ライフサイエンスコーパス: conduction system

1 d embryonic specification of the ventricular conduction system.

2 ex-to-base conduction after emergence of the conduction system.

3 ex network of specialized cells: the cardiac conduction system.

4 to direct distinct functions of the cardiac conduction system.

5 is required for specification of the cardiac conduction system.

6 lar tachycardia (VT) originating high in the conduction system.

7 tention of embryonic cardiac myocytes in the conduction system.

8 different effects of these treatments on the conduction system.

9 ting the critical role of Slc26a6 in cardiac conduction system.

10 in development and maturation of the cardiac conduction system.

11 he atrioventricular bundle and bundle branch conduction system.

12 evelopment of the relevant structures in the conduction system.

13 e reflect a developmental abnormality of the conduction system.

14 onsistent with a recruitment of cells to the conduction system.

15 omyocytes to differentiate into cells of the conduction system.

16 etal muscles, major tendons, and the cardiac conduction system.

17 ialized cells in the sinoatrial node and the conduction system.

18 ene are indeed components of the specialized conduction system.

19 1 years) to assess its effects on the AP and conduction system.

20 n of pacemaking impulses through the cardiac conduction system.

21 nsmitted from Purkinje fibers of the cardiac conduction system.

22 than with other, more distal elements of the conduction system.

23 ning patterning and induction of the central conduction system.

24 n through specialized tissues of the cardiac conduction system.

25 for survival and is regulated by the cardiac conduction system.

26 t as a myocardial tube without a specialized conduction system.

27 rm mRNA is also expressed in the rat cardiac conduction system.

28 ng formation of the myocardial walls and the conduction system.

29 ntricular myocytes, and cells of the cardiac conduction system.

30 roliferation of working myocytes but not the conduction system.

31 tivate transcription in the atrioventricular conduction system.

32 l the precise pattern of Tbx3 in the cardiac conduction system.

33 lized myocytes of the impulse generation and conduction system.

34 fication to development of the valve and the conduction system.

35 3 in development and function of the cardiac conduction system.

36 that plays an important role in the cardiac conduction system.

37 d in epidermal keratinocytes and the cardiac conduction system.

38 iomyocytes known collectively as the cardiac conduction system.

39 pression mainly is restricted to the cardiac conduction system.

40 d specifically in the cardiac pacemaking and conduction system.

41 um during the development of the specialized conduction system.

42 r and atrial myocardium, and the specialized conduction system.

43 lated ion channel dysfunction on the cardiac conduction system.

44 s that originate from defects in the cardiac conduction system.

45 ing, maturation, and function of the cardiac conduction system.

46 ciency causes apoptosis, particularly in the conduction system.

47 mechanisms that control the formation of the conduction system.

48 ts in the atrioventricular and bundle branch conduction systems.

49 ur histological examination of their cardiac conduction systems.

50 l that connexin40 (Cx40) is prominent in the conduction system [4].

51 and X-linked dilated cardiomyopathy, whereas conduction system abnormalities that cause heart block,

52 m recordings in Mybphl mice revealed cardiac conduction system abnormalities with aberrant atrioventr

53 eduction, extent of myocardial necrosis, and conduction system abnormalities with each technique were

54 mice demonstrated structural and functional conduction system abnormalities, including left bundle b

55 malian ventricles that includes the Purkinje conduction system and 214 PMJs distributed throughout th

56 vide insight into development of the cardiac conduction system and accessory pathways.

57 and had normal specification of the cardiac conduction system and apparently normal electrocardiogra

58 compound heterozygous mutant mice and found conduction system and cardiac output defects.

59 est genetic heterogeneity within the central conduction system and coronary smooth muscle.

60 o the electrophysiological properties of the conduction system and govern contraction of the surround

61 g migrating neural crest, the origins of the conduction system and initial embryonic heartbeat, and t

62 lmonary bypass, intraoperative injury to the conduction system and myocardium, postoperative metaboli

63 er of Nkx2.5 in the maintenance of the adult conduction system and rescue of Nkx2.5 conduction diseas

64 tribute to the mature valves and the cardiac conduction system and retain multipotent characteristics

65 imensional relationships between the cardiac conduction system and surrounding structures, we provide

66 r role in the development of the ventricular conduction system and that electrical propagation across

67 include normal morphogenesis of the cardiac conduction system and the normal postnatal involution of

68 , is preferentially expressed in the cardiac conduction system and ventricular myocytes in the heart.

