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1 of the isoindolinone amide scaffold to both configurationally and conformationally lock the bioactiv
2 rcular dichroism spectra, enabling access to configurationally assigned enantiomeric pairs by separat
3 variety of physicochemical descriptors were configurationally averaged during the course of the simu
4 useful descriptors of binding affinity were configurationally averaged for each inhibitor during the
5 l structure around MA changes from static to configurationally averaged or dynamic with temperature b
6 contact with high-energy substrates to form configurationally complex, but robust phases that often
10 in cross-coupling relies on construction of configurationally defined reactants paired with catalyst
11 blocks, in particular, for the synthesis of configurationally defined tetrasubstituted olefins throu
12 usters and carboxylate linkers-that adopts a configurationally degenerate family of disordered states
13 at 2.05 A resolution and in complex with two configurationally distinct steroids at 2.40 and 2.85 A.
15 rmational diastereoisomers derived from each configurationally enantiomeric macrocycle was investigat
18 III) cyclams bind carboxylates strongly, are configurationally flexible, and yet have low activity.
22 e two PyNHC ligands are constitutionally and configurationally inert, while the two acetonitriles are
24 rings has been studied via equilibration of configurationally isomeric 2,2-diaryl-cis-4,6-dimethyl-1
26 he substrate via the reversible formation of configurationally labile aldehydes, thereby enabling a d
27 verall process establishes the capability of configurationally labile aza-sulfur species to be used i
29 this potent mycotoxin proceeds through three configurationally labile intermediates to racemic versic
30 e of the stereocenters was installed using a configurationally labile lithiated primary benzyl benzoa
32 The described methodology is suited to other configurationally labile molecules (for instance, hydraz
33 llithiums 6 were found to be microscopically configurationally labile on the time scale of the thioph
34 ctural studies support that the formation of configurationally labile oxidative addition palladacycle
38 der reactions show inverse behavior from the configurationally matched and mismatched Rh(2)L(4) catal
40 yst Rh(2)(MPPIM)(4), but applications of the configurationally mismatched catalysts result in signifi
42 OMO) --> Ph-NN (LUMO) one-electron promotion configurationally mixes into the ground state of the m-P
47 difference spectrum of BR, especially in the configurationally sensitive retinal fingerprint region.
49 o-C host-guest complexes at 313 nm produced configurationally stable "closed" photoisomers, thus loc
50 rst bay-connected bis-PDI macrocycle that is configurationally stable (DeltaG( ) > 155 kJ mol(-1)).
52 ate of dynamic methyl group exchange between configurationally stable active species and configuratio
53 atively, stereospecific substitution affords configurationally stable alpha,alpha-disubstituted aldeh
55 racterization of oligonucleotides containing configurationally stable analogues of C4-AP, which serve
56 drogen-bonding atropisomerization control of configurationally stable analogues of the biaryl natural
57 PPL was resolved into enantiomers, which are configurationally stable and provide strong chiroptical
59 ach delineates design principles that enable configurationally stable and room-temperature isolable s
62 thio-2-arylpiperidines have been found to be configurationally stable at -80 degrees C, whereas N-Boc
64 riles can be formed by deprotonation and are configurationally stable at low temperature, even for ac
66 alpha-alkoxy-substituted Grignard reagent is configurationally stable at room temperature for 30 min.
68 nstable at -78 degrees C but microscopically configurationally stable at the time scale of their addi
69 catalyzed reduction of an aldehyde to form a configurationally stable atropisomeric alcohol, with the
76 ays, these species are no longer elusive and configurationally stable compounds have been highlighted
78 troduce helical chirality into 2D COFs using configurationally stable enantiopure and racemic [5]heli
80 tion ternary complex crystal structures of a configurationally stable Fapy*dGTP analog, beta-C-Fapy*d
82 cally enriched triplet diradical dication is configurationally stable for 48 h at room temperature, t
83 e isolable P-chiral secondary phosphines are configurationally stable indefinitely in the solid state
84 of N-Boc-allylic and benzylic amines provide configurationally stable intermediates which on conjugat
85 hanism emerges in which the aldehyde traps a configurationally stable intimate ion pair to stereospec
86 the only example of a chiral non-racemic and configurationally stable molecule in which the oxygen at
87 e enantioselective N-chloroaziridines with a configurationally stable nitrogen stereogenic centre.
88 ed a synthesis of enantiomerically enriched, configurationally stable organozinc reagents by catalyti
92 nd activation of cyclopropylamides generates configurationally stable rhodacyclopentanones that engag
96 ough the intermediacy of an enantioenriched, configurationally stable thiiranium ion generated by Lew
97 through the intermediacy of enantioenriched, configurationally stable thiiranium ions generated from
100 show that sulfilimines can be chemically and configurationally stable under physiologically relevant
101 chiral secondary alkylzinc reagents that are configurationally stable under practical experimental co
102 that enantioenriched bromonium chlorides are configurationally stable under solvolytic conditions in
103 monstrate that alkylnickel intermediates are configurationally stable under Suzuki cross-coupling con
104 88% yield and shown to be hydrolytically and configurationally stable under the reaction conditions (
105 Ru catalysts suggesting that the catalyst is configurationally stable under the reaction conditions.
107 was determined by heteronuclear NMR to be a configurationally stable, alpha-lithio, eta(1)-coordinat
108 etrahedral main-group compounds are normally configurationally stable, but P-epimerization of the chi
109 etrahedral main-group compounds are normally configurationally stable, but P-epimerization of the chi
110 the axially chiral biphenyl was found to be configurationally stable, but the resolved enantiomers e
111 stereospecific variants enabling the use of configurationally stable, enantioenriched, main-group or
112 ould behave if their chiral centers were not configurationally stable, highlighting the vital importa
113 s containing four different substituents are configurationally stable, unless bonds to the stereogeni
115 configurationally stable active species and configurationally unstable dormant species with respect
116 hiral alpha-substituted isocyanoacetates are configurationally unstable in some synthetically useful
118 ere is based on the unusual application of a configurationally unstable stereogenic nitrogen, which p
121 -catalyzed cross-coupling reaction between a configurationally well-defined vinyl zinc intermediate 2