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1       Furthermore, divergent reactivity of a conformationally accelerated, intramolecular Mannich cyc
2 with BAX in vivo and could directly bind and conformationally activate BAX in vitro.
3 as previously been shown to functionally and conformationally activate beta-arrestin-1.
4 Such substantial energies have been shown to conformationally activate, or unfold, beta-barrel and al
5 poptosome, in which each subunit needs to be conformationally activated by its ligand before assembly
6                               Prothrombin is conformationally activated by von Willebrand factor-bind
7 e metalloprotease ADAMTS13, which in turn is conformationally activated by VWF.
8                             ADAMTS13 becomes conformationally activated on demand through interaction
9 n (Pm) formation, transient formation of the conformationally activated SK.Pg* catalytic complex inte
10 pendent support for a mechanism in which the conformationally activated SK.Pg* complex catalyzes an i
11                            EscV recruits and conformationally activates the tightly membrane-associat
12  was underscored from enhanced expression of conformationally active Bax in platelets with attenuated
13 ibly through constitutive elimination of the conformationally active Bax.
14 ts of the apoptosome, or overexpressing only conformationally active caspase-9.
15         Expression of acetylated p53 and the conformationally active form of Bax were found to be sig
16 stering of beta1 integrins, and enhances the conformationally active population of surface beta1 inte
17 ocal unfolding that enables the A1 domain to conformationally adapt to shear flow while maintaining i
18     Thus, the data indicate how harnessing a conformationally adaptive dimer can drive large-scale ca
19 e CRP in binding to several other deposited, conformationally altered proteins.
20 SBD suppress domain communication defects by conformationally altering the allosteric interface, ther
21 oxic alpha-synuclein oligomers, resulting in conformationally and functionally modified species.
22 n the cytosol-accessible surface loop and/or conformationally assembled acidic Asp/Glu clusters, lead
23 iation intermediated by hole delocalization (conformationally assisted and thermally dependent) formi
24 x, the GroEL:GroES2 football complex differs conformationally at the GroEL-GroES interface and also a
25         Further, we observed that Fe-Dph4 is conformationally better poised to perform Hsp70-dependen
26 tocol enabling the direct conversion of some conformationally biased allylic amines to the correspond
27     We report an NMR chemical shift study of conformationally challenging seven-membered lactones (1-
28 ggest that three adjacent HA trimers and one conformationally changed HA trimer are minimally require
29 debated how many HA trimers, w, and how many conformationally changed HA trimers, q, are minimally re
30 vity is accessible in one BamA structure and conformationally closed in the other.
31 between the NADPH/FAD and FMN domains in the conformationally closed structure to allow cross-domain
32 em (nN --> sigma*S-X) in 32 was exploited to conformationally constrain a biaryl linkage and allow co
33 RAcP, whereas IL-33 binds to ST2 in order to conformationally constrain the cognate receptor in an IL
34 e substrate binding site; incorporation of a conformationally constrained 4-phenylpiperidine linker g
35                                        Using conformationally constrained acpcPNA probes, double stra
36  analogue in which Pro32 was replaced by the conformationally constrained amino acid alpha-methylprol
37                Control of chi-space utilizes conformationally constrained amino acids that favor, dis
38 tand its bioactive conformation, a series of conformationally constrained analogues of 1 were designe
39 e the bioavailability, we have designed four conformationally constrained analogues of Sal-AMS that r
40                              Homologated and conformationally constrained analogues were prepared.
41 the aryl substitution pattern and developing conformationally constrained analogues, selectivity for
42 noglobulin molecule as a scaffold to present conformationally constrained B-cell epitopes.
43 ic replacement of native alpha residues with conformationally constrained beta-amino acid residues.
44  cell-penetrating motif and converted into a conformationally constrained bicyclic structure through
45                                              Conformationally constrained bithiazoles were previously
46 lizing antibody having the shortest and most conformationally constrained CDR3.
47  the peptidolactone core structure with more conformationally constrained counterparts.
48 re, we describe the synthesis of an array of conformationally constrained cyclic peptides based on an
49                                              Conformationally constrained derivative 36 emerged as th
50             The X-ray crystal structure of a conformationally constrained mutant of the Escherichia c
51 he subsequent discovery of a novel series of conformationally constrained ortho-anilino diaryl ureas.
