ライフサイエンスコーパス: conformational transition

1 network structural model of the cAMP-induced conformational transition.

2 preceded by a Ca(2+)- and membrane-dependent conformational transition.

3 easonable pathway between two endpoints of a conformational transition.

4 e "spring-loaded" model proposed for the HA2 conformational transition.

5 ng at a faster rate than the inactive/active conformational transition.

6 and F286A) that are known to be defective in conformational transition.

7 to the resting SecYEG channel triggers this conformational transition.

8 sition state for the His79-mediated alkaline conformational transition.

9 gether to assemble a connectivity map of the conformational transition.

10 ant for the low rate of the Ca(2)E1P --> E2P conformational transition.

11 w salt conditions, providing a model for the conformational transition.

12 n undergoes a major antiparallel-to-parallel conformational transition.

13 and DNA base is able to complete the O-helix conformational transition.

14 e dihedral angles are often subject to large conformational transition.

15 ocal conformational changes not leading to a conformational transition.

16 -binding residue Ile-25 is critical for this conformational transition.

17 ow a single protein, pH-induced, reversible, conformational transition.

18 , and to provide a new approach to analyzing conformational transitions.

19 the design of inhibitors targeting critical conformational transitions.

20 by a unique combination of electrostatic and conformational transitions.

21 ubdomain suffice to account for the observed conformational transitions.

22 imer's disease assembles through a series of conformational transitions.

23 , and the consequences of mutations on these conformational transitions.

24 ntermediates are provided in our database of conformational transitions.

25 transports dopamine (DA) through a series of conformational transitions.

26 ntra-LBD (cleft closure) and inter-LBD dimer conformational transitions.

27 nt sampling of pathways associated with rare conformational transitions.

28 of symmetry breaking in facilitating channel conformational transitions.

29 he distance to the transition state, for the conformational transitions.

30 geting these interactions and the associated conformational transitions.

31 its selectivity for Na(+) over K(+) in such conformational transitions.

32 vide a detailed molecular description of the conformational transitions.

33 s when used to evaluate rapid macromolecular conformational transitions.

34 a poorly understood progression of regulated conformational transitions.

35 y from one form to another through cycles of conformational transitions.

36 e state and another to facilitate subsequent conformational transitions.

37 d inhibition of DA transport and transporter conformational transitions.

38 by fusion inhibitors (FIs) that disrupt Env conformational transitions.

39 plex which can explain biologically relevant conformational transitions.

40 the spike proteins are regulated to undergo conformational transitions.

41 hedral intermediate sub-states implicated in conformational transitions.

42 nner domain, W69, as being involved in these conformational transitions.

43 uctase domain, and increased the rate of its conformational transitions.

44 ded to investigate a large number of protein conformational transitions.

45 regulated in mouse cells by targeting these conformational transitions.

46 nd geometry that must be associated with the conformational transition activating the DNA-binding dom

47 provides an interesting example of molecular conformational transitions along the association pathway

48 CS dominates at slow conformational transition and low ligand concentration.

49 to induce a modest but clear closed-to-open conformational transition and releases the conformationa

50 arginine loop can induce the A-form-->B-form conformational transition and that a large free-energy b

51 em, we demonstrate that both the rate of the conformational transition and the concentration of ligan

52 used for elucidation of peptide and protein conformational transitions and folding equilibria.

53 which active-site side chains influence the conformational transitions and free-energy landscape tha

54 led description of the dynamics of base-step conformational transitions and of the first steps to the

55 Applications used to investigate DNA conformational transitions and secondary structure forma

56 ydration level occur in the absence of major conformational transitions and serve to stabilize needed

57 Conformational transitions and structural rearrangements

58 EA proteins, is necessary and sufficient for conformational transitions and that their protective fun

59 of dynamics (i.e., ligand diffusion, protein conformational transition, and binding reaction), the ov

60 ations suggest that the mechanism involves a conformational transition, and further evidence suggests

61 ation with fuel strands, environment induced conformational transitions, and covalent chemistry of ol

62 ning effects arise from two distinct coupled conformational transitions, and the transition within th

63 e interactions potentially important for the conformational transition are also identified.

64 ics of actin filaments the mechanisms of the conformational transition are different for the two prot

65 cular-level picture of how E1P to E2P enzyme conformational transitions are coupled to changes in ion

66 Biomolecular conformational transitions are essential to biological f

67 imental data, we propose a model wherein the conformational transitions are important for the mannosy

68 The coverage- and temperature-controlled conformational transitions are reversible and are driven

69 These two conformational transitions are well described by stepwis

70 landscapes to sample specific ligand-induced conformational transitions, as defined by the effector-b

71 To explore the conformational transition associated with oxygenation of

72 TNFR1 to explore backbone dynamics and infer conformational transitions associated with ligand bindin

73 that oligomerization of hCT accompanies the conformational transition at 1 mM concentration.

