ライフサイエンスコーパス: conformational change

1 th the membrane bilayer and on a large-scale conformational change.

2 that the binding site is preserved after the conformational change.

3 on channels is weakened by a slower internal conformational change.

4 rotein interfaces through local unfolding or conformational change.

5 consequence of any substrate-induced enzyme conformational change.

6 l G protein FeoB that undergoes a GTP-driven conformational change.

7 lecular dynamics such as protein folding and conformational change.

8 gh capsid pores are associated with a subtle conformational change.

9 ity of the envelope glycoproteins to undergo conformational changes.

10 ligands, including those that involve large conformational changes.

11 ty in distal loops in response to allosteric conformational changes.

12 Willebrand factor A domains undergoing large conformational changes.

13 s the stoichiometry of ion-substrate-coupled conformational changes.

14 al Langevin equation describing the periodic conformational changes.

15 e gene expression via small-molecule-induced conformational changes.

16 athways of complex reactions and large-scale conformational changes.

17 4 mutations change hydrogen bonding or cause conformational changes.

18 t DNA, Cas9-DNA interactions, and associated conformational changes.

19 his with regards to the RECQL5 mechanism and conformational changes.

20 emperatures possibly arising from C-terminal conformational changes.

21 re local and do not introduce major backbone conformational changes.

22 lity to undergo programmable and predictable conformational changes.

23 he formation of more TRPV1/CaM complexes and conformational changes.

24 aces, likely preventing the hepcidin-induced conformational change, (2) hepcidin binding occurred wit

25 how how sequential, allosterically regulated conformational changes activate AP2 to drive both nuclea

26 causes its membrane accumulation and active conformational change, activating CMA.

27 This conformational change alters the access of a ferrocyanid

28 with umbrella sampling, we study the P1-head conformational change and how it is coupled to the proto

29 onfirming the timescale of substrate-induced conformational change and presence of multiple reaction

30 ow that the approach is sensitive to protein conformational change and solvent accessibility.

31 ogical changes to the tau protein, including conformational changes and aggregation, are major hallma

32 degrees C) and kinetic parameters for enzyme conformational changes and chemistry (rate constants and

33 we apply directed forces to drive the GroEL conformational changes and learn that there is a highly

34 these models have often been complicated by conformational changes and multisite binding equilibria,

35 mbranous proteolipid boundary to explain the conformational changes and oligomeric states of proteins

36 In these measurements, "smearing" due to conformational changes and other entropic factors leads

37 gB conformational changes and their reversibility were meas

38 of the nucleotide, sometimes lead to protein conformational changes, and lead to substantial changes

39 His 212 is located at the fulcrum of these conformational changes, and structural features in its v

40 Specific, OS-induced conformational changes are detected both at the N-termin

41 in T cells in the absence of ligands, these conformational changes are induced through chemical adju

42 om calculated transition timescales that MOR conformational changes are not the rate-limiting step in

43 Significant conformational changes are observed throughout the domai

44 These conformational changes are propagated from the gating ri

45 ese temperature- and polyglutamine-dependent conformational changes are sensitive to bona-fide phosph

46 Chemically induced conformational changes are studied and compared to those

47 surface, together with the length scales of conformational change, are used to quantitatively compar

48 ata acquisition allowed for tracking protein conformational changes as a difference in the number of

49 le indicate that McjD does not undergo major conformational changes as previously proposed for multi-

50 the monomeric Httex1 protein undergoes sharp conformational changes as the polyQ length exceeds a thr

51 To describe conformational changes associated with channel gating, t

52 esident HRas, but not soluble HRas, enhances conformational changes associated with membrane binding

53 rovide evidence that our method can identify conformational changes associated with the binding of al

54 esonance energy transfer to directly observe conformational changes associated with the functional tr

55 ding the enticing prospect of tracking these conformational changes at atomic detail.

56 Conformational changes at the NBDs (the Pgp engines) lea

57 HDX MS revealed conformational changes at the resolution of a few amino

58 fine-tune long-term channel activity through conformational changes at the selectivity filter.