52                                           In conformationally constrained photoprecursors, a radical
53 d linker DNA and showed that tails may adopt conformationally constrained positions due to the insert
54                            Evaluation of the conformationally constrained series in a [(35)S]GTPgamma
55 acologically augmented by converting it to a conformationally constrained tetrahydrofuran to improve
56 noethylamide ligands, the flexible chain was conformationally constrained to reproduce the bioactive
57 s of bicyclic amino acids gave access to two conformationally constrained unnatural amino acids with
58 nthetic biology toolbox lacks extendable and conformationally controllable yet easy-to-synthesize bui
59 torsion balance concept was applied to a new conformationally controlled scaffold and synthesized to
60 own that the site of ubiquinone reduction is conformationally coupled to the NqrB subunit, which also
61 r an experimentally determined evaluation of conformationally dependent (pi) and conformationally ind
62 r E2 conformation and recognition for all 14 conformationally dependent E2 antibodies and subsets the
63 y assessed for the first time, demonstrating conformationally dependent RT rates that increase from 0
64 at, in the kinase-on state, the HAMP is more conformationally destabilized compared with the PIR, whe
65                       We found that reduced, conformationally destabilized proteins are released from
66               Zwitterionic detergents formed conformationally destabilizing interactions with an alph
67  Ionotropic glutamate receptors comprise two conformationally different A/C and B/D subunit pairs.
68 eved through the genetic fusion with a long, conformationally disordered chain of the natural amino a
69 ) transcription factor is autoinhibited by a conformationally disordered serine-rich region (SRR) tha
70 irect evidence is provided for the role of a conformationally distinct "nucleotide-binding" state dur
71 opagated forms of misfolded tau can exist as conformationally distinct "strains" with unique biochemi
72             The seven-transmembrane helices, conformationally distinct from those of G-protein-couple
73 uppressors implies that Tsr-HAMP has several conformationally distinct kinase-active output states an
74 hly efficiently, catalyzing the formation of conformationally distinct monomeric 2dCD4 isomers, and a
75 nte Carlo docking trajectories on each of 10 conformationally distinct ROMK comparative homology mode
76                          Here we present two conformationally distinct structures of C. elegans GluCl
77 rging evidence also suggests the presence of conformationally diverse 'strains' of each type of disea
78                                      Using a conformationally diverse collection of natively folded a
79 ch to discern protein unfolding pathways for conformationally diverse proteins.
80 rion transformation, we infected mice with a conformationally diverse set of amyloids and serially pa
81  of the complex, which may be related to the conformationally driven coupling mechanism and to the ac
82 g proton conduction across the membrane to a conformationally driven pumping cycle.
83 r coactivator CREB binding protein/p300 is a conformationally dynamic domain that complexes with tran
84 en underappreciated significance of discrete conformationally dynamic elements within the context of
85  A di-sulfide bridge was introduced into the conformationally dynamic FimH lectin domain, away from t
86 terminal SCIN domains are characterized by a conformationally dynamic helical motif.
87 ction, a finding that gives insight into how conformationally dynamic IRESs operate.
88 a codon-anticodon interaction and contains a conformationally dynamic loop.
89                                   Hsp90 is a conformationally dynamic molecular chaperone known to pr
90 s show pervasive positive epistasis within a conformationally dynamic network of residues.
91 icant enzymatic activity, suggesting Y731 is conformationally dynamic on the time scale of turnover.
92                       Rather than a clamp, a conformationally dynamic protein assembly typically cont
93 iption of equilibrium folding/unfolding in a conformationally dynamic protein.
94  from others indicating that the on rates of conformationally dynamic proteins approach the limits of
95 e stabilizers to target important regions of conformationally dynamic proteins.
96 ted by subtle domain movements, which reveal conformationally dynamic regions and match biochemical d
97  analysis, may be used to identify and study conformationally dynamic regions in virus particles and
98 for xylopyridine A represents a new class of conformationally dynamic structure-selective quadruplex
99 aspase-6 is inherently and dramatically more conformationally dynamic than closely related caspase-7.
100 L-5-specific alpha subunit that interacts in conformationally dynamic ways with the receptor's betac
101 t after binding, the 40S:HCV IRES complex is conformationally dynamic, undergoing slow large-scale re
102 al models of biomacromolecules: to make them conformationally dynamic.
