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1 tetraenoic acid [15(S)-HETE] and 15-oxo-ETE, confirming the role of 15-LO-1 in mediating AA metabolit
2 ylgeranyl pyrophosphate reversed the effect, confirming the role of 3-hydroxy-3-methylglutaryl coenzy
4 The analysis of in frame deletion mutants confirmed the role of a hydroxymethylglutaryl-coenzyme A
7 iated with lipid responses to SRL treatment, confirming the role of ABCB1 gene in SRL pharmacokinetic
11 logical studies and animal models to further confirm the role of ADE in the development of congenital
12 rophages from A(3)-/- but not A(2A)-/- mice, confirming the role of adenosine A(2A) receptors in this
14 y prevented effects on photosynthetic yield, confirming the role of Agd as a cause of the observed ef
16 all pathogenic repeat carrier brain samples, confirming the role of altered histone methylation in di
17 ble-blind, randomized controlled trials have confirmed the role of alternative tumour necrosis factor
18 es and density functional theory simulations confirmed the role of amine groups for stabilizing key i
19 Mutational studies based on this structure confirmed the role of amino acid residues in the capsid
26 B::lacZ and gdhA::lacZ translational fusions confirmed the role of ArgR in mediating arginine repress
31 ile in patients with previously treated MZL, confirming the role of BCR signaling in this malignancy.
32 dministration of an LTB4 receptor antagonist confirming the role of BLT1 in CD8+ T cell-mediated AHR.
33 BMP inhibitor noggin prevents the disorder, confirming the role of BMP4 in the pathogenesis of the d
34 Consistently, RT-PCR and proliferation assay confirmed the role of both genes in cell cycle progressi
37 delivered into the upper genital tract, both confirming the role of C5 in promoting hydrosalpinx and
38 ish blood and by a fish macrophage cell line confirmed the role of capsule in virulence and highlight
40 tion of CBFbeta in an EBNA3C-conditional LCL confirmed the role of CBF in the regulation of EBNA3C-in
43 y of the model is demonstrated by accurately confirming the role of CD4 help for antibody persistence
46 th the expansion of CD8 tetramer(+) T cells, confirming the role of CD8 T cells in this treatment str
50 l overlap among CESTA and its homologues and confirmed the role of CESTA in the positive control of B
51 components of the pathway are conserved and confirm the role of CgPHO81, CgPHO80, CgPHO4, and CgMSN5
52 Application to data from England and Wales confirms the role of children as key infection spreaders
54 e, we use an in vitro pre-clinical model and confirm the role of cIAP1 in invasion and the role of cI
55 ta and canonical WNT/beta-CATENIN signaling, confirming the roles of classical signaling in human neu
59 Subsequent experiments in mammalian cells confirmed the role of conserved extracellular threonine
61 lar mechanism underlying ADCC, which further confirms the role of Cx50 in the maintenance of human le
62 nt of micro 1 (Cys679 substituted by serine) confirmed the role of Cys679 and suggested that the ds b
63 of tumor necrosis factor alpha (TNF-alpha), confirming the role of cystatin E/M in the regulation of
64 sing radioiodinated D-KRYRR and L-KRYRR, and confirmed the role of D-amino acids in enhancing tumor u
68 somni transmigration across BAT2 monolayers, confirming the role of DR2/Fic in pathogenesis and corre
72 agenesis, CovR binding was reduced in vitro, confirming the role of each thymine pair in binding.
74 elevates pol III transcript expression, thus confirming the role of endogenous Maf1 as an inhibitor o
75 o negatively affect mTOR-FKBP38 interaction, confirming the role of endogenous PA in this regulation.
78 ERM kinase of importance in lymphocytes and confirm the role of ERM phosphorylation in regulating ce
79 BQ788 blocked the effects of IRL-1620, thus confirming the role of ETB receptors in the neurovascula
84 nts with human bone marrow stroma cocultures confirm the role of fibronectin ligation in maintaining
95 ecretion; the effect on insulin and glucagon confirms the role of GLP-1 in glycemic control through i
96 et morphology, and gene expression, and they confirm the role of glucagon as a tonic insulin antagoni
97 covery from agonist-induced desensitization, confirming the role of gravin in organization of G-prote
98 on of (18)O into the Asp carboxyl side chain confirming the role of H2O2 in the oxidation of the Met
99 d isozyme-specific small interfering RNAs to confirm the role of HDACs 1 and 6 as key mediators in fa
100 Knockdown and overexpression lines of HER2 confirmed the role of HER2, which encodes an oxidoreduct
101 l novel capabilities of human FcgammaRI that confirm the role of high-affinity IgG receptors in vivo.
102 rt transplanted over the course of 3 decades confirms the role of HLA-identical sibling transplantati
104 s NPM1/NRAS-G12D-mutant AML and functionally confirm the role of HOXA genes in NPM1c-driven AML.