74 iments, e.g. analysis of protein folding and conformational transitions, be done in cells?

75 ly suggests that the HIV-2 RRE undergoes two conformational transitions before assuming the energetic

76 concepts from network theory to map out the conformational transition between active and inactive st

77 ch a ligand binding event gates a reversible conformational transition between alternate forms of a f

78 Since kinases are tightly regulated by a conformational transition between an active and inactive

79 This binding mode predicts a conformational transition between an ultra-stable closed

80 This pPu/pPy tract undergoes a conformational transition between B-DNA, single-stranded

81 two insert regions are also involved in the conformational transition between the active and inactiv

82 n the second case, the rate constants of the conformational transition between the inside and the out

83 tightly controlled by an ATP-dependent large conformational transition between the open and closed st

84 of DNA engagement undergoes highly quantized conformational transitions between distinct binding, cle

85 ng protein synthesis, the ribosome undergoes conformational transitions between functional states, re

86 Many icosahedral viruses undergo large-scale conformational transitions between icosahedrally symmetr

87 nition complex is highly dynamic, undergoing conformational transitions between many states with diff

88 r in modulating the allosteric interface and conformational transitions between SBD and the nucleotid

89 and RegA at distinct loci by undergoing slow conformational transitions between two metastable states

90 cations that perturb Ca(2+)-binding and the conformational transition by competing with Ca(2+), or b

91 dence for potential intermediates during the conformational transition by following hemifusion of WNV

92 Equilibrium properties of conformational transitions can be obtained directly from

93 re we further explored the importance of the conformational transition capability of alpha1 Na/K-ATPa

94 enerate high ESI charge states, resulting in conformational transitions caused by intramolecular elec

95 first or second) directed the open-to-closed conformational transition, changes in the dominant mode

96 Thus, this membrane curvature-dependent conformational transition, combined with curvature-sensi

97 HIV-1 envelope glycoprotein (Env) undergoes conformational transitions consequent to CD4 binding and

98 broaden our mechanistic understanding of how conformational transitions control ligand recognition by

99 In principle, the nature of conformational transition could be modelled in silico vi

100 The conformational transition depends upon a Ca(2+)binding s

101 The reversibility of their fusogenic conformational transitions differentiates them from many

102 tate of Y101 is uncorrelated with the global conformational transition during activation.

103 The alpha1 Na/K-ATPase undergoes E1/E2 conformational transition during an ion pumping cycle.

104 the four domains of Dpo4 undertook different conformational transitions during 8-oxoG bypass and the

105 ility of the beta8-beta9 loop is crucial for conformational transitions during opening and closing of

106 sing the dye RH421 show that FXYD1 slows the conformational transition E2(2K)ATP --> E1(3Na)ATP but d

107 nzyme undergoes an ATP-modulated endothermic conformational transition (ECT) believed to involve simi

108 proximately 10 kilobases) reveal large-scale conformational transitions elicited by supercoiling.

109 graphically distinct sites are mediated by a conformational transition established between a few pree

110 AlkB depends upon the dynamics of a specific conformational transition, establishing another paradigm

111 Importantly, the conformational transitions executed by telethonin in sim

112 ng device on the force-dependent rate of the conformational transition extracted from the time depend

113 that a microsecond-to-millisecond time scale conformational transition facilitates the proper sequent

114 brand factor is activated through a two-step conformational transition: first, elongation from compac

115 has been proposed that HIV-1 Gag undergoes a conformational transition from a compact conformation in

116 rates decrease while the complex undergoes a conformational transition from a lower to higher affinit

117 f the primary steps in this mechanism is the conformational transition from a state poised to bind ex

118 Conformational transition from a symmetric to an asymmet

119 tease inhibition by serpins requires a large conformational transition from an active, metastable sta

120 , we discovered that the peptide undergoes a conformational transition from an extended to a beta-hai

121 he Na2 site that occurs concomitantly with a conformational transition from an outward-facing to an i

122 ue and provide structural information on the conformational transition from closed to open channel.

