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1 s embraced to achieve its cleavage competent conformation.
2 The channel adopts an open conformation.
3 , molecules 1 and 4 prefer to adopt the Pheq conformation.
4 , folding stem IIB into a proper Rev binding conformation.
5 d shows subtle but clear changes in tertiary conformation.
6 t monoclonal antibody specific for the pre-F conformation.
7 te is closed in a highly strained asymmetric conformation.
8 ng a catalytically competent dimeric cyclase conformation.
9 nd, capturing the receptor in an active-like conformation.
10 One state contains a compact inactive RF2 conformation.
11 bly different from those in the ligand-bound conformation.
12 l apex or rotated into a receptor-accessible conformation.
13 y stabilizing the closed E2 approximately Ub conformation.
14 ethylation or demethylation, and alter their conformation.
15 e trimer to adopt either a closed or an open conformation.
16 hexamer (site I), stabilizing it in the T3R3 conformation.
17 ransport domain toward their own alternative conformation.
18 red for the active site to assume the proper conformation.
19 es that are defined by the twisted molecular conformation.
20 C-terminal domain has a PG-binding-competent conformation.
21 izes the RNA by locking it into a particular conformation.
22 the bulk to a greater degree than is the cis conformation.
23 ually inserted into the membrane in a native conformation.
24 interaction, causing PSD-95 to adopt an open conformation.
25 n, called Pre-F-GCN4t, stabilized in a pre-F conformation.
26 in (Pdx), shows that P450cam adopts the open conformation.
27 es a robust screening system to monitor apoE conformation.
28 nformation, whereas cSH2 prefers a collapsed conformation.
29 isulfide connectivity underlying E1E2 native conformation.
30 fy signals or stabilize a particular protein conformation.
31 access to the pore even in the NBD-dimerized conformation.
32 eters depended on the technique used and BSA conformation.
33 etal coordination in an open non-DNA-binding conformation.
34 glycoproteins, likely through altering their conformation.
35 y alter the proportions of the two CD4-bound conformations.
36 structure dominated by turn and random coil conformations.
37 compaction of the two different families of conformations.
38 the sampling of many potentially productive conformations.
39 served in experiments originate from compact conformations.
40 nomeric spikes similar to one of the crystal conformations.
41 s of EPOR truly represent active or inactive conformations.
42 modynamic stabilities of different molecular conformations.
43 de inhibitors having non-helical or extended conformations.
44 r revealed three dominant classes of subunit conformations.
45 igand that can adopt two distinct rotational conformations.
46 y changing the ensemble of likely low-energy conformations.
47 tate, with the guests bound in axial/diaxial conformations.
48 and other biomacromolecules in their native conformations.
49 e dynamic entities and populate ensembles of conformations.
50 -occluded, inward-occluded, and inward GLUT1 conformations.
51 ate equilibrium between compact and extended conformations.
52 a interacts predominantly in resting channel conformations.
53 xible regions that adopt multiple structural conformations.
54 d interesting to characterize the structural conformations adopted by these intermediates, also calle
57 luding positional sensing, biomacromolecular conformation analysis, and real-time kinetic monitoring
58 mic equilibrium between the known, common Ub conformation and a distinct, second conformation wherein
63 t with the concept that abnormal AAT protein conformation and intrahepatic accumulation have broad ef
64 omputational approaches for measuring genome conformation and nuclear organization, and investigate h
65 ed by binding of l-arginine in a nonoxidized conformation and of 2-oxoglutarate in an unprecedented h
66 t of distinct intramolecular motifs on xylan conformation and on the interaction with cellulose surfa
67 the presence of membranes; conversely, lipid conformation and packing can adapt to the presence of pe
69 ial segment (NIS) adopting a backward-docked conformation and the preceding alpha6 helix partially me
70 the characteristic caliper-like DNA-binding conformation and the second monomer exhibiting disrupted
71 sensing, which range from changes in protein conformation and transcription factor localization to ch
77 ctural determinants that distinguish the two conformations and possible rearrangements of TMHs within
78 ank (PDB), only 22% of them have alternative conformations and the remaining proteins have different
79 noporphyrin molecular dyads having different conformations and therefore different interchromophore e
80 nv has been identified as one such preferred conformation, and a current leading vaccine candidate is
81 loaders bind and stabilize clamps in an open conformation, and in the second stage, clamp loaders pla
83 he Arp2/3 complex, induced the standard open conformation, and two new masses appeared at positions n
84 tern and more precisely tractable chromosome conformations, and the large-scale genomic organization
85 roteins can attain both compact and expanded conformations, and the level of expansion may be regulat
86 ry proteins adopt distinct bound and unbound conformations, and use this structural flexibility to bi
88 uctural and dynamical aspects of the helical conformations are explored, with a focus on contrasting
89 The more axial-rich donors in skew and boat conformations are thus preorganized closer to the assume
92 ignaling potency, suggesting an altered GPCR conformation as the underlying basis for GPCR priming.
