ライフサイエンスコーパス: conformational

1 ain is not the dominant mechanism behind the conformational activation.

2 nexpected stimulation arises from Tg-induced conformational alterations and dynamics in telomeric DNA

3 ein, we report on the synthesis and detailed conformational analysis of a series of (S)-N-(1-tert-but

4 e synthesis, extensive characterization, and conformational analysis of the first peptidomimetics wit

5 Further, conformational analysis of tyrosinase with BA was measur

6 phy, computational studies, and NMR solution conformational analysis was successfully applied to a fr

7 es within the carbohydrate were employed for conformational analysis, and NOE-based distance mapping

8 crystal structures, our understanding of the conformational and dynamic behavior of NS5B in solution

9 However, the extent of conformational and dynamic changes that are propagated t

10 ning surface chemistry, we found that as the conformational and translational dynamics of FN increase

11 This way, nonequilibrium structure and conformational, as well as purely quantum mechanical eff

12 Here we investigate the conformational behavior of the T-domain of colicin N (Co

13 taneously and provide a new model for kinase conformational behavior.

14 ha-epimer revealed that the 4'-OMe imparts a conformational bias toward the North-East sugar pucker,

15 d performing promoter-reporter and chromatin conformational capture (3C) studies in beta cell lines,

16 he formation mechanism was attributed to the conformational change driven by the collective hydrogen

17 To do this, MinE undergoes a remarkable conformational change from a latent 6beta-stranded form

18 They also suggest that this conformational change helps transmit the cholesterol sig

19 Our structure reveals a dramatic conformational change in a loop within the PL-2 epitope

20 these results, we propose a model in which a conformational change in BTN3A1 is a key event of pAg se

21 ng the oligomerization state, heme induces a conformational change in DGCR8.

22 sight on how the probe senses ligand-induced conformational change in RNA.

23 MTs, and structural modeling data suggest a conformational change in the alpha/beta-tubulin heterodi

24 speculated that the dissociation requires a conformational change in the intervening polytopic seque

25 Tmm and first show that NADP(+) undergoes a conformational change in the oxidative half-reaction of

26 , AS-48, which appears to interfere with the conformational change in the viral F protein that is req

27 owed that Ser65 phosphorylation results in a conformational change in which Ub adopts a dynamic equil

28 This conformational change is likely caused by a lack of CH3

29 demonstrate that D-serine rapidly induces a conformational change of the GluN1 subunit intracellular

30 dent release of the ligand associated with a conformational change of the receptor.

31 We suggest that the conformational change of the syntaxin-1 linker region in

32 s, with some proteins undergoing significant conformational change or intermolecular association to g

33 age rates results from a slow, rate-limiting conformational change prior to HJ cleavage: formation of

34 ecular basis of the receptor-binding-induced conformational change required for HIV-1 entry into host

35 lation of ERG at one serine residue causes a conformational change that allows ERK phosphorylation at

36 increase in the alpha-helical content and a conformational change that lead to the exposure of hydro

37 e complex, and undergoes a global pincerlike conformational change that narrows the S-peptide binding

38 ARylated PARP1 by the macro domain induces a conformational change that relieves autoinhibitory inter

39 he in vitro digestion profile shows that the conformational change undergone by AS-48 upon adsorption

40 This conformational change unveils a region of the N-terminal

41 oteins and NPs and the occurrence of protein conformational change upon binding to NPs are two import

42 The enzyme conformational change was validated by 3D fluorescence a

43 causes its membrane accumulation and active conformational change, activating CMA.

44 gh capsid pores are associated with a subtle conformational change.

