ライフサイエンスコーパス: cone photoreceptor

1 zyme in visual excitation pathway in rod and cone photoreceptors.

2 cells, and horizontal cells rather than into cone photoreceptors.

3 ondarily to the non-cell autonomous death of cone photoreceptors.

4 put from short wavelength-sensitive ("blue") cone photoreceptors.

5 ) channels regulate Ca(2+) influx in rod and cone photoreceptors.

6 rized by the degeneration of retinal rod and cone photoreceptors.

7 ds and their most closely related cell type, cone photoreceptors.

8 nctional differences between retinal rod and cone photoreceptors.

9 oth alpha-subunit genes expressed in rod and cone photoreceptors.

10 leads to the premature death of both rod and cone photoreceptors.

11 y, by phototransduction signaling in rod and cone photoreceptors.

12 glion cells that also receive input from rod-cone photoreceptors.

13 tric measure of light intensity relevant for cone photoreceptors.

14 (2)(+) dynamics and their (dys)regulation in cone photoreceptors.

15 tional view that mammalian HBCs only contact cone photoreceptors.

16 also act locally at the level of individual cone photoreceptors.

17 ns, which form direct synaptic contacts with cone photoreceptors.

18 ffecting the density of their afferents, the cone photoreceptors.

19 lpha-tubulin (tdEOS-tubulin) specifically in cone photoreceptors.

20 Prominin-1 expresses in rod and cone photoreceptors.

21 segments, cell bodies, and axons of rod and cone photoreceptors.

22 ogically by progressive loss of rod and then cone photoreceptors.

23 al model to develop gene therapy directed to cone photoreceptors.

24 rection allows for routine imaging of foveal cone photoreceptors.

25 d for the proper functioning and survival of cone photoreceptors.

26 is understood regarding the role of AIPL1 in cone photoreceptors.

27 hibits complete degeneration of both rod and cone photoreceptors.

28 jection for in vivo delivery of retinoids to cone photoreceptors.

29 tinas, which represent an enriched source of cone photoreceptors.

30 ve disorders that solely or primarily affect cone photoreceptors.

31 induced proliferation or the regeneration of cone photoreceptors.

32 ZBED4 mRNA was found to be present in cone photoreceptors.

33 rd early adequate delivery of chromophore to cone photoreceptors.

34 gh-resolution daylight vision is mediated by cone photoreceptors.

35 developed retinal abnormalities and loss of cone photoreceptors.

36 d is critical for the health of both rod and cone photoreceptors.

37 rest the progressive degeneration of rod and cone photoreceptors.

38 or no effect on the survival and function of cone photoreceptors.

39 are extremely long-lived proteins in rod and cone photoreceptors.

40 cover accurate input pathways from surviving cone photoreceptors.

41 biochemical and functional role of CNGB3 in cone photoreceptors.

42 ion/amacrine cells at the expense of rod and cone photoreceptors.

43 n the visual transduction cascade in rod and cone photoreceptors.

44 NGA3 ACHM for clinical trials for therapy of cone photoreceptors.

45 the retinal circuit is provided primarily by cone photoreceptors acting as band-pass filters, but the

46 sitive, but also receive inputs from rod and cone photoreceptors, acting as the primary sensory condu

47 The retina contains cone photoreceptors and ganglion cells that contain the

48 and functionally distinct from classical rod/cone photoreceptors and have unique properties, includin

49 Sall3 is prominently expressed in developing cone photoreceptors and horizontal interneurons of the m

50 to be present only in the outer segments of cone photoreceptors and may correspond to a homotrimer o

51 dings demonstrate nonredundant roles for rod-cone photoreceptors and melanopsin in mediating pupillar

52 ut of Gnb3 in mice results in dysfunction of cone photoreceptors and ON-bipolar cells and a naturally

53 Expressed in cone photoreceptors and ON-bipolar cells, Gbeta3 is esse

54 synaptic contact with both L/M as well as S-cone photoreceptors and only minimal contact with rod ph

55 uronal pathways process signals from rod and cone photoreceptors and support vision over a wide range

56 ith an expression pattern that covaried with cone photoreceptors and that was differentially expresse

57 of complete functional connectivity between cone photoreceptors and the four major types of ganglion

58 t regulates terminal differentiation of both cone photoreceptors and their postsynaptic partners.

