ライフサイエンスコーパス: confer resistance to

1 the chromosome1 locus is not responsible for conferring resistance to 129 mice.

2 Ectopic expression of miR-520g conferred resistance to 5-fluorouracil (5-FU)- or oxalip

3 s to screen for genes that, upon activation, confer resistance to a BRAF inhibitor.

4 p (RGD) integrin ligand and matrix softening confer resistance to a number of drugs, cells become sen

5 ates the transfer of plasmids that variously confer resistance to a range of drugs, including vancomy

6 ating mutations in four genes whose products conferred resistance to a WTA-binding bacteriophage.

7 pounds with little chemical similarity, thus conferring resistance to a broad spectrum of antibiotics

8 ntrogression of a wild relative-derived gene conferring resistance to a fungal pathogen was detected

9 ntegrated into the Bacillus subtilis genome, confers resistance to a broad range of phages, including

10 kinase, the rice (Oryza sativa) protein XA21 confers resistance to a broad spectrum of Xanthomonas or

11 splicing of a gene encoding an ABCC2 protein confers resistance to a Bt toxin.

12 Thus, the env gene of transmitted HIV-1 confers resistance to a late block that is phenotypicall

13 ne A2503 in 23S rRNA, methylating enzyme Cfr confers resistance to a range of ribosome-targeting anti

14 he NorA efflux pump of Staphylococcus aureus confers resistance to a wide range of unrelated substrat

15 low activator BH3s and BCL-XL overabundance conferred resistance to ABT-263.

16 cally relevant FLT3-ITD mutant isoforms that confer resistance to AC220 or sorafenib.

17 expression signature in p53-deficient hearts confers resistance to acute biomechanical stress.

18 Amino acid substitutions known to confer resistance to adefovir were detected at baseline

19 oprotein L1 (ApoL1) is a human serum protein conferring resistance to African trypanosomes, and certa

20 over, PKC activation alone was sufficient to confer resistance to ALK inhibitors, whereas combined AL

21 verexpression of NmU in drug-sensitive cells conferred resistance to all HER-targeting drugs, whereas

22 domain gatekeeper mutation Thr315Ile (T315I) confers resistance to all approved ABL1 inhibitors excep

23 uced IL-10(+)IFN-gamma(+)CD4(+) cells, which confer resistance to allogeneic proliferation in an IL-1

24 tumor also harbored a mutation in MTOR that confers resistance to allosteric mTOR inhibition.

25 g an S31N mutation in M2 proton channel that confer resistance to amantadine and rimantadine.

26 (3')II, a Tn5 transposon-derived kinase that confers resistance to aminoglycoside antibiotics, in Esc

27 in the RmbetaAOR, a gene that we proposed to confer resistance to amitraz, to determine whether selec

28 orphisms in the RmbetaAOR gene are likely to confer resistance to amitraz.

29 ting beta-lactamases revealed that only -Arg conferred resistance to ampicillin/clavulanate.

30 e FWPV block to induction of ChIFN2 but does confer resistance to an established antiviral state.

31 dentify single-nucleotide polymorphisms that confer resistance to an experimental inhibitor effective

32 in the myeloid lineage promoted survival and conferred resistance to an in vivo group B streptococcus

33 FOXC2-dependent tumor metastases but did not confer resistance to androgen deprivation.

34 s elimination of alpha2-6-linked sialic acid conferred resistance to anti-VEGF.

35 the administered drug, as well as genes that confer resistance to antibiotics unrelated to the admini

36 in epidemic strains, other HA mutations can confer resistance to antibodies that recognize the K166

37 he cell cycle machinery in tumor cells often confers resistance to anticancer therapy.

38 ressed in human cancer, and its activity may confer resistance to antitumoral drugs such as Taxol.

39 functions during viral infection, including conferring resistance to antiviral interferon induction,

40 resents a new class of virus resistance gene conferring resistance to any pathogen.

41 High levels of metabolic activity confer resistance to apoptosis.

42 forms promoted motility of U-87 MG cells and conferred resistance to apoptosis.