69 iology and development of the murine cardiac conduction system and will also serve as a baseline for

70 sis and ultimately lead to scar of the fetal conduction system and working myocardium.

71 Tbx5 and Gata4 for proper expression in the conduction system, and Gata4(+/-) mice have short PR int

72 , radiation can damage the heart valves, the conduction system, and pericardium, which may take years

73 r Cx40-independent patterning of the cardiac conduction system, and suggest that the electrophysiolog

74 o the heart muscle tissue, the pacemaker and conduction system, and the coronary vasculature is a cen

75 complex between cardiac myocytes, the heart conduction system, and the NMJ.

76 study, is expressed in the mouse ventricular conduction system, and treatment with a selective SCN10A

77 nital heart disease patients presenting with conduction system anomalies and recent genome-wide assoc

78 Although pathologies of this specialized conduction system are common in humans, especially among

79 hile it has been shown that the cells of the conduction system are derived from myocytes, additional

80 elopment, maturation, and maintenance of the conduction system are not well understood.

81 The heterogeneous cell types of the cardiac conduction system are responsible for coordinating and m

82 A-V node and the His-Purkinje regions of the conduction system are specifically compromised by DMPK l

83 histological abnormalities of their cardiac conduction systems are best interpreted as resulting fro

84 m (e.g. the nodes and bundles of the central conduction system) are controversial, with some proposin

85 ave suggested that components of the cardiac conduction system arise from progressive recruitment of

86 urkinje fibers of the peripheral ventricular conduction system arise from working myocytes during car

87 tricular chamber properties, the ventricular conduction system, as well as heterogeneity of the ventr

88 nt to direct expression to the developing AV conduction system (AVCS).

89 ancer elements in skeletal muscle and in the conduction system but not in cardiac muscle.

90 ession of SCN5A and formation of the cardiac conduction system, but its absence does not cause baseli

91 Nkx2-5 mutations are associated with cardiac conduction system (CCS) defects.

92 veral transcription factors regulate cardiac conduction system (CCS) development and function but the

93 ellular electrical activity, altered cardiac conduction system (CCS) development, and increased arrhy

94 Cardiac conduction system (CCS) disease, which results in disrup

95 lso leads to increased expression of cardiac conduction system (CCS) genes Tbx5, Cx40, and Cx43 throu

96 resulting from abnormalities in the cardiac conduction system (CCS).

97 ts in the transition between ventricular and conduction system cell lineages.

98 cells differentiated into cardiomyocytes and conduction system cells.

99 te to all CNC derivatives, including cardiac conduction system cells.

100 s to convert contractile cardiomyocytes into conduction-system cells as measured by ectopic reporter

101 The cardiac conduction system comprises a specialized tract of elect

102 The cardiac conduction system coordinates electrical activation thro

103 Remnants of the developing specialized conduction system could be the underlying substrate of t

104 Conduction system defects and slowed ventricular conduct

105 hypertrophy, ventricular pre-excitation and conduction system defects coexist.

106 findings of reduced ventricular function and conduction system defects in Mybphl mice support that MY

107 get of Tbx5, did not account for morphologic conduction system defects in Tbx5(del/+) mice.

108 n cardiac death and a complete penetrance of conduction system defects, including spontaneous ventric

109 potential explanation for Holt-Oram syndrome conduction system defects, suggest mechanisms for intraf

110 ants with potential structural or functional conduction system defects.

111 yopathies may also be accompanied by cardiac conduction-system defects that affect the atrioventricul

112 lectrical pathways but not cardiomyopathy or conduction system degeneration.

113 rdiomyopathy, ventricular preexcitation, and conduction system degeneration.

114 of these gene regulatory networks in cardiac conduction system development and discusses how they pro

115 he molecular circuitry controlling mammalian conduction system development and should be invaluable i

116 ased on the current understanding of cardiac conduction system development and the observation that a

117 atively little is known about the process of conduction system development in mammalian species, espe

118 he role of Endothelin signaling in mammalian conduction system development is less clear, and the dev

119 portant differences between murine and avian conduction system development.

120 icating minK expression as an early event in conduction system development.

121 The murine conduction system develops in close association with the

122 Purkinje fibers of the cardiac conduction system differentiate from heart muscle cells

123 familial syndrome of atrial tachyarrhythmia, conduction system disease (CSD), and DCM vulnerability.

124 tions in LMNA is dilated cardiomyopathy with conduction system disease (DCM-CD1).

