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4 Such substantial energies have been shown to conformationally activate, or unfold, beta-barrel and al
5 poptosome, in which each subunit needs to be conformationally activated by its ligand before assembly
9 n (Pm) formation, transient formation of the conformationally activated SK.Pg* catalytic complex inte
10 pendent support for a mechanism in which the conformationally activated SK.Pg* complex catalyzes an i
12 was underscored from enhanced expression of conformationally active Bax in platelets with attenuated
16 stering of beta1 integrins, and enhances the conformationally active population of surface beta1 inte
17 ocal unfolding that enables the A1 domain to conformationally adapt to shear flow while maintaining i
18 Thus, the data indicate how harnessing a conformationally adaptive dimer can drive large-scale ca
20 SBD suppress domain communication defects by conformationally altering the allosteric interface, ther
22 n the cytosol-accessible surface loop and/or conformationally assembled acidic Asp/Glu clusters, lead
23 iation intermediated by hole delocalization (conformationally assisted and thermally dependent) formi
24 x, the GroEL:GroES2 football complex differs conformationally at the GroEL-GroES interface and also a
26 tocol enabling the direct conversion of some conformationally biased allylic amines to the correspond
27 We report an NMR chemical shift study of conformationally challenging seven-membered lactones (1-
28 ggest that three adjacent HA trimers and one conformationally changed HA trimer are minimally require
29 debated how many HA trimers, w, and how many conformationally changed HA trimers, q, are minimally re
31 between the NADPH/FAD and FMN domains in the conformationally closed structure to allow cross-domain
32 em (nN --> sigma*S-X) in 32 was exploited to conformationally constrain a biaryl linkage and allow co
33 RAcP, whereas IL-33 binds to ST2 in order to conformationally constrain the cognate receptor in an IL
34 e substrate binding site; incorporation of a conformationally constrained 4-phenylpiperidine linker g
36 analogue in which Pro32 was replaced by the conformationally constrained amino acid alpha-methylprol
38 tand its bioactive conformation, a series of conformationally constrained analogues of 1 were designe
39 e the bioavailability, we have designed four conformationally constrained analogues of Sal-AMS that r
41 the aryl substitution pattern and developing conformationally constrained analogues, selectivity for
43 ic replacement of native alpha residues with conformationally constrained beta-amino acid residues.
44 cell-penetrating motif and converted into a conformationally constrained bicyclic structure through
48 re, we describe the synthesis of an array of conformationally constrained cyclic peptides based on an
51 he subsequent discovery of a novel series of conformationally constrained ortho-anilino diaryl ureas.
53 d linker DNA and showed that tails may adopt conformationally constrained positions due to the insert
55 acologically augmented by converting it to a conformationally constrained tetrahydrofuran to improve
56 noethylamide ligands, the flexible chain was conformationally constrained to reproduce the bioactive
57 s of bicyclic amino acids gave access to two conformationally constrained unnatural amino acids with
58 nthetic biology toolbox lacks extendable and conformationally controllable yet easy-to-synthesize bui
59 torsion balance concept was applied to a new conformationally controlled scaffold and synthesized to
60 own that the site of ubiquinone reduction is conformationally coupled to the NqrB subunit, which also
61 r an experimentally determined evaluation of conformationally dependent (pi) and conformationally ind
62 r E2 conformation and recognition for all 14 conformationally dependent E2 antibodies and subsets the
63 y assessed for the first time, demonstrating conformationally dependent RT rates that increase from 0
64 at, in the kinase-on state, the HAMP is more conformationally destabilized compared with the PIR, whe
