ライフサイエンスコーパス: conformational flexibility

1 ling virions that are stable and maintaining conformational flexibility.

2 ibitors has proven challenging, due to their conformational flexibility.

3 r out into solution and providing additional conformational flexibility.

4 trate that the complex exhibits considerable conformational flexibility.

5 sorder of the ISP extrinsic domain indicates conformational flexibility.

6 ameters between 0.8 and 0.95, suggesting low conformational flexibility.

7 f aldehyde substrates as a function of their conformational flexibility.

8 ly suited to macromolecules with significant conformational flexibility.

9 borated by MD simulation to have significant conformational flexibility.

10 as well as Cys(154), which is important for conformational flexibility.

11 nteractions and which are more important for conformational flexibility.

12 these modifications often entail restricting conformational flexibility.

13 onformation with limited surface contact and conformational flexibility.

14 ng inhibitors (K(d) = 5-9 pM) have increased conformational flexibility.

15 nits in yeast and 26 subunits in humans) and conformational flexibility.

16 d dimer, binding results in increased global conformational flexibility.

17 o the critical glycine residue marked by its conformational flexibility.

18 ied in the active site pocket and limited in conformational flexibility.

19 ree rotation around the triple bond enabling conformational flexibility.

20 erpeptide hydrogen bonds, which restrict its conformational flexibility.

21 synthetic peptides with different levels of conformational flexibility.

22 s bound during lipid metabolism yet exhibits conformational flexibility.

23 Enzymes are known to exhibit conformational flexibility.

24 e conformations, while Ca(2+) uptake reduces conformational flexibility.

25 le ligands to protein complexes that display conformational flexibility.

26 mational dynamics, many of which increase in conformational flexibility.

27 characterized by having repeat units and low conformational flexibility.

28 ns tend to be located at positions with high conformational flexibility.

29 he structural basis for the bulk of enzyme's conformational flexibility.

30 ely potent, despite retaining germ line-like conformational flexibility.

31 ity of hydrophobic E1-E2 interactions and E1 conformational flexibility allow one E1 to charge multip

32 Two modes of conformational flexibility allow TRIM5alpha to accommoda

33 s protein is a highly dynamic molecule whose conformational flexibility allows it to transiently asso

34 Conformational flexibility allows proteins to adopt mult

35 Additionally, we show that conformational flexibility alone is insufficient to expl

36 ed in the periplasm, but the preservation of conformational flexibility also enables efficient secret

37 Our results provide strong evidence that the conformational flexibility also plays an important role

38 Nucleotide-bound structures showed the same conformational flexibility, although ADP and ATP seemed

39 AMP releases from the two sites (A and B) in conformational flexibility and chemical shift perturbati

40 regions involved in the interaction possess conformational flexibility and conformational exchange o

41 Conformational flexibility and cooperativity in ligand r

42 demonstrate the effect of protein density on conformational flexibility and dimensions of the recepto

43 g the beta-strand would be essential for the conformational flexibility and DNA minor groove binding

44 his hinge region has been implicated in both conformational flexibility and dynamic protein-DNA inter

45 a suggest the fingers domain has significant conformational flexibility and exists in a highly dynami

46 Protein function depends on conformational flexibility and folding stability.

47 e); and screening charge correlations reveal conformational flexibility and interactions among chroma

48 small molecule ligands, indicating that its conformational flexibility and intrinsic dynamics play i

49 y of HH8 may be mediated by a combination of conformational flexibility and less specific intermolecu

50 h better rheological characteristics (higher conformational flexibility and lower rigidity) and great

51 The conformational flexibility and programmed assembly of a

52 ich has been quite successful in elucidating conformational flexibility and Quantitative Stability/Fl

53 o investigate the effects of pressure on the conformational flexibility and relaxation dynamics of IP

54 S cleavage) led to a significant increase in conformational flexibility and resulted in rapid amyloid

55 itiation complexes remains opaque due to its conformational flexibility and size.

