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1 d interacted with Atg5 and also with Atg12-5 conjugate.
2 r functional properties of lysozyme-guar gum conjugate.
3 r bone mineralized matrix (BMM) or a BMM+SIM conjugate.
4 y activators involving fatty acid cysteamine conjugates.
5 c parameters of ursodeoxycholic acid and its conjugates.
6 ark contrast to that of fluorescent antibody conjugates.
7 onal antibodies (mAbs) with and without drug conjugates.
8 ersibility of the boronate/thiosemicarbazone conjugates.
9 may be a potential target for antibody-drug conjugates.
10 than free DOX and GEM and the single drug HA conjugates.
11 te, for both the lysine- and cysteine-biotin conjugates.
12 the antioxidant capacities of the resulting conjugates.
13 tubulogenic assay; furthermore, dimeric-RGD conjugate 3 strongly inhibited in vivo angiogenesis in M
16 se fundamentally important species and their conjugate acids, e.g. HNSO and HSNO, have been the focus
18 cture also reveals the 4'-phosphopantetheine-conjugated acyl-group of ACP occupies the hydrophobic co
19 iazepine (PBD)-based anti-CD19 antibody drug conjugate (ADC) being investigated for treatment of B-ce
21 ategies to produce homogeneous antibody-drug conjugates (ADCs) rely on mutations or inefficient conju
25 talysts for the unreported, enantioselective conjugate addition reaction of the barbituric acid pharm
27 ) were achieved using the diastereoselective conjugate additions of lithium amide reagents in the key
29 lyzed conjunctive cross-coupling between non-conjugated alkenes, aryl iodides, and alkylzinc reagents
30 ybridized biotin-miRNA with streptavidin-HRP conjugates, amperometric detection at -0.20V was carried
31 sp(2)c-COF) that was designed to be fully pi-conjugated and constructed from all sp(2) carbons by C=C
32 s (1 cm(2)) and of general validity for both conjugated and non-conjugated polymers, e.g. poly(9,9-di
33 evidenced by the loss of activity of GalNAc conjugated and unconjugated ASOs in ASGR knockout mice.
35 idyl-hydrazinonicotinamide ((99m)Tc-S-HYNIC)-conjugated anti-FAP antibody 28H1 at 2, 5, and 9 d after
36 atment with RG-101, an N-acetylgalactosamine-conjugated anti-microRNA-122 oligonucleotide, resulted i
37 microglia in the spinal cord using a saporin-conjugated antibody to Mac1, we demonstrate a causal rol
40 trated that PSMA-11-derived dual-labeled dye conjugates are feasible for providing PSMA-specific pre-
41 We describe the application of Rh-catalyzed conjugate arylation to the modification of thiostrepton,
42 control, we establish heterotypic ubiquitin conjugates as important carriers of biological informati
44 e SUR1 in processing cysteine-isothiocyanate conjugates, as well as the S-methyltransferase DTCMT tha
45 ementation of N-acetylgalactosamine (GalNAc)-conjugated ASOs for Asialoglycoprotein Receptor (ASGR)-m
48 c 5,5-dimethylcyclopentadiene monomer into a conjugated backbone is an attractive strategy to high pe
50 critical requirement is the strength of the conjugate base such that an equilibrium exists between p
55 nforced homeostasis in Teff cells exposed to conjugated bile acids (CBAs), a class of liver-derived e
56 CP and OATPs contribute to hepatic uptake of conjugated bile acids in mice, whereas the predominant u
59 osteoadsorptive bisphosphonate-ciprofloxacin conjugate (BV600022), utilizing a "target and release" c
60 at C-terminus of SCRII, SCRII subunits were conjugated by sortase A to form crosslinked SCRII, mainl
64 o improve therapeutic efficacy, polymer drug conjugates carrying synergistic pairs of chemotherapy dr
69 ere accompanied by increased hepatic taurine-conjugated cholic acid and beta-muricholic acid as well
70 MS procedures after urine precipitation with conjugate cleavage (UglucP) or dried urine spot workup b
71 avage (UglucP) or dried urine spot workup by conjugate cleavage and liquid extraction (DUSglucE).