125 ac clinical history or prevalence of cardiac conduction system disease (PEA, 31.6% versus VF, 32.2%;

126 al lupus include anti-SSA/Ro-SSB/La-mediated conduction system disease and endocardial/myocardial dam

127 echanical dissociation, or indicating severe conduction system disease eventually leading to complete

128 In-utero management of tachyarrhythmias and conduction system disease has improved postnatal outcome

129 y with dilated cardiomyopathy and associated conduction system disease in whom prior clinical cardiac

130 In addition, the patient developed cardiac conduction system disease requiring pacing at the age of

131 The outcome of fetal conduction system disease secondary to maternal Sjogren'

132 essive ECG monitoring strategies looking for conduction system disease should be ongoing in all patie

133 with long QT syndrome, Brugada syndrome, and conduction system disease with deletion of lysine 1500 (

134 2 causing Wolff-Parkinson-White syndrome and conduction system disease with onset in childhood and th

135 lamin A/C loci associated with familial AF, conduction system disease, and dilated cardiomyopathy.

136 atic patients, the course is malignant, with conduction system disease, atrial fibrillation, heart fa

137 the long-QT syndrome, Brugada syndrome, and conduction system disease, have been associated with het

138 n involving multiple accessory pathways, and conduction system disease, including sinus and atriovent

139 on, which leads to glycogen accumulation and conduction system disease.

140 syndrome (WPW) and progressive degenerative conduction system disease.

141 ar dystrophy and cardiomyopathy with cardiac conduction system disease.

142 ld lead to improved diagnosis and therapy of conduction system disease.

143 MD (EDMD-AD) and dilated cardiomyopathy and conduction-system disease (CMD1A).

144 Each mutation caused heritable, progressive conduction-system disease (sinus bradycardia, atrioventr

145 s responsible for dilated cardiomyopathy and conduction-system disease are observed in the rod domain

146 utosomal dominant dilated cardiomyopathy and conduction-system disease on chromosome 1p1-q21, where n

147 electively cause dilated cardiomyopathy with conduction-system disease or autosomal dominant Emery-Dr

148 er involving dilated cardiomyopathy, cardiac conduction-system disease, and adult-onset limb-girdle m

149 (EDMD-AD) and in dilated cardiomyopathy and conduction-system disease.

150 utosomal dominant dilated cardiomyopathy and conduction-system disease.

151 oncompaction, which is often associated with conduction system diseases.

152 vents in the absence of skeletal myopathy or conduction system disorders.

153 c death, and absence of skeletal myopathy or conduction system disorders.

154 rt, calcification of cardiac muscle leads to conduction system disturbances and is one of the most co

155 ogether, these data suggest that the cardiac conduction system does not develop by outgrowth from a p

156 ly engraft at high levels in the ventricular conduction system during fetal development in sheep.

157 wever, cells labeled in the proximal cardiac conduction system exhibited neurogenic and gliagenic mar

158 in altered myocyte action potential and mild conduction system expansion but does not alter conductio

159 Specifically, all levels of the conduction system expressed alpha3 immunoreactive protei

160 tes the developing and mature murine cardiac conduction system, extending proximally from the sinoatr

161 ons cause cardiac sudden death syndromes and conduction system failure.

162 effect of septal reduction therapies on the conduction system for patients with hypertrophic cardiom

163 ing the regulatory networks that orchestrate conduction system formation and their role in cardiac rh

164 lysis of the molecular mechanisms underlying conduction system formation should inform our understand

165 lly, the ability to distinguish cells of the conduction system from neighboring working myocytes pres

166 a role in AV node formation, we investigated conduction system function and AV node morphology in adu

167 Thus, our results implicate Gata4 in conduction system function and provide a clearer underst

168 Although several genes involved in mature conduction system function have been identified, their a

169 nduction system expansion but does not alter conduction system function or promote spontaneous arrhyt

170 techniques for evaluating in vivo embryonic conduction system function.

171 In Nkx2-5 haploinsufficiency, the conduction system has half the normal number of cells.

172 involved in regional differentiation of the conduction system has provided insight into how lineage

173 of Tbx3 in adults reveal its requirement for conduction system homeostasis.

174 elopment, maturation, and homeostasis of the conduction system in a highly dosage-sensitive manner.

