ライフサイエンスコーパス: conidia

1 vival following inhalation of fungal spores (conidia).

2 ant reduction in the number and viability of conidia.

3 nflammation to repeated inhalation of fungal conidia.

4 elieved to be caused by airborne Aspergillus conidia.

5 after multiple inhalation exposures to live conidia.

6 erved persistence of ungerminated but viable conidia.

7 elopment of the Th2 response to A. fumigatus conidia.

8 4 to day 28 and investigated on day 28 after conidia.

9 via i.t. instillation with live A. fumigatus conidia.

10 halation of the aerosolized spores, known as conidia.

11 ays that are modulated during infection with conidia.

12 esponse to repeated exposure to A. fumigatus conidia.

13 ion during repeated exposure to A. fumigatus conidia.

14 ular conidiophore that bears spores known as conidia.

15 ets differ in their response to A. fumigatus conidia.

16 lity to phagocytose and inhibit A. fumigatus conidia.

17 himeras following infection with Aspergillus conidia.

18 ent times following pulmonary challenge with conidia.

19 At least one species produces dematiaceous conidia.

20 BL/6 and gp91(phox)(-/-) mice in response to conidia.

21 ithout inactivating intracellular A. terreus conidia.

22 ts a critical early response of AM to fungal conidia.

23 atus, with a limit of detection of 1 x 10(2) conidia.

24 ritin, completely abolished activity against conidia.

25 at peribronchiolar sites but no germinating conidia.

26 al in preventing germination of A. fumigatus conidia.

27 4) and IL-13 than T cells responding to live conidia.

28 in worker ants exposed to Beauveria bassiana conidia.

29 were consistent for DNA from both hyphae and conidia.

30 after CLP, with viable Aspergillus fumigatus conidia.

31 ese parameters at all subsequent times after conidia.

32 ly defined minimal medium produced pigmented conidia.

33 ed with CXCR2+/+ mice at various times after conidia.

34 tratracheal challenge with live A. fumigatus conidia.

35 after pulmonary challenge with A. fumigatus conidia.

36 -type control groups at days 14 and 37 after conidia.

37 ungal and allergic responses to A. fumigatus conidia.

38 changes were analyzed at various times after conidia.

39 n the murine airway response to A. fumigatus conidia.

40 inhalation exposure to Aspergillus fumigatus conidia.

41 sulting in the production of inter-connected conidia.

42 stronger platelet activation than wild-type conidia.

43 levels of airborne Aspergillus and Fusarium conidia.

44 kine production in contrast to the wild-type conidia.

45 ng GFP fusions, was present in young, mature conidia.

46 mentation and multicellular adherence of the conidia.

47 n, hyphal curvature and limited formation of conidia.

48 nd alpha-mannose on Aspergillus and Fusarium conidia.

49 tection was demonstrated over 5 log units of conidia (10 to 10(5) spores).

50 Large splash droplets contained most conidia (4-5.5 mm splashes averaged 308 conidia), but we

51 days 14 and 28 after challenge with swollen conidia, a finding never observed in their allergic wild

52 Morphologically, smooth, ovoid conidia, a greenish gray colony color, slow growth on al

53 Aspergillus conidia activated CD8(+) T cells upon sorting to the Rab

54 gement of MD-2 by PTX3-opsonized Aspergillus conidia activated the TLR4/Toll/IL-1R domain-containing

55 nsitized mice markedly reduced the number of conidia, airway inflammation, and airway hyperresponsive

56 Macrophages stimulated with conidia alone increased NF-kappaB translocation.

57 driven by the A. fumigatus allergen, viable conidia also stimulated pulmonary arterial remodeling in

58 l upon antigenic challenge with A. fumigatus conidia, although this pathway does not seem to allow fo

59 h narrow and cylindrical-to-slightly clavate conidia and a strong, pungent odor.

60 t the Fgsrp1 deletion mutant rarely produced conidia and caused only limited symptoms on wheat heads

61 e fungi reproduce asexually by production of conidia and chlamydospores and in wild habitats by ascos

62 cell responses against inhaled A. fumigatus conidia and demonstrates a benefit for systemic GM-CSF a

63 However, maturing A. fumigatus conidia and germ tubes stimulate NF-kappabeta, secretion

64 Caspofungin- or micafungin-treated conidia and germlings induced less secretion of tumor ne

65 In contrast to treated conidia and germlings, echinocandin-treated hyphae stimu

66 itivity for DNA extraction from A. fumigatus conidia and GHE.