103 ess both receptor and coreceptor binding and conformationally entrap the protein in a destabilized st
104 ew techniques and the significant roles that conformationally excited protein states play in biology.
105 ts and a simple strategy for studies of such conformationally excited states based on measurement of
106 r, it emphasizes the potential importance of conformationally excited states in directing both foldin
107 ly populated, NMR-visible native state and a conformationally excited, NMR-invisible state, correspon
108 ariable regions to preferentially expose the conformationally fixed CD4bs.
109 explore the pharmacophoric features of these conformationally fixed groups, we have synthesized a ser
110 ctionally conserved - but also intrinsically conformationally flexible - scaffolds for translocation
111 k the in vitro exploration to identify novel conformationally flexible and constrained RBP4 antagonis
112  require m-IL-1beta to be unfolded or remain conformationally flexible and is dependent on two KFERQ-
113     Second, a new bimetallic catalyst with a conformationally flexible biphenol linker was synthesize
114                            The presence of a conformationally flexible C6 oxygen atom in the sugar-de
115 omprise stereochemically complex acyclic and conformationally flexible carbon chains make such a task
116                                  A series of conformationally flexible furan-derived allocolchicinoid
117                                   Thirty-six conformationally flexible intermediate complexes involvi
118               The fact that Rap proteins are conformationally flexible is surprising considering that
119 antimicrobial activity, the structure of the conformationally flexible molecules was determined large
120 enesis of prion diseases, is indicative of a conformationally flexible native (N) state.
121 ly applicable to HIV-1 Env and also to other conformationally flexible pathogen antigens.
122 ing four larger (27-28 heavy atoms) and more conformationally flexible photochromic molecules not use
123 Ag(111) via a preprogrammed isomerization of conformationally flexible polymer chains followed by deh
124 ination of the absolute configuration of the conformationally flexible products of copper-catalyzed c
125 e of the GNEIMO method in simulations of the conformationally flexible proteins fasciculin and calmod
126 erminal subdomain are consistent with a more conformationally flexible region.
127     Until now, probing a single structure of conformationally flexible RNA molecules has typically re
128 ra-phosphonate calix[4]pyrrole cavitands are conformationally flexible, always adopting a conformatio
129                   However, these trimers are conformationally flexible, potentially reducing B-cell r
130 rm reveal that AMCP-containing oligomers are conformationally flexible.
131 irs a hydrophobic core of Ig20, generating a conformationally fluctuating molten globule-like state.
132 indicated that compared with WT filamin, the conformationally fluctuating state of the Ig20 mutant ma
133 ase the chance of active-site collision with conformationally fluctuating substrates, and enable regu
134 echanistic model is that the regulatory cues conformationally gate NADPH-binding, implicitly providin
135 long a specific pathway and is thought to be conformationally gated and coupled to local proton trans
136 he NDI stacks in a manner reminiscent of the conformationally gated charge transfer observed in DNA.
137 rpyridine), Co(terpy)2(2+), as a reagent for conformationally gated electron-transfer (gated ET) expe
138 sequence involves four sequential steps: (i) conformationally gated ET (kET = 140 s(-1), 25 degrees C
139      The generality of the approach of using conformationally gated small molecule binding aptamers i
140 dy, we show that in solution Bet v 1.0101 is conformationally heterogeneous and cannot be represented
141 characterization of these highly dynamic and conformationally heterogeneous ensembles has remained ch
142            Our simulation studies revealed a conformationally heterogeneous glycan shield with a netw
143 an emerging tool for resolving structures of conformationally heterogeneous particles; however, each
144 CONTACT, that identifies contact networks of conformationally heterogeneous residues directly from hi
145 ctively, the data show that Ric-8A induces a conformationally heterogeneous state of Galphai and prov
146 s determination of structure and dynamics of conformationally heterogeneous systems by integrating ex
147 mble of slowly (>100 ms) interconverting and conformationally heterogeneous unfolded states that lack
148 e pASK1-CD.14-3-3zeta complex is dynamic and conformationally heterogeneous.