59 nal synapse by signaling between the rod and cone photoreceptors and two general classes of bipolar c

60 e, visual stimulation targeted at individual cone photoreceptors, and a hierarchical computational mo

61 mong different cell classes, as with rod and cone photoreceptors, and adapt by shifting their dynamic

62 e rd1 mutation also prolongs the survival of cone photoreceptors, and partially restores visual funct

63 ral architecture of the visual system inputs-cone photoreceptors-and visual perception and have impli

64 icanthis niloticus) has a high proportion of cone photoreceptors ( approximately 30-40%) compared wit

65 Strips of cone photoreceptors, approximately 12 degrees x 1.8 degr

66 nowing how signals from the three classes of cone photoreceptor are combined in the cortex.

67 Cone photoreceptors are assembled by unknown mechanisms

68 In old world primates including humans, cone photoreceptors are classified according to their ma

69 Rod and cone photoreceptors are coupled by gap junctions (GJs),

70 he elephantnose fish (Gnathonemus petersii), cone photoreceptors are grouped together within reflecti

71 Rod and cone photoreceptors are highly similar in many respects

72 ng cone, cone-rod, and macular dystrophies), cone photoreceptors are more severely affected than rods

73 electroretinogram responses of both rod and cone photoreceptors are normal in knockout mice at 1 mon

74 Cone photoreceptors are the primary initiator of visual

75 In bright light, cone-photoreceptors are active and colour vision derives

76 Retinal rod and cone photoreceptors arguably represent the best-understo

77 sult of testing-induced damage to the rod or cone photoreceptors, as ERG amplitudes and ONL thickness

78 sents evidence regarding the role of rod and cone photoreceptors, as well as the role of recently dis

79 e immunostained with antibodies specific for cones photoreceptors, bipolar cells, mitochondria, Mulle

80 Vertebrate rod and cone photoreceptors both release vesicles at synaptic ri

81 sis with its accumulation and aggregation in cone photoreceptors but without proteostatic impairment

82 hotoentrainment can be maintained by rod and cone photoreceptors, but their functional contributions

83 lase isozymes (RetGC1 and RetGC2) in rod and cone photoreceptors by calcium-sensitive guanylyl cyclas

84 a unique and stereotypic wiring pattern with cone photoreceptors by gaining synapses with specific ph

85 In vertebrate cone photoreceptors, Ca(2+) controls photoresponse sensi

86 as performed in combination with markers for cone photoreceptors (calbindin, XAP-1) and ON bipolar ce

87 Cone photoreceptors carry out phototransduction in dayli

88 Stat3 and Ascl1a proteins following rod and cone photoreceptor cell apoptosis.

89 roid and retinal pigmented epithelium, early cone photoreceptor cell death, and reduced lengths of ro

90 a leucine zipper) is critical for rod versus cone photoreceptor cell fate choice during retinal devel

91 ranscription factor that dictates rod versus cone photoreceptor cell fate in the mammalian retina.

92 te-induced cell death in 661W cells, a mouse cone photoreceptor cell line, shown to express both estr

93 In addition, there was a reduction in cone photoreceptor cell number and cone b-wave amplitude

94 PE65 and raised in constant dark have higher cone photoreceptor cell number, improved cone opsin loca

95 phodiesterase gene Pde6beta and lose rod and cone photoreceptor cells (PRC) within the first 6 wk of

96 nterneurons that receive synaptic input from cone photoreceptor cells and provide the output of the f

97 inal tumor that expresses several markers of cone photoreceptor cells has been described earlier.

98 hotoactivation of visual pigments in rod and cone photoreceptor cells of the retina.

99 vide additional visible light to the rod and cone photoreceptor cells, and thereby improve the visual

100 Muller cells and maintenance of some rod and cone photoreceptor cells, as identified by vimentin, rec

101 To understand the importance of AIPL1 in cone photoreceptor cells, we transgenically expressed hA

102 middle to long wavelength-sensitive (M/LWS) cone photoreceptor cells.

103 e regeneration of visual pigments in rod and cone photoreceptor cells.

104 itive to loss of insm1a expression than were cone photoreceptor cells.

105 e under conditions that fully bleach rod and cone photoreceptor cells.

