ライフサイエンスコーパス: configurationally

1 variety of physicochemical descriptors were configurationally averaged during the course of the simu

2 useful descriptors of binding affinity were configurationally averaged for each inhibitor during the

3 l structure around MA changes from static to configurationally averaged or dynamic with temperature b

4 In this report, configurationally defined and enantiomerically enriched

5 ntio-pure skipped 1,4-diene esters (with two configurationally defined double bonds) is reported.

6 reospecificity and provides urea-stabilized, configurationally defined organolithiums.

7 at 2.05 A resolution and in complex with two configurationally distinct steroids at 2.40 and 2.85 A.

8 ets of hydrogen-bonding interactions to bind configurationally distinct steroids.

9 rmational diastereoisomers derived from each configurationally enantiomeric macrocycle was investigat

10 or explaining the time-dependent friction of configurationally flexible interfaces.

11 III) cyclams bind carboxylates strongly, are configurationally flexible, and yet have low activity.

12 curring within the encounter complex is also configurationally gated.

13 Configurationally homogeneous (E)-silanolates gave sligh

14 Two configurationally immobilized (i.e., "locked") AVB analo

15 e triazole and cyanophenyl groups around the configurationally invertible central nitrogen atom.

16 rings has been studied via equilibration of configurationally isomeric 2,2-diaryl-cis-4,6-dimethyl-1

17 h shared O/F vertices to form a 3D structure configurationally isotypic to zeta-Nb2O5.

18 ransfer principle, controlling the otherwise configurationally labile biaryl axis.

19 this potent mycotoxin proceeds through three configurationally labile intermediates to racemic versic

20 e of the stereocenters was installed using a configurationally labile lithiated primary benzyl benzoa

21 The described methodology is suited to other configurationally labile molecules (for instance, hydraz

22 llithiums 6 were found to be microscopically configurationally labile on the time scale of the thioph

23 ctural studies support that the formation of configurationally labile oxidative addition palladacycle

24 The configurationally locked ligands have improved photostab

25 Activity resided in the configurationally lowest energy (2S,4R,4aR) diastereomer

26 der reactions show inverse behavior from the configurationally matched and mismatched Rh(2)L(4) catal

27 The configurationally "matched" cases provide modest increas

28 yst Rh(2)(MPPIM)(4), but applications of the configurationally mismatched catalysts result in signifi

29 OMO) --> Ph-NN (LUMO) one-electron promotion configurationally mixes into the ground state of the m-P

30 Thus, the preparation of configurationally pure (Z)-1'-lithio-1'-(2,6-dimethylphe

31 Both amino acids were obtained as configurationally pure hydrochloride salts identical in

32 difference spectrum of BR, especially in the configurationally sensitive retinal fingerprint region.

33 A configurationally simple and robust semibatch apparatus

34 ate of dynamic methyl group exchange between configurationally stable active species and configuratio

35 atively, stereospecific substitution affords configurationally stable alpha,alpha-disubstituted aldeh

36 he addition of difluorinated nucleophiles to configurationally stable alpha-aminoaldehydes.

37 racterization of oligonucleotides containing configurationally stable analogues of C4-AP, which serve

38 drogen-bonding atropisomerization control of configurationally stable analogues of the biaryl natural

39 The iridium complex 4 proved to be configurationally stable and resolvable by analytical HP

40 We demonstrate that configurationally stable anomeric stannanes undergo a st

41 hereas N-Boc-2-lithio-2-arylpyrrolidines are configurationally stable at -60 degrees C.

42 thio-2-arylpiperidines have been found to be configurationally stable at -80 degrees C, whereas N-Boc

43 The organolithium is configurationally stable at low temperature, and the asy

44 riles can be formed by deprotonation and are configurationally stable at low temperature, even for ac

45 The [7]helicene is configurationally stable at room temperature and racemiz

46 alpha-alkoxy-substituted Grignard reagent is configurationally stable at room temperature for 30 min.

47 f chirality that, for marinopyrroles A-E, is configurationally stable at room temperature.

48 nstable at -78 degrees C but microscopically configurationally stable at the time scale of their addi

49 catalyzed reduction of an aldehyde to form a configurationally stable atropisomeric alcohol, with the

50 LC studies showed that they are tetravalent, configurationally stable B-chiral acylboronates.

51 The former were microscopically configurationally stable below -95 degrees C, and the la

52 Two configurationally stable carbon-based analogues of pyoch

53 The configurationally stable catalyst is demonstrated to cat

54 The radical cations of the E and the configurationally stable cyclohexene-bridged Z-derivativ

55 of N-Boc-allylic and benzylic amines provide configurationally stable intermediates which on conjugat

56 hanism emerges in which the aldehyde traps a configurationally stable intimate ion pair to stereospec

57 The transformations of configurationally stable substrates take place with high

58 Biquinolyl 2 is less configurationally stable than 1, racemizing rapidly in C

59 Two strategies for the synthesis of configurationally stable twisted polycyclic aromatic com

60 The deprotected guanidinium is configurationally stable under more acidic conditions.

61 that enantioenriched bromonium chlorides are configurationally stable under solvolytic conditions in

62 monstrate that alkylnickel intermediates are configurationally stable under Suzuki cross-coupling con

63 Ru catalysts suggesting that the catalyst is configurationally stable under the reaction conditions.

64 was determined by heteronuclear NMR to be a configurationally stable, alpha-lithio, eta(1)-coordinat

65 the axially chiral biphenyl was found to be configurationally stable, but the resolved enantiomers e

66 ould behave if their chiral centers were not configurationally stable, highlighting the vital importa

67 s containing four different substituents are configurationally stable, unless bonds to the stereogeni

68 configurationally stable active species and configurationally unstable dormant species with respect

69 hiral alpha-substituted isocyanoacetates are configurationally unstable in some synthetically useful

70 ere is based on the unusual application of a configurationally unstable stereogenic nitrogen, which p

71 e, and the alpha-S-substituted analogues are configurationally unstable.

72 -catalyzed cross-coupling reaction between a configurationally well-defined vinyl zinc intermediate 2