ライフサイエンスコーパス: conformational switch

1 divalent metal binding, phosphorylation and conformational switching).

2 The subdomain IIa behaves as an RNA conformational switch.

3 the HHM motif as a copper- and pH-dependent conformational switch.

4 domain could function as a phosphoregulated conformational switch.

5 e heme iron, as a distinctive feature of the conformational switch.

6 JM-3064 undergoes a monovalent ion-dependent conformational switch.

7 tructure that attains the native state via a conformational switch.

8 an be modulated independently using the same conformational switch.

9 iminating the histidine-dependent pH-induced conformational switch.

10 shed results on a system that incorporates a conformational switch.

11 ATP-binding domain (LID) in controlling the conformational switch.

12 luding phosphorylation sites and a potential conformational switch.

13 phosphorylation activates SMO by inducing a conformational switch.

14 is not influenced by a nucleotide-dependent conformational switch.

15 but also reveal molecular mechanism for the conformational switch.

16 l element previously proposed to mediate the conformational switch.

17 with the Ca-ATPase and suggest its role as a conformational switch.

18 acterized the kinetics and energetics of the conformational switch.

19 the activating potential of the short-pitch conformational switch.

20 repeat proteins with function regulated by a conformational switch.

21 a sophisticated biofunctional system using a conformational switch.

22 ural elements of IF2 drive and regulate this conformational switch.

23 mation that regulates ribosome function as a conformational switch.

24 ing a late transition state for the WC-to-HG conformational switch.

25 signaling proteins functioning as allosteric conformational switches.

26 on when looking for suboptimal structures or conformational switches.

27 portant to develop algorithms to predict RNA conformational switches.

28 tematically characterize the role of PTMs as conformational switches.

29 n experimentally known structures of several conformational switches.

30 que subunits must undergo position-dependent conformational switches.

31 tivity of the alphabeta TCR is controlled by conformational switches.

32 to probe the action of these ATP analogs on conformational switching.

33 truncating the expression domain to suppress conformational switching.

34 lectively to the noncanonical NBD to prevent conformational switching.

35 they fail to undergo pH- or ligand-dependent conformational switching.

36 esses by undergoing reversible energetic and conformational switching.

37 s predicted by structural modeling to enable conformational switching.

38 lding stability, such as cofactor binding or conformational switching.

39 lts suggest a novel mechanistic paradigm for conformational switching.

40 equence space underpinned by binding-induced conformational switching.

41 GTPases but is incapable of GTP-binding and conformational switching.

42 es of molecular defects, protein binding and conformational switching, a novel phenotype.

43 deling constitutes a previously unrecognized conformational switch accompanying ligand-dependent PPAR

44 favors vesicle formation by inhibiting this conformational switch, acting to regulate endophilin A1-

45 This ODN-induced conformational switch allows for the transition from an

46 This Arg-Asp conformational switch allows identical ZF modules to rec

47 binding to an A-type template and that this conformational switch allows or enhances subsequent poly

48 This conformational switching alters the energetic contributi

49 losed state, thereby promoting the resulting conformational switch and autophosphorylation of EI.

50 H257 as a major component of the T domain's conformational switch and b) suggested the possibility o

51 Ca(2+) influx, Cpx is predicted to undergo a conformational switch and collapse onto a single SNARE c

52 s, the underlying mechanisms governing prion conformational switch and determining prion "strains" ar

53 tion disrupts the interaction, and induces a conformational switch and dimerization of SMO cytoplasmi

54 ning-defective 1 (Par1) kinases, regulates a conformational switch and is important for bidirectional

55 lding protein induces a single, coat protein conformational switch and not a series of sequential rea

56 e hydrogen bonds between H1 and DNA act as a conformational switch and show that the presence of DNA

57 Together, context-dependent conformational switches and biased dephosphorylation sug

58 ing pathways between secondary structures of conformational switches and outperforms the existing heu

59 regulate the activity of the LC ribozyme by conformational switching and suggest a mechanism by whic

60 or absence of the ATP pyrophosphates as the conformational switch, and elucidated new mechanistic de

61 bipartite MDC1-binding scaffold, an extended conformational switch, and the molecular consequences as

62 control cell proliferation, its well-studied conformational switching, and abundance of documented mu

63 Our results suggest that prion-like conformational switches are evolutionarily conserved and

64 Conformational switches are macromolecules that toggle b

65 Consequently, conformational switches are often defined by comparing t

66 Protein dynamics, including conformational switching, are recognized to be crucial f

67 esidue long N-terminal loop that undergoes a conformational switch as it wraps around c-di-GMP.