59 In contrast, conformational change between the open and closed states

60 tential mechanical connection to communicate conformational changes between periplasmic, membrane, an

61 Several conformational changes between the ATP- and ADP-bound st

62 ecule binding near loop5 prevents a range of conformational changes, blocking motor function.

63 tein that is highly resistant to CD4-induced conformational changes but displays epitopes recognized

64 Herein, we report that these conformational changes can also disturb the protein's ab

65 plus-end microtubule gliding, and undergoes conformational changes consistent with canonical mechani

66 iomimetic ER and may, in addition to protein conformational changes, contribute to the observed NADPH

67 ytic cycle revealing that AC undergoes large conformational changes coupled to substrate activation b

68 he formation mechanism was attributed to the conformational change driven by the collective hydrogen

69 ow-pH pathways; this occurs by pretriggering conformational changes essential for fusion.

70 ctuations that set the stage for large-scale conformational changes essential for translocation and e

71 mporal recruitment of AP-1 and also drives a conformational change favoring an interaction with cargo

72 deformations with FRET measurements of local conformational changes, FluoRBT will enable multidimensi

73 -POLA2 interaction may promote the necessary conformational change for nucleic acid delivery to Pol a

74 d that B. subtilis sigma1.1 requires minimal conformational changes for accommodating RNAP in the DNA

75 rand factor A domains undergoing significant conformational changes for affinity regulation.

76 To do this, MinE undergoes a remarkable conformational change from a latent 6beta-stranded form

77 te was increased-previously shown to cause a conformational change from compact random coil to extend

78 ics: (i) reversible, pH-dependent, G-protein conformational change from the known prefusion conformat

79 strates could be passed, but instead conveys conformational changes from one side of the membrane to

80 Most similar proteins achieve this through conformational changes: GmhA instead employs a delicate

81 A sequence of successive, interlocking conformational changes guides the two substrate types in

82 They also suggest that this conformational change helps transmit the cholesterol sig

83 xploiting the unique structural features and conformational changes identified here may provide new a

84 nnot convert gamma-subunit rotation into the conformational changes implicit in rotary catalysis.

85 Our structure reveals a dramatic conformational change in a loop within the PL-2 epitope

86 these results, we propose a model in which a conformational change in BTN3A1 is a key event of pAg se

87 ng the oligomerization state, heme induces a conformational change in DGCR8.

88 ochore recruitment of Mad proteins [8, 9], a conformational change in Mad2 [10-12], and formation of

89 Our analysis revealed a global conformational change in NhaA with two sets of movements

90 ced additional space by promoting a flexible conformational change in residues Ser773 and Ser774 in t

91 sight on how the probe senses ligand-induced conformational change in RNA.

92 ons in the catalytic head, together with the conformational change in subunit epsilon, work in synerg

93 ite through its LPEL motif, thus promoting a conformational change in TAZ1 that increases the rate of

94 MTs, and structural modeling data suggest a conformational change in the alpha/beta-tubulin heterodi

95 ate that the suppressor substitutions induce conformational change in the complex and movement of the

96 speculated that the dissociation requires a conformational change in the intervening polytopic seque

97 Tmm and first show that NADP(+) undergoes a conformational change in the oxidative half-reaction of

98 g to the internal domain of BTN3A1 induces a conformational change in the position of the B30.2 domai

99 , AS-48, which appears to interfere with the conformational change in the viral F protein that is req

100 owed that Ser65 phosphorylation results in a conformational change in which Ub adopts a dynamic equil

101 gnetic resonance spectroscopy to investigate conformational changes in a C-terminal four-helical bund

102 ease of pyrophosphate (PPi) triggers reverse conformational changes in a polymerase in order to compl

103 o the formation of active dimers and induces conformational changes in a short loop (loop 2) to regul

104 due to the entropy variation associated with conformational changes in brush and matrix chains.

105 ture in SP1 and further global dynamical and conformational changes in CA.

