ライフサイエンスコーパス: conformational state

1 which mimics the bound phosphate in the E2P conformational state.

2 l in which fluctuations occur about a single conformational state.

3 protein structures, preferably in the bound conformational state.

4 drugs that bias receptors toward the desired conformational state.

5 ansitions between the RNA-free and RNA-bound conformational state.

6 , we have trapped the enzyme in a variety of conformational states.

7 the heme group and the enzyme visits several conformational states.

8 lectively stabilize discrete cytochrome P450 conformational states.

9 spontaneous transitions between two distinct conformational states.

10 ons adopted, including transiently populated conformational states.

11 ciated Env but nevertheless sample different conformational states.

12 m, and the transport cycle involves multiple conformational states.

13 tions determine RNA-bound versus ssDNA-bound conformational states.

14 dergoes transitions between two (or several) conformational states.

15 ariety of ligands and captured in a range of conformational states.

16 T has been crystallized in several different conformational states.

17 elements rather than through a few discrete conformational states.

18 ferent peptide sequences revealed a range of conformational states.

19 d four extended arms that exhibit a range of conformational states.

20 oportional to the ratio of affinities of the conformational states.

21 remote isoform-specific residues that affect conformational states.

22 ional dynamics and the binding affinities of conformational states.

23 hods to derive structural models of specific conformational states.

24 tein (SP) folding by cycling through several conformational states.

25 ion procedure, which deconvolutes coexisting conformational states.

26 r determination of the appropriate number of conformational states.

27 s in equilibrium between "open" and "closed" conformational states.

28 he dimeric receptors adopt multiple, defined conformational states.

29 el for driving the metamolecules to distinct conformational states.

30 nterdomain fluctuations and heterogeneity of conformational states.

31 nd structural definition of the constitutive conformational states.

32 scade of interactions leading to alternating conformational states.

33 ensemble of molecules sampling at least two conformational states.

34 atural equilibrium between these two extreme conformational states.

35 ally off states are associated with multiple conformational states.

36 racterize state-specific and ligand-specific conformational states.

37 le were found to be similar in the different conformational states.

38 large malto-oligosaccharide in two different conformational states.

39 formation for receptors trapped in different conformational states.

40 uires that the transporter traverses several conformational states.

41 n the open (low-spin) and closed (high-spin) conformational states.

42 amples multiple discrete, rapidly exchanging conformational states.

43 there are known structures for the different conformational states.

44 Hs, access is gained to phosvitin in various conformational states.

45 lecules that can transiently adopt different conformational states.

46 cell membranes by alternating among distinct conformational states.

47 transporters, Na(+) stabilizes outward-open conformational states.

48 es are used by experimentalists as reference conformational states.

49 binding preference of the dimer in different conformational states.

50 evaluate the plasticity of low-lying protein conformational states.

51 trum of drug-target interactions and dynamic conformational states.

52 xicity depends on their partially structured conformational states.

53 f the system often depends critically on its conformational state a rigorous understanding of the cor

54 n elongated form and presents a continuum of conformational states about two flexible hinge regions,

55 provide high-resolution pictures of selected conformational states accessible to gp120.

56 ented reversible interconversion between two conformational states, accomplished by selective vibrati

57 hich can dramatically alter the abundance of conformational states adopted by a protein.

58 The identification of different conformational states along the reaction coordinate of t

59 t to induce and stabilize an active integrin conformational state and that this requires intact talin

60 robust to determine the affinities of three conformational states and detect even modest differences

61 ence detection, which allows us to study the conformational states and dynamics in the submillisecond

62 y greatly narrowing the distributions of the conformational states and fluctuation rates.

63 er formation and false positives for protein conformational states and no evidence that gas-phase cyt

64 s gave atomic-level models of representative conformational states and of the molecular interactions

65 which substrate binding induces alternating conformational states and provides insight into their sp

66 t nNOS adopts an ensemble of open and closed conformational states and that CaM binding induces a dra

67 ions reveal that BACE1 mainly occupies three conformational states and that the relative populations

68 we obtained insight into the distribution of conformational states and the dynamical properties of th

69 ly determine both binding affinities for the conformational states and the rate constants of conforma

70 l assemblies (hierarchical folding, multiple conformational states and their clustering), RNA motifs,

71 Long-lived conformational states and their interconversion rates cr

72 orchestrated changes in chemical structure, conformational state, and partners.

