ライフサイエンスコーパス: conjugation

1 h space pi-electron delocalization (i.e., pi-conjugations).

2 trap intermediates during Ubl activation and conjugation.

3 e same H-bonding moieties but lack cyclic pi-conjugation.

4 ew known/effective inhibitors of global SUMO-conjugation.

5 the cell prior to substrate transport during conjugation.

6 hibitor, which was deactivated by direct MPP conjugation.

7 PSMA antibody was preserved on site-specific conjugation.

8 oups or withdrawing groups or with increased conjugation.

9 nderstood to destabilize the macrocycle upon conjugation.

10 otein, were selected as sites for fatty acid-conjugation.

11 achinery to the phagosome and ultimately LC3 conjugation.

12 nd immunostaining analyses of synaptic SUMO1-conjugation.

13 iguing alternating antiaromatic and aromatic conjugation.

14 .65-4.93AAE/g (reducing power) upon guar gum conjugation.

15 and underscores the key roles played by the conjugation.

16 iation-specific genes and leads to premature conjugation.

17 tA and extended reaction times for efficient conjugation.

18 ne transfer (HGT) through transformation and conjugation.

19 displays a memory that suppresses subsequent conjugation.

20 zyme Atg12~Atg5-Atg16, which stimulates Atg8 conjugation.

21 chical construction of a synthetic genome by conjugation.

22 et other redox-active side chains for native conjugation.

23 nking and plug-and-display SpyTag/SpyCatcher conjugation.

24 and has been applied extensively for protein conjugations.

25 consist of a maleimide for cysteine antibody conjugation, a hydrophilic spacer, and either an alkyne

26 of homogeneous ADCs with a conserved site of conjugation, a monodisperse drug loading, a lysosomal re

27 may be effectively preserved through direct conjugation, a previously overlooked risk.

28 Complete conjugation across the backbone can be achieved through

29 hthodithiophene-based IOIC2 with a larger pi-conjugation and a stronger electron-donating core shows

30 ction of the cargo but also reversibility in conjugation and activity.

31 ne torsion and, therefore, intramolecular pi-conjugation and aggregation.

32 deficiencies in several factors involved in conjugation and deconjugation of Met1-linked polyubiquit

33 drugs and other cargos as exemplified by the conjugation and delivery of the model probe fluorescein-

34 ers (i.e., porphyrin tapes) exhibit extended conjugation and even delocalization over more than two p

35 onjugated-polymer nanocrystals with extended conjugation and exceptionally high degrees of order usin

36 and provides fundamental knowledge about how conjugation and hyperconjugation impact the stabilizatio

37 Increasing the degree of pi-conjugation and hyperconjugation was shown to benefit al

38 h ProG:Fc binding, therefore avoiding ligand conjugation and purification processes.

39 caffold would minimize steric effects of dye conjugation and retain agonist properties.

40 range of plasmids that can be transferred by conjugation and the efficiency with which transduction o

41 We show that Nedd8 conjugation and the SR exchange factor Cand1 have a prof

42 anoparticles eliminates the need of physical conjugation and thus can be beneficial when designing pr

43 Recent work on conjugation and transduction suggests that transfer by t

44 bility of resistance genes was studied using conjugation and transformation bioassays.

45 ng new compounds with extended systems of pi-conjugation and unique patterns of molecular organizatio

46 ime-consuming and problematic off-chip probe conjugation and washing.

47 improved by sequence modification and lipid conjugation, and by adding linkers between the protein a

48 show that MDCA triggers auxin biosynthesis, conjugation, and catabolism.

49 ed cytotoxic protein expression, target cell conjugation, and LFA-1-, CD2-, and NKG2D-dependent activ

50 onents of the ubiquitin (Ub) conjugation, de-conjugation, and recognition machinery now identified as

51 hanced efficacy, site-specific antibody-drug conjugation, and site-specific modification of antibodie

52 um smegmatis, the ESX-1 T7SS plays a role in conjugation, and the ESX-3 T7SS is involved in metal hom

53 size, surface modification [rifampicin (RF) conjugation], and concentration (2.5 nM) of AuNRs and th

54 d (monomer) Decorated and Light Underpinning Conjugation Approach (ANADOLUCA) method, which utilizes

55 the PE backbone, interrupting intramolecular conjugation as well as blocking chromophore aggregation,

56 ing the crystal structure and performing dye conjugation assay, two sites (W160 and D112) of urate ox

57 loss would be an effective strategy to limit conjugation-assisted persistence of antibiotic resistanc

58 nction, but the published evidence for SUMO1-conjugation at synapses is contradictory.