68 of RyR1 that normally function as part of a conformational switch associated with RyR1 inhibition.

69 ved residue, Phe396, appears to serve as the conformational switch, because flipping of the stacked a

70 EPR shows that this conformational switch behaves similarly in micelles and

71 rs and present a more refined model of their conformational switching behavior.

72 del in which the tubulin monomer undergoes a conformational switch between a "straight" form found in

73 We observed a conformational switch between a stacked and nonstacked s

74 ediction, AmyloidMutants identifies a global conformational switch between Abeta and its highly-toxic

75 P/PAP interactions are linked to a two-state conformational switch between biologically active and in

76 thways not only support the proposed role of conformational switch between hairpin and pseudoknot in

77 mily to play an active role in mediating the conformational switch between inward-open and outward-op

78 dentified two major kinetic pathways for the conformational switch between open and closed states thr

79 e propose that this regulation could drive a conformational switch between the dimeric structures of

80 we report a theoretical investigation of the conformational switch between the Huckel planar and the

81 We also show that the conformational switch between the outward- and inward-op

82 to investigate the kinetic mechanism for the conformational switches between bistable RNA hairpins.

83 n the pseudoknot stability and the resultant conformational switches between different hairpin and ps

84 t intra- and intermolecular interactions and conformational switches between more ordered and less or

85 gnaling through G proteins normally involves conformational switching between GTP- and GDP-bound stat

86 as an allosteric site of hTS to regulate the conformational switching between the active and inactive

87 The capsules undergo reversible conformational switching between the closed "vase" form

88 ere evaluated for their propensity to induce conformational switching between the kite and vase forms

89 Conformational switching between these forms allows adop

90 he lasso peptide benenodin-1, which exhibits conformational switching between two distinct threaded c

91 ational echo chemical-exchange spectroscopy, conformational switching between two well defined substa

92 ouple steps in ATP binding and hydrolysis to conformational switching both in and remote from the act

93 d for a candidate segment that supported the conformational switch by serial truncation removing 22 (

94 ships between the two bistable hairpins, the conformational switch can follow single or multiple domi

95 embles into a dimer in which a metal-induced conformational switch can occur independently in the two

96 noxic conditions and that the aforementioned conformational switch can protect nitrogenase from such

97 The role of these residues as conformational switches can be rationalized based on a m

98 rements suggest that the previously proposed conformational switch caused by Cu(II) binding includes

99 I mutant (A35C/T57C), in which a small-scale conformational switch caused by the ligand binding event

100 The postbinding conformational switch, combined with the prebinding isom

101 Through such conformational switches compatible with rapid diffusion

102 The observed proximal cluster conformational switch, concomitant with the proton trans

103 ot due to the loss of R 507 methylation as a conformational switch-containing peptide reacted under s

104 mophoric chelator, and the concerted binding-conformational switch detected by SPR at equilibrium rev

105 y RNAborMEA, provide additional tools toward conformational switch detection.

106 obal motion that is specifically linked to a conformational switch distant from the binding interface

107 Consequently, the LHCII conformational switch does not involve changes in A/B he

108 new structures provide direct evidence of a conformational switch driven by alphaKG leading to chlor

109 bility of H3, which is proposed to undergo a conformational switch during 30S assembly.

110 which suggests a potential role for a Phe32 conformational switch during normal capsid assembly.

111 core to retain the flexibility required for conformational switching during procapsid assembly and m

112 ther individual Ly49 receptors can undergo a conformational switch enabling them to bind MHC in diffe

113 odifications are similar conceptually to the conformational switching events seen in some marginally

114 gions of the gene 4 protein postulated to be conformational switches for dTTP-dependent helicase acti

115 We show that the conformational switch from 4beta+alpha to 3-alpha struct

116 ther and provide insights into this enzyme's conformational switch from a nonspecific search mode to

117 l Kv7 channels involving a calcium-dependent conformational switch from an apo-CaM form that bridges

118 possibly by protein-binding may activate the conformational switch from the four-helix junction to th

119 e chain and ring formation is facilitated by conformational switching from a C3h to Cs symmetry of mT

120 adenine dinucleotide binding site decouples conformational switching from the flavin photocycle and

121 at the DEP domain of Dishevelled undergoes a conformational switch, from monomeric to swapped dimer,

122 this latter context, as well as others, the conformational switching, from 1,3-alternate to cone upo

123 lenging IgM complexes is dictated by a local conformational switch in a peptide extension.