106 In addition to conformational changes in complementarity-determining re

107 Further, the toxin induces conformational changes in EF-Tu, displacing a beta-hairp

108 eric and dimeric receptors activate distinct conformational changes in G and discuss implications for

109 eric and dimeric receptors activate distinct conformational changes in G.

110 Low-pH-triggered conformational changes in gB reported to date are revers

111 beta2 adrenergic receptor in complex with Gs Conformational changes in Golf activation are shown to b

112 the HIV-1 gp120 glycoprotein to CD4 triggers conformational changes in gp120 that allow high-affinity

113 lycoprotein to the host CD4 protein triggers conformational changes in gp120 that allow its binding t

114 pe that may be fully exposed upon pH-induced conformational changes in HA.

115 We have also shown conformational changes in IP5 2-K and have identified th

116 nel's cleft early during activation, or that conformational changes in KCNQ1 alter its interaction wi

117 Altogether, our studies suggest that the conformational changes in motifs B and D, and the nucleo

118 l in which Src-family kinase binding induces conformational changes in Nef to expose residues critica

119 to the PP2A Aalpha scaffold subunit to drive conformational changes in PP2A.

120 four domains of Scap that undergo concerted conformational changes in response to cholesterol bindin

121 -coated pit (CCP) assembly, are activated by conformational changes in response to phosphatidylinosit

122 r interacts with RPc, leading to significant conformational changes in RNAP and sigma(54) that promot

123 Our data support a model wherein conformational changes in SF3b1 promote U2 association w

124 Although Hsp90 conformational changes in solution have been well-studie

125 werful approach for measuring subtle protein conformational changes in solution.

126 ure of EcAGPase-R130A revealed unprecedented conformational changes in structural elements involved i

127 , which we propose could be a consequence of conformational changes in supramolecular assemblies thou

128 mobilized on the gold surface which leads to conformational changes in the aptamer structure.

129 it is only partially bent, with large-scale conformational changes in the C3 domains that inhibit th

130 d that this effect is not the consequence of conformational changes in the catalyst but rather caused

131 Conformational changes in the CT dimer induced by c-di-A

132 tor binding or by preventing fusion-inducing conformational changes in the Env protein.

133 and concluded that these two mutations cause conformational changes in the Env variant and that these

134 rotein and CD4; (ii) premature triggering of conformational changes in the envelope glycoproteins, le

135 ism of complex formation that involves large conformational changes in the GRK5 RH/catalytic domain i

136 gy measurements, we show that ligand-induced conformational changes in the KcsA channel removes steri

137 DEER) spectroscopy was applied to study the conformational changes in the N-acetylneuraminic acid-sp

138 the sorting platform results in significant conformational changes in the needle complex to provide

139 a sharp bending of the duplex accompanied by conformational changes in the Ni(II) chelate itself.

140 e two CB1-agonist complexes reveal important conformational changes in the overall structure, relativ

141 tes with the ability of ASR to undergo large conformational changes in the process of binding/unbindi

142 the pyocin mimics Fe-Pvd, inducing the same conformational changes in the receptor.

143 Furthermore, binding of ArfA and RF2 induces conformational changes in the ribosomal decoding centre

144 cture also reveals mechanistically important conformational changes in the RING1 and UBA-like domains

145 There are large conformational changes in the substrate binding regions

146 DH2 and the K256Q mutant proteins, revealing conformational changes in the substrate-binding pocket.

147 This induces conformational changes in the tailpiece and the adjacent

148 we detected and characterized ligand-induced conformational changes in the transmembrane and intracel

149 Conformational changes in the transmembrane domain resul

150 to study the Arf1/AP-1 interaction and AP-1 conformational changes in vivo.

151 The shared conformational changes include a distinct movement of tr

152 T domain and JMJD6 likely requires a protein conformational change induced by single-stranded RNA bin

153 We also observed large conformational changes induced by leukotriene C4, explai

154 To characterize conformational changes induced by peptide hormones, we i

155 age indirectly affects signaling by blocking conformational changes induced by weak integrin binding

156 ophilin 3A1 intracellular domain undergoes a conformational change involving the juxtamembrane region

157 This conformational change is an integral part of the catalyt

158 This conformational change is likely caused by a lack of CH3

159 fect binding indicates that a signal peptide conformational change is required during translocation.

