ライフサイエンスコーパス: conjugation of @2 to

1 he microsomal fraction that did not catalyze conjugation of GSH to 1-chloro-2,4-dinitrobenzene, indic

2 hese results suggest differences in rates of conjugation of ubiquitin to 3C proteases are primarily a

3 The 22-20 was made by site-specific conjugation of e-mab to 4 Fabs of v-mab; 20-22 is of the

4 We hypothesized that the site-specific conjugation of albumin to a permissive site of a target

5 Here we demonstrate that conjugation of an adenovirus to a c-kit-retargeted retro

6 The conjugation of ASOs to a receptor ligand can dramaticall

7 We developed a "caged calcium" molecule by conjugation of BIST to a Ca(2+) chelator that upon laser

8 investigate the conditions and components in conjugation of fatty acid to a therapeutic protein resul

9 Conjugation of GIRLRG to a sustained-release nanoparticl

10 II detoxification enzymes that catalyse the conjugation of glutathione (GSH) to a wide variety of en

11 1 was enzymatically active, as determined by conjugation of glutathione to a model substrate, and exh

12 It is based on the conjugation of glycoproteins to a solid support using hy

13 sults demonstrate that Herc5 is required for conjugation of ISG15 to a broad spectrum of target prote

14 To evaluate whether conjugation of MEP to a carrier protein could improve it

15 Conjugation of Nedd8 to a cullin protein, termed neddyla

16 Conjugation of oligonucleotides (ONs) to a variety of re

17 Thus, conjugation of PnPS to a carrier protein that elicits ca

18 achieves remarkable specificity by selective conjugation of ubiquitin (Ub) to a doomed protein in a p

19 Conjugation of ubiquitin (Ub) to a protein substrate tar

20 Conjugations of PMOs to a single CPP were carried out th

21 Recently, conjugation of lipophilic groups to AGs generated a nove

22 that this ncAA (pNCSF) allows the selective conjugation of proteins to amine-containing molecular pr

23 primary and secondary metabolism and for the conjugation of hormones to amino acids.

24 The E2-conjugating enzyme Ubc9 catalyzes the conjugation of SUMOs to -amino groups of lysine residues

25 Chemical conjugation of 2-5A to an antisense oligonucleotide can

26 The conjugation of a ligand to an enzyme is often a necessar

27 The results indicate that conjugation of CFA to an amino acid is required for opti

28 Conjugation of cytotoxic compounds to antibodies that bi

29 Through the conjugation of potent cytotoxicants to antibodies, novel

30 Conjugation of T cells to APCs that were pulsed with con

31 Conjugation of SUMO-1 to AR has been implicated in the r

32 Atg7 is required for the conjugation of Atg12 to Atg5, and Atg8 to phosphatidylet

33 a decrease in autophagy flux and defects in conjugation of ATG12 to ATG5.

34 By conjugation of proteins to beads, Ags can be selectively

35 Conjugation of synthetic materials to biomacromolecules

36 f peripheral substitutents, one for covalent conjugation of the Pc to biomolecules and others to impr

37 Nevertheless, conjugation of LA to BLG aggregates showed complex behav

38 Conjugation of paclitaxel to both PEG sizes significantl

39 The ability of E3alpha to catalyze the conjugation of ubiquitin to both 3C proteases was found

40 Multiple conjugation of CKS-25 to bovine serum albumin and carbon

41 loglutathione transferase FosA catalyzes the conjugation of glutathione to carbon-1 of the antibiotic

42 or systems expressing heterologous antigens, conjugation of antigen to carrier proteins, and plant-ba

43 Our strategy is based on facile conjugation of BTZ to catechol-containing polymeric carr

44 (UbcH8) conjugating enzymes, leading to the conjugation of ISG15 to cellular proteins.

45 These results indicate that conjugation of fatty acids to CGKRK could create an effi

46 mplex appears to have ligase activity in the conjugation of NEDD8 to Cul-2.

