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1 ibit Cas9 function spatially, temporally, or conditionally.
5 d the Wnt1(Cre) and Wnt1(Cre2SOR) drivers to conditionally ablate both Yap and Taz in the CNC of mice
6 erized Cre-expressing Tbx18 knock-in line to conditionally ablate Enpp2 in embryonic DP precursors.
11 mTORC1 or mTORC2 during CNS myelination, we conditionally ablated either Raptor or Rictor in the oli
12 we developed a mouse model in which PDK1 is conditionally ablated in activated CD4 T cells, regulato
13 Cd4-cre Il6st(fl/fl) mice, in which gp130 is conditionally ablated in T cells, with acute lymphocytic
16 ancer of zeste homologs 1 and 2 (Ezh1/2) are conditionally ablated in the embryonic epidermal progeni
18 role of Stat3 in uterine function, Stat3 was conditionally ablated only in the PR-positive cells (PR(
21 ole of TrkB signaling in newborn neurons, we conditionally ablated TrkB-FL in mice via Cre expression
23 n mice in which both BMP1 and TLL1 have been conditionally ablated, including malformed periodontal l
24 ining isoforms of Nrg1 (types I and II) were conditionally ablated, leaving the type III Nrg1 intact.
27 s study, we investigated the consequences of conditionally ablating p53 in the highly relevant Lgr5(+
28 We examined the behavioral significance of conditionally ablating TRPM8-expressing neurons in adult
29 Nevertheless, the use of Cre/loxP systems to conditionally activate or inactivate the expression of g
30 idation of split-protein kinases that can be conditionally activated by an added small molecule chemi
31 of D-2HG, we generated transgenic mice with conditionally activated IDH2(R140Q) and IDH2(R172K) alle
32 h and division processes, which include both conditionally activated mechanisms and constitutive, har
38 urkholderia colonization may be considered a conditionally adaptive trait because it can confer an ad
39 show that defects in tRNA thiolation can be conditionally advantageous, conferring resistance to end
42 ng space-time random effects in an intrinsic conditionally autoregressive model within a Bayesian fra
44 sefulness of synthetic lethal screening of a conditionally BCL6-deficient Burkitt lymphoma cell line,
45 present in only some lines are enriched for conditionally beneficial functions (e.g., defense and de
51 integrated biclustering algorithm identifies conditionally co-regulated modules of genes (biclusters)
53 tone induction and Cre-loxP recombination to conditionally control the expression of oncogenic kras(V
63 ss this issue we have generated a toolkit of conditionally degradable or stabilisable orthologous dCa
64 this, we developed a transgenic strategy to conditionally delete alpha-CaMKII from neural progenitor
65 ock-in mouse will help to reliably track and conditionally delete C3aR expression in experimental mod
67 ock-in mouse will help to reliably track and conditionally delete C5aR2 expression in experimental mo
69 ty we used Tie2CRE-mediated recombination to conditionally delete Id1 against global Id3 ablation (Id
70 e used an intersectional genetic strategy to conditionally delete Lhx2 in posteroventral hypothalamic
71 compared them with two existing models that conditionally delete Tcf4 Our data identify a set of ove
74 ystem whereby endogenous wild-type Mre11a is conditionally deleted and disease-associated MRE11 mutan
77 n adult female mice carrying an OPC-specific conditionally deleted beta-catenin gene, there is reduce
78 y angiocrine Bmp2 signaling in the liver, we conditionally deleted Bmp2 in LSECs using EC subtype-spe
80 n blot analysis of final tumors derived from conditionally deleted E2f3(-/loxP) mammary glands reveal
81 Through detailed genetic analysis of strains conditionally deleted for FcgammaRIIB on defined cellula
83 d ER stress repressor chaperone Grp78 can be conditionally deleted from the intestinal epithelium.
84 o present in mice in which the Oxtr gene was conditionally deleted from the mPFC and in control mice
85 some inactivation (XCI) in early embryos, is conditionally deleted from Xi in somatic cells (Xi(Xist)
87 ing in p53(-/-) mice in which Mcl-1 could be conditionally deleted had been selected for retention of
88 olled by Hdac3 during T cell development, we conditionally deleted Hdac3 using the Lck-Cre transgene.
90 mouse models in which the human APOE gene is conditionally deleted in astrocytes, neurons, or GABAerg
91 in the bone marrow, Spi1 (encoding PU.1) was conditionally deleted in B cells by Cre recombinase unde
92 t mice in which the gene encoding Set7/9 was conditionally deleted in beta cells (Set(Delta)beta).
