ライフサイエンスコーパス: conformational stability

1 entropic contributions of tertiary motifs to conformational stability.

2 ay of N-terminal and C-terminal domains, and conformational stability.

3 important effects of vesicle size on protein conformational stability.

4 the e/e' position, is required for enhanced conformational stability.

5 ing the full-length proteins with impressive conformational stability.

6 se in kcat, which appears to be unrelated to conformational stability.

7 B region contribute jointly to controlling F conformational stability.

8 nto plaques, was highly soluble, and had low conformational stability.

9 with little change to catalytic activity or conformational stability.

10 AMX binds to FGF-1 and enhances its conformational stability.

11 cent segments exhibiting somewhat diminished conformational stability.

12 and thermodynamic data for interpretation of conformational stability.

13 changes are accompanied by perturbations in conformational stability.

14 e unchanged in different buffers to indicate conformational stability.

15 ion but also cell-surface residence time and conformational stability.

16 n a hydrophobic core, the segment has a high conformational stability.

17 ce of the ancillary domain for catalysis and conformational stability.

18 disulfide bond contributes substantially to conformational stability.

19 121A RNase A are approximately equivalent in conformational stability.

20 er histones and of histone H3 in determining conformational stability.

21 g of the enzyme but it may contribute to the conformational stability.

22 ve class 2 are identical in terms of overall conformational stability.

23 ol, indicating only a slight contribution to conformational stability.

24 this minimum results in a large increase in conformational stability.

25 system to probe the impact of PEG on protein conformational stability.

26 titive selection of those with lower initial conformational stability.

27 ciency observed for strains with the highest conformational stability.

28 a different pathway, primarily by perturbing conformational stability.

29 shown to endow a protein with extraordinary conformational stability.

30 y adopted shorter incubation times and lower conformational stabilities.

31 nsitive/R33-incompetent prions had different conformational stabilities.

32 ray of recombinant PrP amyloids with varying conformational stabilities.

33 Protein conformational stabilities against chaotropes and temper

34 We investigated herein the conformational stability, amyloid fibrillation kinetics,

35 ulations of PrP(Sc) particles with different conformational stabilities and aggregate sizes, which fr

36 model of alpha1(IV)1263-1277 to evaluate (a) conformational stability and (b) cellular responses base

37 cally requires one set of residues to ensure conformational stability and an orthogonal set, with cha

38 ns two functional domains, one necessary for conformational stability and biological activity (residu

39 e contribution of each disulfide bond to the conformational stability and catalytic activity of RNase

40 three measurements can be used to assess the conformational stability and conformational heterogeneit

41 were used to probe the relationship between conformational stability and cytotoxicity in a methodica

42 g(2+) are important determinants of both the conformational stability and dimerization of dephospho-E

43 te features of the seeds, as demonstrated by conformational stability and electron microscopy studies

44 omotion, revealing a balance between H stalk conformational stability and F-triggering activity.

45 proteins to maintain a balance between their conformational stability and flexibility.

46 uctural consequences that would diminish the conformational stability and folding efficiency of the p

47 We studied conformational stability and folding kinetics of a three

48 slational modification, which may affect WRN conformational stability and function, contributing to f

49 id fibrils that show dramatic differences in conformational stability and have characterized them by

50 We have compared the conformational stability and inhibitory activity of 3 pl

51 se enzymes by heat and urea to determine the conformational stability and its dependence on temperatu

52 This result suggests a link between PrP(Sc) conformational stability and its fragmentation rate and

53 prompted us to investigate the link between conformational stability and ligand binding properties o

54 molecular dynamics simulations to study the conformational stability and lipid-binding properties of

55 l) molecular dynamics simulations to explore conformational stability and loop dynamics of this quadr

56 The relationship between conformational stability and methionine oxidation in rec

57 on with locked nucleic acids (LNA) increased conformational stability and nuclease resistance.

