ライフサイエンスコーパス: conformational selection

1 ing the spontaneously generated R* state by "conformational, selection".

2 e in the increased activity of Cel7A through conformational selection.

3 t is whether the mechanism is induced fit or conformational selection.

4 ree enzyme and likely involve some degree of conformational selection.

5 g of [Formula: see text] that occurs through conformational selection.

6 ion including lock-and-key, induced-fit, and conformational selection.

7 ally distinct topologies that may facilitate conformational selection.

8 ensemble and thus fine-tune activity through conformational selection.

9 en two classical mechanisms: induced-fit and conformational selection.

10 ds first and then assembles with the core by conformational selection.

11 /TM6 hole is apparently not involved in this conformational selection.

12 e opportunities and limitations of design by conformational selection.

13 relaxation, a key distinguishing feature of conformational selection.

14 ed-fit and of specific hydrogen bonds during conformational selection.

15 esults from a combination of induced fit and conformational selection.

16 ired for polypyrimidine-tract recognition by conformational selection.

17 ts indicate that the binding mechanism obeys conformational selection.

18 might be involved in target binding through conformational selection.

19 conservation of symmetry and ligand-directed conformational selection.

20 Zymogen autoactivation is explained by conformational selection, a basic property of the trypsi

21 lded OMPs to chaperones and, by facilitating conformational selection after release from chaperones,

22 earlier studies have also found cases where conformational selection alone could not adequately expl

23 be targeted by small ligands always includes conformational selection, although other recognition mec

24 TCR binding, incorporating elements of both conformational selection and induced fit in a manner tha

25 With both conformational selection and induced fit models consider

26 ingle-molecule FRET experiments suggest that conformational selection and induced fit of the U2AF(65)

27 We find that both conformational selection and induced fit play a role in

28 These studies support a model in which conformational selection and induced fit play important

29 competing mechanisms of ligand recognition, conformational selection and induced fit, have dominated

30 nition in solution involves a combination of conformational selection and induced fit, rather than bi

31 elative tendencies to fold via mechanisms of conformational selection and induced fit, respectively.

32 ings illustrate the subtle interplay between conformational selection and induced fit.

33 that binding occurs through a combination of conformational selection and induced-fit mechanisms that

34 kinetic measurements to distinguish between conformational selection and induced-fit models.

35 ts suggest that ADP binding to F1 occurs via conformational selection and is preceded by the transiti

36 Mutual conformational selection and population shift followed b

37 According to the "conformational selection and population shift" theory, l

38 data showed that the interaction occurred by conformational selection and the peptide acquired simila

39 g, are strong determinants of the mechanism (conformational selection and/or induced fit) of molecula

40 ligand and receptor structural elements for conformational selection, and support co-evolution of Gn

41 Our data provide strong evidence supporting conformational selection as a major mechanism for substr

42 Our results highlight both local and global conformational selection as a means for universal 3' spl

43 We conclude that conformational selection as a mechanism for a ligand bin

44 study emphasizes the preexisting equilibrium/conformational selection as a mechanism for protein-prot

45 CypA interacts with its substrate via conformational selection as the configurations of the su

46 This observation suggests conformational selection as the general mechanism of all

47 These results identify conformational selection as the mechanism for inhibiting

48 Constrained by the disulfide, conformational selection between weak and tight binding

49 These data suggest a conformational selection binding mechanism in which the

50 nded FKBP51 domain is more consistent with a conformational selection binding process.

51 n k(obs) with [L] is unequivocal evidence of conformational selection, but an increase in k(obs) with

52 r-CBD interface is dispensable for intra-CBD conformational selection, but is indispensable for full

53 ptor activation involves ligand induction or conformational selection, but the molecular basis of the

54 0 muM Mg(2+) generally shifts docking toward conformational selection by stabilizing a folded-like co

55 "induced fit" mechanism (binding first) or "conformational selection" (conformational change first).

56 is only accessible to Abl and not to c-Src (conformational selection control).

57 o shed light on the long debate over whether conformational selection (CS) or induced fit (IF) is the

58 In summary, our results indicate that conformational selection dictates stable retinal binding

59 nding protein (ChoX) to be approximately 90% conformational selection dominant under experimental con

60 loosely coupled to the ATPase reaction, with conformational selection driving the motor mechanism.

61 rbations is reminiscent of binding events by conformational selection encountered in other riboswitch

62 ore enables 627-NLS to bind importin through conformational selection from a temperature-dependent eq

63 Discussion concerning "induced fit" versus "conformational selection" has, however, ignored detoxica

64 like configurations--that implies a role for conformational selection in ligand binding.

65 bstrate access, which extends the concept of conformational selection in trypsin-related proteases.

66 tems agree with our recently proposed hybrid conformational selection/induced-fit models.