47 Our previous studies showed that conjugation of RUB to CUL1 is required for normal SCF(TI

48 ddylase activity is necessary to reverse the conjugation of Nedd8 to cullin, a modification that regu

49 This step is the conjugation of glutathione to cyanidin 3-glucoside (C3G)

50 during the polymerization and allowed direct conjugation of the polymer to cysteine residues of bovin

51 to control rats, suggesting that HNE protein conjugation of GLUT3 contributes to decreases in neurona

52 iochemical analysis, define features for the conjugation of amino acids to diverse acyl acid substrat

53 The conjugation of AQ to DNA through the short and more cond

54 d allows for high yield, nanoscale-precision conjugation of multiple proteins to DNA.

55 We demonstrate that the conjugation of ubiquitin to drICE suppresses its catalyt

56 , and cell labeling is well-established, the conjugation of saccharides to drugs is an active area of

57 tion enzymes that function by catalyzing the conjugation of glutathione (GSH) to electron-deficient c

58 functional dimeric enzymes that catalyze the conjugation of glutathione (GSH) to electrophilic chemic

59 The conjugation of GSH to electrophilic 5-oxoETE in vitro wa

60 In contrast, conjugation of the chelator to epsilon- and fluorescein

61 ubstrate and also exhibited activity for the conjugation of glutathione to ethacrynic acid, a compoun

62 Conjugation of PMA to FLA appears to be a promising path

63 Conjugation of oligosaccharides to fluorophores or gold

64 Conjugation of other pharmaceuticals to folate may also

65 amino-PEG monomers, we demonstrate covalent conjugation of a dye to form a highly efficient QD-dye e

66 raction of the Gag L domain with Tsg101, but conjugation of ISG15 to Gag or Tsg101 was not detected.

67 It is produced by direct conjugation of arachidonic acid to glycine and by oxidat

68 We find that the conjugation of pHLIP to gold nanoparticles increases gol

69 collagen-induced arthritis (CIA) model, that conjugation of C3d to heterologous type II collagen is s

70 Conjugation of Fab to HRG was confirmed by sodium dodecy

71 It is based on the conjugation of glycans to hydrazide beads through the fo

72 y through a sequential pathway involving (i) conjugation of JA to Ile, (ii) oxidation of the JA-Ile c

73 ute to viral immune evasion by directing the conjugation of ubiquitin to immunostimulatory transmembr

74 f of principle, we demonstrate site-specific conjugation of biotin to in vitro-differentiated mouse e

75 Covalent conjugation of ubiquitin to intracellular proteins is a

76 These results indicate that conjugation of MEP to KLH significantly enhances its imm

77 ive an aldehyde functionality permitting the conjugation of the antigens to KLH via reductive aminati

78 ed that establishes conditions of monovalent conjugation of QDs to lipids.

79 Conjugation of siRNAs to lipophilic groups supports effi

80 These data indicate that conjugation of rCTB to liposomes greatly enhances their

81 (4) synthase, thought to be specific for the conjugation of GSH to LTA(4), can also recognize 5-oxoET

82 Ligand-dependent conjugation of SUMO2/3 to LXRs or SUMO1 to PPARgamma tar

83 een developed for site-specific and covalent conjugation of small molecules to mAbs with unique react

84 itin-activating enzyme (E1)) followed by the conjugation of Sumo-1 to Mdm2 by Ubc9, a protein with a

85 They are made by the chemical conjugation of cytotoxins to monoclonal antibodies, whic

86 However, the need for covalent conjugation of small molecules to MPPs can negatively af

87 Conjugation of biomolecules to MPs has been first checke

88 Our results suggest that conjugation of AP-GA to N-(2-hydroxypropyl)methacrylamid

89 The ATE1-encoded Arg-transferase mediates conjugation of Arg to N-terminal Asp, Glu, and Cys of ce

90 The conjugation of inhibitor I to N-(2-hydroxypropyl)methacr

91 In this review, we discuss the chemistry for conjugation of carbohydrates to nanomaterials, summarize

92 en cycloaddition, were employed for covalent conjugation of Pcs to oligonucleotides.