108 anti-IL-7 monoclonal antibody (MAb) in vivo, confirmed the role of IL-7 protein in the observed TgB p
109 nd Vegf expression and new vessel formation, confirming the role of IL-6 trans-signaling in these pro
113 process of tripartite ICE integration and to confirm the role of integrase genes intS, intM, and intG
116 a block in IL-4, IL-5, and IL-13 production, confirming the role of IRE1alpha in the regulation of IL
117 V-1 constructed by site-directed mutagenesis confirmed the role of K103N, G190S, and Y188L substituti
118 uclease complex, allowing us to identify and confirm the role of key residues (Phe123, Met256, and Ty
120 at overexpress adrenergic alpha2A receptors, confirming the role of leucine in insulin secretion.
122 nts defective in relevant defense mechanisms confirmed the role of LPG in oxidant resistance but call
127 (M1R) exhibited enhanced neurite outgrowth, confirming the role of M1R in tonic suppression of axona
128 down experiments on ProGENI-identified genes confirmed the role of many new genes in sensitivity to t
129 king STAT1s or the type I IFN receptor chain confirmed the role of MAPKKs and IRF7 in Tat-mediated mo
133 icted P1 inhibitory reactive site amino acid confirmed the role of Met(26) in mediating inhibition of
135 inhibitor of DNA methyltransferases, further confirmed the role of methylation in PTPRO gene expressi
137 gene that causes recessive form of CMT6 and confirms the role of mitochondrial dysfunction in this c
138 ith mutant MRE11, we experimentally tried to confirm the role of MRE11 in conferring sensitivity to P
139 ramework of the developing brain and further confirms the role of mRNA translation in autism pathogen
140 dria results in defective bacterial killing, confirming the role of mROS in bactericidal activity.
141 re elevated in Msh2-deficient ES cell lines, confirming the role of Msh2 in blocking recombination be
142 reproduced the effect of rapamycin, thereby confirming the role of mTOR and of S6K in the acquired r
143 ockout and transgenic mouse studies, further confirmed the role of mu-calpain in the endothelial adhe
144 ing, identifying new driver genes while also confirming the role of myeloid differentiation primary r
149 growth and invasive morphology in Matrigel, confirming the role of NF-kappaB in epithelial to mesenc
151 inant IL-1beta, and IL-1 receptor antagonist confirmed the role of NLRP3 inflammasome-dependent IL-1b
155 ne profiling of FACS-purified photoreceptors confirmed the role of NR2E3 as a strong suppressor of co
156 functions are limited when RNA is modified, confirming the role of nucleoside modifications in suppr
159 ilm formation in the murine intestinal tract confirmed the role of one of the fimH alleles in this pr
160 f ORF7a leads to a much greater restriction, confirming the role of ORF7a as an inhibitor of BST-2.
161 pidly after injury than control plants, thus confirming the role of P-proteins in sieve tube sealing.
162 ligodeoxynucleotides and integrin activation confirmed the role of P311 in supporting migration of ma
165 tion of conserved ApiAP2 genes in Plasmodium confirmed the role of PbAP2-G and revealed a second ApiA
166 Finally, we present a novel method that confirms the role of PcAce2 in modulating organism virul
169 in vivo and in vitro ubiquitination studies confirm the role of PDLIM2 in formation and degradation
170 nt on the pheromone receptors Ste2 and Ste3, confirming the role of pheromone signalling in sexual bi
171 ailed phenotypic analysis of a phmyb1 mutant confirmed the role of PhMYB1 in the control of cell morp
174 loss of secretin function, and additionally confirms the role of PilT as a conditional antagonist of
175 retreated with the PKC inhibitor Ro-31-8220, confirming the role of PKC in mediating the PMA effect o
178 ymphoid organs are almost devoid of B cells, confirming the role of positive selection by Ag in the d
181 to trigger the alpha-to-beta transformation, confirms the roles of previously indicated residues E48
183 tion of genetically engineered animal models confirms the role of PRKAR1A as a tumour suppressor and
185 face CD45 and restored phosphatase activity, confirming the role of PU.1 in the positive regulation o
191 usefulness of the reverse genetic system to confirm the role of residues or proteins in coronavirus
193 ric analysis of several active site variants confirmed the roles of residues critical to the function
196 involvement of MEK/ERK signaling and further confirm the role of ROS/superoxides in POX-induced apopt
204 ffected by the sl(7) mutation, these results confirm the role of Sl in RTK signaling and provide evid
208 ing activation on this 3D structure, we have confirmed the roles of specialized myofiber tracts such
209 xpressed protein, has the power to reveal or confirm the roles of specific components of signaling pa
211 ldehyde from CO hydrogenation on Ni(110) and confirm the role of subsurface hydrogen in the mechanism
212 diasis resulting from T(H)17 deficiency have confirmed the role of T(H)17 cells and T(H)17 cytokines
