stinct functions of p110beta, we constructed conditional knockout mice.

13 ype I receptor/Alk5 (Wnt1-Cre;Alk5(fl)(/fl)) conditional knockout mice.

14 subepithelial aspect in agrin-deficient and conditional knockout mice.

15 Tsg101-deficient mammary epithelial cells in conditional knockout mice.

16 3 in T cell development by generating NFATc3 conditional knockout mice.

17 nerated conventional and T-cell-specific PP4 conditional knockout mice.

18 ped from mammary tumors that appeared in Blm conditional knockout mice.

19 as conducted using floxed c-jun (c-jun(f/f)) conditional knockout mice.

20 perfusion (I/R) injury in the liver by using conditional knockout mice.

21 inary sodium excretion in control and not in conditional knockout mice.

22 mary mouse embryonic fibroblasts from Tsg101 conditional knockout mice.

23 Arl13b expression in the kidneys from Sec10 conditional knockout mice.

24 significant functional recovery even in Ryk conditional knockout mice.

25 of these genes have been found in the GCs of conditional knockout mice.

26 hich was up-regulated in cDC2s and pDCs from conditional knockout mice.

27 n into the iNKT cell lineage in CD4-cre NKAP conditional knockout mice.

28 n partially rescues the tooth arrest in Sox2 conditional knockout mice.

29 ones were detected in the periphery of Foxn1 conditional knockout mice.

30 e role of RFX in hearing, we generate Rfx1/3 conditional knockout mice.

31 ell-specific hypoxia-inducible factor-1alpha conditional knockout mice.

32 gative regulation of Nrf2 by Hrd1 using Hrd1 conditional knockout mice.

33 .3(+) T cell expansion in Id2 and Id3 double conditional knockout mice.

34 chemoattractant, was significantly lower in conditional knockout mice.

35 this question, we created Treg-specific Cd28 conditional knockout mice.

36 these CDK10 germline mutations, we generated conditional-knockout mice.

37 irways, (2) dependency on DCs using CD11cDTR conditional knockout mice, (3) presence of ongoing airwa

38 ignificantly reduced in both Raptor and Tsc1 conditional knockout mice, albeit with variations in sev

39 , administration of Notch inhibitors in Fbw7 conditional knockout mice alleviated progressive bone re

40 Oocyte-specific, beta1 integrin conditional knockout mice allowed us to obtain mature eg

41 e generated cardiac-specific alpha-E-catenin conditional knockout mice (alpha-E-cat cKO).

42 Surprisingly, the double conditional knockout mice also showed growth plate defec

43 n vitro organoid cultures derived from Snai1 conditional knockout mice also undergo apoptosis when Sn

44 d in pulmonary endothelial cells using Bmpr2 conditional knockout mice and a novel endothelial Cre tr

45 ity alterations were normalized in GABA-CB1R conditional knockout mice and after subchronic treatment

46 Here we use conditional knockout mice and an acute adenovirus-mediat

47 ort, we used glial fibrillary acidic protein conditional knockout mice and derivative glia to determi

48 or adipogenesis in culture and in vivo Using conditional knockout mice and derived white and brown pr

49 We generated Cul4a conditional knockout mice and observed that skin-specifi

50 tasis using acute hippocampal slices from PS conditional knockout mice and primary cultured postnatal

51 Here, we generated RapGEF2 conditional knockout mice and studied its role in embryo

52 Conditional knockout mice and transgenic mice expressing

53 logous to human autosomal dominant PKD (Pkd1 conditional knockout mice) and nephronophthisis (jck and

54 Mixed bone marrow chimeras, conditional knockout mice, and adoptive transfer models

55 glion neuronal cultures are absent in Piezo2 conditional knockout mice, and ex vivo skin nerve prepar

56 circumvent this problem, we generated RIPK1 conditional knockout mice, and show that mice lacking RI

57 (ES) cell clones for the rapid production of conditional knockout mice, and the use of this system in

58 These conditional knockout mice are a useful in vivo model for

59 Male double Smad1 Smad5 conditional knockout mice are fertile but demonstrate me

60 Conditional knockout mice are generated using labor-inte

61 ermore, RBCs from blood-cell-specific Piezo1 conditional knockout mice are overhydrated and exhibit i

62 Here, we have used conditional knockout mice as well as the differentiation

63 lung contusion was significantly reduced in conditional knockout mice at all the time points, when c

64 ble Smad1 Smad5 and triple Smad1 Smad5 Smad8 conditional knockout mice become infertile and develop m

65 dentate gyrus synapses of young Nse-Cre Pten conditional knockout mice before the onset of visible mo

66 nduced tumorigenesis in hepatic beta-catenin conditional knockout mice (beta-cat KO).

67 the postnatal SVZ of hGFAP-cre::Ars2(fl/fl) conditional knockout mice, but are more severe.

