ライフサイエンスコーパス: congenital heart defect

1 hydrometrocolpos, post-axial polydactyly and congenital heart defects).

2 ydrometrocolpos, post-axial polydactyly, and congenital heart defects).

3 genic CHD7 mutation, of whom 220 (74%) had a congenital heart defect.

4 of Fallot (TOF) is the most common cyanotic congenital heart defect.

5 report characterizing ncRNA expression in a congenital heart defect.

6 factors contribute to the presentation of a congenital heart defect.

7 the ductus arteriosus, the third most common congenital heart defect.

8 ntricular septal defects are the most common congenital heart defect.

9 hanical signaling and MET in the etiology of congenital heart defects.

10 ic abnormalities; myopia was correlated with congenital heart defects.

11 ial to mitigate poor growth in children with congenital heart defects.

12 feeding and growth pattern in children with congenital heart defects.

13 elopmental disorder characterized in part by congenital heart defects.

14 This is relevant to congenital heart defects.

15 also associated with cardiac hypertrophy and congenital heart defects.

16 centers of the German Competence Network for Congenital Heart Defects.

17 cases and 49.06% (35.06-63.16) for all major congenital heart defects.

18 28.57% (14.64-46.30) for all cases of major congenital heart defects.

19 s in FGF3 or FGF10 could contribute to human congenital heart defects.

20 cy of pulse oximetry as a screening test for congenital heart defects.

21 ons with a variety of syndromic and isolated congenital heart defects.

22 sity is associated with an increased risk of congenital heart defects.

23 tus arteriosus and is one of the most common congenital heart defects.

24 s necessary to improve repair strategies for congenital heart defects.

25 deling contribute to the etiology of several congenital heart defects.

26 intricate steps of cardiogenesis can lead to congenital heart defects.

27 erhaps defects in this signal play a role in congenital heart defects.

28 e formation of the OFT can result in serious congenital heart defects.

29 pacing technologies to younger patients with congenital heart defects.

30 otect against other birth defects, including congenital heart defects.

31 en found to be responsible for some cases of congenital heart defects.

32 greater understanding of the pathogenesis of congenital heart defects.

33 athic PAH and 2 with PAH in association with congenital heart defects.

34 ght ultimately result in particular types of congenital heart defects.

35 panic disorder), epilepsy, asthma, and some congenital heart defects.

36 d received allograft placement for repair of congenital heart defects.

37 irment could be a significant contributor to congenital heart defects.

38 overing mutations causing a wide spectrum of congenital heart defects.

39 thogenesis of both structural and functional congenital heart defects.

40 wledge about the molecular genetic causes of congenital heart defects.

41 apid identification of disease genes causing congenital heart defects.

42 ecurrence risk for families of children with congenital heart defects.

43 pressed in patients with Down's syndrome and congenital heart defects.

44 atients who underwent open-heart surgery for congenital heart defects.

45 have been proposed as a mechanism for human congenital heart defects.

46 or hemodynamic abnormalities associated with congenital heart defects.

47 rafts to alleviate stenosis during repair of congenital heart defects.

48 of nonvalved allograft tissue used to repair congenital heart defects.

49 retardation, craniofacial abnormalities and congenital heart defects.

50 into the genetic contribution to structural congenital heart defects.

51 eas for future research on and prevention of congenital heart defects.

52 ylaxis for children and adults with repaired congenital heart defects.

53 g cardiopulmonary bypass (CPB) for repair of congenital heart defects.

54 y hypertension in the presence or absence of congenital heart defects.

55 y loci involved in complex disorders such as congenital heart defects.

56 on in this process has major implications in congenital heart defects.

57 raction in postnatal cardiac development and congenital heart defects.

58 type of LQTS, HCM, sudden cardiac death, and congenital heart defects.

59 oxygen species (ROS) levels and the risk of congenital heart defects.

60 short stature, craniofacial dysmorphism, and congenital heart defects.