106 rdigitate with the outer segments of rod and cone photoreceptor cells.

107 Cone photoreceptors cells can use 11-cis-retinal from th

108 S) and medium/long-wavelength-sensitive (ML) cone photoreceptor classes.

109 dle (M)-, and short (S)-wavelength-sensitive cone photoreceptors combine antagonistically to produce

110 counting indicated relatively long surviving cone photoreceptors compared to rods.

111 investigated how the glutamatergic output of cone photoreceptors (cones) in the mouse retina is shape

112 s in expanded dendritic fields and increased cone photoreceptor contacts, demonstrating that DSCAM ac

113 topigment molecule in ipRGCs, as well as rod/cone photoreceptors, contains 11-cis-retinal (a vitamin

114 om several mammalian species with varied rod/cone photoreceptor content identified 18 lincRNAs that w

115 Vegfa in maintaining choroid vasculature and cone photoreceptors, critical for central and color visi

116 Precursor mRNA encoding CNGA3 subunits of cone photoreceptor cyclic nucleotide-gated (CNG) channel

117 The cone photoreceptor cyclic nucleotide-gated (CNG) channel

118 Cone photoreceptor cyclic nucleotide-gated (CNG) channel

119 rly rod death, followed by a slower phase of cone photoreceptor death.

120 ortunity to preserve daylight vision, as the cone photoreceptors degenerate more slowly than do the r

121 In addition, the cone photoreceptors degenerate, but at a slower rate com

122 VAD and Rpe65(-)/(-) mice are different in cone photoreceptor degeneration, photoreceptor-specific

123 Neither ligand altered cone photoreceptor densities.

124 The function of cone photoreceptors depends upon the formation and maint

125 tion and synaptic noise generated in retinal cone photoreceptors determine the fidelity with which li

126 Visual acuity deteriorates rapidly once the cone photoreceptors die, as these cells provide daylight

127 rate rod and medium wavelength-sensitive (M) cone photoreceptors differentiate by repression of a sho

128 rophthalmic and displayed defects in rod and cone photoreceptor differentiation.

129 In this study, the primary cone photoreceptor disorder achromatopsia served as the

130 New cone photoreceptors displayed unambiguous morphological

131 (HIP) that expresses the p53 gene in rod and cone photoreceptors driven by the human interphotorecept

132 from the cytoskeletal scaffold of zebrafish cone photoreceptors during development.

133 utosomal recessive disorder characterized by cone photoreceptor dysfunction.

134 in humans have recently been associated with cone photoreceptor dystrophy, while mouse models carryin

135 At the first stage, rod and cone photoreceptors encode light and communicate with a

136 sducin, cGMP-gated channel, and red opsin of cone photoreceptors (equivalent to rhodopsin of rod phot

137 scription factor Tbx2b, but might also block cone photoreceptor fate.

138 In the retina, rod and cone photoreceptors form distinct connections with diffe

139 lso provide support that partially preserves cone photoreceptors from rapid death in the absence of A

140 t was distributed at the PMC in both rod and cone photoreceptors from the central to peripheral retin

141 l, we identify a critical role of miR-211 in cone photoreceptor function and survival.

142 o unravelling the role of specific miRNAs in cone photoreceptor function and survival.

143 a demonstrate that Cacna1fa is essential for cone photoreceptor function and synaptic ribbon formatio

144 egenerations (IRDs) preferentially affecting cone photoreceptor function are being considered for tre

145 efficient pigment regeneration required for cone photoreceptor function in bright light.

146 l of these explanations imply that decreased cone photoreceptor function is possible, suggesting that

147 1)), retinal degeneration 8 (Crb1(rd8)), and cone photoreceptor function loss 3 (Gnat2(cpfl3)).

148 al amaurosis (LCA) with rapid cone loss] and cone photoreceptor function loss type 1 mice (severe rec

149 ity in retinol isomerase RPE65-deficient and cone photoreceptor function loss type 1 mice increased a

150 In patients with RP, preserved cone photoreceptor function measured by mfERG amplitude

151 Both rod and cone photoreceptor function were greater in treated (thr

152 he critical role of Elovl4 for proper rod or cone photoreceptor function.

153 going apoptosis and compromised both rod and cone photoreceptor function.