56 they complement ordered proteins, and their conformational flexibility and structural plasticity all

57 provide additional insights into the role of conformational flexibility and structural properties of

58 These variations in conformational flexibility and substituent position are

59 and-DNA interactions, demonstrating both DNA conformational flexibility and the ability of two DNA-bo

60 input variables that accounted for both the conformational flexibility and the energetic factor of b

61 tributed to structural factors including the conformational flexibility and the extent of solvent exp

62 poor pharmacokinetic properties due to their conformational flexibility and the interaction of protea

63 Together with their conformational flexibility and the transient nature of t

64 have been limited to smaller glycans, since conformational flexibility and thermal activation during

65 To further explore this apparent IgE-Fc conformational flexibility and to potentially trap a clo

66 We hypothesized that conformational flexibility and transient exposure of non

67 oordinated by PINCH1 LIM1, and suggests that conformational flexibility and twisting between the 2 zi

68 er, low sequence identity between receptors, conformational flexibility, and chemical diversity of li

69 o sapiens fascin-1, and examine its packing, conformational flexibility, and evolutionary sequence co

70 sults suggest that TF possesses considerable conformational flexibility, and in an attempt to provide

71 cterize experimentally owing to their higher conformational flexibility, and thus intrinsic instabili

72 In particular, changes in conformational flexibility are assessed using a Distance

73 ns and their unique inhibitory mechanism and conformational flexibility are exploited to control prot

74 of the R515A mutant protein revealed greater conformational flexibility around the bridge and C-termi

75 nzyme function and support the hypothesis of conformational flexibility as a limiting factor for cata

76 Our results suggest that HCV utilizes conformational flexibility as an immune evasion strategy

77 ly, the repeat expansion conferred increased conformational flexibility, as observed by enhanced phen

78 These results point to conformational flexibility at the interface, which have

79 nce of non-bonding interactions limiting the conformational flexibility at the peptide backbone that

80 ons, largely accounts for the differences in conformational flexibility between LEN and SMA.

81 The greatest conformational flexibility between monomers is found in

82 Conformational flexibility between structural ensembles

83 The linker-helix modulates the conformational flexibility between the two domains, regu

84 successfully capture and compare the role of conformational flexibility between two structural homolo

85 The U-turn displays a high conformational flexibility both when the T-loop is in is

86 p regulate polymerase traffic and that their conformational flexibility buffers the effect of collisi

87 ruption of hydrogen bonding and/or increased conformational flexibility C-terminal to the Ser site wh

88 experimental and computational evidence that conformational flexibility can assist the emergence and

89 This conformational flexibility can be a critical aspect of h

90 ers of millisecond dynamics, suggesting that conformational flexibility can be conserved among analog

91 holo-HpNikR and H74A reveal a high degree of conformational flexibility centered at the DNA-binding d

92 Recently, we have shown that adequate conformational flexibility could be exploited for assemb

93 These results demonstrate that conformational flexibility could be explored to generate

94 Conformational flexibility currently hinders the structu

95 This study indicates a conformational flexibility-dependent mechanism to contro

96 of this epitope in patients, similar to the conformational flexibility described for other enveloped

97 itch through the introduction of conditional conformational flexibility designed to increase the conf

98 Ca(2+)-bound form of Syt1 revealed that Syt1 conformational flexibility drastically increased upon Ca

99 The simulations reveal conformational flexibility, due to the domain-domain geo

100 ence that coupling interactions arising from conformational flexibility during catalysis are a major

101 a dual binding mode that may allow increased conformational flexibility during cellulosome assembly.

102 ted by analyzing its collective dynamics and conformational flexibility, enhancing our understanding

103 N relaxation data indicated a high degree of conformational flexibility for the linker connecting the

104 ructure of free 15.5K, as well as studies of conformational flexibility from 15N NMR relaxation and H

105 de bond to demonstrate that limiting protein conformational flexibility greatly reduced the polymeriz

106 While conformational flexibility has been observed in aldolase

107 Ubiquitin's conformational flexibility has been postulated to underl

108 al aromatic linkage and displaying different conformational flexibility has been synthesized from the

109 Maintaining conformational flexibility improves AMP potency and sele

110 104C and A128C in the PhoQ PD that restrains conformational flexibility in alpha-helices 4 and 5.