160 orted P-CAB-free form, illustrating a common conformational change is required for P-CAB binding.

161 structural information, analysis suggests a conformational change is required to arrive at a catalyt

162 show that the SBD's ability to undergo large conformational changes is already encoded by passive mec

163 gering the protein's functional activity via conformational changes is an intrinsic function of prote

164 secondary structures, which enables dynamic conformational changes, is primarily accomplished by tun

165 l sciences, specifically protein binding and conformational changes, lipid membrane fabrication, memb

166 ide strand are stacked-into the duplex, with conformational changes localized to the bulge site, ther

167 btain control on the nanoscale (through silk conformational changes), microscale (through patterning)

168 Conformational changes near the ketamine-binding site we

169 pon binding Mn(II), T7 DNA primase undergoes conformational changes near the metal cofactor binding s

170 of the precursor peptide and the associated conformational changes needed for the formation of the u

171 assignments show that, upon assembly, large conformational changes occur in loops connecting helices

172 wo intrinsically disordered proteins and the conformational changes occurring in a large cytolytic po

173 Perhaps the most fundamental conformational change of a kinase is the transition betw

174 esulted in compression of the active site, a conformational change of the carboxylate side chain meta

175 itive mechanism in which TRIP8b inhibits the conformational change of the CNBD associated with cAMP r

176 demonstrate that D-serine rapidly induces a conformational change of the GluN1 subunit intracellular

177 of MM LC aggregation kinetics suggests that conformational change of the light chain is rate-limitin

178 endent, relatively fast), and the subsequent conformational change of the protein (charge-independent

179 dent release of the ligand associated with a conformational change of the receptor.

180 We suggest that the conformational change of the syntaxin-1 linker region in

181 The conformational change of triazole polypeptides in respon

182 PIP2 depletion evokes a C-terminal conformational change of TRPC5 proteins leading to dynam

183 pectroscopy makes it possible to monitor the conformational changes of a translational molecular mach

184 vated hydrostatic pressure was used to probe conformational changes of Aquifex aeolicus dihydroorotas

185 is a powerful tool to study interactions and conformational changes of biological molecules in the di

186 dissociation kinetics of very short DNA and conformational changes of biomolecules with much improve

187 ncorporates both molecular factors including conformational changes of CAMs and cellular factor inclu

188 RyR1 Ca(2+) pore in the SR, under control of conformational changes of CaV1.1, located approximately

189 It is suspected that reversible conformational changes of CSP are required for infection

190 Moreover, the conformational changes of DNA cages drive membrane fusio

191 erminations, demonstrated here in a study of conformational changes of DNA upon binding of the minor

192 Extensive analysis has focused on ATP-driven conformational changes of Hsp90; however, little is know

193 ystems to investigate how concerted-distinct conformational changes of hydrocarbons at the interface

194 urA mutations that block Qbeta lysis and the conformational changes of MurA that facilitate A2 bindin

195 To understand the conformational changes of mushroom PPO, the secondary st

196 tomated sample preparation to compare global conformational changes of proteins under different solut

197 prehensive representation as it neglects the conformational changes of proteins which may lead to dif

198 through a nanopore by ions allows monitoring conformational changes of single and native substrate-bi

199 Herein, we report light-induced conformational changes of SPs based on the 1D exotic sta

200 2 complex suggests that Sec3 binding induces conformational changes of Sso2 that are crucial for the

201 the NP by the ssDNA aptamers and subsequent conformational changes of the aptamer probe which affect

202 I activation does not inevitably lead to the conformational changes of the beta2 subunit.

203 h confers substrate specificity by concerted conformational changes of the central beta hairpin and t

204 en rRNA h26, h40, and protein uS2, involving conformational changes of the head as well as surface re