73 cate that ezrin can exist in three different conformational states, and different ligands "perceive"

74 microtubules, how dynamics connect different conformational states, and how these interactions and dy

75 ns, shortens the lifetimes of the individual conformational states, and instills conformational disci

76 second timescales, show complex manifolds of conformational states, and often show state-dependent ph

77 ver, protein chains can adopt a multitude of conformational states, and their biologically active con

78 slower than, the lifetimes of the metastable conformational states, and when the highly anharmonic re

79 The relative probabilities of each conformational state are sensitive to the membrane envir

80 These conformational states are finely tuned by substrate avai

81 Distinct low-energy intermediate conformational states are identified for the IXO- and AR

82 lecule, and x-ray studies show that multiple conformational states are important for DNA polymerase f

83 These conformational states are proposed to be rich in non-can

84 These conformational states are regulated by the differences a

85 Here, however, these conformational states are shown to exist as a structural

86 Different side chain conformational states are stabilized in response to bind

87 till principally limited by the plurality of conformational states, at present, TIMS offers R up to a

88 ient 2.5 +/- 0.5), suggesting at least three conformational states (ATP-bound, ADP-bound, and empty)

89 in a population shift, where more constraint conformational states become highly populated at dynamic

90 ognition of the target-bound hairpin aptamer conformational state by a specific RNA hairpin probe.

91 Ligand binding favors higher-affinity conformational states by increasing forward conformation

92 nd provide the first evidence that transient conformational states can control optical properties of

93 ty of deubiquitinases and indicates that new conformational states can occur when a true substrate, s

94 possibility that switchable phosphoinositide conformational states can serve as lipid recognition and

95 d its cancer mutants sample a similar set of conformational states, cancer mutants could introduce bo

96 ine the role of the N-peptide binding in two conformational states ("closed" vs. "open") of syntaxin-

97 b5 to CYP17A1.pregnenolone induced a set of conformational states closely resembling those of CYP17A

98 due to the transient nature of intermediate conformational states, conformational fluctuations, and

99 MRN exists in at least two distinct conformational states, dependent on ATP binding and hydr

100 rovide evidence showing that these different conformational states determine whether tTG promotes, or

101 as PrP amino acid sequence variants and PrP conformational state), determine the polymorphic depende

102 ates, and different ligands "perceive" ezrin conformational states differently.

103 ividual mRNA molecules alternate between two conformational states, distinguished by 'bursts' of prob

104 ransfer (FRET) spectroscopy to elucidate the conformational states distribution and associated confor

105 form a heterogeneous ensemble with multiple conformational states, each stabilized by characteristic

106 own orientation and may be in one of several conformational states, each with a different molecular s

107 tein Vik1 shows unexpected homology to these conformational states even though it lacks a nucleotide-

108 s the functional importance of higher-energy conformational states (excited states), which often are

109 AgrC are connected by a helical linker whose conformational state exercises rheostat-like control ove

110 scale, we show that there are at least three conformational states explored by the LBD: the low FRET,

111 ng with SNARE assembly by requiring a single conformational state for both of these processes to occu

112 with nucleotide, reveals a newly discovered conformational state for this motor protein.

113 mplex landscape that includes four different conformational states for the unliganded receptor.

114 dinated structural transitions between major conformational states for their function, to prevent sim

115 Protein conformational states-from intrinsically disordered ense

116 pins of the coiled coil and between receptor conformational states generated by adaptational modifica

117 volves transient sampling of a higher energy conformational state, greatly increasing the product dis

118 This metastable conformational state has high affinity for Cdc37 and for

119 Notably, the open exchange-competent conformational state has not been identified.

120 m 2-aminopyrimidine) exhibits three discrete conformational states, highlighting subtle geometric cha

121 ition of STIM1 from a quiescent to an active conformational state, (ii) cytoplasmic STIM1 oligomeriza

122 t with the hypothesis that PAMs may modulate conformational states important for both channel activit

123 dase active state, which is a key non-native conformational state in apoptosis.

124 ltage-gated channel could directly alter its conformational state in membrane.