93 en they are brought together by the covalent conjugation of ubiquitin fused to one fragment to a subs

94 tly cleaved and that Gly-76 was required for conjugation of NEDD8 to other proteins.

95 likely that these additional bands represent conjugation of sentrin to other proteins in a manner tha

96 The conjugation of ubiquitin to other cellular proteins regu

97 Human TLS involves the conjugation of ubiquitin to PCNA clamps encircling damag

98 igation and (ii) the efficient site-specific conjugation of biomolecules to PEG-coated surfaces.

99 This paper presents a robust method for the conjugation of viologens to peptides using an amide coup

100 , which may be ascribed to a reduced rate of conjugation of Atg8 to phosphatidylethanolamine.

101 selectin interaction also is involved in the conjugation of MPs to platelets, and the combination of

102 ies were explored for the efficient covalent conjugation of DNA to poly(N-isopropylacrylamide) (poly(

103 unogenicity as a major concern, we show that conjugation of IT to polyethylene glycol limits immunoge

104 hout the need for immunization of animals or conjugation of an oligosaccharide to protein.

105 Conjugation of carbohydrate antigens to protein carriers

106 SIZ1 is a SUMO E3 ligase that facilitates conjugation of SUMO to protein substrates.

107 Covalent conjugation of TLR agonists to protein Ags often facilit

108 Conjugation of TLR agonists to protein or peptide antige

109 The conjugation of arginine to proteins is a part of the N-e

110 alyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

111 While studies have shed light on the conjugation of Pup to proteins, it was not known if Pup

112 hrough posttranslational modification by the conjugation of ubiquitin chains to proteins targeted for

113 We demonstrated the conjugation of Ufm1 to proteins such as mitochondrial tr

114 Finally, conjugation of the glycan to PSMA oligopeptide is descri

115 ion strategy was developed for site-specific conjugation of proteins to QDs in preparing these QD nan

116 echanism involving transglutaminase mediated conjugation of serotonin to released alpha-granule prote

117 Here we report that the conjugation of Nedd8 to ROC1-CUL1, a subcomplex of the S

118 Conjugation of HuM195 to SCN-CHX-A-DTPA resulted in the

119 In vitro studies showed that conjugation of mPEG(2000) to sCT did not affect the pept

120 Conjugation of the peptide to siRNA led to their enhance

121 all proteolysis is reduced below normal, the conjugation of 125I-ubiquitin to soluble proteins decrea

122 r than previously published, and it includes conjugation of the lentivirus to streptavidin superparam

123 f engineered host-specific bacteriophage and conjugation of the phage to streptavidin-coated quantum

124 multistep process that leads to the covalent conjugation of ubiquitin to substrate proteins.

125 This is regulated at the level of conjugation of ubiquitin to substrates by the anaphase-p

126 The conjugation of ubiquitin to substrates requires a series

127 The conjugation of peptides to such medicinally active organ

128 r normal circumstances, although we observed conjugation of topoisomerase II to SUMO-1 in extracts wi

129 Conjugation of the protein to superparamagnetic iron oxi

130 enza virus, with infection inducing both the conjugation of ISG15 to target proteins and production o

131 Thus, the conjugation of ISG15 to target proteins within stromal c

132 MT3b interacts directly in vitro with NEDD8, conjugation of NEDD8 to target proteins enhances this in

133 The conjugation of polyubiquitin to target proteins acts as

134 The conjugation of ubiquitin to target molecules involves se

135 stem are regulated by the post-translational conjugation of ubiquitin to target proteins.

136 to demonstrate that two enzymes involved in conjugation of bile acids to taurine and glycine, namely

137 nt expansion of the nanotube toolbox through conjugation of (macro)molecules to the cyclic peptides.