67 Conformational selection is an established mechanism in

68 It has been speculated that conformational selection is an integral component of sub

69 Here we show that conformational selection is associated with a rich reper

70 A reaction-controlled model invoking conformational selection is proposed to explain the slow

71 onformational changes, i.e."induced fit" or "conformational selection," mainly determined by the inte

72 r dynamics-generated ensembles suggests that conformational selection may play a hitherto unappreciat

73 host and provides the first observation of a conformational selection mechanism (as opposed to induce

74 The latter is shown to be controlled by a conformational selection mechanism and also by differenc

75 This conformational selection mechanism contrasts with the lo

76 here indicate that the RNA aptamer employs a conformational selection mechanism for binding theophyll

77 This favors a conformational selection mechanism for release of the fi

78 librium dynamics within the domain suggest a conformational selection mechanism in the rapid associat

79 A conformational selection mechanism is proposed to accoun

80 , suggesting that either an induced fit or a conformational selection mechanism should contribute to

81 hese findings can be explained in light of a conformational selection mechanism that dictates that co

82 se, beta-rich conformers self-assemble via a conformational selection mechanism to form energetically

83 Ly49H/m157 and Ly49I/m157 interactions is a conformational selection mechanism where only the extend

84 ation through a significant component of the conformational selection mechanism, because they may inc

85 transition pathway, thus precluding a simple conformational selection mechanism.

86 and suggest that glucagon binds to GCGR by a conformational selection mechanism.

87 which seems to be in contradiction with the conformational selection mechanism.

88 selects the most complementary one, via the conformational selection mechanism?

89 hat binding specificity was controlled by a "conformational selection" mechanism.

90 The data support a passive conformational selection model by which the protein sele

91 sic flexibility of proteins, which follows a conformational selection model for protein-protein inter

92 ur comparative NMR analyses lead to a double conformational selection model in which each apo CBD dyn

93 on, the structural data demonstrate that the conformational selection model is not sufficient to expl

94 tion to the WT-like state, consistent with a conformational selection model of ligand binding, but st

95 This agrees with the conformational selection model of molecular recognition,

96 The conformational selection model requires that the protein

97 vel model of protein regulation, the "Double-Conformational Selection Model", which demonstrates how

98 In the conformational selection model, a protein samples a scar

99 effect is readily interpreted in terms of a conformational selection model, in which p51(L289K) has

100 ation is adequately explained by a two-state conformational selection model, the partial agonism of c

101 e catalytic data confirm an extension of the conformational selection model, wherein different substr

102 he induced fit model and not required by the conformational selection model.

103 rst is the induced fit and the second is the conformational selection model.

104 model where specificity is generated through conformational selection of an intrinsically bent DNA se

105 ss-seeding of amyloid species is governed by conformational selection of compatible (complementary) s

106 Nb binding involves conformational selection of LacY molecules with exposed

107 that complex formation may be facilitated by conformational selection of residual structure in the ac

108 and that capsid assembly likely proceeds via conformational selection of sparsely populated configura

109 ited protein states originate primarily from conformational selections of loops AB and GH, a portal r

110 Previously, conformational selections of the AB and GH loops have be

111 o equilibrium, k(obs), becomes diagnostic of conformational selection or induced fit based on whether

112 These studies validate the conformational selection paradigm for the pleiotropic fu

113 chanism switches from being dominated by the conformational selection pathway at low ligand concentra

114 s formed in the rate-limiting step along the conformational selection pathway but after the rate-limi

115 scription of a high-energy enzyme state in a conformational selection pathway by an experimental stra

116 Strikingly, the assembly rate along the conformational selection pathway resembles that of an is

117 rget molecules through either induced fit or conformational selection pathways.

118 Conformational selection plays a key role in the polymer

119 equired to form the E-S complex suggest that conformational selection plays a role in substrate recog

120 The induced fit and conformational selection/population shift models are two

121 ing may proceed largely through a process of conformational selection rather than induced fit.

122 ignaling pathways, which could be related to conformational selection, signaling amplification, and p

123 esembled the response of proteins undergoing conformational selection, suggesting an energy landscape

124 nt simulations strongly support an "extended conformational selection" synergistic folding mechanism

125 d cross-bridges that appear to result from a conformational selection that occurs during the weak bin

126 with the previously suggested role of E3 in conformational selection, the large positive entropy sug

127 rstood and proposed to primarily operate via conformational selection, the mechanism underlying allos

128 all three collagen chains and binds through conformational selection to a sequence that is one tripl

129 the binding mechanism gradually shifts from conformational selection to induced fit.

130 t between the two TCRs: whereas A6 relies on conformational selection to select and bind different li

131 ding support for adaptive recognition via a 'conformational selection' type mechanism.

132 imetic camelid antibody fragment isolated by conformational selection using yeast surface display.

133 Here we show that the "conformational selection versus induced fit" distinction

134 model of molecular recognition dominated by conformational selection, whereas only minor structural

135 ollows an integrated mechanism that combines conformational selection with induced folding steps.

136 ts suggest that glycan recognition occurs by conformational selection within the ground state; this m