125 DEER) spectroscopy was used to determine the conformational state in solution for the heme monooxygen

126 the clock, switching KaiC between an active conformational state in which its phosphorylation level

127 identity of the synergistic anion(s) and the conformational state in which sTf binds Ti(IV) are not k

128 and appears to correlate with the reversible conformational state in which the capsid is permeable to

129 eceptor, and a coreceptor, capturing an open conformational state in which the fusion machinery on gp

130 rts on functionally significant but distinct conformational states in a native environment without th

131 orylates the enzyme, and by binding to other conformational states in a non-phosphorylating modulator

132 The linker adopts two conformational states in response to temperature-depende

133 e MDM2 lid region is shown to adopt distinct conformational states in the presence of different small

134 5), caused by the presence of multiple local conformational states in this portion of the protein; (i

135 of the interconversion of different membrane conformational states in which there is a balance betwee

136 e 26S proteasome into an intermediate-energy conformational state, in particular upon the addition of

137 e scattering angles, even when only a single conformational state is significantly populated in solut

138 The knowledge of multiple conformational states is a prerequisite to understand th

139 cling between closed/resting and open/active conformational states is often employed to explain Merli

140 sthyretin mutants between the aforementioned conformational states is strongly influenced by cytosoli

141 an ensemble of low Mg(2+), open, asymmetric conformational states is, thus, the key structural signa

142 appear to be able to adopt different stable conformational states, known as protein strains, which c

143 s indicates that alphaTS has three important conformational states: ligand-free, glyceraldehyde-3-pho

144 of the ATPase and the core particle gate, a conformational state likely to facilitate substrate tran

145 , for measurements of the transition between conformational states, nH values can be misleading due t

146 Ribosomes transit between two conformational states, non-rotated and rotated, through

147 These studies provide evidence for conformational states not observed in crystal structures

148 ysis cycle that differ dramatically from the conformational states observed for Cdc48/p97.

149 The discrete, but relatively few, conformational states observed here, and their energetic

150 The sensitivity of profilin to the conformational state of actin indicates a similar allost

151 FRET) can simultaneously report on e.g., the conformational state of double stranded DNA (dsDNA) foll

152 molecule fluorescence techniques reveals the conformational state of individual HIV-1 Gag molecules p

153 conformations associated with the rotational conformational state of its 2B subdomain, and its helica

154 een UvrD subunits that affect the rotational conformational state of its 2B subdomain.

155 ADP from CI slows down, making the inactive conformational state of KaiC more stable.

156 Upon target cell recognition, the conformational state of LFA-1 changed in educated NK cel

157 gative-stain EM, we found that the prefusion conformational state of LT5.J4b12C trimeric Env was larg

158 'stabilized' version, modified to mimic the conformational state of MicA where the ompA-binding site

159 If the conformational state of one protein molecule in a multip

160 minimal temperature dependence of the global conformational state of PGR in solution as measured by a

161 periments show that the extended beta-strand conformational state of PHF6((*)) is readily populated u

162 ) on the C-terminal tail serves to alter the conformational state of PTEN from an open active state t

163 both the ribosome-Sec61 interaction and the conformational state of Sec61 upon ribosome binding.

164 usative link between the phosphorylation and conformational state of tau, microtubuli-based transport

165 ed transition from a dynamic to a more rigid conformational state of the C-terminal domain stabilizes

166 by endogenous AA, which stabilizes a closed conformational state of the channel that leads to extrem

167 The conformational state of the DNA tweezer is controlled by

168 Here we show that the conformational state of the HNH nuclease domain directly

169 e found a novel high affinity outward-facing conformational state of the human SERT induced by seroto

170 e to refine a three-dimensional model of the conformational state of the protein.

171 lay between the syntaxin-1 N-peptide and the conformational state of the protein.

172 The C-terminal tails also impact the conformational state of the substrate protein during cap

173 ovides only a static view of the most stable conformational state of the system.

174 The conformational state of the translocated substrates with

175 begun to be explored: the stabilization of a conformational state of these receptors upon contact wit

176 ing of syntaxin-1, which is dependent on the conformational state of this protein.

177 t categories of inhibitors designed based on conformational states of "closed" and "open" forms of th

178 r shifting the equilibrium between different conformational states of a membrane protein.

179 e a computational method to sample different conformational states of a structure.

180 tion that gamma acts by coupling the extreme conformational states of beta subunits within the alpha3

181 d the allosteric pathways in three different conformational states of beta2-adrenergic receptor (beta

182 ding of a short hydrophobic sequence selects conformational states of clients to favor their producti

183 Defining the conformational states of cytochrome P450 active sites is

184 ure-dynamics function to the vibrational and conformational states of each protein.

185 for the structural investigation of diverse conformational states of flexible (membrane) proteins an

186 Our data reveal an equilibrium between two conformational states of hTDG-DNA complexes, assigned as

187 We also probe conformational states of human P-gp during the catalytic

188 ults invokes the presence of open and closed conformational states of hUNG.