43 between ks-vFLIP and IKKgamma is pivotal in conferring resistance to apoptosis.

44 timulating factor 1 receptor (CSF-1R), which confers resistance to apoptotic pathways driven by tumor

45 ion of ligand-independent AR splice variants confers resistance to AR-targeted therapy and progressio

46 scherichia coli, gapdh and arsJ specifically conferred resistance to arsenate and decreased accumulat

47 pe malaria DNA and mutant malaria DNA, which confers resistance to artemisinin drugs, was also demons

48 nhances FtsZ protofilament bundling, thereby conferring resistance to assembly inhibitors and bypassi

49 ase in DN T cell number may be sufficient to confer resistance to autoimmune diabetes.

50 ct the 23S ribosomal RNA gene mutations that confer resistance to azithromycin.

51 NbCSPR confers resistance to bacteria in an age-dependent and f

52 The receptor kinase XA21 confers resistance to bacterial blight disease of rice (

53 es induced apoptosis, and its overexpression conferred resistance to BCL-2 family-targeting BH3 mimet

54 beta-Lactamases are enzymes that confer resistance to beta-lactam antibiotics in bacteria

55 Here we show that mnhF confers resistance to bile salts, which can be abrogated

56 D458G/V459A, N462K, N462H, G464E, and I483R conferred resistance to both FIP and AS-48 without compr

57 s with GPI-VHH JM4, but not with GPI-VHH E4, confers resistance to both cell-free and T cell-T cell t

58 phila expressing CYP6CY3 demonstrate that it confers resistance to both compounds in vivo.

59 laps with the pathogen infection pathway and confers resistance to both oxidative stress and heat sho

60 elevated expression of either of these genes confers resistance to both type I (permethrin) and type

61 We also found that TdfH confers resistance to calprotectin, an immune effector p

62 wnregulation (CASP3/DR) in tumors frequently confers resistance to cancer therapy and is significantl

63 Palmitoylation commonly confers resistance to cationic antimicrobial peptides, h

64 dentify lymphoma transcriptomic changes that confer resistance to CD20 immunotherapy.

65 hibition of IFNbeta by neutralizing antibody conferred resistance to cell death, and (iii) mouse embr

66 levels of aa-PG in the bacterial membrane to confer resistance to certain antimicrobial compounds and

67 himeric replicons, 2a NS4B was identified to confer resistance to cGAMP.

68 in turn, leads to elevated Akt activation to confer resistance to chemotherapeutic drugs in Rb-profic

69 normal cells activated survival pathways and conferred resistance to chemotherapeutic agents.

70 reas an increase in antioxidant capacity can confer resistance to chemotherapy and is associated with

71 increased nucleotidase activity in vitro and conferred resistance to chemotherapy with 6-mercaptopuri

72 oteins contributes to cancer progression and confers resistance to chemotherapy.

73 ance protein MRP1 is an ATP-driven pump that confers resistance to chemotherapy.

74 and the double mutant E1-K61T E2-D59N) that conferred resistance to CHK-152 and CHK-166 and tested t

75 R) and single strand annealing (SSA), and in conferring resistance to cisplatin and olaparib in human

76 growth, and is active against mutations that confer resistance to clinical inhibitors.

77 ecular function of ClbS, a gene product that confers resistance to colibactin toxicity in host bacter

78 ads to a modest increase in kinase activity, conferring resistance to competitive ATP inhibitors in a

79 In this study, we tested whether EMT confers resistance to complement-dependent cytotoxicity

80 t determines long O-antigen chain length and confers resistance to complement-mediated killing.

81 ECM component of cartilaginous tissues that confers resistance to compression.

82 ons in HNSCC and demonstrated that mutations confer resistance to conventional and molecular targeted

83 licited a higher frequency of Th17 cells and conferred resistance to costimulation blockade following

84 ify mutations in the ROS1 kinase domain that confer resistance to crizotinib and demonstrate that the

85 Mutations in the ALK kinase domain confer resistance to crizotinib in about one-third of th

86 egion correspond to mutations in the rt ORF, conferring resistance to current antiviral therapies.