111 Conformational flexibility in dipyridylethene 9 is clear

112 is work was to examine if sequence-dependent conformational flexibility in DNA plays a role in base e

113 Our results identified the role of conformational flexibility in IL-1ra aggregation and she

114 These results illustrate the role of conformational flexibility in modulating RT kinetics by

115 8 is shown to be located in a region of high conformational flexibility in monomeric Abeta, which upo

116 gands with overlapping binding sites and the conformational flexibility in multi-specific ligand asse

117 Conformational flexibility in regions of intrinsic disor

118 weight), heterogeneity (polydispersity), and conformational flexibility in solution.

119 The observation of conformational flexibility in terminal loop regions coul

120 ntial kinetics, suggesting a large degree of conformational flexibility in the [Re]-Y-betaC19-alpha2

121 back into a "V." The structures also reveal conformational flexibility in the arms that suggests tha

122 e review the role of structural disorder and conformational flexibility in the different aspects of d

123 To investigate whether conformational flexibility in the dsRBD regulates the bi

124 amino acids in the dipeptide that locks its conformational flexibility in the framework.

125 NMR spectroscopy revealed a high degree of conformational flexibility in the HIP/PAP inhibitory pro

126 hydrophobic chain maintains a high level of conformational flexibility in the membrane.

127 This study highlights the importance of conformational flexibility in the molecular recognition

128 94H mutant reveals a significant increase in conformational flexibility in the mutant protein.

129 A and 2.0 A resolution that show significant conformational flexibility in the N-terminal alpha-helix

130 Locally, conformational flexibility in the native state is reduce

131 Kinase activity stemmed from conformational flexibility in the region C-terminal to t

132 try data suggest the importance of intrinsic conformational flexibility in the schistosome eIF4E that

133 tivity in binding, despite a large degree of conformational flexibility in the structure.

134 Structural studies demonstrated conformational flexibility in this antigenic region, whi

135 Our results suggest that the observed conformational flexibility in this conserved antigenic r

136 h-resolution analysis, apparently because of conformational flexibility in this region of Gag.

137 s some activity, indicating a high degree of conformational flexibility in this ribonucleoprotein com

138 The role of conformational flexibility in topological enforcement of

139 eling reveal several sites with considerable conformational flexibility in TsaC that may be important

140 of MBL, implying considerable rotational and conformational flexibility in unbound MBL.

141 have been shown to exhibit a high degree of conformational flexibility, in that they are able to seq

142 Many receptors display conformational flexibility, in which the binding pocket

143 unique U3S molecules reveals a huge range of conformational flexibility, including a "closed" product

144 IgE-Fc conformational flexibility indicated that inhibition cou

145 ddition, the C-terminal portion of gp7 shows conformational flexibility, indicating an induced fit on

146 ut there is still no understanding about how conformational flexibility influences structure, cofacto

147 h mechanism has been hypothesized to require conformational flexibility involving re-orientation and

148 The ability to use conformational flexibility is a hallmark of enzyme funct

149 cale data sets and found that the side-chain conformational flexibility is closely related to the exp

150 Conformational flexibility is emerging as a central them

151 s finding supports the idea that active site conformational flexibility is essential to the acquisiti

152 Conformational flexibility is essential to the functiona

153 The redistribution of conformational flexibility is largely controlled by nons

154 f CCs are available, information about their conformational flexibility is limited.