189 nted three-dimensional information about the conformational states of intact, full-length integrin wi

190 We show that the three conformational states of integrin alpha5beta1 have discr

191 vant PDB structures (which may span multiple conformational states of interest), reconstruction of mi

192 tein structures in the context of individual conformational states of interest.

193 er-domain distance relationships in multiple conformational states of nNOS.

194 an exquisite structural sampling of various conformational states of NS1 that based on the orientati

195 RNA substrate via a population shift of the conformational states of Rho; upon hydrolysis product re

196 A detailed analysis of the conformational states of self-assembled, stereoselective

197 structure represents one of the key unsolved conformational states of SERCA and provides a structural

198 /or ATP concentrations) promoting particular conformational states of SERCA, we found that the effect

199 10, 25 and 37 degrees C to address different conformational states of SGLT1.

200 translocation are performed by two distinct conformational states of SNF2h.

201 n permeabilized cells to delineate different conformational states of TAP in a native subcellular mem

202 three dynamically and structurally distinct conformational states of TAP.

203 cence microscopy, we examined the rotational conformational states of the 2B subdomain of fluorescent

204 mid-Devonian, 415-385 Mya), which alters the conformational states of the active site loop in Escheri

205 scently labelled RNA samples reveal multiple conformational states of the adenine riboswitch.

206 Thus we have investigated various conformational states of the alpha9 dimer in a MOM model

207 that specify the rates of transition between conformational states of the biomolecule.

208 iased agonist, cholecystokinin (CCK) induces conformational states of the CCK2R activating Gq-protein

209 In this work, we explored possible conformational states of the CFTR gating cycle by means

210 Axl crystal structure revealed two distinct conformational states of the enzyme, providing a first g

211 Furthermore, we were able to detect two conformational states of the Galpha Ras domain in slow e

212 In this study, we identify the metastable conformational states of the hIAPP monomer and the dynam

213 o-quinazoline ligands bound to the different conformational states of the HSP70 nucleotide binding do

214 nst cleavage, suggesting a relay between the conformational states of the hydrophobic core and the N

215 tein-protein interface, "freezes" one of the conformational states of the intrinsically disordered Cd

216 Conformational states of the metastable drkN SH3 domain

217 r dynamics (MD) simulations, we revealed the conformational states of the peripheral stalk and assign

218 nsic mobility correlates well with different conformational states of the Pol I cleft, in addition to

219 Upon reconstitution into vesicles, discrete conformational states of the protein (rhodopsin, a metar

220 iviruses, providing detailed pictures of the conformational states of the protein at different stages

221 d on opposite surfaces of LacY to assess the conformational states of the protein complexed with each

222 e revealed detailed snapshots of a subset of conformational states of the RNAP as they exist in cryst

223 global motions throughout SNF that alter the conformational states of the RRM.

224 M. thermoresistibile GlgE we observe several conformational states of the S domain and provide eviden

225 to represent the inward- and outward-facing conformational states of the transporter.

226 ble among coronaviruses and they define four conformational states of the trimer wherein each recepto

227 identification of previously uncharacterized conformational states of this duplex which can explain b

228 ncreases across virus panels) and identified conformational states of virion-bound spikes.

229 this effect requires the description of the conformational states of water and protein molecules at

230 lso suggest that ChoX has several metastable conformational states, of which an apo-closed state is d

231 For the dependence of the conformational state on ligand concentration, curves wit

232 ng affinity and free energy of each integrin conformational state on the cell surface, together with

233 phaS molecules are forced to access a hidden conformational state on the phospholipid bilayer in whic

234 between two approximately equally populated conformational states, one corresponding to the closed s

235 owed that IscU populates two interconverting conformational states: one structured (S) and one largel

236 rae in a ligand-free form in three different conformational states: open, intermediate and closed.

237 nd preventing transitions between functional conformational states or by destabilizing the enzyme and

238 mber of reasonably well-populated metastable conformational states (or local free energy minima) havi

239 ess sparsely populated and transiently lived conformational states--or excited conformational states-

240 our data suggest that previously unobserved conformational states play a role in regulating antitoxi

241 ions suggest a 3A-DNA ensemble with multiple conformational states predominantly across a region of c

242 rization of dynamic exchange between various conformational states provides essential insights into t

243 Transitions between different conformational states range between microseconds to mill

244 hibits structural polymorphism by populating conformational states ranging from a highly ordered, fol

245 of 2OG oxygenase inhibitors based on various conformational states, rather than active site iron chel

246 omodimer that has been shown to exist in two conformational states related to one another by two larg

247 sence of the ligand, which allows to capture conformational states relevant in the activation process

248 tic details and indeed structures of all the conformational states remain elusive.