61 2-8 of pregnancy and their associations with congenital heart defects.

62 highly penetrant and associated with varied congenital heart defects.

63 of women whose pregnancies were affected by congenital heart defects (224 case subjects) or unaffect

64 of women whose pregnancies were affected by congenital heart defects (331 cases) and in a control gr

65 .1 years) because of cardiomyopathy (66%) or congenital heart defects (34%).

66 ardiac abnormalities were diagnosed, such as congenital heart defects (6%), mitral valve abnormalitie

67 Congenital heart defects affect at least 0.8% of newborn

68 Congenital heart defects also are common in patients wit

69 ach high standards of care for children with congenital heart defects, although more data would be ne

70 re not able to demonstrate a higher risk for congenital heart defect among monozygotic twins compared

71 Bicuspid aortic valve (BAV) is a heritable congenital heart defect and an important risk factor for

72 aortic valve (BAV) is the most common adult congenital heart defect and is found in 0.5% to 2.0% of

73 Ten patients with cyanotic congenital heart defects and 10 control subjects were st

74 rovide new insights into the pathogenesis of congenital heart defects and 22q11.2 deletion syndrome p

75 Case infants (n = 998) had nonsyndromic congenital heart defects and control infants (n = 3,029)

76 nts of Chromosome 8p23.1 are associated with congenital heart defects and developmental delay.

77 with variable penetrance identified in other congenital heart defects and dilated cardiomyopathy, thi

78 yos, which will enhance our understanding of congenital heart defects and heart disease.

79 der characterized by post-axial polydactyly, congenital heart defects and hydrometrocolpos, a congeni

80 rge pedigree with concomitant LQTS, HCM, and congenital heart defects and identified a novel CACNA1C

81 tion accounts for approximately 30% of human congenital heart defects and manifests frequently in TBX

82 ios (ORs) for associations between offspring congenital heart defects and maternal hypertensive disor

83 Both technologies produce novel views of congenital heart defects and offer improved quantificati

84 conceptional folic acid on the occurrence of congenital heart defects and orofacial clefts is reporte

85 ic acid and a reduction in the occurrence of congenital heart defects and orofacial clefts.

86 iological mechanisms may be involved in some congenital heart defects and preterm preeclampsia.

87 Patients with congenital heart defects and stenotic or occluded IFV/IV

88 he genetic/epigenetic pathways implicated in congenital heart defects and the mechanisms of cardiac t

89 approaches to understanding the etiology of congenital heart defects and the repair of diseased card

90 will be important to understand the basis of congenital heart defects and to derive cardiac regenerat

91 rol study was conducted in infants born with congenital heart defects and unaffected controls from th

92 nts with Holt-Oram syndrome characterized by congenital heart defects and upper limb abnormalities.

93 ns cause Holt-Oram syndrome characterized by congenital heart defects and upper limb deformations.

94 ht ventricular dysplasia; and delineation of congenital heart defects and valvular abnormalities are

95 This mutation causes heterotaxy and complex congenital heart defects and was mapped to a 2.2-Mb inte

96 h six cases were significant, but not major, congenital heart defects, and 40 were other illnesses th

97 of clinical features including growth delay, congenital heart defects, and craniofacial dysmorphism.

98 ith absent speech, hypotonia, brachycephaly, congenital heart defects, and dysmorphic facial features

99 ve malformations with associated aortopathy, congenital heart defects, and genetic syndromes.