149 roblem is difficult because these states are conformationally highly heterogeneous and cannot be repr
150 f enzymatic cleavage was located at the less conformationally hindered position distant from the turn
151                         We describe here two conformationally homogeneous Envs derived from difficult
152  CD data reported here are the first for any conformationally homogeneous helical peptoids containing
153 nging, requiring the formation of stable and conformationally homogeneous ligand-receptor complexes.
154 ever, one Ab is significantly more rigid and conformationally homogeneous than the others, including
155 ze viruses are thought to be more stable and conformationally homogeneous trimers than those of easy-
156 brane-bound CH120.6 Env is indeed stable and conformationally homogeneous.
157 ermit the presentation of shared epitopes in conformationally identical formats but can affect T-cell
158 ycoside-induced intracellular K(+) depletion conformationally impairs the complex-glycosylated channe
159 is Integrin-Integrin complex correlates with conformationally inactive Integrin.
160 ation of conformationally dependent (pi) and conformationally independent (sigma) contributions to th
161 uestrin in termination of calcium release by conformationally inducing closure of SR channels.
162                          We demonstrate that conformationally intact L1 protein, likely still arrange
163 periments demonstrate that representation of conformationally intact MHC alloantigen by recipient APC
164                     Autoantibodies targeting conformationally intact myelin oligodendrocyte glycoprot
165 strated the maturing epitope to focus on the conformationally invariant portion of the CD4bs.
166 ere designed to anchor the fusion peptide to conformationally invariant residues of the F head.
167 se bound to sugar and peptide Ags revealed a conformationally invariant state of the Ab while binding
168 maintain the POM units connected through the conformationally inward-directed {Mo(2)O(2)S(2)} linkers
169 why some inhibitory serpin families are more conformationally labile than others.
170                         These inhibitors are conformationally less flexible, target gatekeeper mutate
171  illustrate how the ligand-binding pocket is conformationally linked to this conserved triad.
172 ctions between topographically distinct, yet conformationally linked, domains.
173 ture is also reported for the novel, (4)C(1)-conformationally locked bicyclic 1,6-anhydro iduronate l
174                                              Conformationally locked cis diastereomers of bis(sulfide
175 al unambiguously that the free hexoketose is conformationally locked in a single dominant beta-pyrano
176 ctronic structure properties indicative of a conformationally locked iron carbyne unit.
177 n on reactivity and selectivity derived from conformationally locked models in the glucose and galact
178 s between these RRE 'conformers', we created conformationally locked mutants by site-directed mutagen
179               Synthesis of the corresponding conformationally locked sugar modified uridine and guano
180 that connects its C-Mad2-binding site to the conformationally malleable C-terminal region.
181 or identifying small-molecule stabilizers of conformationally malleable proteins, thus facilitating t
182 bound Eis in the AG-binding pocket held by a conformationally malleable region of Eis (residues 28-37
183 oupled receptor sequences have evolved to be conformationally metastable through the design of subopt
184 s is a straightforward strategy to constrain conformationally mobile motifs, but forging a macrocycle
185         Certain 2-aryl-3H-1-benzazepines are conformationally mobile on the NMR time scale.
186 chitecture for human CNTs, revealed extended conformationally mobile regions within transport-domain
187 eveal that ADP-bound actin subunits are more conformationally mobile than ATP-bound subunits.
188  strongly indicative of the involvement of a conformationally mobile transient glycosyl oxocarbenium
189 in variable domains and has been shown to be conformationally mobile.
190 , PH-Tau) mouse model to study the effect of conformationally modified tau in vivo.
191                    While the outer domain is conformationally more stable than other portions of the
192  used to initiate their formation and change conformationally on repeated passage.
193 troduction of the W24A/E262A mutation, which conformationally "opens" CB2SH3+ and allows the pleckstr
194 ur data show that most of the CA sequence is conformationally ordered and relatively rigid in tubular
195                                              Conformationally ordered peptidomimetic oligomers are fi
196 sically disordered regions (IDRs), which are conformationally plastic and do not appear to adopt sing
197 nd) were the source and therefore impart the conformationally plastic character of native EmrE capabl
198  associated with such oxidatively sensitive, conformationally plastic/dynamic repetitive DNA domains.
199                                  A family of conformationally preorganized, [n]polynorbornane-based a
200            A surprising prediction is that a conformationally produced pseudo-enantiomerism in 1,3-bu
201  proteins allow us to propose a model of the conformationally protected ternary complex of nitrogenas
202 ering modeling starting from 5,000 to 12,000 conformationally randomized HS structures gave best fit
203 he carboxyltransferase domain active site is conformationally rearranged upon pyruvate binding.