155 We demonstrate that such conformational flexibility is necessary for binding of L

156 These results support the hypothesis that conformational flexibility is partly required for cataly

157 Conformational flexibility is therefore revealed as a ke

158 of current computational methods in modeling conformational flexibility, it suggests that the experim

159 l residues, exon 1 displays a high degree of conformational flexibility leading to a scaling of the N

160 the complete coatomer and reveal substantial conformational flexibility likely to be critical for its

161 e sulfhydrylase B-isozyme a higher degree of conformational flexibility linked to catalysis.

162 fined structural changes, regions subject to conformational flexibility may be important in fine-tuni

163 hts on the important role that modulation of conformational flexibility may play in defining specific

164 Changing this conformational flexibility may thus change the pattern o

165 s from cellular studies lead us to propose a conformational flexibility mechanism of receptor stabili

166 ion between the differential binding and the conformational flexibility, molecular geometry, and hydr

167 liposome binding assay both suggest that the conformational flexibility observed in the C-terminal lo

168 in complex with PFA1 shows that the greatest conformational flexibility occurs at residues 2 to 3 and

169 unctions and translocation activity requires conformational flexibility of a loop sequence in the pal

170 The short timescale conformational flexibility of Abeta(1-38) is suggested t

171 carboxypeptidases, and suggest a coupling of conformational flexibility of active site loops to the r

172 These structures reveal conformational flexibility of an auxiliary domain (amino

173 l design principles, as well as consider the conformational flexibility of an enzyme that contains a

174 The MD simulations revealed considerable conformational flexibility of antimycin and significant

175 tions, we find that solution pH controls the conformational flexibility of apo BACE-1, whereas bound

176 s not only a tool to probe the impact of the conformational flexibility of Ar-Au-Ar intermediates, vi

177 d only Asn is able to precisely modulate the conformational flexibility of Arg244 required for succes

178 To examine the conformational flexibility of Bfrs in a native-like envi

179 This structural evidence reflects the conformational flexibility of bulged nucleotides in RNA

180 ntroduce proline mutations that restrict the conformational flexibility of CDRs and enhance the kinet

181 been shown that the channel current and the conformational flexibility of colicin E1 channel domain

182 ed by spectroscopic studies to elucidate the conformational flexibility of CYP2B4 in binding imidazol

183 ngle x-ray scattering were used to probe the conformational flexibility of different forms of PMM/PGM

184 s diffuse within the selectivity filter, the conformational flexibility of E177 side chains underpins

185 otein engineering approaches, we uncovered a conformational flexibility of E3 that is required for su

186 n applied to determine structural models and conformational flexibility of each duplex.

187 Our work shows that the reduced conformational flexibility of eosinophil cationic protei

188 Xpot to study a range of features including conformational flexibility of free and cargo-bound Xpot

189 We found that the conformational flexibility of GRK1 was reduced in the pr

190 This conformational flexibility of human apo-CRBP1 facilitate

191 combines the multivalency of dendrimers and conformational flexibility of linear polymers for optima

192 Thus, restricting the conformational flexibility of Lipid A by fixing the mole

193 d ribosomal complexes allowed conclusions on conformational flexibility of mRNA in these complexes.

194 Pepped up: Notwithstanding the intrinsic conformational flexibility of peptides, [Zn(Gly-Thr)(2)]

195 ces for POR A and POR B and suggest a higher conformational flexibility of POR B in the surrounding a

196 This review underscores the conformational flexibility of porphyrinoids, a unique cl

197 Given the conformational flexibility of prion proteins, protein-on

198 MS) was used to map the local changes in the conformational flexibility of procaspase-6 at the discre

199 Internal cavities are crucial for conformational flexibility of proteins and can be mapped

200 At low coverage, conformational flexibility of surface-tethered alkyl cha

201 Here, we show that conformational flexibility of synaptobrevin-2 TMD is ess

202 The conformational flexibility of target proteins continues

203 fic sites of nitration that might affect the conformational flexibility of TCR-CD8 and its interactio

204 cocatalyst for the H2 liberation, enabled by conformational flexibility of the acridine-based pincer

205 Notably, it reduces the normal conformational flexibility of the adjacent substrate bin

206 ructural data that also helped to assess the conformational flexibility of the allosteric activation

207 Additionally, observed conformational flexibility of the Arg463 and Arg536 side

208 d within or near the binding site, increased conformational flexibility of the binding site, a change

209 seven PR-substrate complexes to estimate the conformational flexibility of the bound substrates.