68 independent lines of astrocyte-specific Tsc1 conditional knockout mice by using the Cre-LoxP system.

69 cultured neural stem cells derived from Cic conditional knockout mice bypassed an EGF requirement fo

70 c-Met conditional knockout mice (c-metfl/fl, AlbCre+/-; MetLiv

71 ent tissue- and developmental stage-specific conditional knockout mice carrying Smarcb1 and/or Nf2 de

72 Twenty-five percent of the Cdk5 conditional knockout mice carrying the heterozygous cre

73 al mesencephalon of orthodenticle homeobox 2 conditional knockout mice caused a reduction of midbrain

74 imb perfusion recovery was attenuated in Shc conditional knockout mice compared with littermate contr

75 mic populations are similar in CD4-cre HDAC3 conditional knockout mice compared with wild-type mice,

76 /Ela-CreERT mice) alone or crossed with COX2 conditional knockout mice (COXKO/LSL-Kras/Ela-CreERT).

77 In Cx26 conditional knockout mice (Cx26(Sox10-Cre)) the maturati

78 has been removed, and in the hippocampus of conditional knockout mice defective in heparan sulfate s

79 Here we generated conditional knockout mice deficient in various Slit and

80 EC-specific Snail1 loss-of-function conditional knockout mice die in utero with defects in v

81 Conditional knockout mice died at day 11.5 to 12.5 of em

82 velopmental role, Dbx1 hypothalamic-specific conditional-knockout mice display attenuated responses t

83 T cell-specific Gfi1 conditional knockout mice displayed a striking delay in

84 p(nestin) conditional knockout and Yap(GFAP) conditional knockout mice displayed fewer neocortical as

85 ype controls, oligodendrocyte-specific SOCS3 conditional-knockout mice displayed enhanced c-fos activ

86 We generated Dnmt1 conditional knockout mice (Dnmt1(Deltaalb) ) by crossing

87 associated gliomas, astrocyte-restricted Nf1 conditional knockout mice do not develop gliomas.

88 CD4-cre HDAC3 conditional knockout mice do not have a defect in intrat

89 he E2F1 transcription factor in K5 Cre:Brca1 conditional knockout mice dramatically accelerated tumor

90 Conditional knockout mice (either inducible or permanent

91 elial injury, we demonstrate that myeloid AC conditional knockout mice exhibit impairment of neutroph

92 Furthermore, Bcl-x conditional knockout mice exhibit normal T-dependent hum

93 These conditional knockout mice exhibit preferential T(H)-17 l

94 the blood, spleen, and bone marrow of Mcl-1 conditional knockout mice exhibited an approximately 2-

95 ucture-related gene expression, whereas Tsc1 conditional knockout mice exhibited changes in genes reg

96 with a single necrogenic dose of CCl4, c-met conditional knockout mice exhibited impaired recovery fr

97 The K5 Cre:Brca1 conditional knockout mice exhibited modest epidermal hyp

98 mice, whereas hepatocyte and macrophage Bmp6 conditional knockout mice exhibited no iron phenotype.

99 Two independent Osx conditional knockout mice exhibited similar molar abnorm

100 The Setd1a-cKO (conditional knockout) mice exhibited an enlarged spleen

101 We found that E-cadherin conditional knockout mice failed to survive, dying withi

102 in the metanephric mesenchyme, we generated conditional knockout mice (fgfr(Mes-/-)).

103 Studying conditional knockout mice for ELKS, we find that ELKS en

104 fic gradient of HDAC-activity using compound conditional knockout mice for Hdac1 and Hdac2.

105 Here, we generated double conditional knockout mice for RIM-BP1 and RIM-BP2, and a

106 To this end, we used conditional knockout mice (FoxN1-Gpr177) in which TECs a

107 We show that Mcl-1 conditional knockout mice had a severe defect in neutrop

108 retinal ganglion cell death, similar to Nf1 conditional knockout mice harboring a neomycin insertion

109 Osteoclast-lineage-specific Gna13 conditional knockout mice have a severe osteoporosis phe

110 Consistently, conditional knockout mice have delayed barrier formation

111 nses to TLR stimulation in vitro, and alphav-conditional knockout mice have elevated antibody respons

112 The conditional knockout mice have reduced numbers of thymoc

113 We report that Lim 1 conditional knockout mice have renal hypoplasia and hydr

114 Previous studies using conditional knockout mice have shown that loss of hepato

115 T cell subsets in the thymus, we constructed conditional knockout mice in which IL-7Ralpha or common

116 n constitutive and tamoxifen-inducible Olig2 conditional knockout mice in which Olig2 was deleted spe

117 Conditional knockout mice in which Shc is deleted from e

118 beta-cell biology in vivo, we have generated conditional knockout mice in which the c-met receptor ge