67 Ionotropic glutamate receptors comprise two conformationally different A/C and B/D subunit pairs.
68 eved through the genetic fusion with a long, conformationally disordered chain of the natural amino a
69 ) transcription factor is autoinhibited by a conformationally disordered serine-rich region (SRR) tha
70 irect evidence is provided for the role of a conformationally distinct "nucleotide-binding" state dur
71 opagated forms of misfolded tau can exist as conformationally distinct "strains" with unique biochemi
73 uppressors implies that Tsr-HAMP has several conformationally distinct kinase-active output states an
74 hly efficiently, catalyzing the formation of conformationally distinct monomeric 2dCD4 isomers, and a
75 nte Carlo docking trajectories on each of 10 conformationally distinct ROMK comparative homology mode
77 rging evidence also suggests the presence of conformationally diverse 'strains' of each type of disea
80 rion transformation, we infected mice with a conformationally diverse set of amyloids and serially pa
81 of the complex, which may be related to the conformationally driven coupling mechanism and to the ac
83 r coactivator CREB binding protein/p300 is a conformationally dynamic domain that complexes with tran
84 en underappreciated significance of discrete conformationally dynamic elements within the context of
85 A di-sulfide bridge was introduced into the conformationally dynamic FimH lectin domain, away from t
91 icant enzymatic activity, suggesting Y731 is conformationally dynamic on the time scale of turnover.
94 from others indicating that the on rates of conformationally dynamic proteins approach the limits of
96 ted by subtle domain movements, which reveal conformationally dynamic regions and match biochemical d
97 analysis, may be used to identify and study conformationally dynamic regions in virus particles and
98 for xylopyridine A represents a new class of conformationally dynamic structure-selective quadruplex
99 aspase-6 is inherently and dramatically more conformationally dynamic than closely related caspase-7.
100 L-5-specific alpha subunit that interacts in conformationally dynamic ways with the receptor's betac
101 t after binding, the 40S:HCV IRES complex is conformationally dynamic, undergoing slow large-scale re
103 ess both receptor and coreceptor binding and conformationally entrap the protein in a destabilized st
104 ew techniques and the significant roles that conformationally excited protein states play in biology.
105 ts and a simple strategy for studies of such conformationally excited states based on measurement of
106 r, it emphasizes the potential importance of conformationally excited states in directing both foldin
107 ly populated, NMR-visible native state and a conformationally excited, NMR-invisible state, correspon
109 explore the pharmacophoric features of these conformationally fixed groups, we have synthesized a ser
110 ctionally conserved - but also intrinsically conformationally flexible - scaffolds for translocation
111 k the in vitro exploration to identify novel conformationally flexible and constrained RBP4 antagonis
112 require m-IL-1beta to be unfolded or remain conformationally flexible and is dependent on two KFERQ-
113 Second, a new bimetallic catalyst with a conformationally flexible biphenol linker was synthesize
115 omprise stereochemically complex acyclic and conformationally flexible carbon chains make such a task
119 antimicrobial activity, the structure of the conformationally flexible molecules was determined large
122 ing four larger (27-28 heavy atoms) and more conformationally flexible photochromic molecules not use
123 Ag(111) via a preprogrammed isomerization of conformationally flexible polymer chains followed by deh
124 ination of the absolute configuration of the conformationally flexible products of copper-catalyzed c
125 e of the GNEIMO method in simulations of the conformationally flexible proteins fasciculin and calmod
127 Until now, probing a single structure of conformationally flexible RNA molecules has typically re
128 ra-phosphonate calix[4]pyrrole cavitands are conformationally flexible, always adopting a conformatio
131 irs a hydrophobic core of Ig20, generating a conformationally fluctuating molten globule-like state.
132 indicated that compared with WT filamin, the conformationally fluctuating state of the Ig20 mutant ma
133 ase the chance of active-site collision with conformationally fluctuating substrates, and enable regu
134 echanistic model is that the regulatory cues conformationally gate NADPH-binding, implicitly providin
135 long a specific pathway and is thought to be conformationally gated and coupled to local proton trans
136 he NDI stacks in a manner reminiscent of the conformationally gated charge transfer observed in DNA.