100 ral CNS anomalies, ophthalmologic anomalies, congenital heart defects, and genitourinary abnormalitie

101 Thirty-six patients (40%) had congenital heart defects, and many (31 [86%]) had associ

102 sed risk of bearing children with a range of congenital heart defects, and the risk increases with in

103 k of sudden death after operation for common congenital heart defects; and 2) factors associated with

104 a complex phenotype including LQTS, HCM, and congenital heart defects annotated as cardiac-only Timot

105 Congenital heart defects are a major cause of perinatal

106 cohort study to determine whether offspring congenital heart defects are associated with an increase

107 Implications for the development of human congenital heart defects are discussed.

108 Congenital heart defects are generally assumed to have a

109 Children with major congenital heart defects are risking impaired cerebral g

110 Congenital heart defects are the most common birth defec

111 Congenital heart defects are the most frequent malformat

112 alve morphogenesis involved in the origin of congenital heart defects associated with reduced NOTCH f

113 nd ventricular septum defect, which resemble congenital heart defects attributed to defects in the NC

114 transcription factors cannot only result in congenital heart defects but also alter heart function t

115 ors likely contribute to the pathogenesis of congenital heart defects, but it is unclear whether indi

116 trongest evidence that multivitamins prevent congenital heart defects, but this RCT did not provide e

117 ong women whose pregnancies were affected by congenital heart defects cannot be defined without furth

118 Mothers of 7392 congenital heart defect cases and 56,304 unaffected cont

119 of pulse oximetry for detection of critical congenital heart defects (causing death or requiring inv

120 eening method to detect undiagnosed critical congenital heart defects (CCHD) in asymptomatic newborns

121 Hypoplastic left heart is a severe human congenital heart defect characterized by left ventricula

122 ibrillator (ICD) placement in paediatric and congenital heart defect (CHD) patients.

123 c patent ductus arteriosus (PDA) is a common congenital heart defect (CHD) with both inherited and ac

124 ately 65% of individuals with 22q11DS have a congenital heart defect (CHD), mostly of the conotruncal

125 About half of people with trisomy 21 have a congenital heart defect (CHD), whereas the remainder hav

126 Congenital heart defect (CHD)-related death rates correl

127 n our understanding of the genetic causes of congenital heart defect (CHD).

128 cts (heterotaxy) that were associated with a congenital heart defect (CHD).

129 Congenital heart defects (CHD) are collectively the most

130 Congenital heart defects (CHD) are the leading cause of

131 More children die from congenital heart defects (CHD) each year than are diagno

132 pulmonary hypertension (PHT) and associated congenital heart defects (CHD) has not been evaluated.

133 ing neurocognitive outcomes in children with congenital heart defects (CHD) have focused on high-risk

134 ion in a patient with pathogenically similar congenital heart defects (CHD) to narrow the putative cr

135 This study determines the prevalence of Congenital Heart Defects (CHD), diagnosed prenatally or

136 ic modalities and therapeutic strategies for congenital heart defects (CHD), these malformations stil

137 some 21 (Hsa21), is the most common cause of congenital heart defects (CHD), yet the genetic and mech

138 who undergo early cardiac surgery to repair congenital heart defects (CHD).

139 cription factor NKX2.5 as a cause of various congenital heart defects (CHD).

140 nd distressful comorbidities associated with congenital heart defects (CHD).

141 on (AF) is rising in the aging patients with congenital heart defects (CHD).

142 sociated with an increased risk of offspring congenital heart defects (CHD); however, the causal mech

143 Congenital heart defects (CHDs) affect 2%-3% of newborns

144 en maternal medical conditions/illnesses and congenital heart defects (CHDs) among infants.

145 Congenital heart defects (CHDs) and anomalies in cardiac

146 Congenital heart defects (CHDs) are among the most commo

147 While congenital heart defects (CHDs) are major clinical featu

148 Congenital heart defects (CHDs) are the most common birt

149 Congenital heart defects (CHDs) are the most common deve

150 Congenital heart defects (CHDs) are the most common grou

151 Congenital heart defects (CHDs) are the result of abnorm

152 Maternal diabetes is associated with congenital heart defects (CHDs) as a group, but few stud

153 Congenital heart defects (CHDs) have a neonatal incidenc

154 Congenital heart defects (CHDs) have a neonatal incidenc

155 Congenital heart defects (CHDs) have been associated wit

156 rythematosus (SLE) have an increased risk of congenital heart defects (CHDs) in comparison with child