87 Importantly, 4E-BP2 deletion confers resistance to cytokine treatment in vitro.

88 ; identified genotypic substitutions did not confer resistance to cytomegalovirus antivirals in vitro

89 esting established that ald loss of function conferred resistance to D-cycloserine, and susceptibilit

90 dition to aberrant apoptotic signaling might confer resistance to death signals delivered by CTL.

91 Inactivation of the GR gene also conferred resistance to DEX in a xenogeneic GVHD model i

92 w that a whole-body knockout of Maf1 in mice confers resistance to diet-induced obesity and nonalcoho

93 HLA-DR1-induced Treg cells confer resistance to disease in HLA-DR15/DR1 transgenic

94 hat only binds to XPF-ERCC1 is sufficient to confer resistance to DNA crosslinking agents.

95 RT6 levels increases DNA repair via Chk1 and confers resistance to DNA damage.

96 P. putida arsH expressed in E. coli conferred resistance to each trivalent organoarsenical.

97 emptively determine mutations in ERK1/2 that confer resistance to either ERK inhibitors or combined R

98 EK1 and MEK2 (MEK1/2) MAPK genes in melanoma confer resistance to emerging therapeutic MEK inhibitors

99 hiolation can be conditionally advantageous, conferring resistance to endoplasmic reticulum stress.

100 , we recently reported that DUSP3 deficiency confers resistance to endotoxin- and polymicrobial-induc

101 rsH catalyzes a novel biotransformation that confers resistance to environmental methylated and aroma

102 Polyploidy also frequently confers resistance to environmental stresses not tolerat

103 This mutation was previously found to confer resistance to enviroxime-like compounds, which ta

104 ospectively identify AR mutations that might confer resistance to enzalutamide, we performed a report

105 In contrast, overexpression of AKR1C3 confers resistance to enzalutamide.

106 trated that secondary oncogenic events could confer resistance to ERBB2-directed therapies.

107 in ERK1 (MAPK3) and ERK2 (MAPK1) that could confer resistance to ERK or RAF/MEK inhibitors.

108 t to alter the expression of EMT genes or to confer resistance to erlotinib, it caused downregulation

109 g the known role of MET and EPHA2 kinases in conferring resistance to erlotinib in TKI sensitive stra

110 Deletion of S1P1 in Th17 cells conferred resistance to experimental autoimmune encephal

111 that increases intrinsic growth capacity and confers resistance to extrinsic inhibitory cues.

112 RG26 strain, and multiple mutations in ERG26 confer resistance to FR171456 in growth and enzyme assay

113 ich maps to the side of the FtsZ subunit and confers resistance to FtsZ assembly inhibitory factors i

114 n trigger specific fungal gene silencing and confer resistance to fungal pathogens(1-7).

115 UL97 mutations confer resistance to ganciclovir and valganciclovir, and

116 of these two allergens with lipid components confers resistance to gastrointestinal digestion, reduce

117 The results indicate that Ty-1 confers resistance to geminiviruses by increasing cytosi

118 ecific CD8(+) T cells (HLA-A02/NLV peptide), conferring resistance to glucocorticoids.

119 duced by nutrient and energy deprivation and conferred resistance to glucose deprivation.

120 hat reduce intrinsic Ras GTPase activity and confer resistance to GTPase-activating proteins (GAPs).

121 al muscle-specific deletion of MED13 in mice conferred resistance to hepatic steatosis by activating

122 Metabolic resistance often confers resistance to herbicides of different chemical g

123 omas select for expression of a pathway that confers resistance to high oxygen tension and protects c

124 Heterologous SlRd2 overexpression in yeast conferred resistance to highly toxic LiCl, whereas SlRd2

125 of gene-modified hematopoietic stem cells in conferring resistance to HIV infection.

126 encoding a putative glycosyltransferase that confers resistance to HMOs, suggesting that HMOs may fun

127 the initial finding that cpxA null mutations confer resistance to HU.

128 s were identified in spxA1 mutant cells that conferred resistance to hydrogen peroxide.