123 H26N mutation enhances the dynamics of this conformational transition from pH 5 to 10, likely as a r

124 The peptide exhibits a conformational transition from random coil to beta-sheet

125 eceptor and its environment, and sampled the conformational transition from the crystal structure of

126 the structure of CMG-DNA, we suggest how the conformational transition from the loaded, post-catalyti

127 tubule after the first and before the second conformational transition has occurred, positioning it s

128 0 homologs, and the atomic resolution of the conformational transitions helps elucidate the complex c

129 simulations to accurately describe concerted conformational transitions identifying the overall struc

130 and demonstrate pathways for the closed-open conformational transition in both directions by computin

131 differentially elicit an inactive-to-active conformational transition in K-Ras4B-GTP; in K-Ras4B(G12

132 -limiting step of the overall mechanism is a conformational transition in Ly49 from its backfolded to

133 inding to MinD is sufficient to trigger this conformational transition in MinE.

134 ously shown to oppose the inactive-to-active conformational transition in the absence of cAMP.

135 work of domain contacts that imposes a major conformational transition in the catalytic domain that i

136 Our structures present a trajectory of the conformational transition in the elevator model, reveali

137 Shear forces in the blood trigger a conformational transition in the von Willebrand factor (

138 ransport can be inhibited simply by blocking conformational transitions in a properly folded transpor

139 binding of formins to the barbed end induces conformational transitions in actin filaments by making

140 lation moving windows (PCMW) to characterize conformational transitions in antibodies.

141 dynamic equilibrium in the absence of global conformational transitions in CBD alignment.

142 provides an effective framework to represent conformational transitions in complex biomolecular syste

143 tting, we have studied the effects of EB1 on conformational transitions in growing microtubule ends a

144 , to determine the kinetic mechanisms of the conformational transitions in HIV-1 PR.

145 brane displacements, a distance smaller than conformational transitions in ion channels.

146 tion of methods that can directly reveal how conformational transitions in macromolecular machines ar

147 In turn, the SWAXS data accelerates conformational transitions in MD simulations and reduces

148 Evidencing subtle conformational transitions in proteins occurring upon sm

149 at govern the thermodynamics and kinetics of conformational transitions in proteins, which in turn ar

150 e mass spectrometry was used to monitor slow conformational transitions in RD, using disordered regio

151 Conformational transitions in RNA molecules offer an imp

152 Investigation of beta-sheet-oriented conformational transitions in silk proteins at the nanos

153 ved Y-T coupling mechanism, which propagates conformational transitions in the 455 (alpha4-beta5-alph

154 roughout the StART-like PITP family; and (v) conformational transitions in the C-terminal helix have

155 wing microtubule ends reveal two consecutive conformational transitions in the microtubule end region

156 on how Cu(I) binding initiates a sequence of conformational transitions in the transport cycle.

157 ing in a highly concerted fashion during the conformational transitions, including six conformational

158 Binding leads to a series of conformational transitions, including the closure of the

159 the femtosecond timescale, thus undergoing a conformational transition increasing the available space

160 f kinetically accessed intermediates of fast conformational transitions induced by common relaxation

161 iopen/open enzyme states, followed by enzyme conformational transition into a catalytically viable cl

162 e and NMR spectroscopies, revealing that the conformational transitions involve mostly the cytoplasmi

163 ormance free-energy methods, the sequence of conformational transitions involved in a functional cycl

164 uced by dNTP binding and a subsequent global conformational transition involving all domains of Taq P

165 model in which replacement of Asp68 blocks a conformational transition involving helices II and IV th

166 cleoproteins F and H that may interfere with conformational transitions involving the antisense targe

167 Here we show that this conformational transition is dependent on phosphatidylin

168 anged nucleotide simulations reveal that the conformational transition is more accessible in the GTP-

169 We propose that this binding-induced conformational transition is priming the ParB for polyme

170 d the outward-facing NCX_Mj suggest that the conformational transition is triggered by the rotation o

171 force nor the underlying pathways for these conformational transitions is known.

172 formational ensemble or the mechanism of the conformational transitions is not well understood.

173 the microscopic dynamics of proteins during conformational transitions is set by the intrachain diff

174 This conformational transition locates the aromatic side chai

175 et exhibits frequent backsteps and undergoes conformational transitions manifested in 5-bp backward a

176 Altogether, we propose a model in which conformational transitions observed in PimA might reflec

177 Important conformational transitions occurring during this cycle h

178 ion spectroscopy measurements show that this conformational transition occurs early in the assembly p

179 lar dichroism and fluorescence reveal that a conformational transition occurs in anionic lipid vesicl

180 ed that ATP binding to SynI is mediated by a conformational transition of a flexible loop that opens

181 The modified Cys-242 prevents a conformational transition of a loop adjacent to the ADP/

182 MS platform is demonstrated by exploring the conformational transition of a monoclonal antibody by in

183 ne and the nucleotide-binding domains in the conformational transition of ABC exporters.