59 Further extending the conjugation at the 6-position of 1,3-diphenyl-6-arylfulv

60 obenzamide molecules might exert an extended conjugation at their interface facilitating electro cond

61 Even in the absence of apparent conjugation between the component chromophores, the vali

62 ctroscopic evidence suggests the presence of conjugation between the pi systems of the aryl ligands a

63 freezing without additional reagents and the conjugation can be completed in a few minutes.

64 Once covalently bound, SUMO conjugation can change the stability or functionality of

65 Our results demonstrate that side-chain conjugation can tune energy levels, enhance absorption,

66 Ubiquitin (Ub) E1 initiates the Ub conjugation cascade by activating and transferring Ub to

67 nd protein cofactors that participate in Ubl conjugation cascades.

68 cts as a chromophore enhancer, extending the conjugation chain and facilitating the "harvest" of the

69 ates (ADCs) rely on mutations or inefficient conjugation chemistries.

70 further demonstrate that application of this conjugation chemistry enables facile labeling of bacteri

71 Bioorthogonal conjugation chemistry has enabled the development of too

72 In conclusion, the LepNP85 with optimized conjugation chemistry is a promising candidate for treat

73 The conjugation chemistry is highly robust, enabling the use

74 Horizontal gene transfer (primarily conjugation) could explain this persistence, but it has

75 , with many components of the ubiquitin (Ub) conjugation, de-conjugation, and recognition machinery n

76 odies are highly sensitive to the methods of conjugation, degree of labeling, and contamination with

77 valuated versus PEGylated particles, and PNB conjugation demonstrated the most effective shielding fr

78 nance (SPR) measurements showed that polymer conjugation did not significantly alter the Ab's binding

79 The conjugation-driven radical-assisted C-O bond scission ap

80 Given the complexity of ubiquitin conjugation due to the formation of poly-conjugates of d

81 ng and experimental results demonstrate that conjugation dynamics are dictated by antibiotic-mediated

82 lection, which can both promote and suppress conjugation dynamics.

83 RNF212-dependent SUMO conjugation effected a checkpointlike process that stall

84 The peptide conjugation enables targeting of endosomal membranes so

85 We propose that SUMO conjugation establishes a precondition for designating c

86 ium groups yielded a highly water-soluble pi-conjugation extended viologen, 4,4'-(thiazolo[5,4-d]thia

87 regular intervals into a 2D lattice with pi conjugations extended along both x and y directions and

88 Benefiting from the pi-conjugation extension by fusing two phenyls, IDTN shows

89 erization for narrowing Eg and 2-dimensional conjugation for broadened absorption and enhanced hole m

90 dels and experiments show that interspecific conjugation from P. fluorescens allowed pQBR57 to persis

91 Additionally, extending conjugation from the electron-rich pyrrole results in qu

92 tranasally delivered antigen and transferrin conjugation had a more marked effect on sublingually del

93 reaction to guide site-selective protein/DNA conjugation in a single step with outstanding selectivit

94 s achieved, independent of their sequence or conjugation in an untargeted but highly selective manner

95 conjugation in vitro and for protein-protein conjugation in living cells.

96 the concerted process of E1-E2-catalyzed Ub conjugation in order to separately characterize the proc

97 stabilizing ligand to examine the role of Ub conjugation in targeting proteins to IBs that are compos

98 d to the triazole group being twisted out of conjugation in the developing benzylic radical.

99 acyclophane in competition with through-bond conjugation in the side arms.

100 DFT calculations, reveal highly effective pi-conjugation in thienyl- and furylborane species; the lat

101 ments binding to this site inhibit ubiquitin conjugation in vitro.