67 We examined the interaction between conidia and host cells in a murine bone-marrow-derived m

68 l distinct killing mechanisms of Aspergillus conidia and hyphae by human neutrophils, leading to a co

69 Endocytosed conidia and hyphae caused progressive endothelial cell i

70 ficolin-A significantly binds to Aspergillus conidia and hyphae in a concentration-dependent manner a

71 ry caused by hyphae was not, indicating that conidia and hyphae injure endothelial cells by different

72 ed the interactions of Aspergillus fumigatus conidia and hyphae with endothelial cells in vitro.

73 an platelets were incubated with Aspergillus conidia and hyphae, isolated wall components, or fungal

74 lved in the killing of Aspergillus fumigatus conidia and hyphae, using neutrophils from patients with

75 ides to the surface of Aspergillus fumigatus conidia and hyphae.

76 type-specific mAb, reacts with A. fumigatus conidia and hyphae.

77 re also increased in gp91(phox)(-/-) mice by conidia and in C57BL/6 mice by polystyrene beads, sugges

78 GprH is pre-formed in conidia and is increasingly active during carbon starvat

79 ith resting or swollen Aspergillus fumigatus conidia and monitored for survival and lung inflammatory

80 -(1,3)-Glucan was isolated from A. fumigatus conidia and mycelia cell wall.

81 r macrophages are postulated to kill inhaled conidia and neutrophils are believed to act against hyph

82 mpared with nonsensitized mice that received conidia and normal serum.

83 onidia challenge attenuated the clearance of conidia and significantly increased airway hyperreactivi

84 Cells were unstimulated or stimulated with conidia and simultaneously treated with DEX, GM-CSF, or

85 el interaction was identified between viable conidia and SMAD2/3.

86 ZmLOX3 expression increased production of conidia and sterigmatocystin in both backgrounds.

87 between high levels of Aspergillus fumigatus conidia and the appearance of new cases of IA or have de

88 that was reduced in production of oxylipins, conidia and the mycotoxin sterigmatocystin.

89 nd Arabidopsis were inoculated with Fusarium conidia and this resulted in disease symptoms on anthers

90 rthermore, the genes are highly expressed in conidia and under conditions that favour sexual developm

91 wn pigments as well as enhanced tolerance of conidia and vegetative hyphae against oxidative and ther

92 These findings indicate that H. capsulatum conidia and yeast can produce melanin or melanin-like co

93 llenged with resting or swollen A. fumigatus conidia, and both groups of mice were analyzed prior to

94 velB deletion strains show reduced number of conidia, and decreased and delayed mRNA accumulation of

95 n demonstrate impaired uptake and killing of conidia, and ECs with CFTR mutation undergo more conidia

96 d an intratracheal challenge of A. fumigatus conidia, and pulmonary changes were analyzed at various

97 migatus Ags and challenged with A. fumigatus conidia, and the resulting allergic airway disease was m

98 to dormant conidia, responses are similar if conidia are already germinated at the time of monocyte u

99 Here, we show that conidia are capable of germination on ash leaves and in

100 Conidia are incubated in media containing increasing con

101 oulds) are ubiquitous soil inhabitants whose conidia are inhaled into the respiratory tract, where th

102 atitis, we developed a murine model in which conidia are injected into the corneal stroma.

103 Once inside the host, conidia are phagocytosed by alveolar macrophages.

104 Asperigillus fumigatus spores or conidia are quickly eliminated from the airways of nonse

105 Even though conidia are the predominant infectious particle for H. c

106 Fungal spores (conidia) are rapidly ingested by ECs derived from bronch

107 ary exposure to viable Aspergillus fumigatus conidia as well as vaccination with crude hyphal extract

108 Larvae were injected with conidia (asexual spores) of two different wild-type stra

109 te fungus Aspergillus nidulans, the ratio of conidia (asexual spores) to ascospores (sexual spores) i

110 gh slowly, at alkaline pH, were able to form conidia (asexual spores), and were inhibited by concanam

111 7BL/6 and CXCR2(-/-) mice showed germinating conidia at 6 h but not at 48 h and few inflammatory cell

112 sumed the whole body and grew out to produce conidia at approximately 156 and 204 hpi for C. elegans

113 and was transmitted through asexual spores (conidia) at a rate 3 to 8% of that for full-length CHV1-

114 f chronic lung exposure to live A. fumigatus conidia, beta-glucan recognition via Dectin-1 led to the

115 ter the conidia challenge did not affect the conidia burden but significantly reduced airway hyperrea

116 rophages during infection with H. capsulatum conidia but not H. capsulatum yeast cells.