45 how how sequential, allosterically regulated conformational changes activate AP2 to drive both nuclea

46 degrees C) and kinetic parameters for enzyme conformational changes and chemistry (rate constants and

47 we apply directed forces to drive the GroEL conformational changes and learn that there is a highly

48 mbranous proteolipid boundary to explain the conformational changes and oligomeric states of proteins

49 Significant conformational changes are observed throughout the domai

50 Chemically induced conformational changes are studied and compared to those

51 le indicate that McjD does not undergo major conformational changes as previously proposed for multi-

52 esident HRas, but not soluble HRas, enhances conformational changes associated with membrane binding

53 rovide evidence that our method can identify conformational changes associated with the binding of al

54 esonance energy transfer to directly observe conformational changes associated with the functional tr

55 tential mechanical connection to communicate conformational changes between periplasmic, membrane, an

56 Herein, we report that these conformational changes can also disturb the protein's ab

57 ytic cycle revealing that AC undergoes large conformational changes coupled to substrate activation b

58 ow-pH pathways; this occurs by pretriggering conformational changes essential for fusion.

59 ctuations that set the stage for large-scale conformational changes essential for translocation and e

60 d that B. subtilis sigma1.1 requires minimal conformational changes for accommodating RNAP in the DNA

61 rand factor A domains undergoing significant conformational changes for affinity regulation.

62 strates could be passed, but instead conveys conformational changes from one side of the membrane to

63 xploiting the unique structural features and conformational changes identified here may provide new a

64 nnot convert gamma-subunit rotation into the conformational changes implicit in rotary catalysis.

65 ease of pyrophosphate (PPi) triggers reverse conformational changes in a polymerase in order to compl

66 due to the entropy variation associated with conformational changes in brush and matrix chains.

67 eric and dimeric receptors activate distinct conformational changes in G and discuss implications for

68 eric and dimeric receptors activate distinct conformational changes in G.

69 nel's cleft early during activation, or that conformational changes in KCNQ1 alter its interaction wi

70 Altogether, our studies suggest that the conformational changes in motifs B and D, and the nucleo

71 to the PP2A Aalpha scaffold subunit to drive conformational changes in PP2A.

72 Our data support a model wherein conformational changes in SF3b1 promote U2 association w

73 Although Hsp90 conformational changes in solution have been well-studie

74 ure of EcAGPase-R130A revealed unprecedented conformational changes in structural elements involved i

75 it is only partially bent, with large-scale conformational changes in the C3 domains that inhibit th

76 d that this effect is not the consequence of conformational changes in the catalyst but rather caused

77 the sorting platform results in significant conformational changes in the needle complex to provide

78 This induces conformational changes in the tailpiece and the adjacent

79 we detected and characterized ligand-induced conformational changes in the transmembrane and intracel

80 We also observed large conformational changes induced by leukotriene C4, explai

81 age indirectly affects signaling by blocking conformational changes induced by weak integrin binding

82 gering the protein's functional activity via conformational changes is an intrinsic function of prote

83 ide strand are stacked-into the duplex, with conformational changes localized to the bulge site, ther

84 of the precursor peptide and the associated conformational changes needed for the formation of the u

85 assignments show that, upon assembly, large conformational changes occur in loops connecting helices

86 pectroscopy makes it possible to monitor the conformational changes of a translational molecular mach

87 is a powerful tool to study interactions and conformational changes of biological molecules in the di

88 dissociation kinetics of very short DNA and conformational changes of biomolecules with much improve

89 RyR1 Ca(2+) pore in the SR, under control of conformational changes of CaV1.1, located approximately

90 To understand the conformational changes of mushroom PPO, the secondary st

91 , we used voltage-clamp fluorometry to track conformational changes of the KCNQ3 voltage-sensing doma

92 he highest mass adsorption and could promote conformational changes of the proteins and subsequent ab

93 also reveals the large and highly nonlinear conformational changes of the sheath whose elastic energ

94 s suggests that it neutralizes by inhibiting conformational changes required for entry.

95 ractions with another monomer that undergoes conformational changes stabilizing the dimer assembly.