58 In this study, the conformational stability and physical properties of a si

59 k domain of G plays an important role in the conformational stability and receptor binding-triggered

60 r to study directly the relationship between conformational stability and reductive unfolding kinetic

61 The DeltaP34 variant retains high conformational stability and remains a substrate for thi

62 9D/R91D variant of RNase 1, is shown to have conformational stability and ribonucleolytic activity si

63 ing that the F escape mutants have a reduced conformational stability and that the inhibitors stabili

64 h conditions, we found a correlation between conformational stability and the smallest possible fragm

65 ic structure of URO-D is required to achieve conformational stability and to create a large active-si

66 lations reveal how this ion pairing enhances conformational stability and, at the same time, reduces

67 tural properties as determined by NMR, their conformational stabilities, and their affinities for the

68 nine oxidation in the structural properties, conformational stability, and aggregation behavior of im

69 e guanidine hydrochloride-induced unfolding, conformational stability, and structure of active, circu

70 nt biophysical properties with regard to the conformational stability, and these differences mainly r

71 enaturation experiments also show that their conformational stabilities are intact.

72 tories, indicating that their elasticity and conformational stability are different.

73 ecause the determinants of membrane receptor conformational stability are still poorly understood, id

74 isulfide bonds, which are least important to conformational stability, are most important to catalyti

75 nd, and the magnitude of its contribution to conformational stability, are uncommon to the best of ou

76 Both S- and R-fibrils, however, shared high conformational stability, arguing that the energy landsc

77 These findings highlight conformational stability as a key factor governing membr

78 eukaryotic KatGs have a significantly higher conformational stability as well as a different unfoldin

79 act contributes to the energetics of protein conformational stability as well as protein-ligand inter

80 ials can modulate macromolecular folding and conformational stability, as well as rates of catalysis

81 d a conformation-dependent immunoassay and a conformational stability assay, together with Western bl

82 Using conformational-stability assays, we determined the guani

83 mers in bulk solution had increasingly lower conformational stability at higher temperatures within t

84 gine or alanine residue results in a loss of conformational stability at pH 6.0 of deltadeltaG(o) = 2

85 lphaLA-IIIA, and (d) to clarify the relative conformational stability between alphaLA-IIIA and alphaL

86 eet core size do not underlie differences in conformational stability between strains of mammalian pr

87 The methods exploit the difference of conformational stability between the native and scramble

88 thermodynamic analysis of the differences in conformational stability between the single and double m

89 that maintained ribonucleolytic activity and conformational stability but had a 2.8 x 10(3)-fold lowe

90 is not only critical for preservation of the conformational stability, but also involved in intermole

91 T(m) of rat beta by 3.2 degrees, decreasing conformational stability by 0.74 kcal/mol.

92 e effects of IRKD autophosphorylation on the conformational stability by guanidine hydrochloride (Gdn

93 ribe a strategy for significantly increasing conformational stability by optimizing beta-turn sequenc

94 ics simulations to investigate ligand-linked conformational stability changes associated with this ca

95 esults indicate that the dominant effects on conformational stability come from the electrostatic fre

96 Specifically, conformational stability correlates directly with cytoto

97 mber of residues and has a similar effect on conformational stability, decreasing the midpoint of the

98 Measurements of the change in conformational stability, delta (delta G), for the mutat

99 Measurements of the change in conformational stability, delta(delta G), upon mutation

100 We measured the change in conformational stability, Delta(DeltaG), for hydrophobic

101 It also has a modest conformational stability despite mutations at 12 out of

102 First, the conformational stability determined at or extrapolated t

103 The conformational stability (difference between the free en

104 as glycosylated and trimeric and displayed a conformational stability different from that of Post-F-X

105 Gelatin, on the other hand, retains its conformational stability even at a saturating co-solute

106 , T(m), and deltaC(p), that characterize the conformational stability for each homologue.

107 trometry to provide quantifications of local conformational stability for HIV-1 gp120 in unliganded a

108 263K(R+), which is characterized by very low conformational stability, high sensitivity to proteolyti

109 beta(3)-->cyclic replacements is to enhance conformational stability; however, a crystal structure o

110 lity of the PEG oligomer to increase protein conformational stability; however, the current understan

111 n subjects using two-dimensional immunoblot, conformational stability immunoassay and sucrose gradien

112 The use of different antibodies and of the conformational stability immunoassay indicated that the

113 ing receptor cell-surface residence time and conformational stability in addition to its previously r

114 riers, bis-MTX proved to possess substantial conformational stability in aqueous solution (-3.8 kcal/

115 r unique side-chains contribute favorably to conformational stability in certain beta-turn positions.

116 quivocally reveals a significant decrease of conformational stability in the degraded protein, while

117 ences a significant decrease in beta-hairpin conformational stability in the presence of 150 mM NaCl.