124 s shows that junction formation depends on a conformational switch in an extracellular loop, which ma

125 We previously proposed that an RNA conformational switch in an untranslated satellite RNA (

126 s on either side of the membrane to induce a conformational switch in both FtsA and the FtsBLQ subcom

127 deling, and point to a possible role for the conformational switch in Gre-factor and Gfh1 regulation.

128 irement for this alternative structure and a conformational switch in high-level accumulation of satC

129 uggests that ParB binding to parS triggers a conformational switch in ParB that overcomes a nucleatio

130 al a mechanism that couples a heme-dependent conformational switch in PhuS to protein-protein interac

131 excises this sequence element, leading to a conformational switch in pre-18S rRNA, by which the ribo

132 rate-limiting step in protein folding and a conformational switch in protein function.

133 This suggests a model by which a conformational switch in Sro7 acts to coordinate Rab-med

134 Our results suggest a general model for the conformational switch in the cyclic nucleotide-binding s

135 -tRNA selection by the ribosome depends on a conformational switch in the decoding center of the smal

136 requires H-bonding to Ser119 and a dramatic conformational switch in the F-G fragment, which transmi

137 trong constraints on any proposed role for a conformational switch in the FtsZ monomer.

138 ivity and provide insight into the role of a conformational switch in the functional regulation of th

139 We propose a helix-to-loop conformational switch in the helices flanking the inner

140 Prion diseases are associated with a conformational switch in the prion protein (PrP) from it

141 Specifically, TPP binding triggers a conformational switch in the RNA from a transcriptionall

142 An intracellular conformational switch in the serpentine transmembrane pr

143 Capsid expansion is associated with a conformational switch in the spine helix that is propaga

144 We propose that Ran induces an allosteric conformational switch in the tail that exposes the histo

145 Here we reveal a new snRNA conformational switch in which successive roles for two

146 relate well with the experimentally observed conformational switches in beta(2)AR, namely, the breaki

147 elates well with the experimentally observed conformational switches in rhodopsin and other class A G

148 ndscapes suggest possible mechanisms for the conformational switches in splicing.

149 y located proline and lysine residues act as conformational switches in the in vitro formation of tra

150 iX174 internal scaffolding protein B mediate conformational switches in the viral coat protein.

151 We have discovered ligand-responsive conformational switches in viral IRES elements.

152 Mutations designed to inhibit conformational switching in alpha-helix 3 were introduce

153 Simultaneous examination of conformational switching in Eg5, in parallel with cataly

154 These results reveal conformational switching in KSR as a druggable regulator

155 ssibility for triggering protonation-coupled conformational switching in proteins at membrane interfa

156 These experiments furnish a means to observe conformational switching in real time and enable the pre

157 Metabolite-dependent conformational switching in RNA riboswitches is now wide

158 residues has been implicated in pH-dependent conformational switching in several systems, including t

159 as shown to act as an allosteric effector of conformational switching in the coat protein during in v

160 for the hypothesis that substrate-controlled conformational switching in the SRP provides a mechanism

161 asparagine (N)-linked disaccharides drive a "conformational switch" in a model peptide.

162 To shed light on how the Swi1 conformational switch influences Swi1 function and to de

163 o loss of H5/H4b interaction and promoting a conformational switch interrupting translation and promo

164 The conformational switching involves motion of the distal h

165 f biological information using a prion-based conformational switch is an evolutionary conserved mecha

166 In contrast with other MOs, this conformational switch is coupled with the opening of a c

167 A conformational switch is envisaged that enables the in-l

168 This PHD conformational switch is impaired by a centronuclear myo

169 The very small size of the N-terminal conformational switch is likely to explain the facile ev

170 or challenge with testing designs of protein conformational switches is the need for experimental pro

171 Conformational switching is an overarching paradigm in w

172 pH-induced conformational switching is essential for functioning of

173 Such assembly-coupled conformational switching is reminiscent of viral particl

174 nd in vitro suggests that inhibition of the "conformational switch" isomerization required to trigger

175 ediated translational termination in which a conformational switch leads to peptide release only when

176 A conformational switch may also favor release rather than

177 These studies demonstrate a conformational switch mechanism for PDZ domain function

178 with mutagenesis to probe the ligand-induced conformational switching mechanism.

179 We propose that this conformational switch might control DNA template engagem

180 Key elements of the conformational switch model describing regulation of alf

181 This retroviral conformational switch model illustrates how two-step for

182 sed on in vitro replication experiments, the conformational switch model states that AMV coat protein

183 These methods reveal that conformational switches modulate normal and abnormal inf

184 This conformational switch modulated by cholesterol has impor

185 sults reveal that the trypsinogen to trypsin conformational switch modulates cleavage susceptibility

186 The conformational switch mutations kinetically trapped asse

187 and RNAbor, can be used to predict potential conformational switches; nevertheless, no existent tool

188 The conformational switch occurred when the amino acid seque

189 How this conformational switch occurs is not known.

190 urface exists in different states and that a conformational switch of aromatic side-chains fine-tunes

191 f p14(ARF) exclusively triggers a N-terminal conformational switch of Bak, but not Bax, which allows

192 charge complementarity and anticipation of a conformational switch of CXCR4 upon activation.