205 , we used voltage-clamp fluorometry to track conformational changes of the KCNQ3 voltage-sensing doma

206 he highest mass adsorption and could promote conformational changes of the proteins and subsequent ab

207 also reveals the large and highly nonlinear conformational changes of the sheath whose elastic energ

208 (iii) The observation of conformational changes on DXPS provides support for the

209 n allosteric mechanism, where global protein conformational changes open a pore across the nerve cell

210 ity site is inaccessible because of either a conformational change or binding of detergent at the bin

211 s, with some proteins undergoing significant conformational change or intermolecular association to g

212 ubiquitous in macromolecules, which undergo conformational change or ligand complexation.

213 Binding of PIP2 to ezrin induces a conformational change permitting the insertion of the LO

214 age rates results from a slow, rate-limiting conformational change prior to HJ cleavage: formation of

215 onal hierarchy of interactions and how these conformational changes relate to distinct steps in CCP f

216 gB oligomeric conformational change remained reversible under all cond

217 s local environment initiated global protein conformational change remains elusive.

218 ecular basis of the receptor-binding-induced conformational change required for HIV-1 entry into host

219 s suggests that it neutralizes by inhibiting conformational changes required for entry.

220 ons that decrease hepcidin binding or hinder conformational changes required for ubiquitination and e

221 us virion uncoats in the endosome, whereupon conformational changes result in a dissociation of a sub

222 eIF4E binding to eIF4G601-1196 induced a conformational change, significantly increasing the bind

223 ractions with another monomer that undergoes conformational changes stabilizing the dimer assembly.

224 s weaker and the activation enthalpy for the conformational change step is significantly larger for t

225 observed thermodynamics and kinetics of the conformational change step may help to design better ana

226 an block substrate-binding sites or prohibit conformational changes, substrate composition can interf

227 Two protomers undergo a ratchet-like conformational change that advances pore loop-substrate

228 esidue (D158N) was shown to trigger a global conformational change that affects the other, larger cyt

229 CARMILs bind directly to CP and induce a conformational change that allosterically decreases but

230 the kinase active site, yet causes a global conformational change that allosterically realigns activ

231 lation of ERG at one serine residue causes a conformational change that allows ERK phosphorylation at

232 e channel were found to promote an iris-like conformational change that constricts and dehydrates the

233 Increased force triggers a conformational change that exposes a cryptic site for th

234 egrees C, indicating a temperature-dependent conformational change that is most prominent around the

235 increase in the alpha-helical content and a conformational change that lead to the exposure of hydro

236 e complex, and undergoes a global pincerlike conformational change that narrows the S-peptide binding

237 ARylated PARP1 by the macro domain induces a conformational change that relieves autoinhibitory inter

238 We observed extensive conformational changes that allosterically couple the ex

239 chaperonin nanomachine undergoes ATP-driven conformational changes that are crucial for its folding

240 strates is challenging because PDI catalyzes conformational changes that cannot be easily monitored (

241 s work is inspired by the long-range coupled conformational changes that constitute allosteric functi

242 plasmic loop of MotA undergoes proton-driven conformational changes that drive flagellar rotation.

243 gy of GTP hydrolysis to initiate a series of conformational changes that enable homodimerization and

244 that SecDF undergoes functionally important conformational changes that involve mainly its P1-head d

245 Calcium binding induces conformational changes that likely prime the channel for

246 dies that allowed the first glimpse into the conformational changes that may be required during trans

247 s were used to record the kinetics of enzyme conformational changes that monitor nucleotide binding a

248 the envelope glycoprotein structure and the conformational changes that occur after receptor engagem

249 the agonist transduction pathway and causes conformational changes that oppose channel activation.

