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1 37) for 2 years, starting at the time of the conditioning regimen.
2 relapse, regardless of the intensity of the conditioning regimen.
3 ing fludarabine and melphalan as the optimal conditioning regimen.
4 nrelated donor, but not the intensity of the conditioning regimen.
5 x 108 CD30.CAR-Ts/m2, were infused without a conditioning regimen.
6 pectively, with no significant difference by conditioning regimen.
7 from an unrelated donor and a myeloablative conditioning regimen.
8 and absence of antithymocyte globulin in the conditioning regimen.
9 were compared as part of a nonmyeloablative conditioning regimen.
10 ognostic stratification and the selection of conditioning regimen.
11 a total body irradiation-based myeloablative conditioning regimen.
12 a direct consequence of the intensity of the conditioning regimen.
13 ide, cytarabine, and cyclophosphamide as the conditioning regimen.
14 differences between donor and recipient, and conditioning regimen.
15 randomized phase 3 study of ATG as part of a conditioning regimen.
16 comes, we made sequential changes to the HCT conditioning regimen.
17 fan and cyclophosphamide was the most common conditioning regimen.
18 A matching, calendar year of transplant, and conditioning regimen.
19 receiving nonmyeloablative HCT or ATG in the conditioning regimen.
20 oietic stem cell transplant recipient during conditioning regimen.
21 ecommendations on the optimal high intensity conditioning regimen.
22 onor if the patient receives a myeloablative conditioning regimen.
23 native donor sources and identifying optimal conditioning regimens.
24 , some of which are related to the intensive conditioning regimens.
25 y reflecting progress in supportive care and conditioning regimens.
26 w transplantation, protocols usually include conditioning regimens.
27 transplantation that uses reduced-intensity conditioning regimens.
28 d T-replete grafts with mostly myeloablative conditioning regimens.
29 irradiation or nonmyeloablative chemotherapy conditioning regimens.
30 ive (n = 155) or reduced intensity (n = 102) conditioning regimens.
31 myeloablative allogeneic SCT with TBI-based conditioning regimens.
32 egimens and those who received myeloablative conditioning regimens.
33 d allogeneic SCT following reduced-intensity conditioning regimens.
34 CT from unrelated donors using myeloablative conditioning regimens.
35 s populations, with dissimilar diagnosis and conditioning regimens.
36 SD-HCT (n = 807) following reduced-intensity conditioning regimens.
37 were too old or infirm to tolerate standard conditioning regimens.
38 imited graft cell number or nonmyeloablative conditioning regimens.
39 n (ATG; n = 491) following reduced-intensity conditioning regimens.
40 d donors; 9 patients received busulfan-based conditioning regimens.
41 oablative and 737 received reduced intensity conditioning regimens.
42 loablative and 88 received reduced intensity conditioning regimens.
43 had comparable mortality risks regardless of conditioning regimens.
44 ophils could amplify tissue damage caused by conditioning regimens.
45 been further increased by reduced-intensity conditioning regimens.
46 not statistically different between the two conditioning regimens.
47 ioning phase or the use of reduced-intensity conditioning regimens.
48 plastic syndrome; 98% received myeloablative conditioning regimens 100% received T-replete grafts, 97
49 ene therapy in CLAD using 2 nonmyeloablative conditioning regimens--200 cGy total body irradiation (T
51 th 149 dUCBT recipients, after myeloablative conditioning regimen adjusting for the differences betwe
52 atopoietic cell transplantation (HCT) is the conditioning regimen administered before the hematopoiet
53 inical reports suggest that nonmyeloablative conditioning regimens afford better outcomes in patients
54 of cytotoxic chemotherapy in the transplant-conditioning regimen, allogeneic T lymphocytes were remo
55 (GVHD) in mice receiving a nonmyeloablative conditioning regimen allowing establishment of mixed hem
56 esults in children following a myeloablative conditioning regimen and a matched sibling donor transpl
57 erapy after a reduced-intensity chemotherapy conditioning regimen and allogeneic hematopoietic stem-c
59 Patient 2 experienced skin toxicity from the conditioning regimen and hypertensive crisis that was li
60 ransplantation after a uniform myeloablative conditioning regimen and immunoprophylaxis for graft-ver
61 received a melphalan-based reduced-intensity conditioning regimen and posttransplant cyclophosphamide
62 tion using a short-duration nonmyeloablative conditioning regimen and posttransplant cyclophosphamide
63 rbid conditions, pretransplant chemotherapy, conditioning regimen and source of stem cells, affect tr
65 to the recipient's age, donor selection, the conditioning regimen and the extent of reconstitution.