129 ansporter gene abcA in Staphylococcus aureus confers resistance to hydrophobic beta-lactams.

130 collected from patients harboring mutations conferring resistance to ibrutinib.

131 to CUL4-DCAF15 increase RBM39 stability and confer resistance to indisulam's cytotoxicity.

132 ovide multicellular hosts with nutrients and confer resistance to infection.

133 ion of oligodendrocyte survival in the adult confers resistance to injury and myelin loss.

134 l stabilization of the convertase enzyme and confer resistance to innate control mechanisms; unregula

135 ic (MON810 event with the Cry1Ab gene, which confers resistance to insects) and non-transgenic maize

136 hat intestinal colonization with Barnesiella confers resistance to intestinal domination and bloodstr

137 maturation, (2) a remodelled epithelium that confers resistance to intracellular bacterial colonizati

138 and RHD-defective (K83N, N109D) mutant RUNX1 conferred resistance to ionizing radiation when overexpr

139 oltheta is highly expressed in cancer cells, confers resistance to ionizing radiation and chemotherap

140 single nucleotide polymorphisms (SNPs) that confer resistance to isoniazid, rifampin, ofloxacin, and

141 well as the most frequent mutations in genes conferring resistance to isoniazid (katG and inhA) and r

142 he katG mutation encoding p.Ser315Thr, which confers resistance to isoniazid, overwhelmingly arose be

143 in III of eEF1A prevent ternatin binding and confer resistance to its cytotoxic effects, implicating

144 as is observed frequently in human cancers, confers resistance to killing by DNA-damaging agents.

145 in cereblon attenuate these effects and also confer resistance to lenalidomide.

146 A single amino acid substitution of IKZF3 conferred resistance to lenalidomide-induced degradation

147 huringiensis Cry genes (Bt G. hirsutum) that confer resistance to lepidopteran pests, is extensively

148 the Grb2-binding site on EGFR (Y1068F-EGFR) conferred resistance to ligand-induced degradation, whic

149 503 of 23S rRNA by the Cfr methyltransferase confers resistance to linezolid (and a variety of other

150 The L1198F substitution confers resistance to lorlatinib through steric interfer

151 ntrol of expression of genes associated with conferring resistance to low-level antibiotics to the ba

152 idative stress, PgdA is highly expressed and confers resistance to lysozyme in wild-type cells.

153 Locus belr1 confers resistance to malaria liver stage infection.

154 ) are the three major ABC transport proteins conferring resistance to many structurally diverse antic

155 ATP-binding cassette (ABC) transporter that confers resistance to many anticancer drugs and plays a

156 s expressed in Escherichia coli and shown to confer resistance to MAs(III) and Rox(III) but not to in

157 expression of AfarsM1 in an Escherichia coli conferred resistance to MAs(III) but not As(III).

158 BRAF-inhibitor resistance mechanisms likely confer resistance to MEK-inhibitor monotherapy.

159 de and nicotinamide riboside are reported to confer resistance to metabolic defects induced by high f

160 an allele-specific manner, with the G allele conferring resistance to miR-425.

161 We show that RECQL5, but not BLM, conferred resistance to mitomycin C (MMC, an interstrand

162 16S rRNA methyltransferases confer resistance to most aminoglycosides, but discrimin

163 eration, causes aberrant differentiation and confers resistance to mucosal erosion.

164 data, we identified polymorphisms in E2 that confer resistance to multiple broadly neutralizing mAbs.

165 odifies C8 of A2503 via a similar mechanism, conferring resistance to multiple classes of antibiotics

166 istance (R) gene in Medicago truncatula that confers resistance to multiple races of Colletotrichum t

167 iruses, while APOBEC3A but not mouse APOBEC3 conferred resistance to MVM.

168 er the nuclear import pathways used by HIV-1 confer resistance to MX2, whereas preventing cell divisi

169 tions in the HIV-1 capsid have been shown to confer resistance to Mx2.