210 CNs is mainly ascribed to the high degree of conformational flexibility of the butadiynyl functionali

211 fferential recognition is facilitated by the conformational flexibility of the C-lobe-binding site.

212 glycan sialylation, suggests that increased conformational flexibility of the CH2 domain is associat

213 e domain (Fc) glycan, resulting in increased conformational flexibility of the CH2 domain with corres

214 Steric effects originating in the conformational flexibility of the chlorin macrocycle dir

215 structural insights into the composition and conformational flexibility of the ClpP active site, no r

216 on mobility spectrometry, we demonstrate the conformational flexibility of the CP149 dimer.

217 They also displayed the high degree of conformational flexibility of the Cys364-loop lining thi

218 layer and a plasma membrane environment, the conformational flexibility of the delta-loop initiates C

219 c effects with their ability to restrict the conformational flexibility of the E2.SUMO thioester.

220 cessing of the HIV-1 Env precursor decreases conformational flexibility of the Env trimeric complex,

221 This significant conformational flexibility of the histone tails suggests

222 The remarkable diversity, glycosylation and conformational flexibility of the human immunodeficiency

223 These structural determinants regulate the conformational flexibility of the IgG Fc domain and affe

224 cularly significant because of the intrinsic conformational flexibility of the interacting partners.

225 ogen bond contributing to a reduction of the conformational flexibility of the Le(x) core represents

226 two other Pt(IV) complexes featuring greater conformational flexibility of the ligand scaffold, we sh

227 puter simulation techniques to elucidate the conformational flexibility of the Man-alpha(1-->2)-Man-a

228 by an alkenyl diester bridge to restrict the conformational flexibility of the molecules and reduce t

229 inferred to mainly be involved in enhancing conformational flexibility of the open-closed transition

230 th a diproline segment designed to limit the conformational flexibility of the peptide backbone and r

231 The model explicitly treats the conformational flexibility of the peptides by extensive

232 Finally, to limit the conformational flexibility of the peptides, helix-promot

233 ress with experimental techniques due to the conformational flexibility of the polysaccharide.

234 We suggest that the PrP ORE increases the conformational flexibility of the prion protein, thereby

235 The conformational flexibility of the protease is essential

236 e protein environment and understand how the conformational flexibility of the protein influences the

237 etween the free and ligand-bound states, the conformational flexibility of the protein is typically i

238 unnel as a consequence of the high degree of conformational flexibility of the protein.

239 ific microenvironment, solvent exposure, and conformational flexibility of the protein.

240 any biochemical systems characterized by the conformational flexibility of the reactants.

241 racentrifugation data indicate a significant conformational flexibility of the RepA hexamer.

242 he achievement of the desired objectives the conformational flexibility of the selected cis-enones th

243 It is proposed that the conformational flexibility of the seven-membered ring al

244 Fusion promotion appears linked to the conformational flexibility of the stalk, which must be t

245 Depending on the conformational flexibility of the stator part (the carbo

246 on, a rotamer library was set up to take the conformational flexibility of the tether between the Gd(

247 g tightens the active site and restricts the conformational flexibility of the thiyl radical, leading

248 These structures suggest that the conformational flexibility of the TNpP ligand plays a ke

249 yr-33 and the lipid headgroups can influence conformational flexibility of the trimerization domain a

250 forms of CCR and CAD2 highlight substantial conformational flexibility of these SDR enzymes, which p

251 V-VI moves during binding to Rho*-P and that conformational flexibility of this loop is essential for

252 The localization and conformational flexibility of this loop seems to be impo

253 ino acid substitutions that would affect the conformational flexibility of this segment could alter i

254 Conformational flexibility of TM5 is likely to be a gene

255 hy of a core TRCF-UvrA complex and probe the conformational flexibility of TRCF in the absence and pr

256 minished, but not abolished, by reducing the conformational flexibility of trimers via targeted seque

257 The conformational flexibility of Trp110 appears to be respo

258 only enhanced the solvent accessibility and conformational flexibility of Trp159 in the holo protein

259 ne the solution structure and to analyze the conformational flexibility of two overlapping N-terminal

260 nalyses were carried out to characterize the conformational flexibility of TyrH65-159.