157 patterns with neural tube defects (NTDs) and congenital heart defects (CHDs) in the U.S. National Bir

158 O2, NO2, CO are related to increased risk of congenital heart defects (CHDs) in Wuhan, China.

159 first-trimester screening on the spectrum of congenital heart defects (CHDs) later in pregnancy and o

160 of the results achieved by modern surgery in congenital heart defects (CHDs) over the past 40 years r

161 , there has been a decline in mortality from congenital heart defects (CHDs) over the past several de

162 congenital malformations in humans including congenital heart defects (CHDs), left-right disturbances

163 ease almost always are attributed to complex congenital heart defects (CHDs), reflecting the extreme

164 ed in patients with isolated or nonsyndromic congenital heart defects (CHDs).

165 ecting patients have phenotypes that include congenital heart defects (CHDs).

166 acid and of folic acid food fortification on congenital heart defects (CHDs).

167 ide a rationale for attempting prevention of congenital heart defects (CHDs).

168 scription factor genes cause human inherited congenital heart defects (CHDs); however, their molecula

169 n B6)), was associated with a lower risk for congenital heart defects compared with: 1) absence of na

170 Congenital heart defects comprise the most common form o

171 ice were subviable, smaller in size, and had congenital heart defects, consistent with the severity o

172 By contrast, complex congenital heart defects continue to require open-heart

173 cal and sub-clinical vascular brain lesions, congenital heart defects, coronary heart disease, psychi

174 Presence of any critical or noncritical congenital heart defect detected in infants at birth, co

175 e recently been reported in association with congenital heart defects, developmental delay, schizophr

176 collected data on all operations (1378) for congenital heart defects done by 11 surgeons in five dep

177 fidence interval, 45-82%] increased risk for congenital heart defect for twins).

178 of hCPCs in young patients with nonischemic congenital heart defects for potential use in congenital

179 In this review, progress in identifying new congenital heart defect genes for specific lesions and i

180 The occurrence of a congenital heart defect has long been thought to have a

181 In the recent era, no congenital heart defect has undergone a more dramatic ch

182 Improvement in outcome of infants born with congenital heart defects has been accompanied by an incr

183 though the care of infants and children with congenital heart defects has been revolutionized over th

184 CSCs in very young patients with nonischemic congenital heart defects has not been explored.

185 Bicuspid aortic valve (BAV), the most common congenital heart defect, has been thought to cause frequ

186 egnancies that were affected by nonsyndromic congenital heart defects have alterations in the homocys

187 In severe SMA cases, a growing number of congenital heart defects have been identified upon autop

188 esting may become standard for many forms of congenital heart defects, improving clinicians' ability

189 e NP, was associated with a lower risk for a congenital heart defect in the child (odds ratio (OR) =

190 Hypoplastic left heart syndrome is a rare congenital heart defect in which the left side of the he

191 though underlying heart disease was present (congenital heart defects in 10 and dilated cardiomyopath

192 We collected information on congenital heart defects in 299 patients with a pathogen

193 Offspring congenital heart defects in a previous pregnancy were al

194 dysmorphia, increased risk of leukemia, and congenital heart defects in approximately 50% of cases.

195 reening method for the detection of critical congenital heart defects in asymptomatic newborn babies.

196 pulse oximetry for the detection of critical congenital heart defects in asymptomatic newborn babies.

197 A public inquiry into surgery for paediatric congenital heart defects in Bristol, UK, underscored the

198 Allografts used in the repair of congenital heart defects in children induce a persistent

199 Treatment of congenital heart defects in children requiring right ven

200 may be a viable strategy for suppression of congenital heart defects in fetuses of diabetic pregnanc

201 pina bifida, cleft lip, anal atresia, severe congenital heart defects in general, or tetralogy of Fal

202 ations in a Hox mouse model, which mimic the congenital heart defects in HOXA1 syndrome patients.

203 he MEF2C and TDGF1 genes are associated with congenital heart defects in humans.