93 in the Hedgehog (Hh) signaling pathway, was conditionally deleted in cells expressing the MF-associa
94 severely impaired in mice in which Irf4 was conditionally deleted in mature B cells, after immunizat
95 t to report that mice in which TAK1 has been conditionally deleted in osteoclasts develop osteopetros
96 subunit of the epithelial sodium channel was conditionally deleted in taste buds (alphaENaC knockout)
97 activin-like kinase 3 (Alk3; or Bmpr1a) was conditionally deleted in the epicardium and EPDCs using
98 test whether LepR regulates SSC function, we conditionally deleted Lepr from limb bone marrow stromal
99 c stem cells (HSCs) in which Dnmt3a had been conditionally deleted markedly overexpress the histone 3
100 To specifically investigate such role, we conditionally deleted Nemo from osteoclast and myeloid p
103 in murine hematopoiesis and in leukemia, we conditionally deleted p110alpha in HSCs using the Cre-lo
106 Atoh1 expression in hair cell maturation we conditionally deleted the gene in the inner ear at vario
108 t of MEF2 factors in muscle regeneration, we conditionally deleted the Mef2a, c, and d genes, singly
110 ts of endothelial CXCR7 in breast cancer, we conditionally deleted this receptor from vascular endoth
111 ing of the role of VHL in chondrogenesis, we conditionally deleted VHL in mesenchymal progenitors of
115 ed Bmp signaling in mouse OFT development by conditionally deleting both Bmp4 and Bmp7 in the second
118 tion of mTOR complex 1 (mTORC1) signaling by conditionally deleting Raptor causes severe defects in i
121 ndochondral ossification of the epiphyses by conditionally deleting the Phd2 gene in osteoblasts and
122 Using the "anchor away" (AA) technique to conditionally deplete select subunits within Mediator an
123 lated the severity of tissue injury, Id1 was conditionally depleted in the endothelium of mice, which
124 Experiments with granulocyte-specific CXCL12 conditionally depleted mice and a CXCR4 antagonist revea
130 ental evidence for the direct involvement of conditionally disordered regions in unfolded protein bin
132 decipher the role of ERK1/2 in RPE cells, we conditionally disrupted the Erk1 and Erk2 genes in mouse
134 CGI methylation regulates transcription, we conditionally disrupted two major DNA methyltransferases
141 ribe a new, efficient method for identifying conditionally essential genes in Tn-Seq experiments with
142 a role in brain development, 3) carnitine, a conditionally essential nutrient with an important role
146 chondrial citrate, cancer cells rely on the 'conditionally essential' amino acid glutamine (Q) as an
147 course of dynamic network inputs, provides a conditionally exact and several orders-of-magnitude fast
148 To this end, we generated a mouse model to conditionally express a membrane-bound self-antigen on F
149 y targeting adult neural precursor cells, we conditionally express an activated form of an FGF recept
150 kappaB kinase beta transactivated) mice that conditionally express an activator of the NF-kappaB path
152 ere, we generated human ES cells designed to conditionally express heterozygous and homozygous STXBP1
153 this system to trace lymphocyte fate and to conditionally express oncogenes or silence tumour suppre
155 amoxifen-regulated Cre recombinase system to conditionally express the HPV oncogenes E6 and E7 as wel
156 11 signaling in vivo, we generated mice that conditionally express the human DLBCL-derived CARD11(L22
158 We employed mice with an inducible Cre, and conditionally expressed DTA to deplete or GFP to track S
160 stly euchromatic chromosome arms to suppress conditionally expressed genes involved in flowering or D
162 mate-sensing fluorescent reporter (iGluSnFR) conditionally expressed in On-Off DSGCs showed that glut
169 vascular integrity by using nondiabetic mice conditionally expressing a diphtheria toxin receptor in
170 present study, we investigated the impact of conditionally expressing a FLAG-tagged version of IncD i
177 duced epigenetic changes are associated with conditionally heritable adaptive phenotypic stress respo
178 of a genome to accumulate mutations that are conditionally hidden and only reveal phenotype-altering
179 ively (i.e., in a continually "ON" state) or conditionally (i.e., in response to a specific transcrip
180 cells can be used along with Flt3 ligand to conditionally immortalize early hematopoietic progenitor
181 oned medium was shown to induce and maintain conditionally immortalized cells, which was accompanied
182 ) signaling molecules were evaluated for two conditionally immortalized fetal NSC lines derived from