102 Therefore, combining conjugation inhibition and promoting plasmid loss would

103 These bonds extend aromatic conjugation into the combined graphene oxide sheets and

104 results indicate that incorporating extended conjugation into the electron-donating fused-ring units

105 Small ubiquitin-like modifier (SUMO) conjugation is a reversible post-translational modificat

106 Ubiquitin conjugation is a reversible process mediated by deubiqui

107 Similar to ubiquitin, conjugation is achieved through a cascade of activities

108 ation of OsOTS1 protein indicating that SUMO conjugation is an important response to drought stress i

109 pi-Conjugation is manifested in these COFs in significantly

110 Although nonspecific conjugation is suitable for most in vitro applications,

111 Conjugation is the main process through which antibiotic

112 hile the Ub-CR conformation is defective for conjugation, it demonstrates improved binding to PINK1 t

113 that measures cytosolic exchange across the conjugation junction to rapidly probe the effects of HAP

114 We previously demonstrated that this conjugation leads to multiple substitution degrees and p

115 polyacetylene block copolymers exhibit long conjugation length and uniform trans-configuration and s

116 nformation, which implies that the effective conjugation length N is extended up to 10.5 modifying th

117 When the conjugation length of the molecule is further increased

118 Precisely, we will focus on conjugation machinery in the SUMO, NEDD8, ATG8, ATG12, U

119 E2s resulting in the fidelity of the Ub/UBL conjugation machinery.

120 SUMO protease can rapidly reverse SUMO conjugation making this modification system highly dynam

121 Therefore, direct conjugation may be a common route for plant metabolism o

122 Therefore, ASO and hormone/drug conjugation may provide a novel strategy for obesity and

123 We highlight the broad utility of this conjugation method to enable precise addition of payload

124 The field of protein conjugation most commonly refers to the chemical, enzyma

125 dies enable us to articulate the role of the conjugation motif in iSF.

126 al cysteine-containing tag for site-specific conjugation), named scVR1 and scVR2 with enhanced affini

127 Because of the cross-conjugation nature and poor electronic interaction betwe

128 Conjugation of a chloramphenicol-specific DNA aptamer to

129 By conjugation of a large, neutral dendrimer to a caged GAB

130 revealed a central role for neddylation (the conjugation of a Nedd8-moiety to Cullin proteins) in the

131 Conjugation of a ruthenium complex (N3) to a TiO2 nanopa

132 ty of this method is illustrated through the conjugation of a series of polar and nonpolar labels ont

133 philic side chains and was applicable to the conjugation of a variety of organic compounds, including

134 f chemical reactions was investigated by the conjugation of absorption spectroscopy, stopped-flow, NM

135 A strategy for the conjugation of alcohol-containing payloads to antibodies

136 obial cocktails, which was based on the heat conjugation of amino acids in the presence of phosphoric

137 The array is fabricated using non-covalent conjugation of an aptamer-anchor polynucleotide sequence

138 surface that are effective for the covalent conjugation of antibody without further surface modifica

139 The conjugation of ASOs to a receptor ligand can dramaticall

140 a decrease in autophagy flux and defects in conjugation of ATG12 to ATG5.

141 uence of this recruitment is the TCR-induced conjugation of Bcl10 with linear-linked polyubiquitin ch

142 Conjugation of beta-sheet peptide motif to the CHP resul

143 n high demand for their great utility in the conjugation of biomolecules in live cells.

144 igation and (ii) the efficient site-specific conjugation of biomolecules to PEG-coated surfaces.

145 In this review, we discuss the chemistry for conjugation of carbohydrates to nanomaterials, summarize

146 This platform is based on the conjugation of CD124/IL-4Ralpha-targeting peptide with G

147 sponses can only be achieved by the covalent conjugation of CPSs with carrier proteins to produce gly

148 Conjugation of cytotoxic agents to these nnAAs, yields h

149 ies were explored for the efficient covalent conjugation of DNA to poly(N-isopropylacrylamide) (poly(

150 rthogonal protection to enable site-specific conjugation of each drug.

151 tudy was undertaken to analyze the effect of conjugation of egg-white lysozyme with guar gum.