204 ations in GATA4 and TBX5 are associated with congenital heart defects in humans.

205 The risk of congenital heart defects in infants of women who had pre

206 that perturb neural crest development cause congenital heart defects in laboratory animals and in ma

207 hypertension, was associated with offspring congenital heart defects in later pregnancies (early pre

208 ington Infant Study, a case-control study of congenital heart defects in liveborn infants conducted i

209 Identification of ASD or other congenital heart defects in more than one family member

210 tool for the preoperative diagnosis of major congenital heart defects in most children undergoing pri

211 d mortality after the surgical correction of congenital heart defects in neonatal patients.

212 Screening for critical congenital heart defects in newborn babies can aid in ea

213 f NFAT, suggesting a potential mechanism for congenital heart defects in Noonan syndrome.

214 intake of methyl nutrients, and the odds of congenital heart defects in offspring.

215 as been associated with an increased risk of congenital heart defects in offspring; however, the resu

216 on genetic cause of cognitive impairment and congenital heart defects in the human population.

217 on, 316 children with sporadic, nonsyndromic congenital heart defects, including 76 coarctation of th

218 TBX20 are associated with multiple forms of congenital heart defects, including cardiac septal abnor

219 Sema3D morphants have subsequent complex congenital heart defects, including hypertrophic cardiom

220 se mutations are highly penetrant for varied congenital heart defects, including progressive atrioven

221 the cardiac outflow tract (OFT) causes many congenital heart defects, including those associated wit

222 le the survival of infants and children with congenital heart defects, including those with univentri

223 Congenital heart defects, inguinal hernia, or hypospadia

224 omalous pulmonary venous return (TAPVR) is a congenital heart defect inherited via complex genetic an

225 Many congenital heart defects involve anomalies in cardiac se

226 Congenital heart defects involving left-sided lesions (L

227 Congenital heart defect is more common in twins than in

228 for patients surviving operation for common congenital heart defects is 25 to 100 times greater than

229 Although the prognosis for patients with congenital heart defects is improved by surgical treatme

230 Elucidating the causes of congenital heart defects is made difficult by the comple

231 ective endocarditis after surgical repair of congenital heart defects is unknown.

232 The type of congenital heart defect, maternal body mass index (BMI;

233 s and many case series reports indicate that congenital heart defects may be more common in monochori

234 d in all 24 probands and three parents, with congenital heart defects most frequent (83%).

235 eview of 1- and 2-year outcomes of a Complex Congenital Heart Defect Neurodevelopmental Follow-Up pro

236 ions such as those with sickle cell disease, congenital heart defects, neutropenia, and indwelling ce

237 some 16, trisomy of which is associated with congenital heart defects observed in Down syndrome.

238 Congenital heart defects occur at a rate of 5% and are t

239 ined that a wide spectrum of the most common congenital heart defects occur in 11q-, including an unp

240 More congenital heart defects occurred in the offspring of af

241 We investigated congenital heart defect occurrence in all twins and 5% o

242 twins compared with dizygotic twins, and the congenital heart defect occurrence was also increased in

243 women (BMI: 19-24.9) to have children with a congenital heart defect [odds ratio (OR): 1.15; 95% CI:

244 sing the SNF1LK locus has been implicated in congenital heart defects often observed in patients with

245 Congenital heart defects often result from improper diff

246 he chance that offspring will be born with a congenital heart defect or an orofacial cleft are review

247 ntified pregnancies complicated by offspring congenital heart defects or early preterm preeclampsia,

248 incidence of endocarditis after surgery for congenital heart defect, particularly valvular aortic st

249 as a molecular signature that differentiated congenital heart defect phenotypes.

