ライフサイエンスコーパス: congenic strain

1 rrowed the region to 2.7 cM in a reduced MHC congenic strain.

2 ts identified in heterozygotes from a D2-cpk congenic strain.

3 e of Szf1 in both an independent cross and a congenic strain.

4 ze a series of recombinants derived from the congenic strain.

5 their chromosomal location on Chr 19 in each congenic strain.

6 in size on the linkage map using a series of congenic strains.

7 provided by the examination of knock-out and congenic strains.

8 CT development, we created double and triple congenic strains.

9 al backcrossing and intercrossing to produce congenic strains.

10 dominant when 2 loci were combined in double congenic strains.

11 cell responses are elicited in H13a and H13b congenic strains.

12 recognize only the H4 Ag from this panel of congenic strains.

13 njury in mice with the lpr mutation, but not congenic strains.

14 enic interval in three independently derived congenic strains.

15 ntervals that have been isolated in separate congenic strains.

16 and HG.CAST-(D11Mit260-D11Mit255)N(6) (HG11) congenic strains.

17 tal BXSB strain, developed in three of these congenic strains.

18 ime-consuming to generate and backcross onto congenic strains.

19 ually requiring years to develop and analyze congenic strains.

20 on of either recombinant inbred, consomic or congenic strains.

21 Our study demonstrates that the MAIThi congenic strain allows phenotypic and functional charact

22 In these congenic strain analyses, the Nppa and Fv1 loci, in addi

23 In this study, using both linkage and congenic strain analyses, we demonstrate contributions f

24 Congenic strain analysis narrowed the genetic interval s

25 of PIA was investigated using F1 hybrid and congenic strain analysis to determine the influence of M

26 werful techniques of microarray analysis and congenic-strain analysis may greatly facilitate unravell

27 nterval of 0.15 cM by a combination of novel congenic strains and an ancestral haplotype analysis app

28 Using Ly5-marked congenic strains and B6 host mice, additional experiment

29 After breeding BALB- and B6a-rd3/rd3 congenic strains and finding significant differences in

30 ng a combination of novel, interval-specific congenic strains and recombinant progeny testing.

31 tic map is relatively well defined, and both congenic strains and recombinant strains are available t

32 ng Scg5 expression in two mouse chromosome 2 congenic strains and three additional F2 intercrosses.

33 maps, rapid marker-assisted construction of congenic strains, and evolutionary comparisons.

34 itions), four NOD-derived diabetes-resistant congenic strains, and two nondiabetic control strains.

35 nes involved in sex determination, we used a congenic strain approach to determine which chromosomal

36 Congenic strains are constructed by repeated backcrossin

37 In the analysis of complex traits, congenic strains are powerful tools because they allow c

38 Experiments involving a congenic strain (B6.D2-Mtv7(a)/Ty) enabled more precise

39 The resulting congenic strain, B6.kd, was mated with partners homozygo

40 tly on a C57BL/6 background to produce three congenic strains: B6.NZMc1 carrying Sle1, B6.NZMc4 carry

41 The availability of B6-based congenic strains bearing individual NZW-derived lupus su

42 was equivalent between the B3501 a and alpha congenic strains but the alpha strain was more virulent

43 ed in a cross between B6 and a B6.SPRET Ath1 congenic strain, but was unaffected in a B6 x B6.H Ath1

44 ts of Crgn1 and Crgn2, we generated a double-congenic strain by introgressing these loci from glomeru

45 at hg and D10Mit69 cosegregate in a cross of congenic strains C57BL/6J-hghg x C57BL/6J.