175 ss clear, and the development of the cardiac conduction system in mice lacking Endothelin signaling h

176 we assessed the specification of the cardiac conduction system in mouse embryos lacking all Endotheli

177 ly evaluated the effects of ibutilide on the conduction system in patients with accessory pathways (A

178 d the presence of the developing specialized conduction system in the MA-Ao region starting at embryo

179 he electrophysiologic characteristics of the conduction system in these patients with PJRT, particula

180 birth with hyperplastic working myocytes and conduction system including two nodes and internodal tra

181 Cells of the conduction system, including Purkinje fibers, terminally

182 hat Tbx5 is expressed throughout the central conduction system, including the atrioventricular bundle

183 escent reporter gene in cells of the cardiac conduction system, including the distal Purkinje fiber n

184 Components of the murine conduction system, including the peripheral Purkinje fib

185 Development of the cardiac conduction system is a complex biological process that c

186 The cardiac conduction system is a complex network of cells that tog

187 The cardiac conduction system is a network of cells responsible for

188 The cardiac conduction system is a specialized tract of myocardial c

189 The cardiac conduction system is an anatomically discrete segment of

190 mice that the number of cells in the cardiac conduction system is directly related to Nkx2-5 gene dos

191 topological shift marking maturation of the conduction system is sensitive to variation in hemodynam

192 es is controlled by the terminal part of the conduction system known as the Purkinje fiber network.

193 dial-specific CHF1/Hey2-KO mice with cardiac conduction system LacZ reporter mice and stained for con

194 of ventricular myocytes into the ventricular conduction system lineage.

195 le exit of specified cardiomyocytes toward a conduction system lineage.

196 ngenital heart diseases that include cardiac conduction system malformations.

197 isoform-specific antibodies and histological conduction system markers.

198 preserved expression of previously described conduction system markers.

199 nd T-box proteins, are essential for cardiac conduction system morphogenesis and activation or repres

200 insufficiency caused a maturation failure of conduction system morphology and function.

201 ll lineage specification into trabecular and conduction system myocytes is a new mechanistic pathway

202 Martin Flack and Arthur Keith studied the conduction system of a mole and found a structure in the

203 ion of conduction defects in the specialized conduction system of Cx40(-/-) mice and provide new insi

204 gnaling connects a sagittally-oriented, fast-conduction system of the deep layers with the transverse

205 umentation of amyloid deposits involving the conduction system of the heart.

206 ols for generation and isolation of specific conduction system precursors.

207 ly differentiates as cells of the peripheral conduction system (Purkinje fibers) and that this occurs

208 ther AF variants have diverse effects on the conduction system, ranging from none to extensive.

209 e, we assessed the genome-wide occupation of conduction system-regulating transcription factors TBX3,

210 ent of specific subcomponents of the cardiac conduction system remains challenging.

211 oral patterning of Hcn4 expression in the AV conduction system required cis-regulatory elements with

212 t expression of a unique panel of atrial and conduction system-restricted target genes, as well as th

213 potential characteristics of the specialized conduction system (SCS).

214 The cardiac pacemaking and conduction system sets and maintains the rhythmic pumpin

215 ike phenotype based on ectopic expression of conduction system-specific genes and cell autonomous cha

216 Conduction-system-specific expression for Id2, a member

217 gulation by Nkx2-5 and Tbx5 in vitro and for conduction-system-specific gene expression in vivo.

218 ed cells incorporated within any part of the conduction system suggest that such cells share closer l

219 In the ventricular conduction system, Tbx5 haploinsufficiency caused patter

220 escribe a novel marker of the murine cardiac conduction system that identifies this specialized netwo

221 he AV junction region contains a specialized conduction system that is anatomically isolated from ord

222 explore early steps in the patterning of the conduction system that previously have been inaccessible

223 or specification and function of the cardiac conduction system, this work has important implications

224 on system LacZ reporter mice and stained for conduction system tissue.

225 selectively in either cardiomyocytes or the conduction system to achieve cell type-specific, noninva

226 dings indicate that Tbx3 is required for the conduction system to establish and maintain its correct

227 it appears that different components of the conduction system utilize unique modes of developmental

228 atrial myocardium (PAM) and the ventricular conduction system (VCS) and is essential for maintaining

229 n of Tbx5 from the mature murine ventricular conduction system (VCS), including the AV bundle and bun

230 that is coexpressed with Cx45 in the cardiac conduction system was posttranscriptionally reduced by 7

231 lecular composition of the mouse ventricular conduction system we used microdissection and transcript

232 on delineates the embryonic and fully mature conduction system, we tested the ability of several endo

233 mprise the main gap junctions in the SAN and conduction system, were unchanged by TBX18.

234 t of macrophages residing within the cardiac conduction system, which orchestrates cardiac rhythm.

235 3-dimensional representations of the cardiac conduction system within the intact human heart.