96 NA duplexes without undergoing rate-limiting conformational changes that precede activation.

97 steresis, in which substrate binding induces conformational changes that promote assembly of a high-a

98 e, we utilize EPR spectroscopy to target the conformational changes that take place in the full CusB

99 of agonists to VFD2 of TAS1R2 leads to major conformational changes to form a TM6/TM6 interface betwe

100 nding on the PAM sequences, LbCpf1 undergoes conformational changes to form altered interactions with

101 icate the NIS of kinesin-1 undergoes similar conformational changes under tension in the two-head bou

102 Integrins undergo large-scale conformational changes upon activation.

103 This resistance to CD4-induced conformational changes was associated with a lower affin

104 Detection of such conformational changes was enabled by a fluorogenic liga

105 le Env is triggered to undergo entry-related conformational changes when gp120 binds sequentially to

106 Connecting conformational changes with catalysis in modular enzymes

107 SCCH domain alternation is accompanied by conformational changes within the Uba1 adenylation domai

108 of the nucleotide, sometimes lead to protein conformational changes, and lead to substantial changes

109 iomimetic ER and may, in addition to protein conformational changes, contribute to the observed NADPH

110 secondary structures, which enables dynamic conformational changes, is primarily accomplished by tun

111 l sciences, specifically protein binding and conformational changes, lipid membrane fabrication, memb

112 e molecular chaperone Hsp90 depends on large conformational changes, the rearrangement of local motif

113 4 mutations change hydrogen bonding or cause conformational changes.

114 t DNA, Cas9-DNA interactions, and associated conformational changes.

115 his with regards to the RECQL5 mechanism and conformational changes.

116 emperatures possibly arising from C-terminal conformational changes.

117 re local and do not introduce major backbone conformational changes.

118 lity to undergo programmable and predictable conformational changes.

119 he formation of more TRPV1/CaM complexes and conformational changes.

120 ity of the envelope glycoproteins to undergo conformational changes.

121 e gene expression via small-molecule-induced conformational changes.

122 Furthermore, PGR was resistant to conformational collapse or alpha-helix formation upon th

123 dually increased activity, thus defining the conformational constraints in the catalytic process.

124 overlooked orbital delocalization effects in conformational control and molecular recognition phenome

125 ification reaction for the checkpoint is the conformational conversion of "open" mitotic arrest defic

126 We further demonstrated that the conformational cross-talk between alphaL alphaI and beta

127 llow completion of a closed-open-inactivated conformational cycle in a single voltage-gated sodium ch

128 This work thus provides insights into the conformational cycle of Roco proteins and suggests a lin

129 nd demonstrate the need to utilize chromatin conformational data for the prediction of position effec

130 he uncatalyzed reaction, the introduction of conformational descriptors, and the use of computed inte

131 ulting in a unique storage- and pH-dependent conformational destabilization and refolding of the hole

132 m Dark state to Light state with significant conformational deviation.

133 ovel class of FRET-based reporter to monitor conformational differences corresponding to states sampl

134 s(1,2,4,5,6)P5 These features are main-chain conformational differences in loops adjacent to the acti

135 The conformational differences stem from the orientations of

136 e design principle of NDP-V is to reduce the conformational disorder in the backbone of a previously

137 and its effects on gating, also altered the conformational displacement between the VAMP721 SNARE an

138 Despite their conformational diversity, ncRNAs mostly preserve their s

139 On the basis of the conformational dynamicity of the -B(OH)2 functional grou

140 by capsaicin, providing an optical marker of conformational dynamics at the selectivity filter.

141 nal modification of U56 and U93 alters snRNA conformational dynamics by distinct mechanisms and that

142 he three CKI1RD variants exhibited different conformational dynamics in solution.

143 , modifications to cytosine affect the local conformational dynamics of a DNA duplex in a confined en

144 formation on the structural propensities and conformational dynamics of Ascl1.