93 icate that the macrocycle adopts a boat-like conformation at the final station, which contrasts with
95 aracterized by different aromatic side-chain conformations at the RNA-binding surface allow for high-
96 tructures, template 1-MeA rotates to the syn conformation but pairs differently with dTTP versus dCTP
97 o a simple binary switch between two defined conformations, but the activated receptor is in equilibr
99 aled molecular-level perturbations of fibril conformation by the PD-related mutations that are not ap
101 e inhibitor and IRAP that are unique to this conformation can explain the strong selectivity compared
103 phosphorylation sites is required for a GC-A conformation capable of transmitting the hormone binding
105 serve chromatin interactions by a Chromosome Conformation Capture (3C)-based method, in primary human
108 expression, DNA methylation, and chromosome conformation capture experiments into network models tha
109 ian genomes using data from a new chromosome conformation capture procedure that allows us to first i
111 inhibit GTP binding/signalling by driving a conformation change that disorganizes the TG2 GTP bindin
116 twofold noncrystallographic symmetry axis, a conformation clearly distinct from that of actin subunit
119 namics simulations to determine ensembles of conformations corresponding to the denatured, transition
120 ies form Watson-Crick-like base pairs, their conformation could not be directly deduced from the expe
121 uantitative trait loci (eQTL) or Hi-C genome conformation data and reports the most likely candidate
123 ed for the first time that MK-2 has a folded conformation defined by the isoprenyl side-chain folding
125 amyloid structures distinguished by amyloid conformation-dependent monoclonal antibodies have simila
126 to understand how a protein's 3-dimensional conformation determines its capacity to interact with po
127 We show that NEMO adopts a more compact conformation (Dmax=320A) than predicted for a fully exte
128 a rather broad distribution in polymer chain conformation due to the strong steric hindrance of bulky
129 cal activity due to their fragile structural conformation during formulation, storage, and delivery.
131 -chemistry structure of hPolbeta in the open conformation, following incorporation of (-)3TC-MP, with
132 activity resulting from the complex form, a conformation for domain switching, allows FIN219 to swit
133 these structures also revealed well-ordered conformations for the EF loop of VP2, the GH loop of VP3
135 quantitative trait loci (meQTLs), chromatin conformation from publicly available datasets (Hi-C and
136 C)) to selectively propagate optimized prion conformations from larger ensembles generated in the spe
143 is due to an alternative nucleotide binding conformation in the precatalytic ternary structures (hPo
144 of calcium, are compacted but adopt an open conformation in the presence of calcium, enabling actin
146 energy simulations elucidate the active site conformations in the AppA (activation of photopigment an
147 inus, which was suggested to adopt different conformations in the inward facing, outward facing and a
149 termed the stalk, which adopts a beta-strand conformation, instead of forming an alpha-helix as obser
150 its postfusion (post-F) or prefusion (pre-F) conformation is a target for neutralizing antibodies and
152 the rotating lever arm toward the poststroke conformation is almost flat, implying that the lever arm
155 ther, these data suggest that Arp2/3 complex conformation is highly polymorphic and that its activiti
156 sion state and triggering to the post-fusion conformation is important for understanding F protein fu
158 und to be catalyzed; additionally, the trans conformation is selectively solvated within the bulk to
163 tion of the -1 subsite mannoside to an (O)S2 conformation, matching that predicted by theory and supp
164 However, dynamic sampling of alternative conformations (microstates) in allosteric molecules comp
165 pport the concept that modulating mutant HTT conformation might provide novel therapeutic and diagnos
166 m" of heterologous interactions, enforcing a conformation more similar to that of homologous (i.e., n
169 the Hi-C technique, the study of the spatial conformation of a genome is becoming an important topic
170 ombination of structural features within the conformation of a protein; not only its percentage secon
173 t the D145E mutation destabilises the native conformation of EF-hand IV, leading to a transient unfol
176 , consistent with CD4-induced changes in the conformation of gp120 and the antibody binding site.