117 signals mainly localized to the cytoplasm in conidia but to the cytoplasm and nucleus in hyphae.

118 most conidia (4-5.5 mm splashes averaged 308 conidia), but were splashed <30 cm horizontal distance.

119 hat is not present on the surface of dormant conidia, but is present after cellular swelling and loss

120 oth monocyte subsets efficiently phagocytose conidia, but only CD14(+)CD16(-) monocytes inhibit conid

121 D and rat SP-D bind to Aspergillus fumigatus conidia, but the ligand remains unidentified.

122 Host hemocytes can recognize and ingest its conidia, but this capacity is lost on production of hyph

123 ing of L-ficolin-opsonized live A. fumigatus conidia by flow cytometry and microscopy.

124 ch to clone some of the genes induced in the conidia by hard surface contact.

125 GM-CSF could promote resistance to conidia by maintaining proinflammatory responses.

126 These experiments suggest that P. citricarpa conidia can be dispersed from infected oranges by splash

127 m to nonsensitized mice for14 days after the conidia challenge attenuated the clearance of conidia an

128 s-sensitized mice during days14-30 after the conidia challenge did not affect the conidia burden but

129 observed in CCR4-/- mice at all times after conidia challenge in contrast to CCR4+/+ mice.

130 irway hyperresponsiveness at day 7 after the conidia challenge in these mice.

131 R5+/+ and CCR5-/- mice for 12 days after the conidia challenge significantly reduced the peribronchia

132 After the conidia challenge, mice lacking CCR4 (CCR4-/- mice) exhi

133 monas exotoxin, from days 38 to 44 after the conidia challenge.

134 th wild-type controls at all times after the conidia challenge.

135 mRNA expression was increased 30 days after conidia challenge.

136 igatus-sensitized mice both before and after conidia challenge.

137 rol mice at days 2, 21, 30, and 40 after the conidia challenge.

138 sion was significantly elevated 7 days after conidia challenge; however, soluble IL-4R mRNA expressio

139 and goblet cell hyperplasia at day 38 after conidia challenge; however, the effects of IL-4 immunone

140 No mortality was observed in conidia-challenged sham-operated mice.

141 ient mice challenged with resting or swollen conidia compared to TLR9(+/+) mice.

142 e were significantly reduced at day 21 after conidia compared with Stat6+/+ mice, but both groups exh

143 However, 10(2)- and 10(3)-fold higher conidia concentrations were required for 100% lethality.

144 increased exponentially soon after wild-type conidia contacted their host plants .

145 ormally high levels of airborne A. fumigatus conidia correlated with new cases of IA, even in patient

146 At days 3 and 7 after conidia, CXCR2-/- mice exhibited significantly greater m

147 Humans inhale mold conidia daily and typically experience lifelong asymptom

148 Autoclave-killed conidia did not elicit a SiTf induction response from wo

149 f complement activation, ficolin-A-opsonized conidia did not lead to lectin pathway-specific C4 depos

150 BDP-PCZ transfer to conidia did not require phagocytosis and was markedly en

151 ation, and repeated exposure to A. fumigatus conidia did not result in hyphal growth or accumulation

152 mutant produced more compact assemblages of conidia, displayed a reduced and delayed spore dispersal

153 /-) mice exhibit an accelerated clearance of conidia during fungal asthma.

154 ophages bind and ingest A. fumigatus resting conidia efficiently, there is little inflammatory respon

155 ake or killing of intracellular A. fumigatus conidia either in vitro or in a murine model of pulmonar

156 e marrow (d 0), animals were challenged with conidia either intravenously or via nasal instillation o

157 When the conidia escape from early killing and germinate, the ext

158 ic cells activated in vitro with Aspergillus conidia expressed higher TNF-alpha, CXCL10, and CXCL2 le

159 independent from DHN-melanin, as A. terreus conidia expressing wA showed no increased intracellular

160 droplets from diseased oranges, which exuded conidia for over one hour during repeated wetting.