145 Here, we address the redox-dependent conformational dynamics of hPDI through molecular dynami

146 exchange mass spectrometry, we measured the conformational dynamics of intracellular half constructs

147 energy transfer, we show that Psi56 dampens conformational dynamics of stem II and stabilizes stem I

148 lly, our structure provides insight into the conformational dynamics of TFIIH and the regulation of i

149 ric effector and triggers the interdependent conformational dynamics of the Cas9 catalytic domains (H

150 microseconds to milliseconds, to reveal the conformational dynamics of the endonuclease Cas9 during

151 ensor-based experiments, we investigated the conformational dynamics of the kinase-substrate interfac

152 eved that enzyme catalysis is facilitated by conformational dynamics of the protein scaffold that sur

153 To this end, we investigated the conformational dynamics of two key Arabidopsis thaliana

154 Protein loops show rich conformational dynamics properties on a wide range of ti

155 on perturbation, TNFalpha exhibits increased conformational dynamics spanning from the trimerization

156 affinity, secondary and tertiary structure, conformational dynamics, and thermal stability.

157 AmtB-GlnK in the absence of lipids indicates conformational dynamics.

158 However, it remains unclear how the Hsp70 conformational ensemble is populated at each point of th

159 es of S-glutathionylation on the equilibrium conformational ensemble of BAK1 using all-atom molecular

160 Understanding of the conformational ensemble of flexible polyelectrolytes, su

161 e most accurate representation of Abeta10-40 conformational ensemble.

162 Because conformational ensembles are an inevitable feature of pr

163 accuracy in generating polypeptide backbone conformational ensembles for intrinsically disordered pe

164 fields and resolve subtle differences in the conformational ensembles of nucleic acids, on the order

165 scopy has recently been used to characterize conformational ensembles of proteins in the microcrystal

166 We find that the contribution of conformational entropy can range from favorable to unfav

167 We use the principles of the conformational entropy model to engineer curvature sensi

168 ctive segregation of PGNPs is induced by the conformational entropy penalty arising from local pertur

169 Thus, we propose that a threshold for the conformational entropy provided by structural fluctuatio

170 receptor trimers-of-dimers, and results from conformational entropy within the trimer-of-dimers geome

171 e-quarter of these complexes, the absence of conformational entropy would render the resulting affini

172 crocycle upon its activity, 3D geometry, and conformational entropy.

173 the prime targets of protective immunity are conformational epitopes at the dimer interface.

174 e 1 and 3-phenyl-3-silatetrahydropyran 4 the conformational equilibria could be frozen and assigned.

175 cture and function are dictated by a dynamic conformational equilibrium and that subtle changes in li

176 ansferase (ATP-PRT) is a hexameric enzyme in conformational equilibrium between an open and seemingly

177 These data collectively suggest that conformational equilibrium of the A3B active site loops,

178 +) binding and beryllofluoridation alter the conformational equilibrium of the beta3-alpha3 loop clos

179 We report studies of the conformational equilibrium of this enzyme using small-an

180 finity of Na(+) to bind the channel when the conformational equilibrium shifts toward the conductive

181 enzyl-l-hydantoin (L-BH) does not shift this conformational equilibrium, but systematic co-addition o

182 ers the thermodynamics and kinetics of local conformational exchange as well as overall rocking motio

183 Comparison of the intermediate conformational families of K6-, K11-, and K63-linked diU

184 Our results provide strong evidence that the conformational flexibility also plays an important role

185 input variables that accounted for both the conformational flexibility and the energetic factor of b

186 Together with their conformational flexibility and the transient nature of t

187 ons, largely accounts for the differences in conformational flexibility between LEN and SMA.

188 experimental and computational evidence that conformational flexibility can assist the emergence and

189 s not only a tool to probe the impact of the conformational flexibility of Ar-Au-Ar intermediates, vi

190 able insights into regulatory mechanisms and conformational flexibility of uPA and trypsin-like serin

191 x nature of correlations between light-chain conformational flexibility, thermodynamic stability and

192 e conformations, while Ca(2+) uptake reduces conformational flexibility.

193 ling virions that are stable and maintaining conformational flexibility.

194 s spectrometry is used to track snapshots of conformational fluctuations in the phosphotransferase ad

195 Conformational fluctuations within scFv antibodies are c

196 play between covalent protein modifications, conformational fluctuations, catalysis, and transient pr

197 Conformational freedom of the FMN domain is thought to b

198 eudoknot provided the strongest restraint on conformational freedom with the effect being most appare

199 g a wide variety of molecular complexity and conformational freedom.