46 A congenic strain (called 'ZORI' here) with defects in Rag

47 reeding to construct two sets of overlapping congenic strains, called genome-tagged mice (GTMs), that

48 Congenic strains can now be constructed guided by the tr

49 Congenic strains can then be developed to fine-map a tra

50 We subsequently produced B6.NZMc1, a congenic strain carrying the NZM2410-derived Sle1 genomi

51 asured in B6-Ldlr(-/-)Cdkn2a(+/-) mice and a congenic strain carrying the region of homology with the

52 ts is to localize them in crosses, construct congenic strains carrying individual QTLs, and finally m

53 We previously produced three congenic strains carrying lupus susceptibility genes (Sl

54 Immunization of congenic strains carrying the entire chr15 and separatel

55 The analysis of congenic strains carrying these loci is now providing fu

56 In this article, we analyze data from congenic strains carrying two chromosome intervals (a do

57 candidate gene-methods used include creating congenic strains, comparative genomics and gene expressi

58 ines from the B6.CAST Ldlr(-/-) chromosome 6 congenic strain (CON6.Ldlr(-/-)) and analyzed aortic les

59 and nonepileptic ABP mice identified, and a congenic strain confirmed, a quantitative trait locus (Q

60 le and phenotypically indistinguishable from congenic strains containing proteasomes.

61 s for gene identification include the use of congenic strains containing QTL regions introduced from

62 The construction of NOD congenic strains containing selected segments of the dia

63 , two of which were confirmed by analysis of congenic strains containing the donor genomic segment fr

64 Through the use of a series of novel congenic strains containing the Idd3/Il2 region and diff

65 Only macrophages from the congenic strains containing the Idd4 locus showed IL-12p

66 Using congenic strains containing the LEW rat chromosomal segm

67 s between CAST/Ei and C57BL/6, the resulting congenic strains cover about 80% of the autosomal chromo

68 mouse strains (AcB/BcA panel of recombinant congenic strains) created from influenza-susceptible A/J

69 fts prime for accelerated rejection of 11/13 congenic strains defining single BALB/c minor H Ags indi

70 Analysis of congenic strains demonstrated that the FcgammaR and SLAM

71 For the triple congenic strain, depending on the analysis, the overall

72 A WF.COP-D2Mit29/D2Rat201 homozygous congenic strain derived at the N10 generation was treate

73 ty, we created a panel of single- and double-congenic strains derived from 129.MOLF-Chr19.

74 t harbor susceptibility genes and a panel of congenic strains derived from a selected CSS to determin

75 l characterization of a genome-wide panel of congenic strains derived from the donor strain DBA/2J on

76 ilar to the Swiss-derived intercrosses, nine congenic strains, derived from 129S6/SvEvTAC, AKR/J, APN

77 The congenic strains described here provide a foundation upo

78 of 5-LO mRNA were reduced about 5-fold in a congenic strain, designated CON6, containing the resista

79 The congenic strain, designated S.R(chr 9), had a lower bloo

80 ) integrins (SAMP1/YitFc Itgb7(-/-)) using a congenic strain developed via marker-assisted selection.

81 to distinguish between the urinary odours of congenic strains differing only in single genes within t

82 The congenic strains each with their characteristic TGCT inc

83 n and virulence gene regulation by utilizing congenic strains, each harboring a unique S. aureus agr

84 te this process is to construct a library of congenic strains encompassing the entire genome of one s

85 del is dramatically altered depending on the congenic strain examined.

86 F1 hybrids between resistant and susceptible congenic strains exhibit a reduced tumor incidence and a

87 Mice from recombinant congenic strains expressing Sle1c2 exhibited increased C

88 surface levels of Ly-49s3 were lower, in MHC congenic strains expressing the putative Ly-49s3 ligand(

89 on these chromosomes, but the chromosome 17 congenic strain failed to trap a contrasting QTL allele.

90 in this case, alcohol preference) and (ii) a congenic strain for identification of cis regulation.