72 demonstrate that, upon photoactivation, the conjugate cleaves the DNA backbone specifically near the
73 it to prepare novel two-dimensional (2D) pi-conjugated COFs, as crystalline powders and exfoliated m
74 (also known as DS-8201) is an antibody-drug conjugate comprised of a humanised antibody against HER2
75 alirine (SGN-CD33A, 33A) is an antibody-drug conjugate consisting of pyrrolobenzodiazepine dimers lin
78 tively, with potencies similar to chemically conjugated counterparts, and longer plasma circulation t
82 le fluorescent receptor 1 was synthesized by conjugating diaminomaleonitrile (DMN) with benzothiazole
83 of the approach was performed by correlating conjugated diene concentrations measured by spectrophoto
85 ene, and butylated hydroxyanisole (BHA)] for conjugated dienes (during a 90-day period) and for malon
87 d a lower generation of oxidation compounds (conjugated dienes in chains having also hydroperoxy/hydr
88 x-generated alpha-amino radical species with conjugated dienes using a unified cobalt and iridium cat
89 b tesirine is a first-in-class antibody-drug conjugate directed against delta-like protein 3 (DLL3),
90 of CA units coupled increases; 3) betaLg-CA conjugates displayed comparable or superior water solubi
91 bioorthogonal reactions with the fluorophore-conjugated DpTz reagents afforded the fluorescently labe
93 he therapeutic efficacy of site-specifically conjugated duocarmycin- and monomethyl auristatin E (MMA
96 e, we report that the stability of Ubiquitin-conjugating enzyme E2S (UBE2S) is regulated by the PTEN/
98 sive enzyme-substrate interaction (ubiquitin-conjugating enzyme UBE2D3 with substrate PCNA), and endo
99 ation can be linked to reduced NCE (E2 NEDD8-CONJUGATING ENZYME) NEDD8 thioester levels, either by cr
101 e binding of an E3 ubiquitin ligase to an E2-conjugating enzyme, leading to prolonged inflammatory si
108 and selectively remove K48-linked ubiquitin conjugates from a subpopulation of damaged lysosomes to
109 and easy production of well-defined antibody conjugates from a variety of antibody sequence and speci
112 Conclusion Targeted monoclonal antibody-conjugated HNPs can serve as a catalyst for photothermal
113 aches to prepare functional redox-active and conjugated homopolymers as well as the construction of c
114 en together, our results suggest that Bio-IL conjugated hydrogels could be implemented and readily ta
116 lized with a near infrared (NIR) fluorophore-conjugated immunoassay to Carbohydrate Antigen 19-9 (CA
117 Immunological evaluations of the resultant conjugates in mice revealed that they elicited robust GM
119 ilic polyethylene glycol (PEG), a bortezomib-conjugating intermediate, and a dendritic doxorubicin-af
120 Pluronic P85 (LepNP85) and administered this conjugate intranasally using the nose-to-brain (INB) rou
121 SubPc-TCBD-aniline systems showed that each conjugate is a racemic mixture of two atropisomers resul
123 se, the DNA damage-responsive E3 ligase RNF8 conjugates K63-linked ubiquitin chains to tankyrase 1, w
127 selectivity were studied in the synthesis of conjugated linoleic acid (CLA) partial glycerides, which
129 anding the conformations and arrangements of conjugated materials as solids is key to their prospecti
132 ART analogue, SMART-OH, and its polymer-drug conjugate, methoxy-poly (ethylene glycol)-block-poly (2-
135 cular those obtained via self-assembly of pi-conjugated molecules, are dynamic materials possessing u
136 We further show that the optimal dual drug conjugate more effectively inhibits the growth of an agg
140 h chiral self-assembly of nucleobase-peptide conjugates (NPCs), where achiral nucleobases are helical
141 ynthesis and characterization of new peptide conjugates obtained by hierarchical co-assembly of L,L-d
146 heterocycles are a ubiquitous skeleton of pi-conjugated organic compounds, and their incorporation re
148 ctrodes by oxidative polymerizations, are pi-conjugated organic semiconductors, or which provide the
149 that the superior tumor distribution of the conjugate over nanoparticles will be accentuated in clin
151 ates, the amount of FCN-DNA dispensed on the conjugate pad and the dispensing cycles of the capture D
152 dy-decorated silica beads (Ab-SiO2) onto the conjugate pad and the sample flows by capillarity throug
153 very platform, (ii) polyethylene glycol-PLGA conjugate (PEG-PLGA, p) to help maintain an appropriate
154 d after tail vein injection (150 mug of each conjugate per mouse) at 1, 7 and 13 days post-injection.