154 etinography (ERG) was used to assess rod and cone photoreceptor function.

155 Cone photoreceptors function under daylight conditions a

156 time- and dose-dependent declines in rod and cone photoreceptor functions as early as 120 days of age

157 enes covaried with multiple genes within the cone photoreceptor gene network.

158 nerate a coexpression network of established cone photoreceptor genes as a reference standard.

159 In mutant dogs, rod and cone photoreceptors have a sensory cilium, but develop a

160 The light responses of rod and cone photoreceptors have been studied electrophysiologic

161 mination of the alternative roles of Grk1 in cone photoreceptor homeostasis.

162 um (RPE) supplies 11-cis-RAL to both rod and cone photoreceptors; however, stringent demands imposed

163 can be probed at the level of the individual cone photoreceptor in living eyes.

164 Cone photoreceptors in 40 eyes of 20 subjects aged 19-29

165 ological and anatomic rescue of both rod and cone photoreceptors in a preclinical model of RP.

166 rs are able to efficiently transduce rod and cone photoreceptors in addition to retinal pigment epith

167 olarized distribution of Crumbs2a protein in cone photoreceptors in both unperturbed and regenerated

168 regeneration is critical for the function of cone photoreceptors in bright and rapidly-changing light

169 visual system is the continuous function of cone photoreceptors in bright daylight.

170 cal for the continuous function of mammalian cone photoreceptors in daylight vision.

171 In this study, selective ablation of cone photoreceptors in live mouse retina and tracking of

172 Relatively retained rod and cone photoreceptors in mid- and far-peripheral temporal-

173 periodic, almost crystalline distribution of cone photoreceptors in the adult teleost fish retina.

174 function and visual behavior and preserving cone photoreceptors in the GC1 knockout (GC1KO) mouse fo

175 us and specific expression of p53 in rod and cone photoreceptors in the mature retinas of HIP mice le

176 ation: early dysfunction and loss of rod and cone photoreceptors in the outer retina and, progressive

177 tina that convey visual signals from rod and cone photoreceptors in the outer retina to higher-order

178 esult in dysfunction and/or death of rod and cone photoreceptors in the retina.

179 on of the visual pigment by light in rod and cone photoreceptors initiates our visual perception.

180 te how inner retinal circuitry mediating rod-cone photoreceptor input contributes to functionally dis

181 These findings suggest that cone photoreceptor inputs shape bandpass filtering in bi

182 d cone-rod dystrophy, which primarily affect cone photoreceptors instead of rods.

183 retina, depend on signals from both rod and cone photoreceptors, interactions occurring in retinal c

184 first decomposes the outputs of the rod and cone photoreceptors into approximately 12 parallel infor

185 layers away from the fovea, migration of the cone photoreceptors into the fovea, and elongation of th

186 c disorder of color vision where one type of cone photoreceptor is missing.

187 sitivity of cGMP-gated (CNG) ion channels in cone photoreceptors is modulated by CNG-modulin, a Ca(2+

188 In the human, cone photoreceptors (L, M, and S) and the melanopsin-con

189 nted the long- and mid- wavelength sensitive cone photoreceptors (L- and M-cones) from adapting.

190 *-HA) expression rescues the degeneration of cone photoreceptors lacking Ranbp2.

191 e of foveal hypoplasia and disruption of the cone photoreceptor layer.

192 In retinitis pigmentosa, loss of cone photoreceptors leads to blindness, and preservation

193 Cone photoreceptor length and the thickness of intrareti

194 l bodies of red-, green-, and blue-sensitive cone photoreceptors localized asymmetrically on the cell

195 Cross-sectional imaging showed foveal cone photoreceptor loss with a ring of minimally preserv

196 intrinsic to vertebrate vision where rod and cone photoreceptors mediate dim- and bright-light vision

197 Retinal cone photoreceptors mediate fine visual acuity, daylight

198 As cone photoreceptors mediate vision in bright light, thei

199 CRALBP, encoded by RLBP1) can lead to severe cone photoreceptor-mediated vision loss in patients.

200 etermined if treatment with HDACi can rescue cone photoreceptor-mediated visual function.