204 tructural basis for further investigation of conformationally regulated models of transbilayer TCR si
205                     Each novel CAR exhibited conformationally relevant expression on the surface of t
206                          How AAA+ chaperones conformationally remodel specific target proteins in an
207 ze various 5-membered cyclic carboxamides to conformationally restrain key pharmacophoric groups with
208 ligases interact with protein substrates and conformationally restrain the ubiquitin-E2-conjugating e
209 l and a carboxylic acid, were grafted onto a conformationally restrained spirocyclic scaffold, and to
210 entropic gain resulting from releasing these conformationally restrained waters to the bulk solvent i
211  with the procapsid during DNA translocation conformationally restrict the nuclease domain, inhibitin
212 chemical modifications to Ang II to generate conformationally restricted (disulfide-crosslinked) pept
213                                              Conformationally restricted 2'-spironucleosides and thei
214 d for complete regioselective 5-O-opening of conformationally restricted 3,5-O-di-tert-butylsilylene-
215 hybridization strategy was used based on the conformationally restricted 3-hydroxycyclopent-1-enecarb
216                                  A series of conformationally restricted acetanilides were synthesize
217 of oriented bilayers in conjunction with the conformationally restricted amino acid L-3-(trifluoromet
218 ained compounds can be considered as achiral conformationally restricted analogues of threonine with
219 immunologically by their reactivities with a conformationally restricted anti-F protein monoclonal an
220 mylin and its disruption by a novel class of conformationally restricted beta-sheet breaker hybrid pe
221 ve 3,9-diazatricyclo[5.3.0.0(1,5)]decanes as conformationally restricted bis-pyrrolidines.
222  a loss in entropy as chains transition to a conformationally restricted bridged state.
223 ex units, large flexible substituents become conformationally restricted by the interactions leading
224  Additionally, we used the unique chiral and conformationally restricted character of the (PhPro)4 sh
225 d a Lewis base, with highly preorganized and conformationally restricted chiral cavities of [2]rotaxa
226 ynthesis and evaluation of both flexible and conformationally restricted compounds derived from salvi
227 ues to arrive at a novel series containing a conformationally restricted core.
228 e incorporation of the previously unexplored conformationally restricted cyclic systems into peptides
229                 Locked nucleic acid (LNA), a conformationally restricted DNA analogue, is potentially
230 y while storing an enzyme subpopulation in a conformationally restricted form that is readily activat
231 to the stereoselective synthesis of four new conformationally restricted Glu analogues, 2a-d.
232                                              Conformationally restricted H stems remained capable of
233 ituted perhydroquinoxalines were designed as conformationally restricted kappa-opioid receptor agonis
234 LR4.MD-2-specific ligands, we have developed conformationally restricted Lipid A mimetics wherein the
235 ild method for the synthesis of strained and conformationally restricted macrocycles.
236  oligonucleotides modified with LNA or other conformationally restricted monomers.
237 ast to wild-type LacY, the properties of the conformationally restricted mutant Cys154-->Gly do not c
238                           The development of conformationally restricted nucleotide building blocks c
239 tions to the sugar ring of affinity-inducing conformationally restricted nucleotide building blocks s
240 se insights will impact the future design of conformationally restricted nucleotides for nucleic acid
241                                              Conformationally restricted nucleotides such as locked n
242               Oligonucleotides modified with conformationally restricted nucleotides such as locked n
243                                            A conformationally restricted P2' methyl group provided in
244   Herein, we introduced a novel strategy for conformationally restricted peptide design adopting a mi
245 ent FDA approval of Symlin, which is a large conformationally restricted peptide.