91 istence of such an interaction, we developed congenic strains for Chr 2 and 10 by introgressing the l

92 Congenic strains for chromosomes 1, 5, and 10 had signif

93 carrying two chromosome intervals (a double congenic strain) for two pairs of loci: Idd3 and Idd10 a

94 strain and the diabetes-resistant NOD.Idd3/5 congenic strain, genome-wide microarray expression analy

95 Immunized H-2(d)-congenic strains had more rapid, sustained, and elevated

96 C.D2-Chr 4 congenic strains harboring DBA/2 alleles associated with

97 ify and map tumor loci from M19 we generated congenic strains harboring MOLF chromosome 19 segments o

98 Traditionally, the development of a congenic strain has been a time-consuming endeavour, req

99 Analysis of additional congenic strains has also localized Idd5.2 to a small re

100 reviously showed that the recombinant inbred congenic strain HcB-19 has a spontaneous mutation of the

101 rmal placental development, we characterized congenic strains homozygous for the hypomorphic Egfr(wa2

102 this study, using a series of novel NOD.B10 congenic strains, Idd5.1 has been defined to a 2.1-Mb re

103 The locus was confirmed by constructing a congenic strain in which the chromosome 6 segment from C

104 cell death susceptibility was observed in a congenic strain in which the highly susceptible FVB/N st

105 on the maze, anxiety levels were tested in a congenic strain in which the rdl allele has been replace

106 Thus, we have tested a number of knockout/congenic strains in a series of behavioral tests in whic

107 n virulence was observed between a and alpha congenic strains in multiple inbred-mouse genetic backgr

108 imilar results were observed in an SS.5(Lew)-congenic strain, in which a smaller region of chromosome

109 A congenic strain introgressing the R low-blood-pressure Q

110 e diabetes, and demonstrates that the use of congenic strains is an effective mapping strategy, even

111 We generated an A/J congenic strain lacking c-Kit by introgression of the Wv

112 distribution of these response phenotypes in congenic strains linked control of phenotypes with speci

113 By congenic strain mapping using autoimmune NOD.C57BL/6J co

114 eral meta-analysis was further filtered by a congenic strain microarray set, from which cis-regulated

115 However, no difference between NOD and the congenic strain NOD.B10 Idd9R1, which has the B10 allele

116 In this investigation, two congenic strains, NZM2328.C57L/Jc1 (NZM.C57Lc1) and NZM2

117 hether dietary responsiveness is involved, a congenic strain of C3H carrying an apoE-null allele (apo

118 Interestingly, in a congenic strain of mice carrying low-affinity, ligand-bi

119 Using a newly discovered congenic strain of mice, we show a previously unrecogniz

120 significant muscle inflammation in multiple congenic strains of C57BL/6 and NOD mice.

121 Incipient congenic strains of D2R-deficient mice demonstrated an o

122 Congenic strains of mice deficient in TLR4 demonstrated

123 ce as well as in SWXJ recombinant inbred and congenic strains of mice derived from SWR and SJL showed

124 interval-specific bidirectional recombinant congenic strains of mice were generated and studied for

125 gion of approximately 0.5 megabases by using congenic strains of mice, constructed by placing the Pas

126 etected by genome scanning using recombinant congenic strains of mice.

127 benz(a)anthracene (DMBA) was investigated in congenic strains of mice.

128 to appropriate control proteins) in various congenic strains of mice.

129 s, we conducted infection experiments in MHC-congenic strains of mice.

130 Two purebred congenic strains of PPARalpha-null mice were developed t

131 nterval within the MHC-II locus of three MHC-congenic strains, of which two were protected from sever

132 stituted chromosomes; (2) to rapidly develop congenic strains over a narrow region using several appr

133 Six congenic strains possessing portions of Candq1 introgres

134 methods that can reduce the time needed for congenic-strain production by 18-24 months.

135 In summary, the congenic strains provide a new resource for the explorat

136 Metabolite profiling in congenic strains provided evidence of QTL replication.

137 the form of 10 interval-directed recombinant congenic strains (RCS), with NON/Lt as the background st

138 This review focuses on two new recombinant congenic strains (RCSs) developed by introgressing multi

139 A series of congenic strains recombinant for regions of mouse chromo

140 lar among CIA-susceptible and nonsusceptible congenic strains, regardless of class II haplotype.

141 The C. gattii congenic strains represent a new resource for exploring

142 ificantly to TGCT, when combined in a double congenic strain resulted in greater than expected TGCT i

143 A congenic strain, S.R(chr9), constructed by introgressing

144 strains were constructed from the progenitor congenic strain, S.R(chr9).