170 We identify a single-amino acid mutation conferring resistance to mycolactone, which localizes it

171 domain that decrease enzymatic activity but confer resistance to NA inhibitors have been characteriz

172 ich (4 in N4, 4 in N5, 4 in N6, and 4 in N8) conferred resistance to NAIs (oseltamivir carboxylate, z

173 single point mutations within 16S rRNA that confer resistance to negamycin are in close proximity of

174 ) was up-regulated by dual stress in leaves, conferring resistance to nematodes when overexpressed.

175 which are not at mAb contact residues, also conferred resistance to neutralization by plasma from HC

176 nly for occluding many epitopes but also for conferring resistance to neutralization by all but a sma

177 his report, we identify a viral polymorphism conferring resistance to neutralization by both polyclon

178 to be activated by these proteases, thereby conferring resistance to new pathogens.

179 Consistent with this regulation, SdsN137 confers resistance to nitrofurans.

180 which the D168V and R155K residue mutations confer resistance to NS3 protease inhibitors.

181 tance associated mutation in the NS5A region conferring resistance to NS5A inhibitors, such as ledipa

182 However, in 10 patients the V321I change conferring resistance to nucleos(t)ide NS5B polymerase i

183 (dNTP)-binding pocket, including those that confer resistance to nucleoside/nucleotide analogs, affe

184 The mutation also conferred resistance to oligomer disassembly by guanine

185 RT mutations that confer resistance to one drug can be hypersensitive to a

186 -glycosylation of Tfp with O-ag specifically confers resistance to opsonization during host-mediated

187 Changes in the microbiota can confer resistance to or promote infection by pathogenic

188 ions and methylations in helices H89 and H91 confer resistance to orthosomycins and revealed the sequ

189 We simulated random mutations conferring resistance to oseltamivir.

190 ations selected for in FLT3/ITD alleles that confer resistance to other TKIs, including the F691L gat

191 ever, IFN responsiveness of some tumor cells confers resistance to OV treatment.

192 in Pseudomonas aeruginosa PA14, trmJ, which confers resistance to oxidative stress.

193 Finally, deletion of NQM1 is shown to confer resistance to oxidizing substances.

194 the formation of the antimetabolite, thereby conferring resistance to PAS.

195 dent microbiota can promote immune function, conferring resistance to pathogens and parasites by both

196 hairpin RNA-mediated down-regulation of Puma conferred resistance to PDGF-mediated apoptotic priming.

197 However, the success of genes that confer resistance to pests induces a co-evolutionary res

198 transformation, and that elevated MYC levels confer resistance to pharmacologic inhibitors of BCR sig

199 Mapping of S. meliloti mutations conferring resistance to PhiM12, N3, or both phages simu

200 Stable expression of mutant PIK3CB variants conferred resistance to PI3K inhibition that could be ov

201 Concordantly, low Bak expression in AML confers resistance to PIK-75-mediated killing.

202 n levels are regulated by PIs, which in turn confers resistance to PIs.

203 -root invasion, non-lethal synthetic peptide confers resistance to plantain against the key nematode

204 ely disables its abilities to promote HR and confer resistance to platinum salts and PARP inhibitors.

205 ression of ERAS in human melanoma cell lines conferred resistance to PLX4720 and induced hyperphospho

206 No single BCR-ABL mutation conferring resistance to ponatinib was detected.

207 Targeting polyphosphate or factor XII conferred resistance to prostate cancer-driven thrombosi

208 Beyond conferring resistance to proteasome inhibitors, proteaso

209 rassinolide-resistant 1-1D (bzr1-1D) mutants conferred resistance to Pseudomonas syringae.

210 expression specifically in macrophages also confers resistance to Pseudomonas infection, highlightin

211 se PpsA, which converts pyruvate to PEP, can confer resistance to pyruvate-induced lysis when ppsA is

212 lead compound, 5, inhibited IN mutants that confer resistance to quinoline-based compounds.

213 These data show that NRAS mutations confer resistance to RAF inhibitors in mutant BRAF cells

214 reens to identify B- or C-RAF mutations that confer resistance to RAF inhibitors.