119 and synaptic structures and function in Pten-conditional knockout mice in which the gene was deleted

120 , spatial memory, and metabolic functions of conditional knockout mice in which the inactivation of t

121 Double conditional knockout mice, in which both receptors were

122 cy in the postnatal brain by generating Cdk5 conditional knockout mice, in which Cdk5is selectively e

123 Nse-Cre Pten conditional knockout mice, in which Pten is ablated in g

124 In CD4-cre NKAP conditional knockout mice, invariant natural killer T ce

125 however, that RPE iron accumulation in these conditional knockout mice is not as great as in systemic

126 Bone marrow from conditional knockout mice lacking Adam10 in the myeloid

127 Conditional knockout mice lacking ADORA2B on myeloid cel

128 gnificance of this interaction, we generated conditional knockout mice lacking all multidomain RIM is

129 Here we generate conditional knockout mice lacking Arf6 in neurons, oligo

130 the requirement for cyclin A function using conditional knockout mice lacking both A-type cyclins.

131 sence of NF186, they fail to do so in double conditional knockout mice lacking both NF186 and the par

132 we show that rat insulin promoter (RIP)-Cre conditional knockout mice lacking Pcdh-gammas in a broad

133 induced SNS injury, while NPY injection into conditional knockout mice lacking the Y1 receptor in mac

134 Syk-conditional knockout mice lacking this kinase specifical

135 e describe opioid-induced behaviors of Lmx1b conditional knockout mice (Lmx1bf/f/p), which lack centr

136 rrow cells (BM) from LacZ(+) Mekk3-deficient conditional knockout mice (Mekk3(Deltaflox/-) mice) were

137 By using the Cre-Lox conditional knockout mice model injected with carcinogen

138 rmation, we generated astrocyte-specific Nf1 conditional knockout mice (Nf1(GFAP)CKO) by using Cre/Lo

139 In contrast to astrocyte-restricted Nf1 conditional knockout mice, Nf1+/- mice lacking Nf1 in as

140 In CD4-cre NKAP conditional knockout mice, NKAP-deficient RTEs fail to c

141 e impaired T lymphocyte maturation in c-FLIP conditional knockout mice occurs at the single-positive

142 Both whole-body (Lgr4(-/-)) and monocyte conditional knockout mice of Lgr4 (Lgr4 CKO) exhibit ost

143 In addition, Tsc1 conditional knockout mice presented severely disorganize

144 Conditional knockout mice producing GFP-tagged synaptota

145 D)-induced PDAC development, we crossed Pten conditional knockout mice (Pten(lox/lox)) to mice with c

146 Inactivation of the FN gene in FN conditional knockout mice reduced pFN levels to <2% and

147 Here, we generated conditional knockout mice removing the active zone prote

148 iciency in CMFs in fibroblast-specific MyD88 conditional knockout mice resulted in a strong increase

149 Analysis of the Bmp6 conditional knockout mice revealed that liver endothelia

150 Analysis of cell-specific IL-15Ralpha conditional knockout mice revealed that macrophages and

151 ardial electrical activation pattern in Cx43 conditional knockout mice revealed that ventricular cond

152 In Ldlr/XBP1-conditional knockout mice, serum levels of IgG, IgE, and

153 report that forebrain-specific Presenilin-1 conditional knockout mice show defects in enrichment-ind

154 Finally, experiments with TbetaRII conditional knockout mice show that abrogation of TGFbet

155 e show early embryonic lethality, post-natal conditional knockout mice show weight loss, fat depletio

156 Pten conditional knockout mice showed a striking progressive

157 Raptor conditional knockout mice showed decreased extracellular

158 The liver-specific Jag1 conditional knockout mice showed normal bile duct develo

159 stomorphometric analysis revealed that STAT5 conditional knockout mice showed reduced bone mass, with

160 Primary nociceptor-specific Cdk5 conditional-knockout mice showed reduced TRPV1 phosphory

161 However, both lines of conditional knockout mice suffer from progressive hind l

162 Here, we use conditional knockout mice targeting all RIM isoforms exp

163 In conditional knockout mice, temporal axons display no maj

164 dedicated to controlling the forelimb in Ryk conditional knockout mice than in controls (wild-type or

165 ifferentiation less effectively in the STAT5 conditional knockout mice than in the wild-type mice aft

166 We find that conditional knockout mice that delete the transcriptiona

167 hemojuvelin in skeletal muscle, we analyzed conditional knockout mice that lack muscle hemojuvelin.

168 proprioception to twitching in newborn ErbB2 conditional knockout mice that lack muscle spindles and

169 Using newly generated constitutive and conditional knockout mice that target all neurexin-3alph

170 dress this question, we produced triple cKO (conditional knockout) mice that allow ablating all neure

171 ined insertions that can be used to generate conditional knockout mice, thereby providing extensive p

172 In CD4-cre NKAP conditional knockout mice, thymic development including

173 genetic complementation system derived from conditional knockout mice to address the function and re

174 (MLNs) or intestines of wild-type and alphav conditional knockout mice to assess generation of Tregs.