178 physiology, the in vivo oligomeric state and conformation of insulin in its storage granules in the p
181 ment of therapeutics aimed at correcting the conformation of polyglutamine-expanded proteins as well
183 h a recent proposal that eIF4A modulates the conformation of the 40S ribosomal subunit to promote mRN
184 ich states that collagen binding changes the conformation of the A1 domain to a high-affinity GPIbalp
186 to mimic the suggested bioactive gamma-turn conformation of the Bip-Lys-Tyr tripeptide in Urocontrin
188 lical hairpin in the NTD of DnaB altered the conformation of the helical hairpin and/or compromised i
189 accine designers have sought to restrict the conformation of the HIV-1 Env trimer to its prefusion-cl
190 The resulting conformation is similar to the conformation of the inhibitor in the active site of BACE
193 clear compartments depends on NCoA-2 and the conformation of the receptor as assessed with synthetic
196 fect of chaperone activity on the functional conformation of the temperature-sensitive mutant cystic
197 the impact of ATP, MalE, and maltose on the conformation of the transporter during the transport cyc
198 previously unreported, predeoligomerization conformation of the trimer that has been shown to be sam
200 xhibits preferential binding toward the open conformation of vinculin, suggesting that the MAPK1-vinc
201 ORE spectroscopy validate that the perturbed conformation of Y731 in R411A-alpha2 is dynamic, reformi
202 lpha) disrupts the H-bonding environment and conformation of Y731, ostensibly breaking the RT pathway
204 e process initiated in RPc and that the RNAP conformations of intermediates are significantly differe
207 rticularly by stabilizing clinically favored conformations of target proteins, with orally available,
209 dynamics studies to determine the preferred conformations of the A-A noncanonical pairs in (CAG)n an
210 Previous reports show that fH binds various conformations of the cellular prion protein, leading us
213 t occur between the prefusion and postfusion conformations of the fusion protein.IMPORTANCE Due to la
214 c exchange between partially closed and open conformations of the SAM-II riboswitch in the absence of
215 tain more accurate descriptions of alternate conformations of the two proteins, we first performed co
216 delta1 may up-regulate currents by promoting conformations of the voltage sensor that are associated
217 radical generation reveal that Y731 changes conformation on the ns-mus time scale, significantly fas
218 his gp140 trimer, which adopts two principal conformations, one closed and the other slightly open.
219 the four-way junction exists as a mixture of conformations, one of which is most likely the open-X st
220 ing DFT/B3LYP/pcJ-1 approximation applied to conformations optimized at DFT/B3LYP/6-311++G** level su
224 suggested that outward and outward-occluded conformations present multiple beta-d-glucose and maltos
225 on sites, whereas inward-occluded and inward conformations present only a single beta-d-glucose inter
227 N582, suggesting that rapid folding of local conformation prevents glycosylation of this site in wild
228 phetamine, that is thought to disrupt DAT OF conformation, reduced the concentration of wild-type DAT
230 ructure, allowing RNA molecules to adopt the conformations required for interaction with their target
231 either the gauche-gauche or the gauche-trans conformation (respectively, axial or equatorial to the b
232 a C(11)=C(12) double bond locked in its cis conformation (Rh6mr), employs an atypical isomerization
233 sts that UBP684 binding may induce switch in conformation similar to glutamate LBD locked state.