66 adiation-free GVHD preventative anti-CD3/CD8 conditioning regimen and transplanted with bone marrow (
69 ntrol at the time of SCT, incorporation into conditioning regimens and finally, using maintenance app
70 this replication attempt, such as different conditioning regimens and I-BET151 doses, are factors th
71 r in patients who received reduced-intensity conditioning regimens and those who received myeloablati
72 TRM, further studies are needed to optimize conditioning regimens and to define the optimal timing o
73 n the expression of PD-1 were induced by the conditioning regimen, and declined after bone marrow tra
74 icenter study with uniform GVHD prophylaxis, conditioning regimen, and donor source, we explored the
75 , there were no complications related to the conditioning regimen, and GVHD did not develop after tra
76 lking, possibly with hypomethylating agents, conditioning regimen, and potential post-HCT treatment,
78 em cells, administering an immunosuppressive conditioning regimen, and re-infusing the autologous hae
79 eed for pretransplant chemotherapy, the best conditioning regimen, and the optimal long-term follow-u
80 rticularly those related to genotype, use of conditioning regimen, and use of alternative donors.
81 or acute leukemia, all given a myeloablative conditioning regimen, and with available allele HLA typi
83 lignancies with total-body irradiation (TBI) conditioning regimens, and considered for patients under
84 radiation (TBI) or busulfan/cyclophosphamide conditioning regimens, and received four doses of methot
85 e animal model using 2 clinically applicable conditioning regimens, and they provide support for the
90 ated mortality; therefore, reduced-intensity conditioning regimens are being used to improve outcomes
92 encouraging, mostly when thiotepa-containing conditioning regimens are used, both in newly diagnosed
93 ue-specific homing was not solely due to the conditioning regimen, as NK cells proliferated and reach
94 antithymocyte globulin (ATG) as part of the conditioning regimen (ATG group), whereas 579 did not (n
95 mes can be optimized by peritransplant TKIs, conditioning regimen, BCR-ABL monitoring, and relapse ma
96 e combined with a standard reduced-intensity conditioning regimen before allogeneic hematopoietic cel
98 eceiving ablative intravenous busulfan-based conditioning regimens before a related or volunteer-unre
99 Bortezomib has also been incorporated into conditioning regimens before autologous stem cell transp
100 y metastases, routinely uses lymphodepletive conditioning regimens before T-cell transfer, like recen
102 and Australia who received a busulfan-based conditioning regimen between March 18, 2001, and Feb 12,
104 a clinically relevant, nonmyeloablative host-conditioning regimen can be used to overcome the immune
108 lentiviral vector after a reduced-intensity conditioning regimen combined with anti-CD20 administrat
109 re given more intense total body irradiation conditioning regimens combined with autologous bone marr
110 omising data have been reported from a novel conditioning regimen combining NMA with ibritumomab tiux
111 o received busulfan-containing myeloablative conditioning regimens, compared with non-Gilbert's syndr
119 matopoietic stem cell transplantation with a conditioning regimen consisting of cyclophosphamide and
120 pic lung transplant model, we investigated a conditioning regimen consisting of pretransplant T cell
121 uller et al showed, using a nonmyeloablative conditioning regimen consisting of total lymphoid irradi
125 ults during the transplant period, including conditioning regimens, corticosteroids, infections, and
127 e examined the effect of a reduced-intensity conditioning regimen designed to enhance myeloid engraft
128 s receiving adoptive immunotherapy following conditioning regimens designed to enhance T-cell functio
129 as resulted in the development of less toxic conditioning regimens, designed to allow the benefits of
130 o overcome these limitations, we optimized a conditioning regimen employing anti-CD45 radioimmunother
131 Here, we ask whether a nonmyeloablative conditioning regimen establishing mixed donor-host chime
132 e the development of safer reduced-intensity conditioning regimens, expanded donor pools, advances in
133 bles: patient age, donor type, disease risk, conditioning regimen, FEV1, carbon monoxide diffusion ca
134 igh-dose cyclophosphamide was developed as a conditioning regimen for allogeneic bone marrow transpla
136 evaluate the efficacy of a reduced-intensity conditioning regimen for allogeneic HSC transplantation
137 3-based myeloablation may be used as a novel conditioning regimen for hematopoietic cell transplantat
138 in patients according to age (P = .047), the conditioning regimen for hematopoietic stem cell transpl
139 ndard doses of radioimmunotherapy given as a conditioning regimen for hematopoietic stem-cell transpl
140 yte immune globulin (ATG) in a myeloablative conditioning regimen for patients with acute leukemia wo
141 efficacious, reduced-toxicity, myeloablative-conditioning regimen for patients with AML or MDS underg
142 ent alternative to cyclophosphamide plus TBI conditioning regimen for patients with refractory acute
143 imab (BFR), as a nonmyeloablative allogeneic conditioning regimen for patients with relapsed lymphoma
145 d the recent development of nonmyeloablative conditioning regimens for allogeneic hematopoietic stem
146 have an adjunctive role in nonmyeloablative conditioning regimens for allogeneic stem cell transplan
150 provide an attractive alternative to current conditioning regimens for HSCT in the treatment of non-m
152 phosphamide, the foundation of virtually all conditioning regimens for stem cell transplantation, is
153 dynamics and have implications for design of conditioning regimens for transplantation purposes.