145 s in ischemic tissue injury, and generated a congenic strain set with wide allele dose-dependent vari

146 The two congenic strains show the same virulence in different mo

147 lated on a C57BL/6 background in the B6.Sle1 congenic strain, Sle1 results in the production of high

148 the construction of two sets of heterozygous congenic strains spanning the mouse genome.

149 fluence on selection of KLRH1(+) NK cells in congenic strains suggested that KLRH1 may have an MHC li

150 e location of Gct4, we created an additional congenic strain (SWR.CAST-X) that contains most of the g

151 d stem cell frequency in B6.C-H25, a C57Bl/6 congenic strain that carries a portion of chromosome 1 d

152 We have generated a congenic strain that contains the suppressor allele from

153 In contrast, BM from a B6 congenic strain that expresses the H-2T(a) allele, B6.A-

154 t in DBA/2 or C.D2-Pctr1, a resistant BALB/c congenic strain that harbors DBA/2 chromatin surrounding

155 all of these compounds were stimulatory in a congenic strain that overexpresses TraR and no compound

156 useful tools we have developed thus far is a congenic strain that possesses a segment of chromosome 4

157 We generated a MAIThi congenic strain that was then crossed to a transgenic Ro

158 analysis and the generation of novel Idd5.1-congenic strains that differ at the disease-associated C

159 and BALB/c.DBA2 Idh-lb-Ityr-Pep-3b mice are congenic strains that differ at the Ity/Lsh/Bcg locus an

160 Congenic strains that differ from C57BL/10 at (1) H3a, (

161 We found 3 congenic strains that each harbored tumor promoting loci

162 similar levels of holo-APP expression in the congenic strains, the levels of APP C-terminal fragments

163 pertaining to T1D; descriptions of NOD mouse congenic strains; the Beta Cell Gene Expression Bank, wh

164 knockout strains have been bred to be B6.129 congenic strains, they can be used to test for QTLs in t

165 e additional selection capacity should allow congenic strains to be produced in fewer generations tha

166 As in NOD mice and in diabetes-resistant NOD congenic strains to characterize the association of auto

167 In this study, we used newly developed congenic strains to further localize Idd10.

168 esponses to the HIV-1 Envelope, we have used congenic strains to identify a critical role for MHC cla

169 lso discuss a strategy for using recombinant congenic strains to separate and reassemble interacting

170 The congenic strain was almost completely resistant to diet-

171 A double congenic strain was also constructed with both the Chr 2

172 The BALB-Min (C.B6-Apc(Min/+)) congenic strain was generated by backcrossing into BALB/

173 overt, obese phenotype in either of the two congenic strains was not observed.

174 Using a chromosome 1 congenic strain, we improved the genetic analysis and ma

175 From crosses of the SWR.CAST-X and SWR.SJL-X congenic strains, we derived males carrying unique combi

176 Using NOD.B10 Idd5 congenic strains, we determined that a 2.1-Mb region con

177 By using congenic strains, we have been able to show that iron up

178 Congenic strains were constructed by introgressing Lewis

179 The resulting congenic strains were then used to test the impact of ma

180 s test focused on the obesity-resistant 6C2d congenic strain, which carries the Obrq2a(A/J) allele on

181 ort the development of a small-donor-segment congenic strain, which confirms capture of a gene affect

182 are in agreement with the data on the SHR.4 congenic strain, which suggested that the QTL containing

183 This congenic strain will be invaluable for determining wheth

184 and protein, and decreased TCR signaling in congenic strains with B6-derived Idd18.2 susceptibility

185 susceptible C57BL/6J background to generate congenic strains with CAST alleles encompassing 67-162 M

186 In NOD congenic strains with genes that contribute to protectio

187 Studies of other B10 congenic strains with hybrid H-2 loci and selected F1 an

188 The congenic strain, with normal vision, had higher levels o

189 reviously isolated this region in reciprocal congenic strains (WKY.SHR-Sa and SHR.WKY-Sa) derived fro