184 erstanding of the multistaged, force-induced conformational transition of alpha-catenin to the activa

185 a provides a global view that shows stepwise conformational transition of an ensemble as a function o

186 We observed a highly cooperative conformational transition of beta-sheet to alpha-helix u

187 Conformational transition of calmodulin from the Ca(2+)-

188 We disclose the conformational transition of Cas9 from its apo form to t

189 We report on a conformational transition of dengue virus when changing

190 les of DIMS MD and FRODA trajectories of the conformational transition of diphtheria toxin, a particu

191 (gated ET) experiments to study the alkaline conformational transition of K79H variants of yeast iso-

192 Here, we show that the conformational transition of Mad2 is regulated by phosph

193 of mechanistically distinct pathways for the conformational transition of MsbA, a bacterial ABC expor

194 e explore the mechanism of the alpha-to-beta conformational transition of RfaH in the full-length pro

195 Previously, we showed that a conformational transition of Syx, related to calcium-tri

196 ed by NMR in real-time, demonstrate that the conformational transition of the N-terminal 13 residues

197 benzenes, the complexity of the photoinduced conformational transition of the pentameric foldamer 105

198 nce between the two scenarios is whether the conformational transition of the protein from the unboun

199 et in the kinase domain potentially drives a conformational transition of the R-loop, which is essent

200 ral requirements followed by a rate-limiting conformational transition of the substrate and protein.

201 We have analyzed the DFG conformational transition of the two kinases using massi

202 s time scale of the His79-mediated alkaline conformational transition of these variants.

203 We identify key ligand-induced conformational transitions of a conserved tryptophan sid

204 on a system by coupling into the equilibrium conformational transitions of a protein.

205 ions are complementary approaches that probe conformational transitions of biomolecules in solution,

206 al basis for LPS recognition, delineates the conformational transitions of MsbA to flip LPS, and pave

207 probe the structural dynamics, topology and conformational transitions of regulatory membrane protei

208 cal properties, including the elasticity and conformational transitions of the double-stranded (dsRNA

209 nt models of transport, which invoke various conformational transitions of the FG nucleoporins induce

210 ar dynamics (aMD) simulations to explore the conformational transitions of the GPCR from the active s

211 ptide shows that surface interactions induce conformational transitions of the monomer, which facilit

212 calculation of the kinetic constants for the conformational transitions of the peptide with the Asp r

213 the absence of SAM, frequent open-to-closed conformational transitions of the pseudoknot occur, akin

214 our observations suggest that "open/closed" conformational transitions of the TL may be linked to in

215 Here we investigated the conformational transitions of this domain during oligome

216 cally important chaperonin, such as that the conformational transitions of this protein complex in it

217 Thermally induced conformational transitions of three proteins of increasi

218 and critical conditions for electron-induced conformational transitions, offering new rules to design

219 t also perturb lipid structure by undergoing conformational transitions or by zipping up into the bil

220 a significant impact on the dynamics of the conformational transitions or on the binding properties

221 Finally, by examining the conformational transition pathway between the allosteric

222 omputational strategy for characterizing the conformational transition pathway is presented to bridge

223 models of the intermediate states along the conformational transition pathway reveal that the free e

224 r intermediate state is identified along the conformational transition pathway, and the key structura

225 it is necessary to gain knowledge about the conformational transition pathways connecting the crysta

226 We performed a detailed analysis of conformational transition pathways for a set of 10 prote

227 Hence, there appears to be a number of conformational transitions possible in HIV-1 monomeric g

228 transient residue-residue contacts along the conformational transitions predicted by the computations

229 processes are carried out through molecular conformational transitions, ranging from the structural

230 ns affect zoospore transmission by affecting conformational transitions rather than directly affectin

231 acellular pH, pH 7.4-7.3, shut the pore by a conformational transition referred as steady-state desen

232 ith LeuT fold, which are recognizable in the conformational transitions related to function.

233 he divalent metal ions affect the HNH domain conformational transition remains elusive.

234 complementary base pairs in RNA duplexes are conformational transitions required to accomplish a plet

235 the mechanism of the His73-mediated alkaline conformational transition requires three ionizable group

236 detailed understanding of their photoinduced conformational transitions, resembling similar processes

237 all-atom transition pathways for three main conformational transitions responsible for the alternati

238 The conformational transitions result in three supercoiling

239 pon dsDNA binding, cGAS is activated through conformational transitions, resulting in formation of a

240 looped-out of the duplex, with the resulting conformational transitions shifting the cleavable phosph

241 across the binding groove of a PDZ domain, a conformational transition, similar to the one occurring

242 9 and accelerates the rate-limiting E1P-E2P conformational transition (site B).