118 a direct coupling of disulfide reduction to conformational stability in this set of protein variants

119 Correlations between spectral changes and conformational stability indicate that the latter measur

120 vide a framework for understanding how local conformational stability influences entropic change, con

121 veals phenotypes for receptor activation and conformational stability intermediate between the wild-t

122 These data indicate that conformational stability is a key determinant of RNase A

123 Protein conformational stability is an important concern in many

124 ancreatic ribonuclease A (RNase A) with high conformational stability, is cytotoxic and has efficacy

125 imilar structural basis for strain-dependent conformational stability may apply to brain-derived PrP(

126 s in each variant agree with the equilibrium conformational stability measured by urea denaturation (

127 e of SHa(Sc237), as demonstrated by relative conformational stability measurements.

128 The results showed that conformational stability, monitored using the Cm value,

129 Intrigued by this result, we measured the conformational stabilities of 30 prion isolates from syn

130 dduct is found to be related to the relative conformational stabilities of bicyclic radical intermedi

131 While the conformational stabilities of bovine-derived and Tg(BoPr

132 The conformational stabilities of eight proteins in terms of

133 At pH 7 and 25 degrees C, the conformational stabilities of the ribonucleases are (kca

134 ide chain and was influenced by the relative conformational stabilities of the turn structure and the

135 The conformational stabilities of the vnd (ventral nervous s

136 ly for the differential effects of pH on the conformational stabilities of the wild-type and variant

137 tein A (OmpA) were measured to determine the conformational stabilities of this model system for memb

138 ium (TPA(+)) and guanidinium (Gdm(+)) on the conformational stabilities of tryptophan zipper (trpzip)

139 Herein, we report the kinetics and conformational stabilities of two unique fusion proteins

140 Here, the pH dependencies of the conformational stabilities of wild-type RNase A and the

141 The conformational stability of 1,8-diquinolylnaphthalenes i

142 yp residue is known to increase markedly the conformational stability of a collagen triple helix.

143 l assessment of the relationship between the conformational stability of a eukaryotic membrane protei

144 In the present study, we evaluated the conformational stability of a group of cyclin-dependent

145 of high concentrations on the colloidal and conformational stability of a particular protein.

146 ly characterized the functional activity and conformational stability of a PorB class 2 protein from

147 Comparison of the conformational stability of a series of 1,8-dipyridylnap

148 cy to the native alpha-helical forms and the conformational stability of alpha-PrP.

149 te here the unfolding-refolding pathways and conformational stability of alphaLA-IIIA using the metho

150 ion or modification of helix A decreases the conformational stability of APRin as assessed by thermal

151 Literature studies have speculated that the conformational stability of beta-peptides is greater tha

152 In this study, we examine the effect on conformational stability of beta-sheet lengthening perpe

153 cular chaperone required for maintaining the conformational stability of client proteins regulating c

154 ies on the ability of Cdc37 to challenge the conformational stability of clients by locally unfolding

155 en identified as contributing factors to the conformational stability of collagen-mimetic peptide seq

156 nderstanding of environments that affect the conformational stability of collagen.

157 rsal sites may be the key determinant of the conformational stability of cyt c.

158 C termini (residues 4 and 118) increases the conformational stability of G88R RNase A and C65A/C72A/G

159 of hydrogen bonding by peptide groups to the conformational stability of globular proteins was studie

160 Here we report the conformational stability of homodimeric desulfoferrodoxi

161 ine residue can have dramatic effects on the conformational stability of HPr.

162 KAI1/CD82, the TM interactions maintain the conformational stability of KAI1/CD82, evidenced by the

163 I-bound precursors by ERAP1/2 increases the conformational stability of MHC I/peptide complexes.

164 rgent micelles have been used to explore the conformational stability of Mistic as a function of its

165 an amino acid substitution that affected the conformational stability of neuroserpin.

166 sulfide bond plays a significant role in the conformational stability of ONC.

167 terms of a superior chemical, structural and conformational stability of PBTTT, which can be ascribed

168 This higher conformational stability of Pdx might be due to the pres

169 by the presence of ions and its role on the conformational stability of peptides remains only partia

170 ond results in a loss of 2-3 kcal/mol in the conformational stability of PLA2.