201 current makes the light response of rod and cone photoreceptors more transient, an effect similar to

202 has sought to evaluate the integrity of the cone photoreceptor mosaic in four patients previously de

203 (AOSLO) enables direct visualization of the cone photoreceptor mosaic in the living human retina.

204 bute substantially to the reflectance of the cone photoreceptor mosaic.

205 blems.Digital micrographs were obtained from cone photoreceptor mosaics visualized by anti-opsin immu

206 We created mice lacking RDH10 either in cone photoreceptors, Muller cells, or the entire retina.

207 Rod and cone photoreceptor neurons utilize discrete PDE6 enzymes

208 riking example is the apical localization of cone photoreceptors nuclei at the outer edge of the oute

209 s the genetic sources of marked variation in cone photoreceptor number among inbred lines of mice, id

210 The mouse retina shows marked variation in cone photoreceptor number, some of which must be control

211 ates the cGMP sensitivity of the channels in cone photoreceptors of striped bass (Morone saxatilis).

212 ssion of visual pigment proteins (opsins) in cone photoreceptors of the retina.

213 We report here a mechanism whereby zebrafish cone photoreceptors of the same type are produced by sym

214 us laevis ortholog of prominin-1, in rod and cone photoreceptors of this frog.

215 d and localized in outer segments of rod and cone photoreceptors of X. laevis.

216 e sustained delivery of retinoids to rod and cone photoreceptors of young mice lacking a normal suppl

217 The classical rod and cone photoreceptors, on the other hand, mediate image vi

218 rily due to the lack of a unified concept of cone photoreceptor organization and its role in retinal

219 odel recapitulates many observed features of cone photoreceptor organization during retinal growth an

220 s down the cause of acute vision loss to the cone photoreceptor outer segment and will refocus the se

221 zebrafish consisting of disorganized rod and cone photoreceptor outer segments resulting in abnormal

222 ntricity, with the two groups having similar cone photoreceptor packing densities beyond 0.5 mm retin

223 We evaluated the relationship between cone photoreceptor packing density and outer nuclear lay

224 A) was used to calculate the interaction for cone photoreceptor packing density between age, meridian

225 eridional difference in cone densities, with cone photoreceptor packing density decreasing faster wit

226 eceptors within the strips were counted, and cone photoreceptor packing density was calculated.

227 As expected, cone photoreceptor packing density was higher close to t

228 Cone photoreceptor populations were counted in C57BL/6J

229 Retinoblastomas can arise from cone photoreceptor precursors in response to the loss of

230 ntal cells and an increase in the numbers of cone photoreceptor precursors.

231 The ability to directly assess cone photoreceptor preservation with SD-OCT and/or adapt

232 opment of HC dendrites and triad synapses of cone photoreceptors proceeds normally in the absence of

233 complex consists of four cell types (rod and cone photoreceptors, projection neurons and parapineal n

234 Rod and cone photoreceptor (R(ROD), S(ROD), R(CONE), S(CONE)) an

235 erior pineal complex anlage differentiate as cone photoreceptors rather than parapineal neurons.

236 es in light-evoked responses between rod and cone photoreceptors remains unclear.

237 ures by using intermittent light to activate cone photoreceptors repeatedly in humans.

238 Hz) for 30 min, which was given to activate cone photoreceptors repeatedly, elicited sustained pupil

239 on are initiated in rod and several types of cone photoreceptors, respectively; these photoreceptors

240 Electroretinograms revealed abnormal cone photoreceptor responses from wud mutants, indicatin

241 ave revealed that loss of SynJ1 also affects cone photoreceptor ribbon synapses, causing pronounced m

242 specifically investigate the development of cone photoreceptor ribbon synapses.

243 illing of a depleted vesicle release pool at cone photoreceptor ribbons is 0.7-1.1 s.

244 stent with this, short- wavelength sensitive cone photoreceptors (S-cones) did not show the adaptive

245 Noise in the responses of cone photoreceptors sets a fundamental limit on visual s

246 enes expressed in mutant rod or both rod and cone photoreceptors show significant downregulation, whi

247 In cone photoreceptors, similar to bipolar cells, fusion of

248 ffects of RetGC1 deficiency on human rod and cone photoreceptor structure and function are currently

249 common mechanism that controls both rod and cone photoreceptor subtype specification, regulating dis

250 d an unaltered distribution of the different cone photoreceptor subtypes upon Pde6h ablation.