215 ed mutation in the rigosertib-binding pocket conferred resistance to rigosertib, establishing that ri

216 n does not lie at the gatekeeper residue, it confers resistance to ROS1 kinase inhibition through ste

217 Campylobacter jejuni, was recently shown to confer resistance to roxarsone.

218 , we identified 211 amino-acid substitutions conferring resistance to ruxolitinib (INCB018424) and cr

219 GmSNAP11 is identified as a novel minor gene conferring resistance to SCN.

220 strategy in the context of AR mutations that confer resistance to second-generation AR antagonists.

221 iferative and invasive capacity in vitro and confers resistance to selective PI3Kdelta inhibitor, CAL

222 PmrA-dependent LPS modifications confer resistance to serum, Fe(3+), and several antimicr

223 l components in Mycobacterium smegmatis that confer resistance to several structurally and mechanisti

224 pha2 ouabain binding site (alpha2(R/R) mice) confers resistance to several forms of hypertension.

225 ing to promote disease progression and might confer resistance to single-compound approaches.

226 falciparum ATPase 4 (pfatp4) mutations that confer resistance to (+)-SJ733 carry a high fitness cost

227 d as treatment-emergent variants but did not confer resistance to sofosbuvir in the replicon system.

228 The Rhg1 locus of soybean, which confers resistance to soybean cyst nematode (SCN), is a

229 sC, gltK/gltJ, yciB, and ftsH mutations that confer resistance to specific CdiA-CTs.

230 -risk acute lymphoblastic leukemia (ALL) and confer resistance to standard chemotherapy.

231 that ATP-binding cassette member B5 (ABCB5) confers resistance to standard-of-care MCC chemotherapeu

232 ich result in multicellular communities that confer resistance to stress conditions such as desiccati

233 pumps function as multidrug efflux pumps by conferring resistance to structurally diverse antibiotic

234 dium channel gene previously demonstrated to confer resistance to synthetic pyrethroids to quantify c

235 enetic defects control immune mechanisms and confer resistance to T-cell-based immunotherapy.

236 tified by genome-wide association studies to confer resistance to T1D and result in the reduction in

237 hages in the pancreas as both types of cells confer resistance to T1D upon transfer to 13R(+/+) mice.

238 xpression of Ccl11; however, the same allele confers resistance to T1D.

239 T3SS2) to identify human genome disruptions conferring resistance to T3SS-dependent cytotoxicity.

240 rexpression of it enhanced proliferation and conferred resistance to tamoxifen.

241 Compensatory signaling pathways in tumors confer resistance to targeted therapy, but the pathways

242 Our results therefore suggest that mutations conferring resistance to targeted therapy occur naturall

243 Ribosome protection proteins (RPPs) confer resistance to tetracycline by binding to the ribo

244 ed efflux pump of Staphylococcus aureus that confers resistance to tetracycline and certain unsaturat

245 romosomally encoded Tet38 efflux transporter confers resistance to tetracycline and fitness in absces

246 f PAX5 and CD19 and overexpress Smad7, which confers resistance to TGF-beta-mediated suppression of B

247 l domain of elongation factor Ts (EF-Ts) and confer resistance to the CdiA-CT(EC869) tRNase toxin fro

248 all secondary KD mutants previously shown to confer resistance to the first highly active FLT3 TKI qu

249 le PR inhibitors or mutant Gag proteins that confer resistance to the maturation inhibitor Bevirimat.

250 usly unreported adaptive mutations that each confer resistance to the ss-lactamase inhibitor tazobact

251 y of the most commonly selected mutations to confer resistance to the sshRNAs was confirmed in vitro

252 aintain homeostasis on perturbations and may confer resistance to the toxic insult.

253 plemented an S1PL-deficient yeast strain and conferred resistance to the antimicrobial sphingolipid D

254 resence of a D or S residue at this position conferred resistance to the disease.