246                            Importance of the conformationally restricted peptides for drug design aga
247 ional methods for accurate de novo design of conformationally restricted peptides, and the use of the
248 two-electron reduction of the sterically and conformationally restricted quinone substrate by the can
249 by dehydrogenative coupling of a tertiary or conformationally restricted secondary alcohol with dieth
250 ers of these PBIs are kinetically trapped in conformationally restricted states through intramolecula
251                 We have designed a series of conformationally restricted tetrahydrothiophene-based GA
252                             Preactivation of conformationally restricted thioglycoside 6 employing p-
253         These scaffolds could be regarded as conformationally restricted Tn antigen mimics, as we hav
254 tent helical handedness is preferred for the conformationally restricted transoid binaphthalene polym
255 dies determine that chiral polymers based on conformationally restricted transoid binaphthyl units di
256 ke particle (VLP) vaccine platform (PP7) for conformationally-restricted presentation of a modified A
257 cedure to a variety of chiral lipophilic and conformationally rigid amines and heterocycles by decarb
258     [Ar2N3]Mo(N)(O-t-Bu), which contains the conformationally rigid pyridine-based diamido ligand, [2
259 Ps, its general acid IPD-loop is most likely conformationally rigid, in contrast to the flexible WPD
260 in the lectin domain that would otherwise be conformationally rigid.
261 adduct MRS5704 35 (K(i) hA(3) 68.3 nM), were conformationally rigid; receptor docking identified a la
262        We report here such a unique class of conformationally robust modularly tunable folding molecu
263 x with a covalent noradrenaline analog and a conformationally selective antibody (nanobody) verified
264                                  Here we use conformationally selective inhibitors as chemical probes
265        Here, we monitor by NMR the effect of conformationally selective inhibitors on kinase backbone
266            Effective clinical application of conformationally selective kinase inhibitors requires ta
267         We conclude that CCL17 and CCL22 are conformationally selective ligands of CCR4 and interact
268  capture this active conformation, we used a conformationally selective synthetic antibody fragment (
269 sting that the MAPK1-vinculin interaction is conformationally selective.
270 formational extension of FN as assessed by a conformationally sensitive antibody.
271                         These data suggest a conformationally sensitive determinant on DRalpha1-MOG t
272            We previously demonstrated that a conformationally sensitive domain of one G protein, i.e.
273 try and flow cytometry using antibodies with conformationally sensitive epitopes supports proteolysis
274  receptor surface trafficking, reactivity to conformationally sensitive monoclonal antibodies, and li
275 d residues in those proteins were located in conformationally sensitive regions that underlie contrac
276 mbrane-impermeant sulfhydryl reagent was not conformationally sensitive.
277 e derivatives for surface modifications with conformationally slightly flexible diamondoid homologues
278         In the complex, two RGMB ectodomains conformationally stabilize the juxtamembrane regions of
279                                              Conformationally stabilized alpha-helical peptides are c
280 C38.01-11, by using virus-like particles and conformationally stabilized Env trimers as B cell probes
281  the IL-2:IL-2Ralpha interaction, while also conformationally stabilizing the IL-2:IL-2Rbeta interact
282                          DRPs appeared to be conformationally stable as intact conglutins.
283 ions also in single-molecule measurements on conformationally stable beta-peptides with non-polar sub
284 gle-crystal X-ray analyses indicate that the conformationally stable host/guest metal adducts display
285 ein design can generate small, thermally and conformationally stable protein scaffolds that accuratel
286 f kinase inhibitors through the synthesis of conformationally stable pyrrolopyrimidines.
287 these distorted regions can assume different conformationally stable states.
288           The resulting rationally designed, conformationally stable template enables further optimiz
289 hat protein containing 1 can be ligated to a conformationally strained trans-cyclooctene in vitro and
290               Utilization of Ag complexes of conformationally strained trans-cyclooctenes should grea
291 ed and copolymerized with fluorene to give a conformationally switchable conjugated copolymer.
292 ings indicate that the AD and PD of CfaE are conformationally tightly coupled and support the hypothe
293               Rhodium complexes derived from conformationally transformable alpha,omega-bisphosphite
294  scalable approach to the total synthesis of conformationally unrestricted, electronically isolated a
295 r across the substrate access channel, and a conformationally unstable catalytic loop in Rpn11.
296 emical chaperones to restore the function of conformationally unstable p53 cancer mutants, to the dev
297 ellent paradigm for rescuing the function of conformationally unstable p53 mutants because it has a u
298  is rigid, supporting the lid, while Rpn1 is conformationally variable, positioned at the periphery o
299 through the measurement of distances between conformationally well-defined spin labels.
300 irtue of the strategic placement of an added conformationally well-defined, rigid, and extended C20'

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