155 Herein, we describe a simple histidine (H) conjugated perylene diimide (PDI) bolaamphiphile (HPH) a
162 perties and inherent mechanical flexibility, conjugated polymer field-effect transistors (FETs) are p
164 this review, we summarize the key aspects of conjugated polymer nanoparticles optical properties and
165 ive nonconjugated polymer that converts to a conjugated polymer via an extensive rearrangement of the
168 ion incorporating high-performance ambipolar conjugated polymers and unipolar small molecules as the
169 ce strong memory behavior from common p-type conjugated polymers by adding n-type dopant 2-(2-methoxy
170 a of excitons in oligomers of the ubiquitous conjugated polymers poly(3-hexylthiophene) (P3HT), poly(
171 general validity for both conjugated and non-conjugated polymers, e.g. poly(9,9-di-n-octylfluorene-al
172 been reported for solution-processed n-type conjugated polymers, with a thermoelectric power factor
176 developed porphyrin-peptoid (pigment-helix) conjugates (PPCs) that can modulate the donor-acceptor e
179 urodegenerative diseases; accordingly, these conjugates promote rapid proteasomal clearance of aggreg
182 en and ibuprofen, in their parent form, were conjugated quickly and directly with glutamic acid and g
184 geting and endosomal escape, and cholesterol-conjugated RNAi triggers, which together result in HBV g
186 ry antibody and horseradish peroxidase (HRP)-conjugated secondary antibody onto AgNPs-rGO modified-SP
189 es, semiconductor-metal heterostructures, pi-conjugated semiconductor nanoparticles, organic-inorgani
190 ght-harvesting systems based on dye-doped pi-conjugated semiconductor polymer nanoparticles and self-
194 the trivalent N-acetylgalactosamine (GalNAc)-conjugated siRNA in mice relative to the un-modified siR
195 e role of protein oligonucleotide number and conjugate size on this observation, which revealed the i
196 a series of novel Pt-bisacetylide containing conjugated small molecules possessing an unconventional
198 ically inhibit this pathological pathway, we conjugated SOD with antibodies (Ab/SOD, size 10nm) to p
200 ASGR for the effective uptake of GalNAc-ASO conjugates, suggesting broad opportunities to exploit re
207 ly, we develop a GPC2-directed antibody-drug conjugate that is potently cytotoxic to GPC2-expressing
209 er, chlorin e6, can be repurposed for PCI by conjugating the chlorin to a cell penetrating peptide, u
211 a membrane-activatable polymeric nanodrug by conjugating the photosensitizer protoporphyrin IX (PpIX)
212 DNA probe used in the preparation of FCN-DNA conjugates, the amount of FCN-DNA dispensed on the conju
214 ification occurring during inflammation, and conjugated them to virus-like particles, followed by imm
216 nd quantify for the first time a dipeptide S-conjugate to 3MH, the gammaGluCys-3MH, in Sauvignon B.
217 anti-ICAM-1 antibodies and administered the conjugate to 8 wk old C57BL/6J mice 30 min after moderat
219 gh signal characteristics were retained when conjugated to a large protein, indicating potential for
220 enzene derivative in which the nucleobase is conjugated to a phenyldiazene tail is studied in view of
221 The ribosome-inhibiting protein saporin was conjugated to a Siglec-8-specific antibody to examine th
222 each comprising an anti-CD3 scFv covalently conjugated to a stabilized dimer of different antitumor
223 D2 receptors (D1R and D2R) when the PTL was conjugated to an engineered cysteine near the dopamine b
224 ced by exploiting the same targeting ligand, conjugated to an imaging agent, to select patients whose
226 response to (4-hydroxy-3-nitrophenyl)acetyl conjugated to chicken gamma globulin and found a similar
227 an-binding malachite green (MG-dextran), was conjugated to concanavalin A (Con A), an enzyme with spe
229 The kinase inhibitor crizotinib was directly conjugated to Dha through its piperidine motif, and its
230 study was to demonstrate whether L1 peptides conjugated to FHs promote tissue regeneration in a wound
232 a methodology using antibody fragments (Fab) conjugated to gold nanoparticles (immunogold) to map the
234 ction consists of a melittin-derived peptide conjugated to N-acetylgalactosamine for hepatocyte targe
235 based and protein-based hosts that have been conjugated to near-infrared-absorbing Au nanoshells (SiO