193 dicate unambiguously that the open-to-closed conformational switch of EI is triggered by complete sup

194 otoga maritima, here we report a pH-mediated conformational switch of HK853 that shuts off its phosph

195 he region corresponding to the "safety belt" conformational switch of Mad2, suggesting conformational

196 These results suggest that a prion-like conformational switch of MAVS activates and propagates t

197 a regulatory Raf molecule in cis to induce a conformational switch of MEK, facilitating MEK's phospho

198 potential contribution of an Mg(2+)-mediated conformational switch of MicA for the regulation of MicA

199 Thus, current views on the pH-induced conformational switch of PBPs hold true only for the lig

200 Ubiquitin binding induces a conformational switch of Rpn11's Insert-1 loop from an i

201 e assays were performed, which confirmed the conformational switch of the aptamer rather than the apt

202 We propose a conformational switch of the essential Lys176 from the "

203 Here, we investigate the conformational switch of the human mitochondrial transcr

204 and that it might also enforce a favourable conformational switch of the trans-amide group into the

205 ding domains provides a power stroke for the conformational switch of the two membrane domains from t

206 We also detected a conformational switch of this motif between the non-MT-b

207 es, the pyridine ring of ZnClTerp blocks the conformational switch of Trp-248 required for receptor a

208 of the residues around position 28 modulate conformational switches of the AB loop relevant to ligan

209 ic operator site and defines a mechanism for conformational switching of a key residue (Gln56) to acc

210 is based on the principle of target-induced conformational switching of an aptamer linked to an elec

211 Thus, thermally induced conformational switching of benenodin-1 may also be rele

212 During virus assembly and maturation, conformational switching of capsid subunits is required

213 The subsequent addition and conformational switching of coat proteins to the growing

214 sembly requires a homodimerization-dependent conformational switching of CTD.

215 und room temperature, frequent bidirectional conformational switching of individual molecules from co

216 We observe and induce conformational switching of individual molecules via sca

217 Here, we identified a novel spontaneous conformational switching of nucleosomes under physiologi

218 Pseudouridylation impacts conformational switching of stem II by Mg(2+) or the U2

219 uridine 56 and 93 pseudouridylation impacts conformational switching of stem II.

220 -exposed loop in coat protein is critical in conformational switching of subunits during both procaps

221 the proteasome side, binding of Ubp6 favors conformational switching of the 26S proteasome into an i

222 in which Prohead I assembly is regulated by conformational switching of the hexamer.

223 vidences that very affine ligands can induce conformational switching of the human telomeric G-quadru

224 a stabilized ATP-binding site indicates fast conformational switching of the original aptamer before

225 the mobile C terminus of cTnI ensures proper conformational switching of troponin-tropomyosin.

226 Conformational "switching" of the riboswitch aptamer dom

227 between the head and stalk plays a role in "conformational switching" of the head group to facilitat

228 cogenic Neu* mutant appears to inhibit this "conformational switching" of TM dimers, as we observe th

229 se hydrogen-bond contacts serve as potential conformational switches offering new opportunities for f

230 results paint a picture of peptide flips as conformational switches, often enabled by glycine flexib

231 ligand binding and the subsequent allosteric conformational switch on mRNA transcript length has not

232 Gentamicin works by flipping a conformational switch on the ribosome, disrupting the re

233 indicate that certain DNA/RNA coronae act as conformational switches on SWCNTs, which reversibly modu

234 onized nucleobases are required for folding, conformational switching, or catalysis in a number of fu

235 We find three types of conformational switch pathways for RNA hairpins: refoldi

236 sent study we focus on the role the putative conformational switch plays in arginine methylation.

237 This conformational switch positions the nuclease Nob1 for cy

238 ment in the expression platform controls the conformational switching process.

239 preserve nitrogenase activity, including a "conformational switch" protein (FeSII, or "Shethna") tha

240 We propose that this conformational switch provides a mechanical feedback sys

241 Discovery of such dynamic conformational switching provides insight into how a rib

242 use they do not support NBD dimerization and conformational switching, rather than by limiting enzyma

243 t sorafenib may affect SHP-1 by triggering a conformational switch relieving its autoinhibition.