213 essing an inactive mutant (DeltaZn/DeltaZn), confirming the role of TACE in PMA-induced c-Kit sheddin
216 tions had better outcomes 90 days after ICH, confirming the role of TGF-beta1 in functional recovery
218 tative PCR, and pyrosequencing, were used to confirm the role of the candidate gene in determining sp
219 itoring PA reassortment in seasonal flu, and confirm the role of the Caspase-1 gene in influenza path
228 s in primary progressive aphasia and further confirm the role of the uncinate fasciculus in semantic
230 mutational analysis of the miR-155 promoter confirmed the role of the Ets2 binding site proximal to
236 ing B cell-specific knockdown strategies, we confirmed the role of the miR-155 target Aicda (activati
237 and cell surface/solid-phase binding assays confirmed the role of the NGR domain in promoting AAV2-i
239 f oleosin in a range of sec61 mutant alleles confirmed the role of the SEC61 translocon in insertion
240 truction of bona fide sat operon mutants and confirmed the role of the SRP pathway in acid resistance
241 tion were inhibited by unconjugated aptamer, confirming the role of the aptamer in receptor-mediated
242 mide blocked the modulatory effects of ACTH, confirming the role of the cAMP/PKA pathway in microEOD
243 and Madin-Darby canine kidney Tet-Off cells, confirming the role of the carboxyl-terminal phosphoryla
244 catalytic activity and acetate competition, confirming the role of the cavity in acetate escape.
245 was converted into a classical endo enzyme, confirming the role of the extended Arg(203)-Ala(230) lo
246 ults in a constitutively activated integrin, confirming the role of the extracellular clasp in restra
247 the cells to 3-nitropropionic acid (3-NPA), confirming the role of the nitronate monooxygenase prote
249 istance defect in the counter-immune mutant, confirming the role of the protein in resistance to macr
250 and 190 copies/100,000 cells, respectively), confirming the role of the thymus in maintaining the per
251 Furthermore, electron population analysis confirms the role of the alkene as a "stepping stone" fo
254 irection and localization of these responses confirms the role of the mu-opioid receptor system in th
255 onal overlap among members of the family and confirm the role of these phosphatases in the control of
256 ndings justify future prospective studies to confirm the roles of these molecules in mediating chemot
258 nd Uhpra1, and their subsequent replacement, confirmed the role of these genes in initiation of the s
259 on and quantification by confocal microscopy confirmed the role of these genes in the maturation of t
260 mains IIIS6 and IVS6 of alpha(1CII) subunits confirmed the role of these L-type-specific amino acid r
264 s that are crucial for c-di-GMP binding, and confirmed the roles of these residues through biochemica
265 and accuracy of single nose poke responses, confirming the role of these areas in guiding responses
266 ce conditions but not for random conditions, confirming the role of these regions in the representati
267 synaptic potentiation in an intact circuit, confirming the role of these vesicular SNAREs in setting
273 The phenotypes of the Scnm1Delta3-5 mutant confirm the role of this splice factor in processing the
274 sure that lead normal cells to tumorigenesis confirm the role of this steroid hormone in cancer initi
275 ing the individual RRM domains from hnRNP LL confirm the role of this transcription factor in activat
277 for the propane monooxygenase enzyme (PrMO) confirmed the role of this enzyme in the biotransformati
278 ntation using a recombinant wild-type allele confirmed the role of this mutation in the cytadherence
280 reversed the anti-apoptotic effects of NRG4, confirming the role of this cascade in NRG4-induced cell
281 ion probability was highly significant, thus confirming the role of this DUT mutation in this syndrom
282 ibody shifted nuclear protein-DNA complexes, confirming the role of this factor in regulating the exp
284 value and a much lower catalytic efficiency, confirming the role of this residue in substrate binding
285 ocked proton transfer by binding to Glu-282, confirming the role of this residue in the identified pa
286 egregating with macular dystrophy phenotypes confirms the role of this gene in a subset of dominant m
287 etic complementation of a Thf1 knockout line confirms the role of this gene in chloroplast and leaf d
288 ndent, tissue-specific growth regulation and confirmed the roles of three such genes in the phytochro
290 did those from their wild type counterparts, confirming the role of TopIIbeta in neurite outgrowth.
292 ometric evidence in vivo as well as in vitro confirmed the role of transient receptor potential chann
297 complex mutation linked to human disease and confirms the role of very short telomeres as a diagnosti
298 ocked down transgenic tobacco plant analysis confirmed the role of XET gene in roots growth and droug
300 eased in ZAT6 overexpressing plants, thereby confirming the role of ZAT6 in regulating Pi homeostasis
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