243 Gq/11 pathway is associated with a specific conformational transition stabilized by the agonist, whe

244 xperimental observations, and proceeds via a conformational transition state, with Huckel pi-bond shi

245 ergy hill, on the way to a cumulenic, purely conformational transition state.

246 Computational methods can identify conformational transition states from structural changes

247 ding and Mg2+ plays an important role in the conformational transition step.

248 prestin with at least two voltage-dependent conformational transition steps having distinct electrom

249 studies of the mechanisms of macromolecular conformational transitions such as protein folding are e

250 er the free energy landscape controlling the conformational transitions suffered by such proteins.

251 Important conclusions are that the conformational transition that leads to occlusion with b

252 of these ligand-gated receptors is driven by conformational transitions that are induced by the assoc

253 compared suggest the presence of long-lived conformational transitions that are not included in a si

254 ing an ensemble approach to characterise the conformational transitions that are often responsible fo

255 With this approach, we study the conformational transitions that arise due to supercoilin

256 le to the intra- and extracellular milieu by conformational transitions that confer marked changes in

257 uggest that enantiomer recognition occurs at conformational transitions that initiate amino acid tran

258 quires that the particle undergo a series of conformational transitions that lead to cell entry and g

259 eage commitment, discussing TCR force-driven conformational transitions that may optimally expose the

260 ase I (KF) achieves this through a series of conformational transitions that precede the chemical ste

261 assemble into large transmembrane pores via conformational transitions that remain to be structurall

262 Elucidation of the conformational transitions that the HIV-1 envelope prote

263 rocess of Rho through a 0.1 millisecond-long conformational transition, the time scale seen also in e

264 ing-dissociation events are fast compared to conformational transitions, the rate of approach to equi

265 s well as to account for regions involved in conformational transitions through the correct sampling

266 The timescale of conformational transitions thus plays a crucial role in

267 a a Dynamic mode, followed by an SRP-induced conformational transition to a Stable mode that activate

268 A protein will often undergo a conformational transition to form the functional complex

269 ft-handed dimer gets tilted en bloc, whereas conformational transitions to alternative (e.g. right-ha

270 eover, we estimate the energetic cost of the conformational transitions to be smaller than 1 kcal/mol

271 pha-helices in the native state must undergo conformational transitions to beta-strands upon aggregat

272 the beta2-alpha2 loop and the propensity for conformational transitions to disease-related forms of P

273 form at the CD4 interface during large-scale conformational transitions to the CD4-bound state from t

274 Na2 binding and release associated with the conformational transition toward the inward-open state,

275 mechanisms of CYP3A4 cooperativity involve a conformational transition triggered by an allosteric lig

276 mber of complex biological processes-protein conformational transitions, (un)binding, and assembly pr

277 s indicates that each CmeB subunit undergoes conformational transitions uncoordinated and independent

278 esults provide a physical explanation of the conformational transitions underlying this behavior.

279 into understanding the molecular basis of TL conformational transition upon substrate binding during

280 ( approximately 1 s(-1) at 277 K) related to conformational transitions upon binding.

281 a the alteration of the kinetic landscape of conformational transitions upon drug-binding.

282 matically interrogated and scrutinized these conformational transitions using a panel of antibody pro

283 crucial iso-parallel dimer that mediates the conformational transition was discovered computationally

284 solve the dynamic features of Ca(2+)-induced conformational transitions we analyze here distinct spli

285 f propofol binding sites affects the channel conformational transition, we performed a total of 1.5 m

286 To explore structural dynamics during the conformational transition, we studied simulations of a m

287 but Na(+) binding and the voltage-dependent conformational transitions were unaffected.

288 s work highlights an important hairpin to G4 conformational transition which can be used in manipulat

289 This conformational transition, which has not been observed p

290 n the stochastic modulation of J-coupling by conformational transitions, which in the case of aziridi

291 antiapoptotic Bcl-2 family member, undergoes conformational transitions, which leads to two conformat

292 membrane, it is expected that blocking these conformational transitions will prevent transport activi

293 Understanding the features that govern such conformational transitions will shed light on human dise

294 Notably, we predict a conformational transition with increasing polymer length

295 , our study correlates ACKR3 ligand-specific conformational transitions with chemokine-dependent rece

296 omic normal mode analysis, and simulation of conformational transitions with our coarse-grained virtu

297 Our findings support the notion that a conformational transition within the Munc18-1 domain 3a

298 rs govern CD4 triggering by participating in conformational transitions within gp120 and regulating t

299 ATP-driven conformational transitions within the D2 ring alter the

300 ay represent general features for functional conformational transitions within the folded state.