244 ic regulation of PDHK2 activity serving as a conformational switch required for communication between

245 234, Gly237, and Gly241, probably forming a "conformational switch" requisite for substrate turnover;

246 for FMRP arginine methylation and a role for conformational switch residues in arginine modification.

247 This remarkable conformational switch resulting from the presence of a s

248 cts as a major component of the pH-dependent conformational switch, resulting in destabilization of t

249 west step (bottleneck) of the hexane-induced conformational switch seems to be correlated with the sl

250 velopment of additional algorithms to detect conformational switches seems important, especially sinc

251 This conformational switch should be incorporated into models

252 to contain a global, or local, pH-dependent conformational switch should be possible.

253 Z13e1 and 4E10 epitope structures reveals a conformational switch such that neutralization can occur

254 tructural details of a nucleotide-controlled conformational switch that allosterically modulates the

255 We propose that the CXC motif functions as a conformational switch that couples Site-I and Site-II in

256 ivation, helix A is immobilized as part of a conformational switch that couples the opposing domains

257 Such motif repositioning may serve as a conformational switch that creates the docking site for

258 nd direction of RNA helix motions, guiding a conformational switch that enforces the hierarchy of pro

259 rgy transfer signal, we directly observe the conformational switch that is associated with IF2 activa

260 ption device-receptor interaction triggers a conformational switch that is propagated as a domino-lik

261 tabilities of these intermediates causes the conformational switch that may underlie a human telomera

262 h ribosomal protein L13a and GAPDH induces a conformational switch that rescues mRNA binding and rest

263 h a precursor-receptor complex and undergo a conformational switch that results in activation for pro

264 single active site that is transformed by a conformational switch that toggles its competency for ca

265 structure experiences a quadruplex-promoted conformational switch that triggers not only its quadrup

266 These structures illustrate a mechanism of conformational switches that accompany formation of sign

267 group of ATP during step 1, and the protein conformational switches that accompany substrate binding

268 Heterotrimeric G proteins are conformational switches that turn on intracellular signa

269 tion within the RyR1 3D architecture and the conformational switching that underlies CaM regulation o

270 ese noncatalytic regions work together as a "conformational switch" that modulates kinase activity in

271 ge in Cre subunit DNA affinities during the "conformational switch" that occurs prior to the second s

272 During the conformational switching, there occurred a significant r

273 metry of the molecule, mutations can cause a conformational switch to a nearly degenerate yet distinc

274 cooperatively use multiple primases and this conformational switch to control initiation frequency, p

275 1-microtubule ternary complex functions as a conformational switch to control outer arm activity.

276 sm by which CheY(P) binding could induce the conformational switch to CW rotation.

277 lving His453, a key residue that undergoes a conformational switch to directly interact with and opti

278 Mutating R 507 in the conformational switch to K also truncates the first stra

279 and showed that PHD movements function as a conformational switch to regulate dynamin self-assembly,

280 The [2.2.2] lactonization acts as a conformational switch to superdisarm iduronate component

281 chanism of FtsZ modulation by PC190723 and a conformational switch to the high-affinity state that en

282 transfer at Ser16 induces a more pronounced conformational switch to the R state in phosphorylated P

283 These data uncover a novel ligand-induced conformational switch to trigger filamin phosphorylation

284 at the ribosome uses local as well as remote conformational switches to govern induced-fit mechanisms

285 Thus, conformational switching to an alternative monomeric fol

286 This conformational switching towards the OFF state is observ

287 ion of protein function is often linked to a conformational switch triggered by chemical or physical

288 ular spur gears due to the linear-to-helical conformational switching triggered by complexation/decom

289 terminus to the exosite of IDE and undergo a conformational switch upon binding to the catalytic cham

290 simulation gives indications for a possible conformational switch upon cleavage of the disulphide bo

291 The present work investigates this conformational switch via extensive atomically detailed

292 The subtle bidirectional t-SNARE conformational switch was mediated by the ionic layer.

293 To link ligand/aptamer binding to conformational switching, we constructed models of an S-

294 To identify a simplified code for conformational switching, we have redesigned two natural

295 release the intercalating doxorubicin via a conformational switch when in an ATP-rich environment.

296 ptors, CPR5 undergoes an oligomer to monomer conformational switch, which coordinates CKI release for

297 is a key requirement for the binding-induced conformational switching, which allows for direct naked-

298 int mutations are sufficient to control this conformational switch with disease mutants G272V and Del

299 tial of amyloid structures and suggests that conformational switching within individual fibrils may a

300 id is capable of accommodating a significant conformational switching within individual fibrils.