200 BiP chaperone cycle that reveals surprising conformational heterogeneity of ATP-bound BiP that disti

201 ey clinical and preclinical relevance to the conformational immunoassay, and provide supportive evide

202 y and supporting an (O)S2 --> B2,5 --> (1)S5 conformational itinerary for GH125 alpha-mannosidases.

203 Navigation of the conformational landscape defined by this bioinformatics-

204 Histone H1 shifts the conformational landscape of the nucleosome by drawing th

205 des a challenge for probing their complex 3D conformational landscape, both experimentally and comput

206 The resulting detailed conformational landscapes complement in an integrative m

207 nging task due to the high complexity of the conformational landscapes of proteins and their rugged e

208 ylene (DESVS), with novel Se...O noncovalent conformational locks is designed and synthesized.

209 We describe a novel approach to produce conformational monoclonal antibodies selected to specifi

210 Several contact, but not conformational, mutp53s enhance the interaction between

211 on of proteins with designer single-molecule conformational phenotypes of interest.

212 Finally, we discuss the implications of GPCR conformational plasticity for drug design.

213 study the folding, unfolding, misfolding and conformational plasticity of the high-efficiency framesh

214 ecules has hindered characterization of such conformational plasticity.

215 ve proved difficult due to its apparent high conformational plasticity.

216 simulations are used to model changes in the conformational preferences of a model peptide during the

217 t allow the accurate prediction of the sugar conformational preferences of chemically modified nucleo

218 influencing intermolecular interactions and conformational preferences.

219 e at codon 129 of the prion protein gene and conformational properties of the scrapie PrP (PrP(Sc)) g

220 the charge patterning within RAM affects its conformational properties, the affinity of NICD to CSL,

221 investigate the underlying mechanism of this conformational rearrangement and its implications for he

222 ipid bilayer act synergistically to induce a conformational rearrangement in the C-terminal domain of

223 nation for the gating compliance is that the conformational rearrangement of a single channel directl

224 This coincides with a large conformational rearrangement of miropin, which inserts t

225 A heme-dependent conformational rearrangement of the C-terminal domain of

226 tical domains, such as those that impair the conformational rearrangement required for proteinase ina

227 that the protein-protein interaction induces conformational rearrangement, promoting a ligand switch

228 loop is therefore an essential regulator of conformational rearrangements during ion channel opening

229 es on representative examples of geometry or conformational rearrangements for each selected class of

230 on intermediates to undergo ligand-dependent conformational refolding.

231 f RNA synthesis and ligand binding-dependent conformational refolding.

232 dies have deepened our understanding of GPCR conformational regulation by different ligands.

233 tors of polyQ amyloid growth that focuses on conformational requirements for fibril and nucleus elong

234 active site; however, there is evidence that conformational restriction of the substrate may play a r

235 This shows that both conformational rigidity and dynamics are essential for c

236 han other frequently invoked factors such as conformational rigidity or fundamental length-scale limi

237 ven longer DAD, establishing that stochastic conformational sampling is required to achieve reactive

238 We use coarse grained protein conformational search, efficient robust dimensionality r

239 rget molecules through either induced fit or conformational selection pathways.

240 ignaling pathways, which could be related to conformational selection, signaling amplification, and p

241 hypothetical outcomes, collagen has limited conformational selectivity for binding A1.

242 -D4 cleft provide a structural basis for the conformational selectivity of the interaction.

243 Here, we used several conformational-sensitive antibodies targeting G-protein

244 This generates a conformational shift in the p17 R76G mutant which enable

245 ATP, but not NAD(+), causes a conformational shift to a less compact structure.

246 tween GTPase heads and a favorable crossover conformational shift, catalyzed by GTP hydrolysis, that

247 drolytic state was required for a pronounced conformational shift.