175 We generated Lman1 conditional knockout mice to characterize the FVIII secr

176 In this issue, Boutin et al. use conditional knockout mice to demonstrate that sensing of

177 We generated conditional knockout mice to examine the in vivo role of

178 We generated Jak2 conditional knockout mice to study essential functions o

179 Herein, we used conditional knockout mice to study Heph's role in retina

180 ity in the embryonic gut mesenchyme and used conditional knockout mice to study its function.

181 Finally, conditional knockout mice unable to perform FcgammaR-med

182 Conditional knockout mice utilized a new iCre driven by

183 ntrast, a single WT allele of Gata4 in Gata6 conditional knockout mice was sufficient for normal panc

184 Using Cre-lox conditional knockout mice, we demonstrate that lipoprote

185 Using conditional knockout mice, we demonstrate that the Merli

186 Using conditional knockout mice, we examined the electrophysio

187 Using CNIH-2 and CNIH-3 conditional knockout mice, we find a profound reduction

188 Using conditional knockout mice, we found that Gli3 deficiency

189 Using conditional knockout mice, we found that T cells lacking

190 Employing B cell-specific conditional knockout mice, we have demonstrated here tha

191 Using a genetic approach with conditional knockout mice, we identified IECs as the dom

192 Using kinase inhibitors, RNAi, and conditional knockout mice, we investigated the role of c

193 Using conditional knockout mice, we show here that Nedd4-1 and

194 Using conditional knockout mice, we show here that Rac1 and Cd

195 Using ASB2 conditional knockout mice, we show that ASB2alpha is a c

196 Employing conditional knockout mice, we show that depletion of ADA

197 Here, using dual conditional knockout mice, we show that genetic redundan

198 Using BMDC from wild type and conditional knockout mice, we show that neuropilin-1 (NR

199 Using Ubc13 conditional knockout mice, we show that somatic deletion

200 Using Hk2 conditional knockout mice, we showed that HK2 is require

201 Conditional knockout mice were born at the expected Mend

202 SOAT2 conditional knockout mice were bred with LDLr(-/-) mice

203 beta1 integrin conditional knockout mice were crossed to Ptf1a-Cre mice

204 The resultant Pnn conditional knockout mice were examined by histologic an

205 To answer this question, GAK conditional knockout mice were generated and then mated

206 COX10 conditional knockout mice were generated by crossing a L

207 Conditional knockout mice were generated to characterize

208 lls from the hypoxia-inducible factor-1alpha conditional knockout mice were isolated and evaluated fo

209 Calpain conditional knockout mice were studied in the model.

210 n2 expression, surgical transplant and novel conditional knockout mice were super-ovulated and analyz

211 To strengthen its role, beta-catenin conditional knockout mice were treated with 3,5-diethoxy

212 These conditional knockout mice were viable and grew normally,

213 an early lethal phenotype, we have generated conditional-knockout mice where alpha3 is deleted specif

214 Here we report that Hif1a(f/f);Tie2-Cre conditional knockout mice, which lack HIF-1alpha express

215 sponsive genes in the early tumors of FIP200 conditional knockout mice, which was accompanied by incr

216 Pten in hematopoietic cells by crossing Pten conditional knockout mice with a knock-in mouse expressi

217 In our current study, we crossed our Lpd conditional knockout mice with a mouse line expressing C

218 he mammalian nervous system, we treated Pten conditional knockout mice with CCI-779, a specific mTor

219 a physiologic context in vivo, we generated conditional knockout mice with EpCAM-deficient LC and ch

220 ramatically reduced in the absence of EpCAM, conditional knockout mice with EpCAM-deficient LCs and c

221 Topical immunization of conditional knockout mice with EpCAM-deficient LCs with

222 s to externally applied proteins, we studied conditional knockout mice with EpCAM-deficient LCs.

223 Tid1 protein was achieved by crossing these conditional knockout mice with general deletor mice.

224 We crossed Hdac3 conditional knockout mice with Mb1-Cre knockin animals t

225 Notch pathway function, we crossed the Jag1 conditional knockout mice with mice carrying the hypomor

226 To address these questions, we generated conditional knockout mice with specific deletion of Atg3

227 oter, resulting in generation of viable Cdk5 conditional knockout mice with the restricted deletion o

228 d in hepatocytes by crossing "floxed" Tgfbr2 conditional knockout mice with transgenic mice expressin

229 Previously, we created conditional knockout mice with Treg-specific deletion of

230 We studied MxCre Notch1(lox/lox) mice (conditional knockout mice without tissue-specific disrup