152 (GSTM1) encodes an enzyme that catalyzes the conjugation of electrophilic compounds with glutathione

153 moted azide-alkyne cycloaddition allowed the conjugation of fatty acid (palmitic acid analog) to Uox

154 investigate the conditions and components in conjugation of fatty acid to a therapeutic protein resul

155 Conjugation of fatty acid, a natural human serum albumin

156 These results indicate that conjugation of fatty acids to CGKRK could create an effi

157 Conjugation of fluorescein isothiocyanate (10.86 +/- 0.9

158 unogenicity as a major concern, we show that conjugation of IT to polyethylene glycol limits immunoge

159 an be extended to other PTM biosignatures by conjugation of other affinity ligands on the nanoprobe.

160 Exposure to PN and glutathione resulted in conjugation of PDI possibly at active site tyrosine resi

161 Conjugation of polyethylene glycol (PEG) to therapeutic

162 SUMO1-conjugation of proteins at neuronal synapses is consider

163 that this ncAA (pNCSF) allows the selective conjugation of proteins to amine-containing molecular pr

164 olizing enzymes whose shared function is the conjugation of reduced glutathione (GSH) to endo- and xe

165 The chemical conjugation of RNase A with HA both increased the supram

166 Conjugation of SAN1 did not disrupt any of its antiangio

167 sing tagged SUMO1, we could not detect SUMO1-conjugation of seven previously proposed synaptic SUMO1-

168 Conjugation of siRNAs to lipophilic groups supports effi

169 However, the need for covalent conjugation of small molecules to MPPs can negatively af

170 lational modification pathway catalyzing the conjugation of small ubiquitin-like modifier (SUMO) prot

171 odification of cellular proteins through the conjugation of small ubiquitin-related modifier (SUMO) a

172 Conjugation of SUMO (Small Ubiquitin-like Modifier) prot

173 The E2-conjugating enzyme Ubc9 catalyzes the conjugation of SUMOs to -amino groups of lysine residues

174 Our findings indicate that SUMO1-conjugation of synaptic proteins does not occur or is ex

175 Conjugation of the aptamer-functionalized luminescent na

176 Without the conjugation of the fluorophore to the CDs, the particle

177 series: this is in agreement with increased conjugation of the pi-system in the para series.

178 Conjugation of the small ubiquitin-like modifier (SUMO)

179 n photophysical properties with extension of conjugation of the synthesized heteroacenes was studied.

180 This particular geometry extends the pi-conjugation of the systems, which is in agreement with a

181 interaction, resulting in a less pronounced conjugation of the TAPP core and the thiophene units.

182 In eukaryotes, the conjugation of the ubiquitin-like protein NEDD8 onto pro

183 Conjugation of two 9-aminoacridine pharmacophores, using

184 s offer proof-of-concept of how the covalent conjugation of two angiogenesis-related small modules ma

185 How the NEL domain catalyzes the conjugation of Ub onto substrates, recognizes host E2s,

186 imental data, in relation with structure and conjugation of various subfamilies of push-pull nitrogen

187 Extending the conjugation of viologen by a planar thiazolo[5,4-d]thiaz

188 Covalent conjugation of water-soluble polymers to proteins is cri

189 t and most versatile reactions available for conjugations of biomolecules and biomaterials.

190 method has been developed utilizing protein conjugation on solid-phase.

191 SUMO (Small Ubiquitin-like Modifier) conjugation onto target proteins has emerged as a very i

192 The optical phase conjugation (OPC) through photonic nanostructures in coh

193 ile genetic elements and occurs primarily by conjugation or bacteriophage transduction, with the latt

194 In particular, the CPT (charge conjugation, parity reversal and time reversal) theorem,

195 hanophores are designed to regenerate the pi-conjugation pathway between the electron donor and elect

196 berrant neddylation of Ubc12 and other NEDD8 conjugation pathway components in SENP8-deficient cells.

197 e potential of the Lx technology as a robust conjugation platform for the preparation of anticancer A

198 and Ube2S-dependent Lys11-linkage ubiquitin conjugation plays an important role in regulating DNA da

199 Thus, by moving the conjugation point from the terminus of the nucleic acid

200 s terminated by a thiol-linker to serve as a conjugation point to carrier proteins and surfaces for i

201 e and is applicable for optimizing synthetic conjugation procedures, testing commercial imaging antib

202 and performing high-throughput validation of conjugation procedures.