171 s for this correlation, we proposed that the conformational stability of prion fibrils controls their

172 t the proposed hypothesis that a decrease in conformational stability of prions results in an increas

173 ct specific noncovalent contributions to the conformational stability of proteins [alanine-based heli

174 irs and hydrogen bonds can contribute to the conformational stability of proteins and peptides.

175 e used to directly measure the colloidal and conformational stability of proteins in highly concentra

176 rent understanding of how PEG influences the conformational stability of proteins is incomplete.

177 t strategy will be useful for increasing the conformational stability of proteins.

178 backbone amides have been implicated in the conformational stability of proteins.

179 rsion revealed that monensin also alters the conformational stability of PrP(C), leading to increased

180 ive strategy that specifically addresses the conformational stability of PrP(Sc) and that has been us

181 define differences between strains has been conformational stability of PrP(Sc) as defined by resist

182 tained in both hosts, but the solubility and conformational stability of PrP(Sc) differed for the CWD

183 We characterized the conformational stability of recombinant human NGAL and t

184 Conformational stability of rhIL-1ra was monitored by eq

185 P, and Q77G) that significantly increase the conformational stability of RNase Sa.

186 Comparison of the conformational stability of ryanodine- and Imperatoxin A

187 ealed a startling asymmetry in the intrinsic conformational stability of secondary structure in the t

188 ible explanation for the correlation between conformational stability of synthetic prions and incubat

189 n the incubation period to prion disease and conformational stability of synthetic prions.

190 309V) and a type 2M mutation (G1324S) on the conformational stability of the A1 domain and the single

191 al changes exhibited at the active site, the conformational stability of the activation loop is decre

192 apoE aggregation in which differences in the conformational stability of the amino-terminal domain me

193 Decreasing the conformational stability of the amino-terminal domain of

194 A decrease in conformational stability of the amino-terminal domain of

195 Investigation of the conformational stability of the atropisomers at enhanced

196 The conformational stability of the C40A/G88R/C95A and C65A/

197 translocator chaperones, we investigated the conformational stability of the chaperone LcrH (Yersinia

198 ied Asn residues and these contribute to the conformational stability of the coiled-coil peptides.

199 t unfavorable steric dispositions affect the conformational stability of the collagen triple helix mo

200 demanding groups at proline residues on the conformational stability of the collagen triple helix wa

201 3-Hyp and 4-Hyp have distinct effects on the conformational stability of the collagen triple helix.

202 Conformational stability of the complex is evaluated bas

203 ned and served as a relative measure for the conformational stability of the corresponding collagen t

204 reased the folding efficiency as well as the conformational stability of the DeltaF508-CFTR, manifest

205 e in the testis enzyme, and as a result, the conformational stability of the domain is increased.

206 egation-prone states being controlled by the conformational stability of the domain.

207 grees of freedom involved in maintaining the conformational stability of the duplex and the related s

208 bond to ERDD RNase 1 not only increases the conformational stability of the enzyme but also increase

209 ore the role of the subunit interface in the conformational stability of the enzyme.

210 or determining both site-specific and global conformational stability of the fibrillar form.

211 The conformational stability of the histidine-containing pho

212 ibe several approaches to characterizing the conformational stability of the human adenosine A(2)a re

213 direct comparison of sites critical for the conformational stability of the human and E. coli enzyme

214 In addition, aminoglycoside binding enhanced conformational stability of the human mitochondrial heli

215 The conformational stability of the I variant has been chara

216 de new, to our knowledge, information on the conformational stability of the junction and distributio

217 he differential agretopic index, and (b) the conformational stability of the MHC I-peptide interactio

218 The conformational stability of the mutant was lower than th

219 Y73.D99 H-bond correlates directly with the conformational stability of the mutant.

220 The conformational stability of the mutants is also unpertur

221 copy to analyze the structural integrity and conformational stability of the mutants.

222 tructure is thermodynamically coupled to the conformational stability of the native envelope glycopro

223 His119 for catalysis and (2) to enhance the conformational stability of the native enzyme.

224 y to aggregate correlates inversely with the conformational stability of the native state of the prot

225 sp 76 was replaced by Asn, Ser, and Ala, the conformational stability of the protein decreased by 3.1

226 u at position 49 in E.coli HPr increased the conformational stability of the protein substantially be

227 conformation and do not appear to affect the conformational stability of the protein.

228 drogen bonds make large contributions to the conformational stability of the proteins.