249 xane molecular machines, in which some of co-conformational states remain unbalanced and not at the e

250 The model incorporates only three conformational states (resting, open, and desensitized)

251 alogs, we were able to observe four distinct conformational states (s1 to s4).

252 Each inhibitor alters the conformational states sampled by the enzyme, either by r

253 Whether beta1 integrin ectodomains visit conformational states similarly to beta2 and beta3 integ

254 omain between the outward- and inward-facing conformational states, sparing the equivalent step(s) du

255 ion but also through accommodating different conformational states such as DNA breathing and dimer sp

256 is hormone are available and fall into three conformational states: T6, T3R(f)3, and R6 As there is s

257 Furthermore, two UvrD conformational states, termed "closed" and "open," corre

258 essed UNC gp160 exists in a less "triggered" conformational state than soluble gp120 and that MAb bin

259 This movement results in a conformational state that is incompatible with DNA bindi

260 inesin heavy chains, KLCs exist in a dynamic conformational state that is regulated by self-interacti

261 Conformational states that are competent to bind immune-

262 Such transitions involve short-lived conformational states that are difficult to detect exper

263 ional changes to efficiently populate global conformational states that are productive for translatio

264 ries also provide insights into intermediate conformational states that could be relevant to catalysi

265 ApoMT is comprised of a wide range of conformational states that populate between globular-lik

266 ate method by which to consider the range of conformational states that proteins may occupy, includin

267 ere, we report the discovery of two distinct conformational states that slowly exchange within the dy

268 nd type II) on the basis of the two dominant conformational states that the Fc domain may adopt.

269 er (smFRET) to investigate the cleft closure conformational states that the glycine-binding domain of

270 nhibitory antibodies to beta1 integrins, the conformational states that these antibodies stabilize, a

271 d desensitization of pLGICs, through several conformational states, that are, thus far, incompletely

272 ntly lived conformational states--or excited conformational states--that play important roles in dive

273 One of these conformational states, the open state, binds to the GPCR

274 nformational transitions, which leads to two conformational states: the cytoplasmic and membrane-boun

275 minal tail switches from a relaxed, flexible conformational state to an ordered state upon MMOH reduc

276 tial configurations that span the accessible conformational states to aid sampling.

277 t, c) Identification of kinetically distinct conformational states to be used for the rational design

278 Proteins commonly sample a number of conformational states to carry out their biological func

279 ies suggest the protein may sample different conformational states to enable the binding of two very

280 when mutated, lock DNGR-1 in one of the two conformational states to potentiate cross-presentation.

281 lculated the relative energies of side-chain conformational states to provide a backbone-dependent (B

282 Pase that cycles between active and inactive conformational states to regulate a variety of cell sign

283 Transient conformational states triggered by pH are of emerging in

284 thermodynamic model of the different stable conformational states underlying this system at the nucl

285 Thus, stabilization of off-pathway conformational states unique to GRK2 will likely be key

286 thermally unstable, even though its overall conformational state was similar to wild type, as judged

287 The distribution of CYP17A1 conformational states was influenced by temperature, bin

288 c parameters that characterize the different conformational states were quantified as well as the amo

289 c complex are closely associated in a stable conformational state, whereas nonamer regions are perpen

290 to Syt1 may induce major changes in the Syt1 conformational state, which in turn may initiate the fus

291 in TADs can easily fluctuate between several conformational states, which are hierarchically organize

292 uctures for all these functionally important conformational states with conventional high-resolution

293 n inhibitory interaction with multiple SERCA conformational states with distinct effects on SERCA's k

294 iving single molecules of GFP into different conformational states with optical tweezers and simultan

295 gives rise to the stabilization of open-like conformational states with overall increased backbone dy

296 hat couples the free-energy profile of motor conformational states with that of the ATP hydrolysis cy

297 he solution is represented by an ensemble of conformational states with tightly coupled domains.

298 otein (SSB4) and by identifying two distinct conformational states, with and without ssDNA, we assemb

299 ic agonists induce transitions between these conformational states, with efficacy determined by occup

300 ces, indicating the coexistence of different conformational states within the fibril.