203 This approach is mutation free and drug conjugation proceeds rapidly at neutral pH in a single s

204 ncreasing protein permeability via a polymer conjugation process that co-localizes permeation enhance

205 Due to the nature of the lysine conjugation process, the ADC molecules are heterogeneous

206 The optical phase conjugation property had correlation with the laser ligh

207 ons of graphene without the need of chelator conjugation, providing a promising alternative radiolabe

208 e likely due to pQBR57's lower intraspecific conjugation rate in P. putida By contrast, in two-specie

209 ce, but it has been suggested that very high conjugation rates would be required.

210 fast (>10(3) M(-1) s(-1)) and bioorthogonal conjugation reaction that joins semicarbazide to an aryl

211 brid agents, necessitates precise control of conjugation reactivity.

212 PEG conjugation reduces protein interactions with the oligon

213 protein were used to determine the degree of conjugation required to detect IgG binding.

214 Conjugation resulted in ADCs with unimpaired mAb-binding

215 al of the anthryl moiety with no significant conjugation, resulting in a small HOMO-LUMO gap (HLG) an

216 ously expressed variants or through chemical conjugation, resulting in altered mechanical, surface an

217 ications or degradation during isolation and conjugation, resulting in production problems and lower

218 nd include verification of ferulic acid (FA) conjugation, rheological measurements, and O2 monitoring

219 g conventional lateral flow membranes (e.g., conjugation, sample, absorption and nitrocellulose), wer

220 owever, for broad applications of fatty acid-conjugation, several issues should be addressed, includi

221 Ubiquitin conjugation signals for selective protein degradation by

222 as the starting material, and a well-defined conjugation site for antibody modifications.

223 tly extends the flexibility in selecting the conjugation site in expressed protein ligations with no

224 conjugates (ADCs) that can be optimized for conjugation site, drug to antibody ratio (DAR) and linke

225 dvances in engineering the antibody, linker, conjugation site, small-molecule payload, and drug-to-an

226 rient uptake, signal transduction, adhesion, conjugation, sporulation, and outer membrane protein fol

227 ally functionalized by a myriad of acid-base conjugation strategies for applications ranging from pro

228 mplementing the existing toolbox of chemical conjugation strategies.

229 A side-chain conjugation strategy in the design of nonfullerene elect

230 scientific fields as a simple and versatile conjugation strategy.

231 nd conjugated to ASOs using a solution phase conjugation strategy.

232 Further, the LC3 conjugation system and the IFN-inducible GTPases were ne

233 ws a novel function of the autophagy-related conjugation system but also indicates that mammalian cel

234 regarding the role of the autophagy-related conjugation system in mediating the closure of autophago

235 ule-associated-protein-1-light-chain-3 (LC3) conjugation system of autophagy and then targeted by imm

236 Chimeric conjugation systems composed of the IMCpKM101 joined to

237 Recent studies have shown that conjugation systems of Gram-negative bacteria are compos

238 The development of novel site-specific conjugation technologies enables the systematic study of

239 full potential, sophisticated site-specific conjugation technologies to connect the drug to the anti

240 eater control is desirable in the stochastic conjugation technology used to synthesize antibody-drug

241 Relaxases play essential roles in conjugation, the main process by which bacteria exchange

242 selectivity of chemical methods for protein conjugation, there are increased efforts to develop bioc

243 ol the arrangement of adjacent systems of pi-conjugation, thereby creating molecular materials with v

244 d and prepared to support a more extended pi-conjugation through its structure in contrast with its h

245 ontrolling the stability of OsbZIP23 by SUMO conjugation through manipulating specific SUMO protease

246 ression of exogenous NEDD8 can trigger NEDD8 conjugation through the ubiquitylation machinery.

247 tive mAbs and ADCs were characterized, after conjugation to a DFO chelator and (89)Zr radiolabeling,

248 Subsequent D-AB3 conjugation to a fluorophore-labeled semicarbazide allow

249 ide analogues are dramatically improved upon conjugation to a lipid prodrug.

250 hetic group, followed by a copper-free click conjugation to a modified adnectin to generate (18)F-BMS

251 equipped with suitable functional groups for conjugation to antibodies and other delivery systems.

252 alic acid (Sia) biosynthesis, transport, and conjugation to be essential for infection.

253 ed to incorporate coordinating groups or for conjugation to biomolecules.