229 stent a greater contribution by Arg50 to the conformational stability of the reactive-site loop in CM

230 stro-intestinal digestion, combined with the conformational stability of the resulting DRPs provide c

231 cle have been shown to result in the loss of conformational stability of the sarcoplasmic reticulum (

232 eins, we observed that calcium increases the conformational stability of the scavenger-rich cysteine

233 d exerts a critical role in the dynamics and conformational stability of the selectivity filter and m

234 our results support the hypothesis that the conformational stability of the SMI is a critical determ

235 We determined the shift in relative conformational stability of the SRP upon substrate bindi

236 nergy of the T1 tetramer as a measure of the conformational stability of the structure is also pH-dep

237 suggested that this modification affects the conformational stability of the Switch II domain, which

238 gnition through affects on the structure and conformational stability of the switch regions.

239 We also characterized the conformational stability of the thermophilic HPr protein

240 The chirality and relative conformational stability of the three ferric complexes o

241 ese observations led us to conclude that the conformational stability of the trans-enamine form is cr

242 The effect of the soluble tail on the conformational stability of the transmembrane domain of

243 ke large but comparable contributions to the conformational stability of these proteins.

244 anar tryptophan indole group, perturbing the conformational stability of trpzip peptides.

245 dissociation (CAD)] is used to evaluate the conformational stability of various protein segments spe

246 termine whether the alterations affected the conformational stability of wtr-K2tPA.

247 The decrease in the conformational stability of X28-PR and X28-delta TF*PR*d

248 c and spectroscopic techniques to assess the conformational stability of zwittergent-solubilized clas

249 fied the regions of LUSH that show increased conformational stability on binding alcohols.

250 ty and dynamics in molecular recognition and conformational stability, our understanding of these rel

251 This covalent construct offered conformational stability over the noncovalent complexes

252 These results suggest that conformational stability represents a further dimension

253 SEC and far-UV CD for aggregate content and conformational stability, respectively.

254 We conclude that decreased conformational stability shared by all of these mutant S

255 rminal globular domain in the fragment has a conformational stability similar to that of the same reg

256 n the MD simulations revealed that they have conformational stability similar to that seen for compar

257 Conformational stability studies showed that the half-ma

258 We have used NMR spectroscopy and conformational stability studies to quantify changes in

259 s from scrapie strains in sheep by combining conformational stability studies with studies using nove

260 The PSAM retained high conformational stability, suggesting that the flat beta-

261 ceptor-mediated proliferative activities and conformational stabilities than those which had the L0 l

262 dow the collagen triple helix with much more conformational stability than do hyp residues.

263 The domains of abatacept exhibit different conformational stabilities that are highly pH dependent,

264 the three isoforms have large differences in conformational stability that can influence aggregation

265 rates of H/D exchange) revealed decreases in conformational stability that correlate with the observe

266 x conformation and presumably contributes to conformational stability through a hydrogen-bonding netw

267 network in bound PMI that contributed to its conformational stability, thus enhanced binding to the 2

268 Zinc also provides conformational stability to hAGT that may influence its

269 t this smaller pore range may offer enhanced conformational stability to immobilised enzymes while no

270 synthetic nonnative lipid, which can provide conformational stability to the protein complex, may be

271 ne the correlations of the dipole moment and conformational stability to the self-assembly and solar

272 e hypothesized that the lactam ring promoted conformational stability to yield analogues with increas

273 nges to side chains can confer extraordinary conformational stability upon a protein without perturbi

274 t of temperature and pressure on polypeptide conformational stability using a two-dimensional square

275 g of the intermediate as well as the overall conformational stabilities varied among aminolevulinate

276 Comparative analysis of conformational stabilities was performed for two widely

277 Conformational stability was assessed by differential sc

278 uration experiments revealed that the fibril conformational stability was controlled by the region th

279 rotective antibody, its vaccine efficacy and conformational stability were significantly reduced with

280 d function, but contributes significantly to conformational stability when its stabilizing potentials

281 affecting cell-surface receptor turnover and conformational stability, whereas mutation at TM7(N422D)

282 of Cu(2+) at His-13 has little effect on the conformational stability, whereas the copper-binding sit

283 for proper subunit interactions that provide conformational stability which in turn is necessary for

284 chains appears to contribute to beta-hairpin conformational stability, which is consistent with resul

285 description of the allosteric coupling of A1 conformational stability with the force dependent catch