137 rpyridine), Co(terpy)2(2+), as a reagent for conformationally gated electron-transfer (gated ET) expe
138 sequence involves four sequential steps: (i) conformationally gated ET (kET = 140 s(-1), 25 degrees C
139 The generality of the approach of using conformationally gated small molecule binding aptamers i
140 dy, we show that in solution Bet v 1.0101 is conformationally heterogeneous and cannot be represented
141 characterization of these highly dynamic and conformationally heterogeneous ensembles has remained ch
143 an emerging tool for resolving structures of conformationally heterogeneous particles; however, each
144 CONTACT, that identifies contact networks of conformationally heterogeneous residues directly from hi
145 ctively, the data show that Ric-8A induces a conformationally heterogeneous state of Galphai and prov
146 s determination of structure and dynamics of conformationally heterogeneous systems by integrating ex
147 mble of slowly (>100 ms) interconverting and conformationally heterogeneous unfolded states that lack
149 roblem is difficult because these states are conformationally highly heterogeneous and cannot be repr
150 f enzymatic cleavage was located at the less conformationally hindered position distant from the turn
152 CD data reported here are the first for any conformationally homogeneous helical peptoids containing
153 nging, requiring the formation of stable and conformationally homogeneous ligand-receptor complexes.
154 ever, one Ab is significantly more rigid and conformationally homogeneous than the others, including
155 ze viruses are thought to be more stable and conformationally homogeneous trimers than those of easy-
157 ermit the presentation of shared epitopes in conformationally identical formats but can affect T-cell
158 ycoside-induced intracellular K(+) depletion conformationally impairs the complex-glycosylated channe
160 ation of conformationally dependent (pi) and conformationally independent (sigma) contributions to th
163 periments demonstrate that representation of conformationally intact MHC alloantigen by recipient APC
167 se bound to sugar and peptide Ags revealed a conformationally invariant state of the Ab while binding
168 maintain the POM units connected through the conformationally inward-directed {Mo(2)O(2)S(2)} linkers
173 ture is also reported for the novel, (4)C(1)-conformationally locked bicyclic 1,6-anhydro iduronate l
175 al unambiguously that the free hexoketose is conformationally locked in a single dominant beta-pyrano
177 n on reactivity and selectivity derived from conformationally locked models in the glucose and galact
178 s between these RRE 'conformers', we created conformationally locked mutants by site-directed mutagen
181 or identifying small-molecule stabilizers of conformationally malleable proteins, thus facilitating t
182 bound Eis in the AG-binding pocket held by a conformationally malleable region of Eis (residues 28-37
183 oupled receptor sequences have evolved to be conformationally metastable through the design of subopt
184 s is a straightforward strategy to constrain conformationally mobile motifs, but forging a macrocycle
186 chitecture for human CNTs, revealed extended conformationally mobile regions within transport-domain
188 strongly indicative of the involvement of a conformationally mobile transient glycosyl oxocarbenium
193 troduction of the W24A/E262A mutation, which conformationally "opens" CB2SH3+ and allows the pleckstr
194 ur data show that most of the CA sequence is conformationally ordered and relatively rigid in tubular
196 sically disordered regions (IDRs), which are conformationally plastic and do not appear to adopt sing
197 nd) were the source and therefore impart the conformationally plastic character of native EmrE capabl
198 associated with such oxidatively sensitive, conformationally plastic/dynamic repetitive DNA domains.