261 able insights into regulatory mechanisms and conformational flexibility of uPA and trypsin-like serin

262 rmational changes, and the resulting protein conformational flexibility often hinders their structura

263 rate of deuterium exchange, an indicator of conformational flexibility, only decreased during an acc

264 ifferent target molecules, restricting their conformational flexibility or changing their subcellular

265 that nuclear accumulation of Elk-1 involves conformational flexibility prior to its phosphorylation

266 ird of all proteins and are characterized by conformational flexibility, protease sensitivity, and th

267 ed in a single conformation, suggesting that conformational flexibility regulates TnsE activity.

268 the complex-induced DNA bending, facilitate conformational flexibility required for specific cleavag

269 We demonstrate that conformational flexibility results in an unexpected bind

270 studied here lack the ribose ring and their conformational flexibility results in greater stability

271 Loop regions that exhibit the most conformational flexibility show the least sequence conse

272 These dynamics require conformational flexibility, such that the peptide produc

273 ower concentrations increased the radius and conformational flexibility, suggesting a distortion of t

274 would not fold correctly and would lack the conformational flexibility that animates their three-dim

275 Comparison with homologous structures shows conformational flexibility that appears to be a recurrin

276 ations, suggests that the epitope displays a conformational flexibility that contributes to neutraliz

277 latter membrane fusion requires an S protein conformational flexibility that is facilitated by proteo

278 J structural dynamics also informs about its conformational flexibility that may have significance fo

279 d in a cross-over loop that is known to have conformational flexibility, the results described here s

280 This intrinsic large-scale conformational flexibility therefore enables 627-NLS to

281 x nature of correlations between light-chain conformational flexibility, thermodynamic stability and

282 ious conformations disclosed the antibody 3D conformational flexibility through the distribution of i

283 trimer of gp120-gp41 heterodimers, relies on conformational flexibility to function in fusing the vir

284 nsport, suggesting that kinesin exploits its conformational flexibility to interact with microtubules

285 ate that the peptide must possess sufficient conformational flexibility to switch between a hairpin a

286 ge central cavity, which confers substantial conformational flexibility to the crucial residue Arg9,

287 Importin alpha3 uses its greater conformational flexibility to wedge the RCC1 beta-propel

288 show that pleurocidin displays much greater conformational flexibility when compared with magainin 2

289 hy individuals (Gly299:Pro306) exhibits high conformational flexibility, whereas the loop carrying am

290 PolC exhibits the potential for large-scale conformational flexibility, which could encompass the ca

291 HIV-1 CA capsid protein possesses intrinsic conformational flexibility, which is essential for its a

292 tain a high degree of structural freedom and conformational flexibility, which is expected to enhance

293 acteristics of this modified PNA, possessing conformational flexibility while maintaining sufficient

294 d/receptor scaffolds, intended to vary their conformational flexibility, will affect their associatio

295 mportance of mutations that optimize protein conformational flexibility with function during evolutio

296 polyglutamine regions, demonstrated dramatic conformational flexibility, with an accessible hinge sep

297 e alpha-helix C is responsible for increased conformational flexibility within the active site and co

298 the scissile bond and acts as an inducer of conformational flexibility within the carboxyl-terminal

299 ps in these structures show a high degree of conformational flexibility within the three crystal form

300 consideration of frayed ends and the hairpin conformational flexibility yields an alternate interpret