138 Successful conjugation of 3 to the monoclonal antibody trastuzumab

139 Conjugation of antigens to the highly immunogenic choler

140 The enzymatic conjugation of arginine to the N-termini of proteins is

141 Conjugation of biotin to the C4S dodecasaccharide photoa

142 silane-modified glass substrate, followed by conjugation of biotin to the nanorods.

143 Conjugation of bulky substituents to the reducing end N-

144 overed enzyme that selectively catalyzes the conjugation of carbohydrates to the cysteine thiol of pr

145 Conjugation of DNA to the Fe(III)-HOPO ICP particles by

146 in vitro activity of Ubc7 by preventing the conjugation of donor Ub to the acceptor.

147 Conjugation of fluorophores to the terminal phosphate mo

148 nthetic procedures are described that permit conjugation of folic acid to the 5'-OH of FdUMP[10] via

149 macromolecular contrast agents based on the conjugation of gadolinium chelates to the interior and e

150 Conjugation of guanidinoneomycin to the plant toxin sapo

151 In this work, we demonstrated that the conjugation of lactoferrin to the dendrimer led to an en

152 The evidence for successful conjugation of NPs to the LBL films can be seen both in

153 Conjugation of ovalbumin to the micelles significantly e

154 tein or peptide can enable the site-specific conjugation of PEG to the protein without a loss of its

155 By simple postsynthetic click conjugation of polymers to the passenger strand of an si

156 We have previously shown that conjugation of protein antigen to the iron transport mol

157 In eukaryotes, the conjugation of proteins to the small ubiquitin-like modi

158 enching and activation based upon the direct conjugation of quenching moieties to the porphyrinic mac

159 Tandem mass spectrometry confirms conjugation of SUMO1 to the epsilon-amino group of Lys27

160 icle-based diagnostics typically involve the conjugation of targeting ligands to the nanoparticle to

161 Fc-directed conjugation of the antibody to the MNPs aids in reducing

162 ted cells/tissues without requiring physical conjugation of the drug to the peptide (bystander effect

163 Without the conjugation of the fluorophore to the CDs, the particle

164 Finally, successful conjugation of the glycopeptide to the keyhole limpet he

165 This approach generally requires chemical conjugation of the ligand to the force reporting tether

166 The conjugation of this ligand to the bioceramics induced a

167 In vitro, the conjugation of transferrin to the polypropylenimine dend

168 bstrate to the SCFSkp2 complex catalyzes the conjugation of ubiquitin molecules to the bound substrat

169 karyotes, both pathways are regulated by the conjugation of ubiquitin to the PCNA sliding clamp by di

170 tin ligase Itch associated with and promoted conjugation of ubiquitin to the transcription factor TIE

171 slot-blot hybridization studies showed that conjugation of CDPI3 to these ODNs increased both the sp

172 Conjugation of cytotoxic agents to these nnAAs, yields h

173 The conjugation of ubiquitin to these proteins requires inte

174 These findings demonstrate that conjugation of SUMO to TR has a TR-isoform preference an

175 that posttranslational modification of TR by conjugation of small SUMO to TRalpha and TRbeta plays an

176 However, by conjugation of DM1 to trastuzumab, the safety was improv

177 ings indicate that despite their small size, conjugation of dyes to truncated somatostatin and bombes

178 nder conditions of rapid Ime2p turnover, and conjugation of Ime2p to ubiquitin required GRR1.

179 We now show that this results in erroneous conjugation of NEDD8 to ubiquitin substrates, such as p5

180 Conjugation of proteins to ubiquitin plays a central rol

181 this study, we proposed the PTX-S-S-VE, the conjugation of paclitaxel (PTX) to vitamin E (VE) throug

182 Conjugation of CTB to VLPs also enhanced the SIV VLP-spe

183 sembly state of the antigen, suggesting that conjugation of self-peptides to VLPs promotes survival o