201 proteins allow us to propose a model of the conformationally protected ternary complex of nitrogenas
202 ering modeling starting from 5,000 to 12,000 conformationally randomized HS structures gave best fit
204 tructural basis for further investigation of conformationally regulated models of transbilayer TCR si
207 ze various 5-membered cyclic carboxamides to conformationally restrain key pharmacophoric groups with
208 ligases interact with protein substrates and conformationally restrain the ubiquitin-E2-conjugating e
209 l and a carboxylic acid, were grafted onto a conformationally restrained spirocyclic scaffold, and to
210 entropic gain resulting from releasing these conformationally restrained waters to the bulk solvent i
211 with the procapsid during DNA translocation conformationally restrict the nuclease domain, inhibitin
212 chemical modifications to Ang II to generate conformationally restricted (disulfide-crosslinked) pept
214 d for complete regioselective 5-O-opening of conformationally restricted 3,5-O-di-tert-butylsilylene-
215 hybridization strategy was used based on the conformationally restricted 3-hydroxycyclopent-1-enecarb
217 of oriented bilayers in conjunction with the conformationally restricted amino acid L-3-(trifluoromet
218 ained compounds can be considered as achiral conformationally restricted analogues of threonine with
219 immunologically by their reactivities with a conformationally restricted anti-F protein monoclonal an
220 mylin and its disruption by a novel class of conformationally restricted beta-sheet breaker hybrid pe
223 ex units, large flexible substituents become conformationally restricted by the interactions leading
224 Additionally, we used the unique chiral and conformationally restricted character of the (PhPro)4 sh
225 d a Lewis base, with highly preorganized and conformationally restricted chiral cavities of [2]rotaxa
226 ynthesis and evaluation of both flexible and conformationally restricted compounds derived from salvi
228 e incorporation of the previously unexplored conformationally restricted cyclic systems into peptides
230 y while storing an enzyme subpopulation in a conformationally restricted form that is readily activat
233 ituted perhydroquinoxalines were designed as conformationally restricted kappa-opioid receptor agonis
234 LR4.MD-2-specific ligands, we have developed conformationally restricted Lipid A mimetics wherein the
237 ast to wild-type LacY, the properties of the conformationally restricted mutant Cys154-->Gly do not c
239 tions to the sugar ring of affinity-inducing conformationally restricted nucleotide building blocks s
240 se insights will impact the future design of conformationally restricted nucleotides for nucleic acid
244 Herein, we introduced a novel strategy for conformationally restricted peptide design adopting a mi
247 ional methods for accurate de novo design of conformationally restricted peptides, and the use of the
248 two-electron reduction of the sterically and conformationally restricted quinone substrate by the can
249 by dehydrogenative coupling of a tertiary or conformationally restricted secondary alcohol with dieth
250 ers of these PBIs are kinetically trapped in conformationally restricted states through intramolecula
254 tent helical handedness is preferred for the conformationally restricted transoid binaphthalene polym
255 dies determine that chiral polymers based on conformationally restricted transoid binaphthyl units di
256 ke particle (VLP) vaccine platform (PP7) for conformationally-restricted presentation of a modified A
257 cedure to a variety of chiral lipophilic and conformationally rigid amines and heterocycles by decarb
258 [Ar2N3]Mo(N)(O-t-Bu), which contains the conformationally rigid pyridine-based diamido ligand, [2
259 Ps, its general acid IPD-loop is most likely conformationally rigid, in contrast to the flexible WPD
261 adduct MRS5704 35 (K(i) hA(3) 68.3 nM), were conformationally rigid; receptor docking identified a la
263 x with a covalent noradrenaline analog and a conformationally selective antibody (nanobody) verified
268 capture this active conformation, we used a conformationally selective synthetic antibody fragment (
273 try and flow cytometry using antibodies with conformationally sensitive epitopes supports proteolysis
274 receptor surface trafficking, reactivity to conformationally sensitive monoclonal antibodies, and li
275 d residues in those proteins were located in conformationally sensitive regions that underlie contrac
277 e derivatives for surface modifications with conformationally slightly flexible diamondoid homologues
280 C38.01-11, by using virus-like particles and conformationally stabilized Env trimers as B cell probes
281 the IL-2:IL-2Ralpha interaction, while also conformationally stabilizing the IL-2:IL-2Rbeta interact
283 ions also in single-molecule measurements on conformationally stable beta-peptides with non-polar sub
284 gle-crystal X-ray analyses indicate that the conformationally stable host/guest metal adducts display
285 ein design can generate small, thermally and conformationally stable protein scaffolds that accuratel
289 hat protein containing 1 can be ligated to a conformationally strained trans-cyclooctene in vitro and
292 ings indicate that the AD and PD of CfaE are conformationally tightly coupled and support the hypothe
294 scalable approach to the total synthesis of conformationally unrestricted, electronically isolated a
296 emical chaperones to restore the function of conformationally unstable p53 cancer mutants, to the dev
297 ellent paradigm for rescuing the function of conformationally unstable p53 mutants because it has a u
298 is rigid, supporting the lid, while Rpn1 is conformationally variable, positioned at the periphery o
300 irtue of the strategic placement of an added conformationally well-defined, rigid, and extended C20'
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