250 NA duplexes without undergoing rate-limiting conformational changes that precede activation.

251 the sterol binds to Scap, triggering several conformational changes that prevent the Scap-SREBP compl

252 s with a previously known site, resulting in conformational changes that produce a non-conductive sta

253 steresis, in which substrate binding induces conformational changes that promote assembly of a high-a

254 of the viral and cellular membranes through conformational changes that remain largely uncharacteriz

255 , decreases helix 1 flexibility, and induces conformational changes that restrict DNA interactions wi

256 e, we utilize EPR spectroscopy to target the conformational changes that take place in the full CusB

257 n binds to ephrin B2/3 receptors, inducing G conformational changes that trigger F protein refolding.

258 ear loop5, where it blocks the ATP-dependent conformational changes that we characterized.

259 e molecular chaperone Hsp90 depends on large conformational changes, the rearrangement of local motif

260 s in the N-terminal domain of APE1 induces a conformational change; this in turn enhances the AP endo

261 ay changes upon channel opening and identify conformational changes throughout the entire AMPA recept

262 eveal that the 5'-AUAGC-3' bulge undergoes a conformational change to assemble a functional hnRNP A1-

263 tructural data suggest that PRORP2 undergoes conformational changes to accommodate its substrate.

264 o the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated ap

265 ld inactivation and ligands that require Env conformational changes to bind efficiently.

266 nformation upon binding CaM, with associated conformational changes to both CaM lobes as indicated by

267 cture-based spectral modeling, we assign the conformational changes to compression and rotation of a

268 of agonists to VFD2 of TAS1R2 leads to major conformational changes to form a TM6/TM6 interface betwe

269 nding on the PAM sequences, LbCpf1 undergoes conformational changes to form altered interactions with

270 achinery and explain how GTP binding induces conformational changes to promote GTPase domain dimeriza

271 e domain, forming a gating ring that couples conformational changes triggered by cyclic nucleotide bi

272 icate the NIS of kinesin-1 undergoes similar conformational changes under tension in the two-head bou

273 Lastly, we discuss how conformational changes under the presence of DeltapH/zea

274 he in vitro digestion profile shows that the conformational change undergone by AS-48 upon adsorption

275 This conformational change unveils a region of the N-terminal

276 eover, the nonplanar precursor 2 underwent a conformational change upon adsorption on surfaces, and o

277 d by our group not only could reveal protein conformational change upon adsorption to NPs, owing to i

278 oteins and NPs and the occurrence of protein conformational change upon binding to NPs are two import

279 Its catalytic activity is triggered by a conformational change upon Ca(2+)/calmodulin (Ca(2+)/CaM

280 Integrins undergo large-scale conformational changes upon activation.

281 Jag1 undergoes conformational changes upon Notch binding, exhibiting ca

282 ncoded CrkII-based biosensor which undergoes conformational changes upon tyrosine-221 phosphorylation

283 The enzyme conformational change was validated by 3D fluorescence a

284 This resistance to CD4-induced conformational changes was associated with a lower affin

285 Detection of such conformational changes was enabled by a fluorogenic liga

286 aising the question of the occurrence of the conformational change when the enzyme is on an electrode

287 ight into how complex DNA structures undergo conformational changes when exposed to intercalators and

288 le Env is triggered to undergo entry-related conformational changes when gp120 binds sequentially to

289 lassic examples of dynamic allostery without conformational changes, where distal side-chain dynamics

290 ed on sequential charge transfer assisted by conformational changes which facilitate the indirect ele

291 activated through an energetically demanding conformational change, which helps position the side cha

292 f the substrate fragments to drive an enzyme conformational change, which locks the orotate ring of t

293 ation of proline 205 of BRD4 and induces its conformational change, which promotes its interaction wi

294 Connecting conformational changes with catalysis in modular enzymes

295 show that ligand binding to BTN3A1 induces a conformational change within the intracellular domain th

296 evious work in our laboratory suggested that conformational changes within a C-terminal domain of the

297 bundle stability, but also indicate distinct conformational changes within the helix bundle.

298 tiple intermediate steps and state-dependent conformational changes within the transport domain that

299 SCCH domain alternation is accompanied by conformational changes within the Uba1 adenylation domai

300 These fast fluctuations guide protein conformational changes, yet their role for protein stabi