250 Because atrial incisions from repair of congenital heart defects provide a substrate for re-entr

251 This new model for a common congenital heart defect provides novel insights into the

252 tions in live born null mice include complex congenital heart defects, pulmonary reversal or isomeris

253 Some Hug mutants exhibit congenital heart defects ranging from mild pulmonary ste

254 dividuals, a total of 584 twins (1.4%) had a congenital heart defect registered in the Danish Nationa

255 Screening for congenital heart defects relies on antenatal ultrasonogr

256 Congenital heart defects remain a leading cause of infan

257 ntrolling AHF development and their roles in congenital heart defects remain incompletely elucidated.

258 ongenital heart defects for potential use in congenital heart defect repair warrants exploration.

259 Isolated congenital heart defects resulting from isomerisms and d

260 s, a metabolic profile that is predictive of congenital heart defect risk would help to refine curren

261 neural crest in chick embryos and resembles congenital heart defects seen in humans.

262 dividuals typically have mental retardation, congenital heart defects, seizures, a characteristic fac

263 of Down's syndrome were more likely to list congenital heart defects (SMOR 29.1, 95% CI 27.8-30.4),

264 re is a lack of comparable data for specific congenital heart defects such as in repaired tetralogy o

265 included 49 articles that focused on complex congenital heart defects such as tetralogy of Fallot, sy

266 inheritance of NKX2.5 mutations with various congenital heart defects suggests that this transcriptio

267 September 30, 1997, who were recovering from congenital heart defect surgery and had transthoracic in

268 higher in women with pregnancies affected by congenital heart defects than in women without such a hi

269 -5-expressing cells leads to the most common congenital heart defect that is also a subset of abnorma

270 NKX2.5 mutations were found in patients with congenital heart defects that are transmitted in an auto

271 to characterize three patients with 11q- and congenital heart defects that carry interstitial deletio

272 It identifies cases of critical congenital heart defects that go undetected with antenat

273 k suggests a role for the SHF in a subset of congenital heart defects that have overriding aorta and

274 gene(s) that causes at least a subset of the congenital heart defects that occur in 11q-.

275 rnal metabolic risk profile for nonsyndromic congenital heart defects that would enhance current prev

276 whenever IART occurs late after repair of a congenital heart defect, the atrial flutter isthmus shou

277 Congenital heart defects, the majority of which affect t

278 It is not clear whether the risk of congenital heart defects, the most common malformations,

279 gation deficiencies lead to life-threatening congenital heart defects, the variables controlling the

280 Although genetic variation contributes to congenital heart defects, their precise molecular bases

281 e being made to prevent fetal hydrops due to congenital heart defects, to recruit hypoplastic ventric

282 D13L), which is mutated in patients with the congenital heart defect transposition of the great arter

283 reoperative diagnosis of children with major congenital heart defects undergoing primary complete rep

284 during pregnancy and her child's risk for a congenital heart defect using data from the population-b

285 of pulse oximetry for detection of critical congenital heart defects was 76.5% (95% CI 67.7-83.5).

286 The absolute prevalence of congenital heart defects was higher for infants of women

287 However, the absolute risk of congenital heart defects was low.

288 alse-positive rate for detection of critical congenital heart defects was particularly low when newbo

289 dditional affected individual with RHD and a congenital heart defect, we found a homozygous loss-of-f

290 In 35 cases, congenital heart defects were already suspected after an

291 ifferent ages undergoing cardiac surgery for congenital heart defects were isolated and cultured unde

292 ifferent ages undergoing cardiac surgery for congenital heart defects were isolated and cultured unde

293 Congenital heart defects were noted in four of the five

294 Offspring congenital heart defects were strongly associated with e

295 ight also provide clues to better understand congenital heart defects, which are the most common birt

296 in half of newborn mice mainly associated to congenital heart defects, while Loxl2 overexpression tri

297 iewed the records of 503 children with major congenital heart defects who underwent primary complete

298 ighly significant trend of increasing OR for congenital heart defects with increasing maternal obesit

299 is highly specific for detection of critical congenital heart defects with moderate sensitivity, that

300 We identified 113 candidate genes for congenital heart defects within these CNVs, including BT