255 but none of the four induced Xa27-like genes conferred resistance to the dTALE-containing Xoo strains

256 More recently, point mutations conferring resistance to the Bruton tyrosine kinase inhi

257 R p.T790M mutation, the most common mutation conferring resistance to the EGFR inhibitor gefitinib, a

258 gamma) is the major proinflammatory cytokine conferring resistance to the intracellular vacuolar path

259 class A beta-lactamase family are capable of conferring resistance to the last resort antibiotics, ca

260 the minor allele of each respective variant conferring resistance to the miRNA either by disruption

261 ing this method, we identified two mutations conferring resistance to the mutagen 5-fluorouracil (5-F

262 ing tumor cells (CTCs) in the bloodstream by conferring resistance to the shear stress and attack fro

263 including in human breast cancer cell lines, confers resistance to the anti-cancer drug and TOP2 inhi

264 MCR-1 is a lipid A modifying enzyme that confers resistance to the antibiotic colistin.

265 ve transposon (CTn) in Bacteroides spp. that confers resistance to the antibiotics erythromycin and t

266 leted bone marrow-derived macrophages (BMDM) confers resistance to the development of glioma.

267 ddition, the activation of HGF/MET signaling confers resistance to the effects of cancer treatments.

268 rent FLT3-ITD (internal tandem duplication), confers resistance to the FLT3 protein tyrosine kinase i

269 sses, namely the immune receptor XA21, which confers resistance to the Gram-negative bacterium, Xanth

270 terize a mutation in the capsid protein that confers resistance to the inhibitor.

271 nding cassette transporters, and a gene that confers resistance to the insecticide dieldrin.

272 1/2 mitogen-activated protein kinases (MAPK) confers resistance to the RAF inhibitors vemurafenib and

273 Mutations that confer resistance to these drugs reduce the ability of H

274 Smoothened mutations, including SMO(D477G), confer resistance to these inhibitors.

275 36, SF3B1-K1071, SF3B1-R1074 and SF3B1-V1078 confer resistance to these modulators, suggesting a comm

276 onfirmed by genetic mapping of the mutations conferring resistance to thiazolopyridine ureas.

277 oli dsbB gene and selected dsbB mutants that confer resistance to this drug using two approaches.

278 ly, overexpression of VGF in sensitive cells conferred resistance to TKIs and induced EMT, increasing

279 guanine methyltransferase (MGMT) cDNA, which confers resistance to TMZ.

280 e transporter found in Escherichia coli that confers resistance to toxic polyaromatic cations due to

281 e, posttranslational regulation of caspase-8 confers resistance to TRAIL-induced cell death in normal

282 Mutations conferring resistance to translation inhibitors often al

283 can also become targets for immunotherapy or confer resistance to treatment.

284 ese escape mutations into the parental virus conferred resistance to TRIM5 on macaques.

285 Mutation of Cys342 of XPB to threonine conferred resistance to triptolide on the mutant protein

286 Several genes/loci were also found to confer resistance to two or more antileishmanials.

287 at protein that in addition to potato aphids confers resistance to two additional phloem-feeding inse

288 ible wheat variety Fielder was sufficient to confer resistance to Ug99, confirming that CNL13 is Sr13

289 eat (Triticum turgidum ssp. durum) gene Sr13 confers resistance to Ug99 and other virulent races, and

290 KAE609 resistance mutations in ScPMA1 do not confer resistance to unrelated antimicrobials, but do co

291 preventing spontaneous chromosome breaks and conferring resistance to UV radiation and cisplatin.

292 d in the production of virulence factors and conferring resistance to various antibiotics in pathogen

293 n and disrupts the p53/MDM2 regulatory axis, conferring resistance to various chemotherapeutics.

294 ary or secondary, is a cell-autonomous trait conferring resistance to VEGF blockade.

295 ty of the algorithm by identifying mutations conferring resistance to Vemurafenib.

296 lleles unknown in laboratory mice that might confer resistance to virulent strains of T. gondii.

297 single-nucleotide changes within ORF54 that conferred resistance to VZV-specific portal protein inhi

298 the predominant mechanism of weight loss and confers resistance to weight gain from a high-fat diet,

299 Transgenic expression of the pepper Bs2 gene confers resistance to Xanthomonas campestris pv. vesicat

300 56 is a versatile antiviral host factor that confers resistance to YFV, DENV2, and HCoV-OC43 through