238 to carboxylic acid; the resulting DA-TAT is conjugated to poly(ethylene glycol)-poly(epsilon-caprola
239 amma-peptide nucleic acid (gamma-PNA) probes conjugated to polystyrene beads have been reported for t
240 odynamic diameter, DH of 105.12 +/- 1.13 nm) conjugated to recombinant scavenger receptor class B, me
242 ion, LC3 is cleaved by the protease ATG4 and conjugated to the autophagosomal membrane; however, its
244 A bifunctional analogue, macropa-NCS, was conjugated to trastuzumab as well as to the prostate-spe
246 gy transfer efficiency from the various AuNP conjugates to pendant ytterbium(III) cations, a Dexter-t
249 se serum and 100 mM EDTA, whereas the nickel-conjugated trimers were not stable under these condition
252 desaturation of N-protected lactams to their conjugated unsaturated counterparts under mildly acidic
253 teasomes hydrolyzed the associated ubiquitin conjugates, Usp14 and Ube3c dissociated rapidly (unlike
254 untries to study the benefit of pneumococcal conjugate vaccine (PCV) in protecting against invasive p
255 a introduced universal 7-valent pneumococcal conjugate vaccine (PCV7) from 2005, replaced by 13-valen
256 Introduction of the heptavalent pneumococcal conjugate vaccine (PCV7) in 2000 reduced macrolide-resis
257 ction of MenAfriVac, a meningococcal group A conjugate vaccine developed for the African meningitis b
258 ed persons with a quadrivalent meningococcal conjugate vaccine in accordance with Advisory Committee
259 full extent to which childhood pneumococcal conjugate vaccines (PCV) can indirectly reduce illness i
262 h, even though highly effective pneumococcal conjugate vaccines (PCVs) are used in national immunizat
263 OM) burden following rollout of pneumococcal conjugate vaccines (PCVs) have exceeded predictions of v
264 ciated with the introduction of pneumococcal conjugate vaccines (PCVs) in five countries in the Ameri
265 t the capsule are protective, polysaccharide conjugate vaccines, which are constructed against the mo
267 emissivity into the "backward" (i.e., phase-conjugated) version of that beam; another gives the over
268 In addition, antimicrobial activity of the conjugate was determined against two gram positive (Stap
269 yl lipid A-Thomson-Friedenreich (TF) antigen conjugate was obtained to demonstrate the feasibility of
271 tags, and cytotoxic behavior of the designed conjugate was studied in normal and cancer cell lines.
276 ling due to the high atomic complexity of Ub conjugates, where Ub is attached to other Ub molecules a
277 tes the initial formation of a semicarbazone conjugate, which rearranges into a stable diazaborine.
279 ss to a new set of nucleic acid-nanoparticle conjugates, which may be useful as programmable material
280 ful for building a homogeneous antibody-drug conjugate with a precise drug-to-antibody ratio of 2.
281 a first-in-class DLL3-targeted antibody-drug conjugate with encouraging initial safety and efficacy p
282 n, we have generated a novel FA-Qdot 605 dye conjugate with superior sensitivity and flexibility to a
283 er, poly(beta-amino ester) (PBAE), with PBAE conjugated with 5kDa polyethylene glycol (PEG) molecules
284 therapy based on a monoclonal antibody (mAb) conjugated with a near-infrared (NIR) phthalocyanine dye
285 luronan and heparosan were then successfully conjugated with Alexa Fluor 488 DIBO alkyne, demonstrati
286 rapeutic and diagnostic multifunctional HNPs conjugated with anti-MG1 monoclonal antibodies were synt
289 ate of micelles of a recombinant polypeptide conjugated with doxorubicin via an acid-labile hydrazone
290 nslational modification of cellular proteins conjugated with either ubiquitin (Ub) or Ub-like interfe
293 sativum) using cleavage by bound preproteins conjugated with the artificial protease FeBABE and cyste
296 mple functionalization allows preparation of conjugates with fluorophore, affinity handle, and pharma
297 escribe "semisynthetic" pH-sensitive protein conjugates with organic fluorophores, carbofluorescein,
299 ility for both mycotoxins and mycotoxin-AITC conjugates, with duodenal fractions representing 63.5% o
300 secondary and tertiary amine-linked protein conjugates without affecting the structure and function
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