254 loyed to overcome this limitation, including conjugation to carrier proteins and/or formulation with

255 es recombinant engineering and site-specific conjugation to create multispecific, multivalent antibod

256 intercellular adhesion molecule-1 for T-cell conjugation to dendritic cells (DC).

257 KAP1 and the proximal coupling of ubiquitin conjugation to ER degradation (CUE) domain in SMARCAD1 m

258 yubiquitin by the CUE (coupling of ubiquitin conjugation to ER degradation) domain of the subunit ASC

259 hieve variable degrees of gambogic acid (GA) conjugation to facilitate ligand-receptor stoichiometry

260 Conjugation to genetically encoded self-labeling tags or

261 or loss of the carbamoyl group, followed by conjugation to glucose or cysteine, but also reduction o

262 te structure-controlled thermal transitions, conjugation to human lysozyme through the retained end-g

263 mide linker (Au102_C6MI) for maleimide-thiol conjugation to nanocapsid cysteines.

264 In addition, because the approach utilizes conjugation to native antibody cysteine residues, it is

265 ) chain transfer agent, with and without pre-conjugation to polyethylene glycol (PEG).

266 The ubiquitin-like protein ISG15 and its conjugation to proteins (ISGylation) are strongly induce

267 ave not been explored as probes for covalent conjugation to proteins, possibly because they were assu

268 olecular "stapler" for site-specific protein conjugation to strengthen or add protein functionality.

269 Because Gly76 is normally used for Ub conjugation to substrates, ADP-ribosylation of the Ub ca

270 hat controls vital biological events through conjugation to target proteins.

271 for reconstituting LDL particles, including conjugation to the apolipoprotein, insertion into the ph

272 OTUB1 binding but inversely correlates with conjugation to the protein degradation-associated Lys-48

273 -ORF3 facilitates the initial acceptor SUMO3 conjugation to TIF-1gamma as well as poly-SUMO chain elo

274 DNA/AuNPs allows for multiple reactions and conjugations to be performed within the colloidal suspen

275 bile acid synthesis and increases bile acid conjugation, transport, and excretion, thereby protectin

276 rate contribute to maximal pPARKIN ubiquitin conjugation turnover.

277 Prior to conjugation, UFM1 undergoes activation by its cognate ac

278 Chelator conjugation was confirmed by electrospray ionization-mas

279 difluoro boron complex, and the extent of pi-conjugation was extended using Sonogashira cross-couplin

280 oreactivity of the antibody on site-specific conjugation was investigated in vitro.

281 ne with a centrosymmetry, shows elongated pi-conjugation with 14 pi-electrons and one more sp(3) carb

282 to precisely monitor the efficiency of drug conjugation with a catalytic assay.

283 ized orthotopic GBM xenografts in vivo after conjugation with a near-infrared dye.

284 mg mL(-1) ) in N,N-dimethylformamide and for conjugation with amines.

285 spersity, and drug loading were used for the conjugation with ascorbic acid (PLGA-b-PEG-Asc) to facil

286 mization of the p53-MDM2/MDMX inhibitors and conjugation with bioactive carriers.

287 nto the sensor surface through high-affinity conjugation with biotin.

288 stages: (i) chemical synthesis of MPNs, (ii) conjugation with DNA and purification of monovalent MPNs

289 dification of surface wetting properties and conjugation with fluorescent tags are demonstrated to hi

290 a recombinant human apoA-I, with or without conjugation with keyhole limpet hemocyanin, were fused w

291 ssay was performed using biotin-anti-TGF and conjugation with peroxidase-labeled streptavidin (poly-H

292 Conjugation with polysaccharides like guar gum may broad

293 he features that facilitate the unusual acyl conjugation with S-adenosylmethionine (SAM).

294 Through conjugation with small organic molecules such as glucose

295 Conjugation with the TT protein yielded large polydisper

296 erminal sortase motif to allow site-specific conjugation with various Ag payloads.

297 nthesis of a GM2 derivative suitable for the conjugation with various biomolecules.

298 ented features are attributed to extended pi conjugation within the helical carbenic ligand and effic

299 id, a strong detergent, greatly enhanced the conjugation yield likely due to the enhanced solubility

300 of initial activity of free ureaseNPs with a conjugation yield of 1.63mg/cm(2).