234 brils could be used as immunogens to prepare conformation-specific antibodies and as novel tools to d
236 the B[a]P moiety is in a non-solvent exposed conformation stacked within the DNA helix, where it effe
237 are known to adopt higher and lower activity conformations, structural determinants for the different
238 lly complex disorders followed by chromosome conformation studies in relevant tissues can be successf
239 DFNKF sequence is not stable in antiparallel conformation, suggesting that the residue flanking the a
240 -acid-binding cleft of RNAP samples distinct conformations, suggesting different functional states du
242 sification of protein kinase active/inactive conformations, taking into account more structures and m
244 ar size, and likely with a different overall conformation than those formed along the on-pathway, sug
246 trikingly, the AAUAAA PAS assumes an unusual conformation that allows this short motif to be bound di
248 zation requires the protein to adopt an open conformation that exposes the surfaces engaging in inter
249 oxoglutarate in an unprecedented high-energy conformation that favors ethylene, relative to succinate
252 cells cholesterol keeps TCRs in the resting conformation that otherwise would become spontaneously a
254 olded state towards a compact, pre-organized conformation that resembles the ligand-bound state.
255 e-to-proline mutation, locking the loop in a conformation that sterically blocks binding and neutrali
256 igh-mannose glycoform preferentially samples conformations that are more competent to FcgammaRIIIa bi
257 ng, indicating a shift toward outward-facing conformations that can be interpreted using conventional
258 a corA gene can adopt two mutually exclusive conformations that dictate accessibility of a rut site t
262 transport by confirming at least four GLUT1 conformations, the so-called outward, outward-occluded,
263 ible N-terminal loop for adopting its active conformation, thereby effecting substrate specificity.
264 he propensity of Env to sample the CD4-bound conformation, thereby increasing susceptibility to ADCC.
265 s helical transitions leading to post-fusion conformations, thereby favoring the pre-fusion state.
267 ytoplasmic domain of subunit a (aNT) changes conformation to bind rotor subunit d However, insufficie
269 as protein kinases adopt a diverse array of conformations to respond to regulatory signals in signal
270 ly to peer algorithms, and can approach goal conformations to within a low all-atom RMSD by directing
271 -RD captured a low populated protein-folding conformation triggered by the Glu-145 replacement of Asp
272 ituted MalFGK2 in nanodiscs and analyzed its conformations under 10 different biochemical conditions
274 creased RNA hydrogen bonding and changed RNA conformation upon IRP1 binding and illustrate how small,
275 whether this difference is due to an altered conformation upon RNAP binding or to differences in intr
276 y stabilize the dimer-prone or monomer-prone conformations, validated in-solution, and introduced to
277 sults suggest that TMAO stabilizes collapsed conformations via a mechanism that is distinct from glyc
279 d aPRP a significant change to less extended conformations was observed, while P-B peptide did not di
282 c rings and these adopt a twisted "S"-shaped conformation when bound to A. thaliana AHAS (AtAHAS) wit
283 fts the equilibrium towards an active T-loop conformation whereas addition of the inhibitors MLN8054
284 homology 3 (SH3) domain, leading to a closed conformation, whereas a non-phosphorylatable S561A mutat
285 we observe that nSH2 prefers an extended CaM conformation, whereas cSH2 prefers a collapsed conformat
286 ommon Ub conformation and a distinct, second conformation wherein the last beta-strand is retracted t
287 tionic AMPs typically exhibit an amphipathic conformation, which allows increased interaction with ne
288 adduct is able to move to a solvent-exposed conformation, which enables error-prone DNA replication
289 to such sites induces changes in the filter conformation, which play a key role in defining both sel
290 PKC-phosphorylated AT1R in a distinct active conformation, which triggers MAPK recruitment and recept
291 M2 is splayed open, reminiscent of the open conformation, while the intracellular-half is constricte
292 exists in dynamic equilibrium with holo-like conformations, while Ca(2+) uptake reduces conformationa
293 on, whereas GTP promotes a compact, inactive conformation whose ability to polymerize is unknown.
294 ob-into-hole assembly, proved to be a stable conformation with homogeneous distribution, confirming i
296 pendent of size and charge but did depend on conformation, with regular, spherical particles being de
297 ptides bind in a bidirectional yet conserved conformation within the substrate-binding cleft of OGA.
298 rst, the motor domain attains the poststroke conformation without directing the lever arm forward; an
299 irected sampling correctly identified the on-conformation; without the ligand, only off-conformations
300 for xyloglucans in both extended and coiled conformations, yet xyloglucan chains were not directly v
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