155 received allogeneic HCT after high-intensity conditioning regimens for treatment of hematologic malig
156 the use of myeloablative IV-BU vs TBI-based conditioning regimens for treatment of myeloid malignanc
158 aft-versus-host disease (GVHD), steroid use, conditioning regimens, ganciclovir use, HLA matching, ci
159 r development of GVHD when the pretransplant conditioning regimen generates substantial proinflammato
160 monstrated, likely reflecting differences in conditioning regimens, graft components and posttranspla
161 his complete short-duration nonmyeloablative conditioning regimen had durable lung allograft acceptan
162 stem cell transplantation with conventional conditioning regimens has been associated with significa
163 n addition, utilization of reduced-intensity conditioning regimens has been successful extending acce
164 t of non-myeloablative and reduced-intensity conditioning regimens has enabled older or medically inf
168 tudies of BMT in the late 1980s, a number of conditioning regimens have been designed to improve outc
170 lopment of nonablative and reduced-intensity conditioning regimens, have enabled the extension of tra
171 nsplantation, particularly reduced-intensity conditioning regimens, have increased the availability o
173 and in the late phase were nonmyeloablative conditioning regimen (HR, 35.08 [95% CI, 3.90-315.27]),
174 educed intensity compared with myeloablative conditioning regimens (HR 1.36, 1.10-1.68, p=0.0041), tr
175 c cell transplantation (HCT) after high-dose conditioning regimens imposes prohibitively high risks o
176 ng graft-versus-host disease (GVHD) from the conditioning regimen in conjunction with alloreactive do
177 ll patients, we have used a nonmyeloablative conditioning regimen in conjunction with stem cells from
178 alpha-emitter, astatine-211 ((211)At), as a conditioning regimen in dog leukocyte antigen-identical
180 e suggested: use of a fludarabine-containing conditioning regimen in the context of T-cell-depleted m
181 vide support for the use of nonmyeloablative conditioning regimens in preclinical protocols of retrov
183 BI to the widely used fludarabine, melphalan conditioning regimen, in hopes of reducing relapse and d
188 ients were treated with an immunosuppressive-conditioning regimen including thymectomy or thymic irra
189 (+)Foxp3(+) (Treg) compartment after several conditioning regimens, including T cell-depleted and T c
191 n the induction of GVHD of the colon linking conditioning regimen-induced mucosal injury and lipopoly
193 ed before and after changes in myeloablative conditioning regimen intensity (high vs. standard intens
194 ed for recipient cytomegalovirus serostatus, conditioning regimen intensity, total nucleated cell dos
195 of this radiation-free and GVHD preventative conditioning regimen is hindered by the cytokine storm s
196 It has gradually been recognized that the conditioning regimen is important but not critical for t
198 lack of neoplasia, the toxicity of stringent conditioning regimens is difficult to justify, and reduc
199 tioning with standard antithymocyte globulin conditioning regimens, lower rates of acute and chronic
200 ditioning regimen (RIC) with a myeloablative conditioning regimen (MAC) before allogeneic transplanta
201 identical sibling donors after myeloablative conditioning regimens, mainly for hematologic malignanci
204 tuximab and the use of radioimmunotherapy in conditioning regimens may further increase response rate
205 AK1/2 inhibitor therapy in future transplant conditioning regimens may provide an opportunity to over
206 nts and eliminating TBI from transplantation conditioning regimens may reduce the relative risk of tM
207 uggest the possibility that nonmyeloablative conditioning regimens might be effectively used to promo
209 es lie in determining the safest preparative conditioning regimen, minimizing graft-versus-host disea