161 filamentous fungi involves the formation of conidia, formed on specialized structures called conidio

162 Here, we compared the interaction of conidia from both fungal species with MUTZ-3-derived den

163 dA hydrophobin, and Aspergillus and Fusarium conidia from clinical isolates that were treated with hy

164 Conidia from the DeltapkaR mutant are more sensitive to

165 We compared lung immune responses to conidia from two fungal isolates that expressed differen

166 nnate immunity, inhaled A. fumigatus spores (conidia) germinate in the lung, forming hyphae that inva

167 cA was found to be significantly impaired in conidia germination, growth in normoxia and hypoxia, and

168 important role in control of asexual spore (conidia) germination.

169 altered cellular lipid profiles were seen in conidia grown on a variety of substrates including potat

170 ment when grown on solid media, although its conidia had normal pigmentation.

171 nose-only inhalation to A. fumigatus viable conidia, heat-inactivated conidia (HIC), or HEPA-filtere

172 . fumigatus viable conidia, heat-inactivated conidia (HIC), or HEPA-filtered air twice a week for 13

173 At all times after conidia, histological analysis revealed an absence of go

174 q data were generated with RNA isolated from conidia, hyphae, and perithecia.

175 te defense against Aspergillus by opsonizing conidia, immobilizing this fungus through enhanced adher

176 intranasal exposure to Aspergillus fumigatus conidia in C57BL/6 mice results in a chronic pulmonary i

177 ower microscopy demonstrated the presence of conidia in splash droplets from diseased oranges, which

178 resence of glucose, and rapid germination of conidia in the absence of external carbon sources.

179 otent at arresting the growth of Aspergillus conidia in vitro, indicating the presence of a reactive

180 t early transcription in mouse AM exposed to conidia in vivo targets neutrophil recruitment, and that

181 wn about their molecular responses to fungal conidia in vivo.

182 nse to live Aspergillus fumigatus spores, or conidia, in A. fumigatus-sensitized mice.

183 en the lungs are exposed to large numbers of conidia, in addition to the phagocytic activity of AM, e

184 Neither live nor killed conidia increased tissue factor activity of endothelial

185 Thus, A. fumigatus conidia induced a coordinated expression of genes import

186 nstrate that uptake of Aspergillus fumigatus conidia induced drastic spatial redistribution of TLR9 t

187 Live conidia induced more endothelial cell injury than did li

188 corneal infection, we showed that DeltarodA conidia induced significantly higher cytokine production

189 Repeated exposure to A. fumigatus conidia induced T cell activation in the lungs and the c

190 d-dispersed, insect-vectored or water-spread conidia infect ash and may sporulate in planta, as well

191 mice repeatedly challenged with A. fumigatus conidia, inflammation was attenuated (with the most sign

192 flies by injecting them with a standardized conidia inoculum.

193 Following introduction of conidia into the lung, microarray analysis of AM showed

194 is mechanism in AM following introduction of conidia into the mouse lung using transcriptional, lumin

195 Recognition of conidia involves integrin CD11b/CD18 (and not dectin-1),

196 duction in response to Aspergillus fumigatus conidia is antagonized by granulocyte-macrophage colony-

197 opportunistic pathogen Aspergillus fumigatus conidia is essential given the important role they play

198 nature induced in macrophages in response to conidia is independent of Toll-like receptor (TLR) signa

199 ral and biophysical-biological properties of conidia is not fully characterized.

200 ction in a fungal species with multiple cell conidia is poorly understood.