248 e mechanistic insights provided by the novel conformational snapshot of Uba1 presented in this study

249 activity, indicating that modulation of the conformational space accessible for the two bonds depart

250 es of the hybrid material nearly doubles its conformational space and accessible surface area.

251 These findings imply that the conformational space available to simple peptide-based c

252 inding and sequence-dependent alterations of conformational space by structural analysis of all relev

253 The impact of substituent effects on the conformational space was investigated by Monte Carlo sim

254 form, such that it is able to sample a broad conformational space.

255 that detects regions of interest in protein conformational space.

256 beam deposition, which allows chemical- and conformational-specific selection and gentle deposition.

257 s very dynamic molecules with a more complex conformational spectrum than anticipated from functional

258 mers in bulk solution had increasingly lower conformational stability at higher temperatures within t

259 een UvrD subunits that affect the rotational conformational state of its 2B subdomain.

260 gative-stain EM, we found that the prefusion conformational state of LT5.J4b12C trimeric Env was larg

261 These conformational states are finely tuned by substrate avai

262 /or ATP concentrations) promoting particular conformational states of SERCA, we found that the effect

263 Axl crystal structure revealed two distinct conformational states of the enzyme, providing a first g

264 tein-protein interface, "freezes" one of the conformational states of the intrinsically disordered Cd

265 ble among coronaviruses and they define four conformational states of the trimer wherein each recepto

266 cell membranes by alternating among distinct conformational states.

267 s in equilibrium between "open" and "closed" conformational states.

268 amples multiple discrete, rapidly exchanging conformational states.

269 s in the (4)H3 conformation, suggesting that conformational strain induced through a cyclopropyl unit

270 e differences in AD, cementing the idea that conformational strains of oligomers could be significant

271 ting aptamer retains its biologically active conformational structure capable of binding to endogenou

272 Conformational studies of the basic units of these folda

273 Conformational studies revealed a constrained conformati

274 osslinking mass spectrometry to dissect five conformational substates of the complex, including one i

275 ve site arrangement or by thermally sampling conformational substates.

276 embles into a dimer in which a metal-induced conformational switch can occur independently in the two

277 urface exists in different states and that a conformational switch of aromatic side-chains fine-tunes

278 to contain a global, or local, pH-dependent conformational switch should be possible.

279 ural elements of IF2 drive and regulate this conformational switch.

280 acterized the kinetics and energetics of the conformational switch.

281 These methods reveal that conformational switches modulate normal and abnormal inf

282 Thus, thermally induced conformational switching of benenodin-1 may also be rele

283 Pseudouridylation impacts conformational switching of stem II by Mg(2+) or the U2

284 We now report that the same conformational TR-FRET based immunoassay detects polyglu

285 the structure of CMG-DNA, we suggest how the conformational transition from the loaded, post-catalyti

286 and demonstrate pathways for the closed-open conformational transition in both directions by computin

287 inding to MinD is sufficient to trigger this conformational transition in MinE.

288 Here we show that this conformational transition is dependent on phosphatidylin

289 he divalent metal ions affect the HNH domain conformational transition remains elusive.

290 Na2 binding and release associated with the conformational transition toward the inward-open state,

291 The reversibility of their fusogenic conformational transitions differentiates them from many

292 roughout the StART-like PITP family; and (v) conformational transitions in the C-terminal helix have

293 force nor the underlying pathways for these conformational transitions is known.

294 We identify key ligand-induced conformational transitions of a conserved tryptophan sid

295 al basis for LPS recognition, delineates the conformational transitions of MsbA to flip LPS, and pave

296 ptide shows that surface interactions induce conformational transitions of the monomer, which facilit

297 -Poz1-Rap1 assembly through mutation of the "conformational trigger" in Poz1 leads to unregulated tel

298 posits within the brain cluster as clouds of conformational variants in different AD cases.

299 nal interactive surfaces and condenses these conformational variants into a uniform population with m

300 repancy can be attributed to the presence of conformational variants of HLA-I on SAB, assessment of w