211 Most UCB recipients received a myeloablative conditioning regimen; most MMRDT recipients did not.
214 success to progressive modifications of the conditioning regimen; nevertheless, the improvement may
215 splant practices, including the intensity of conditioning regimens, new immunosuppressive therapies,
216 ms' tumor, systemic lupus erythematosus, and conditioning regimen of bone marrow transplant for Hurle
217 hat cGVHD induced by allogeneic HSCT after a conditioning regimen of cyclophosphamide and total-body
218 T cells 2 days after a low-dose chemotherapy conditioning regimen of cyclophosphamide plus fludarabin
222 ney recipients also received a pretransplant conditioning regimen of four plasmapheresis treatments f
223 er kilogram of body weight after receiving a conditioning regimen of low-dose cyclophosphamide and fl
226 Using a GVHD protective nonmyeloablative conditioning regimen of total lymphoid irradiation and a
227 were included if they had received high-dose conditioning regimens of cyclophosphamide plus total bod
228 Impact of total-body irradiation (TBI) in conditioning regimen on outcome for patients with mantle
229 effect of a pharmacologic, nonmyeloablative, conditioning regimen on the development of EGFP+ donor/r
230 facilitating the matching of donor type and conditioning regimens, or indeed alternative therapies (
232 llows: cord blood transplantation (P<0.001), conditioning regimen (P=0.030), acute GVHD (P=0.003), an
233 s remains limited and problematic, but novel conditioning regimens, particularly in the haploidentica
234 as also impacted by patient age, donor type, conditioning regimen, platelet count, and etiology of MD
235 upport the concept that lung damage from the conditioning regimen plays a crucial role in the develop
237 ults of childbearing age who receive similar conditioning regimens prior to allogeneic transplantatio
239 odalities are based mainly on high-intensity conditioning regimens, recently introduced reduced-inten
240 We found that total body irradiation, a conditioning regimen required to permit engraftment of a
245 cal variables, including underlying disease, conditioning regimen, stem cell donor status, duration a
246 n, NJ), CECs were counted before (T1), after conditioning regimen (T2), at engraftment (T3), at GvHD
247 ultiple myelomas received a nonmyeloablative conditioning regimen that consisted of 60 mg/kg cyclopho
248 in published reports and showed that only a conditioning regimen that contained busulfan was signifi
249 ients were treated with an immunosuppressive conditioning regimen that included thymectomy, splenecto
250 PEX syndrome using a novel reduced-intensity conditioning regimen that resulted in stable donor engra
251 T cells (Tregs) surviving a nonmyeloablative conditioning regimen that undergo robust homeostatic exp
253 nsplantation, the chemotherapy and radiation conditioning regimens that precede hematopoietic stem ce
254 st candidates for this strategy, the optimal conditioning regimen, the best time for response assessm
255 HD models include the irradiation only-based conditioning regimen, the homogenous donor/recipient gen
256 cells was dependent on the intensity of the conditioning regimen, the leukemic status of the recipie
257 ose, reduced-intensity, and nonmyeloablative conditioning regimens, the most commonly used agents and
258 d mortality associated with nonmyeloablative conditioning regimens, the question of whether a patient
259 necessitated the use of a mild pretransplant conditioning regimen; therefore, in vivo drug selection
260 In patients who received CY/TBI or melphalan conditioning regimens, those with Gilbert's syndrome had
261 ing less intensive, and therefore less toxic conditioning regimens, thus allowing the graft-versus-ma
262 re needed to define optimal intensity of the conditioning regimen, timing of transplantation within a
263 e results of sequential modifications of the conditioning regimen to improve the outcome of unrelated
265 be safely combined with a reduced-intensity conditioning regimen to yield encouraging overall surviv
267 or reduce the need for potentially hazardous conditioning regimens to achieve optimal antitumor respo
268 ative sources of stem cells and a variety of conditioning regimens to achieve their engraftment have
270 ological malignancies, the reduced intensity conditioning regimen used in the context of nonmalignant
272 tation outcome irrespective of donor choice, conditioning regimen used, and underlying genetic diagno
274 -TCD (P<0.001), high-intensity myeloablative conditioning regimens used in cohort 1 (P = 0.02), and m
276 ndergone transplantation after pretransplant conditioning regimen using plasmapheresis and/or intrave
277 y have been performed with reduced intensity conditioning regimens using unmanipulated peripheral blo
279 ut not recipient age or the intensity of the conditioning regimens, was the most important factor inf
280 o reduce or eliminate total body irradiation conditioning regimens, we have sought to develop canine
285 onfounding variables, such as donor type and conditioning regimen, were included in a multivariate re
286 pment of nonmyeloablative or "low-intensity" conditioning regimens, which have expanded the applicati
287 osis) who received an alemtuzumab-containing conditioning regimen who developed autoimmune cytopenias
288 he use of a mobilized blood cell graft and a conditioning regimen with > 450 cGy total body irradiati
289 or acute leukemia underwent an experimental conditioning regimen with 10 doses of total lymphoid irr
290 In this study, we tested a radiation-free conditioning regimen with a T-cell-depleted graft to eli
291 ute myeloid leukemia patients receiving this conditioning regimen with age and disease risk index-mat
293 rary controls (n = 22) who received the same conditioning regimen with sirolimus and mycophenolate mo
295 TGF-beta-generating recipient Tregs after a conditioning regimen with total body irradiation and led
297 linical outcome using this approach requires conditioning regimens with total body irradiation, lymph
298 arrow ablation have been superseded by safer conditioning regimens, with occasional complete remissio
299 kemia), from a matched family donor, after a conditioning regimen without irradiation, the latter inc
300 mab (4/25), 1.9% for ATG (2/102), and 0% for conditioning regimens without lympho-depleting antibodie
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