201 ice to viable, resting Aspergillus fumigatus conidia leads to the development of chronic pulmonary in

202 aks of abnormally high A. fumigatus airborne conidia levels (175, 50, 25, 20, 160, and 400 CFUs/m(3))

203 -6 months), the median airborne A. fumigatus conidia levels were 0 colony-forming units (CFUs) per cu

204 velopment leading to the formation of mature conidia may require environmental signals to regulate fl

205 CD-1 mice showed that infection with 5 x 106 conidia/mouse consistently caused 100% mortality by day

206 Cell surface defects were rectified in the conidia mutated in downstream melanin biosynthetic pathw

207 Moreover, DCs confronted with A. terreus conidia neither produced pro-inflammatory nor T-cell sti

208 Interestingly, at day 3 after conidia, neutrophil recruitment and airway hyperresponsi

209 sion in human monocytes (HMCs) infected with conidia of A. fumigatus using DNA microarray analysis.

210 t (DeltacsmA, DeltacsmB, and DeltacsmA/csmB) conidia of A. fumigatus.

211 d at relatively low challenge doses with the conidia of Aspergillus fumigatus administered to recombi

212 suppressed hyphal growth of most germinating conidia of B. cinerea and was eventually lethal to infec

213 genes induced by hard-surface contact of the conidia of Colletotrichum gloeosporioides, chip6, encode

214 Conidia of H. minnesotensis adhered to passing nematodes

215 Furthermore, compared to A. fumigatus, the conidia of N. udagawae require longer incubation periods

216 Conidia of representative Fusarium from the 2004-2006 ke

217 Conidia of selected lines also germinated fifty percent

218 Conidia of the Deltaace2 mutant were larger and had acce

219 Resting conidia of the filamentous fungus are constantly inhaled

220 essed mouse model, intranasally administered conidia of the mutant are significantly less virulent th

221 disks from 'Ogy' plants were inoculated with conidia of the poplar pathogenic fungus Septoria musiva,

222 Airborne spores (conidia) of these filamentous fungi express a surface pr

223 Interestingly, foot cells of mutant conidia often differentiated into conidiogenous cells, r

224 showed reduced germination of DeltaBbcyp52x1 conidia on grasshopper wings as compared with the wild-t

225 germ tubes were produced from individual Bgt conidia on the surface of the Arabidopsis leaves.

226 y little is known at a molecular level about conidia or about their interaction with cells of the hos

227 Aspergillus fumigatus conidia or Candida albicans yeast cells were added to br

228 els of fungal DNA with Aspergillus fumigatus conidia or hyphae.

229 n control experiments, protease treatment of conidia or roots had no effect on growth and development

230 lmonary challenge with Aspergillus fumigatus conidia (or spores).

231 not respond chemotropically to mat A males (conidia) or form mature fruiting bodies (perithecia) or

232 hes were <1 mm diameter but carried only 0-4 conidia per droplet.

233 onary antifungal immune responses to swollen conidia, possibly through the regulation of dectin-1 exp

234 Injection of E. rostratum conidia preexposed to 0.32 mg/mL of methylprednisolone f

235 given intratracheal or s.c. immunization of conidia prior to corneal infection exhibited enhanced fu

236 Conidiation was reduced > 80%; however, conidia produced by the DeltaOhmm strain germinated sign

237 mutant had dysmorphic conidiophores, reduced conidia production and abnormal conidial cell wall archi

238 wn-regulation of growth and up-regulation of conidia production between 18 and 24 hours of growth.

239 Its conidia production is prolific, and so human respiratory

240 A perA null mutant has decreased conidia production, increased susceptibility to triazole

241 ggest that exposure of chitin in germinating conidia promotes eosinophil recruitment and ultimately i

242 migatus and block the growth of A. fumigatus conidia (proportion with growth blocked, 69%).

243 -splash dispersal of Phyllosticta citricarpa conidia (pycnidiospores) from infected oranges was studi

244 After phagocytosis, A. fumigatus conidia rapidly escaped from DCs, whereas A. terreus con

245 us encountered during human disease: resting conidia (RC), swollen conidia (SC), and hyphae (H).

246 rapidly escaped from DCs, whereas A. terreus conidia remained persisting with long-term survival.

247 onocytes differ in their response to dormant conidia, responses are similar if conidia are already ge

248 t masks Dectin-1 and Dectin-2 recognition of conidia, resulting in impaired neutrophil recruitment to

249 human disease: resting conidia (RC), swollen conidia (SC), and hyphae (H).

250 as noted irrespective of pH, and DeltaBbpacC conidia showed subtle increases in UV susceptibility.