251 Rod and cone photoreceptors support vision across large light in

252 d opsin expression provided enhanced rod and cone photoreceptor survival and function, as measured by

253 The effects of aging and light exposure on cone photoreceptor survival were compared between mouse

254 ed retinal degeneration, and their effect on cone photoreceptor survival, we generated an Rpe65/P25L

255 neurons, impairs synaptogenesis, and reduces cone photoreceptor survival.

256 The mammalian cone photoreceptor synapse provides advantages for compa

257 We then demonstrate that cone photoreceptor synapses are assembled before the ela

258 tropic glutamate receptors (mGluRs) regulate cone photoreceptor synaptic transmission, although the m

259 Results show that the cone photoreceptor system was more severely affected tha

260 to two visual arrestins that bind to rod and cone photoreceptors (termed arrestin1 and arrestin4), th

261 l evidence for synaptic transmission between cone photoreceptor terminals and ORDs suggests a novel p

262 onses using two-photon imaging in individual cone photoreceptor terminals and to probe phototransduct

263 bipolar cells juxtaposed to CB(1)-containing cone photoreceptor terminals.

264 B6/J has 70% more cone photoreceptors than A/J.

265 nd relative retention of the central retinal cone photoreceptors that lack function.

266 fail to produce rods and generate functional cone photoreceptors that predominantly express S-opsin.

267 consequently results in the death of rod and cone photoreceptors that they support, structurally and

268 and has evolved over time to produce rod and cone photoreceptors that vary in a species-specific mann

269 is deletion also caused rapid dysfunction of cone photoreceptors, the cells responsible for fine visu

270 Before the maturation of rod and cone photoreceptors, the developing retina relies on lig

271 In cone photoreceptors, the molecular identity of the modul

272 ugh "duplex" retinae containing both rod and cone photoreceptors, the signals from which are processe

273 Instead, foveal cone photoreceptors themselves exhibited slower light re

274 ropagation of visual signals from individual cone photoreceptors through parallel neural circuits was

275 that is mediated by activity of both rod and cone photoreceptors through the ON and OFF pathways.

276 toactivation is critical for the function of cone photoreceptors throughout the day.

277 and strength of the functional input of each cone photoreceptor to each ganglion cell.

278 We found that Pias3 acts in mouse cone photoreceptors to activate expression of M opsin an

279 photoreceptors may be more susceptible than cone photoreceptors to the effects of ocriplasmin.

280 relative contribution of melanopsin and rod-cone photoreceptors to the pupillary light reflex in hum

281 ssible to resolve the contribution of single cone photoreceptors to the response of central visual ne

282 the phototransduction cascade of vertebrate cone photoreceptors to tune gain, inactivation, and ligh

283 Cone photoreceptors transmit signals at high temporal fr

284 periments, we demonstrate the feasibility of cone photoreceptor transplantation into the wild-type an

285 ion of color relies on signals from multiple cone photoreceptor types.

286 long (L) and middle (M) wavelength-sensitive cone photoreceptor types.

287 Rod and cone photoreceptors use a specialized structure called t

288 Rod and cone photoreceptors use similar but distinct sets of pho

289 ntravenous injection of IAA on swine rod and cone photoreceptor viability and morphology was followed

290 cent studies have implicated TH signaling in cone photoreceptor viability.

291 implicated thyroid hormone (TH) signaling in cone photoreceptor viability.

292 Using mice in which cone photoreceptors were ablated, we found that rods sig

293 rod-derived electroretinogram response, but cone photoreceptors were non-functional in the absence o

294 synaptic terminals of short and long/middle cone photoreceptors, whereas Pde6h(-/-) retinae remained

295 (+) signaling is well exemplified by retinal cone photoreceptors, which, with their distinct compartm

296 vision in birds is mediated by four types of cone photoreceptors whose maximal sensitivities (lambdam

297 reduced in numbers, reconnected to undamaged cone photoreceptors with correct wiring patterns.

298 They showed substantially retained cone photoreceptors with disproportionate cone function

299 GABAergic interneuron that samples from all cone photoreceptors within reach and modulates their glu

300 Cone photoreceptors within the strips were counted, and