183 High-concentration thrombin directly injured conditionally immortalized human and rat podocytes.
184 Here, we devised a strategy to generate conditionally immortalized human beta cell lines based o
186 Chromatin immunoprecipitation experiments in conditionally immortalized human podocytes and gel shift
188 ytosis and the role of CLC-5, we established conditionally immortalized proximal-tubular epithelial c
191 ck down Insr or its substrates Irs1 and Irs2 conditionally in 3T3-L1 murine preadipocytes/adipocytes
195 inase kinase directly downstream of ZPK/DLK, conditionally in neurons did not have excess facial moto
196 enetic silencing of PLD4, either globally or conditionally in proximal tubular epithelial cells, prot
204 ial behavioral impairments in mice with Pten conditionally inactivated in dopaminergic neurons that a
206 mice, namely C3 mice in which c-Jun had been conditionally inactivated in Schwann cells (C3/Schwann c
208 ne the in vivo function of menin in bone, we conditionally inactivated Men1 in mature osteoblasts by
209 nants in which both EBNA3A and EBNA3C can be conditionally inactivated or using virus completely lack
210 To investigate Pitx2 postnatal function, we conditionally inactivated Pitx2 in the postnatal atrium
212 ect of its loss on outcomes in the brain, we conditionally inactivated the murine Pten gene in neonat
215 nhancers by the bromodomain inhibitor JQ1 or conditionally inactivating an EBV oncoprotein or NF-kapp
216 e, we modeled critical telomere attrition by conditionally inactivating Pot1a, a component of the she
220 , partitioning strategies involve estimating conditionally independent models of molecular evolution
224 SPC-rtTA(+/-)TetoCre(+/-)LoxP-VEGF-A(+/+) to conditionally induce VEGF-A isoform deletion specificall
226 protein 1-mediated mitochondrial fission was conditionally interrupted in cardiac myocytes, we propos
229 pmental processes, such as axon guidance, we conditionally knocked out Celsr3 in the hippocampus 1 we
231 in epidermal development and homeostasis, we conditionally knocked out SRF in epidermal keratinocytes
232 signaling in bladder cancer progression, we conditionally knocked out the Tgfbr2 in mouse model afte
233 enic mice with Zbtb20 floxp mice to generate conditionally knockout mice (cKO) in which Zbtb20 was sp
234 from ET(flox/flox);Tie2-Cre( + ) mice, which conditionally lack ET-1 in hematopoietic stem cells and
239 or sequences that function in vivo to rescue conditionally lethal mutants of Escherichia coli (auxotr
241 nes for safety and efficacy and is currently conditionally licensed for use for veterinary purposes i
242 uated vaccine for RVF, the MP-12 vaccine, is conditionally licensed for veterinary use in the United
244 receptor (GR)-based fusion protein system to conditionally localize GR-UVR8 to the nucleus, we have d
245 The Kv2.1 voltage-gated potassium channel is conditionally localized to large PM clusters that repres
246 /PTEN-deficient human cancers while p110beta conditionally mediates PI3K/AKT signaling only upon HER2
252 power of our multiyear study to distinguish conditionally neutral QTL from those that reflect fitnes
254 -descent mutants in the sample, again tested conditionally on the number of forward mutations mapped
255 origenesis when the remaining Kras allele is conditionally oncogenic, there is a moderate imbalance o
257 e, as of 2015, no other RVF vaccine has been conditionally or fully licensed for use in the United St
258 equence variant data can be generated either conditionally or unconditionally on pedigree members' qu
262 test this hypothesis, we generated mice that conditionally overexpressed human hyaluronidase 1 (HYAL1
263 a Notch gain-of-function transgenic mouse by conditionally overexpressing the Notch1 intracellular do
264 a new and widely applicable tool to generate conditionally phosphorylated proteins to identify those
265 emented within the network itself but can be conditionally provided by extrinsic neuromodulatory inpu
270 nal landmarks that direct Rsr1p to bud sites conditionally regulated the fMAPK pathway, corresponding
271 provides significant insights into how light conditionally regulates plant growth through controlling
274 which, to our knowledge, is a novel finding conditionally replicated by using an independent sample.
275 e constructed a serotype 5/3 adenovirus that conditionally replicates in tumor cells expressing MDA-7
276 tential to decrease the fitness of HIV-1 and conditionally replicative lentiviral vectors have a prom
278 inations were tested in primary cultures and conditionally reprogrammed cells generated from nasal br
281 Consistent with results obtained using a conditionally rescued mpk3 mpk6 double mutant generated
283 has been developed to replace protamine as a conditionally reversible, nucleic acid condensing agent.
285 e of Htt in synaptic connectivity in vivo by conditionally silencing Htt in the developing mouse cort
286 Thus, growth-independent fermentation can conditionally stabilize or destabilize a mutualism, indi
287 of cytotoxic drugs covalently attached via a conditionally stable linker to monoclonal antibodies (mA
290 genesis in disrupted rats using oxytocin and conditionally suppressing the production of new neurons
291 ndent RNA substrate, a signal amplifier that conditionally synthesizes long fluorescent strands only
293 , we have used technology that enables us to conditionally target K-RasG12D expression in Surfactant
297 spikelets transmitted through gap junctions conditionally trigger postjunctional spikes, depending o
298 tion, LIG4 mainly expressed in the crypts is conditionally upregulated in ISCs, accompanied by Wnt/be
299 l axis of the sea urchin embryo is specified conditionally via a regulated feedback circuit involving
300 mutant lacking both of these proton pumps is conditionally viable and retains significant vacuolar ac
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