251 MN-mediated host defenses against infectious conidia (spores) of this organism have yielded conflicti

252 that DeltarodA and hydrofluoric acid-treated conidia stimulate significantly higher NF-kappaB p65 nuc

253 Infection with hyphae, but not with conidia, stimulated endothelial cells to synthesize E-se

254 NF-kappaB to the nucleus in unstimulated and conidia-stimulated macrophages.

255 kappaB degradation by GM-CSF with or without conidia stimulation, with corresponding effects on trans

256 The conidia subsequently germinate and produce a budding yea

257 Conidia swelled, formed differentiated germination-struc

258 tosis-like features in Aspergillus fumigatus conidia, the most prevalent human mold pathogen.

259 After nasal instillation of conidia, the survival was 25%, 35%, and 85% for mice in

260 anamorphic (asexual) form produces prolific conidia, thought to function solely as spermatia (male g

261 ombination with their function as spermatia, conidia thus act to maximise gene flow between sympatric

262 When challenged with resting conidia, TLR9(-/-) mice exhibited significantly lower ai

263 and opsonization led to enhanced binding of conidia to A549 airway epithelial cells.

264 The capacity of A. fumigatus conidia to activate platelets is at least partly due to

265 lenged with two inhalation exposures of live conidia to induce airway disease.

266 Furthermore, while A. fumigatus conidia triggered expression of DC activation markers su

267 ndependent isolates, which failed to produce conidia under any conditions tested, were only distantly

268 t layers in all three chitin synthase mutant conidia was associated with an activation of human dendr

269 However, endothelial cell injury caused by conidia was dependent on fungal viability, whereas injur

270 Ficolin-A binding to conidia was increased under low-pH conditions, and opson

271 trast, ingestion and killing of A. fumigatus conidia was MyD88 independent.

272 (BAMs) from mice in response to Aspergillus conidia was tested after in vivo administration of salin

273 re challenged intranasally with A. fumigatus conidia weekly, and leukocyte composition, activation, a

274 In this model, Aspergillus fumigatus conidia were administered into the lungs of neutrophil-d

275 At day 0, Aspergillus fumigatus conidia were administered intranasally.

276 phal growth in tissue, Aspergillus fumigatus conidia were allowed to form mycelia in tissue culture m

277 H. capsulatum conidia were also cytotoxic to amoebae.

278 Specifically, germinating A. fumigatus conidia were associated with Clec7a and were predicted t

279 Approximately 99% of A. fumigatus conidia were cleared within 24 h after inoculation, and

280 Wild-type conidia were covered with a highly hydrophobic layer of

281 ected from antifungals, whereas A. fumigatus conidia were efficiently cleared.

282 Conidia were endocytosed 2-fold more avidly than hyphae,

283 es to pulmonary instillation of A. fumigatus conidia were examined.

284 se reported earlier: firstly, aerially borne conidia were harvested, and then used for inoculations,

285 Aspergillus fumigatus conidia were incubated in 0.2% glucose RPMI 1640 contain

286 s of airway neutrophils and macrophages, and conidia were more rapidly eliminated from these mice com

287 Within DCs A. terreus conidia were protected from antifungals, whereas A. fumi

288 CD54, MHCII and CCR7, persistent A. terreus conidia were significantly less immunogenic.

289 an fungal pathogen, produces asexual spores (conidia), which are the main mode of propagation, surviv

290 responses induced by heat-killed Aspergillus conidia, which have minimal beta-glucan expression on th

291 gs and formed oxidase-active aggregates with conidia, which inhibited germination.

292 o, with mycelia in the environment producing conidia, which probably act as infectious propagules upo

293 At all times after conidia, whole lung levels of IL-4, IL-5, and eotaxin/CC

294 unologically inert; however, deletion mutant conidia with modified surfaces could activate human dend

295 t result in hyphal growth or accumulation of conidia with time.

296 Following incubation of conidia with various concentrations of antifungal drug,

297 e fungi is the production of asexual spores (conidia) within fruiting bodies called conidiomata.

298 repeated intranasal exposure to Aspergillus conidia would induce pulmonary arterial remodeling in th

299 onoclonal antibodies (MAb) labeled pigmented conidia, yeast, and the isolated particles as determined

300 sed daily to hundreds of viable A. fumigatus conidia, yet considerable numbers of them survive years