ライフサイエンスコーパス: connective tissue growth factor

1 modulation, including the down-regulation of connective tissue growth factor.

2 carcinoid tumors, including neurotensin and connective tissue growth factor.

3 ondin, plasminogen activator inhibitor 1, or connective tissue growth factor.

4 can be rescued by the addition of exogenous connective tissue growth factor.

5 expression of extracellular matrix genes and connective tissue growth factor.

6 members, collagen-interacting proteins, and connective tissue growth factor.

7 alization of TAZ and increased expression of connective tissue growth factor.

8 ed the angiogenesis-promoting gene Cyr61 and connective tissue growth factor.

9 KLF5 synergistically enhances expression of connective tissue growth factor.

10 xpression of several key genes, particularly connective tissue growth factor.

11 pregulation of type II TGF-beta receptor and connective tissue growth factor.

12 ro-fibrotic marker gene expression including connective tissue growth factor.

13 d cytoskeletal reorganization to TGF-beta or connective tissue growth factor.

14 61, nephroblastoma overexpressed) family of connective tissue growth factors.

15 the transcription of a second growth factor, connective tissue growth factor 1 (CTGF), which could me

16 d 21-fold increase, respectively, P < 0.05), connective tissue growth factor (2.5-fold increase, P <

17 We found that connective tissue growth factor a (ctgfa) is induced in

18 Newt connective tissue growth factor, a secreted protein reco

19 cked LATS1 from inhibiting the expression of connective tissue growth factor, a YAP-regulated gene.

20 minantly by inhibiting PDGF-, TGF-beta-, and connective tissue growth factor-activated MAPK and JNK s

21 , green fluorescent protein (Ad CMV.GFP), or connective tissue growth factor (AdCMV.CTGF) were inject

22 as either transforming growth factor beta or connective tissue growth factor alone produce only a tra

23 oalveolar lavage fluid and assessed for KGF, connective tissue growth factor, alpha-smooth muscle act

24 CCN2 (connective tissue growth factor), an important regulator

25 Upregulation of connective tissue growth factor, an essential downstream

26 esis, were increased and expression level of connective tissue growth factor, an inhibitor of adipoge

27 rization induced the autocrine growth factor connective tissue growth factor and activated ERK surviv

28 Connective tissue growth factor and alpha-smooth muscle

29 expression of two TEAD-dependent genes, the connective tissue growth factor and amphiregulin genes.

30 hat encodes growth regulators, including the connective tissue growth factor and an avian proto-oncop

31 duced upregulation of the fibrogenic protein connective tissue growth factor and collagen III in vitr

32 ury as well as decreased renal expression of connective tissue growth factor and collagens I and IV.

33 Connective tissue growth factor and cytokine-like protei

34 Aldosterone increased connective tissue growth factor and hydroxyproline expre

35 Increased expression of connective tissue growth factor and insulin-like growth

36 In addition, connective tissue growth factor and plasminogen activato

37 sts, in contrast, promoted a SMAD3-dependent connective tissue growth factor and plasminogen activato

38 thelial cell-cycle arrest via SMAD3-mediated connective tissue growth factor and plasminogen activato

39 of growth regulators that includes the human connective tissue growth factor and the chicken protoonc

40 mRNA levels of profibrotic genes, including connective tissue growth factor and tissue inhibitor of

41 produce only a transient fibrotic response, connective tissue growth factor and transforming growth

42 d in the renal expression of growth factors (connective tissue growth factor and vascular endothelial

43 Other molecular (collagen IV and connective tissue growth factor) and histological (tubul

44 or-beta, endothelin-1, angiotensin II, CCN2 (connective tissue growth factor), and platelet-derived g

45 up-regulated, including COL1A1, COL1A2, and connective tissue growth factor, and 206 genes were down

46 ally, dabigatran etexilate reduced collagen, connective tissue growth factor, and alpha-smooth muscle

47 SCAI interfered with TGF-beta1-induced SMA, connective tissue growth factor, and calponin protein ex

48 iators, transforming growth factor-beta1 and connective tissue growth factor, and diminished myofibro

49 Increases in mRNA levels of TGF-beta1, connective tissue growth factor, and endothelin-1 after

50 including transforming growth factor beta1, connective tissue growth factor, and endothelin-1.

51 including transforming growth factor beta1, connective tissue growth factor, and interleukin-13.

52 dothelial plasminogen activator inhibitor 1, connective tissue growth factor, and interleukin-8.

53 itor-1, parathyroid hormone-related peptide, connective tissue growth factor, and matrix metallopepti

54 , including transforming growth factor-beta, connective tissue growth factor, and matrix metalloprote

55 genic and proinflammatory factors (TGF-beta, connective tissue growth factor, and monocyte chemoattra

56 on (>95%) and subsequent PAI-1, fibronectin, connective tissue growth factor, and p21 expression in h

57 genetic protein 7, hepatocyte growth factor, connective tissue growth factor, and pirfenidone have sh

58 Plasminogen activator inhibitor 1, connective tissue growth factor, and TGF-beta1 were upre

59 pression of transforming growth factor-beta, connective tissue growth factor, and type III collagen.

60 pression of transforming growth factor-beta, connective tissue growth factor, and vascular endothelia

61 ctor alpha, transforming growth factor beta, connective tissue growth factor, and vascular endothelia

62 anti-apoptotic protein Bcl-xL, beta-catenin, connective tissue growth factor, and vascular endothelia

63 rming growth factor-beta, interleukin-4, and connective tissue growth factor are implicated in induci

64 CCN1 (cysteine-rich 61) and CCN2 (connective tissue growth factor) are growth factor-induc

65 mbined elimination of TGF-beta signaling and connective tissue growth factor as a potential therapeut

66 sm of type I collagen production and suggest connective tissue growth factor as its potent mediator.

67 entire coding region of human CTGF (encoding connective tissue growth factor) as a probe and by 5'RAC

68 ed increased expression of both collagen and connective tissue growth factor, as well as nuclear enri

69 s recent information regarding insights into connective tissue growth factor biology and, using scler

70 Thus the constitutive overexpression of connective tissue growth factor by fibroblasts present i

71 e myosins, NotchR and Wnt pathway genes, and connective tissue growth factor by Pofut1 in skeletal mu

72 Connective tissue growth factor (CCN2) drives fibrogenes

73 if hypoxia-inducible factor (HIF)-1alpha and connective tissue growth factor (CCN2) form a regulatory

74 Connective tissue growth factor (CCN2) is a matricellula

75 The matricellular protein connective tissue growth factor (CCN2) is secreted into

76 Connective tissue growth factor (CCN2), a member of the

77 at activated PSCs of the fibrogenic protein, connective tissue growth factor (CCN2), and to determine

78 ecreted matricellular proteins that includes connective tissue growth factor (CCN2), NOV (CCN3), WISP

79 Pathways of liver fibrosis are controlled by connective tissue growth factor (CCN2).

80 sed nuclear YAP and expression of downstream connective tissue growth factor (CCN2).

81 Connective tissue growth factor (CCN2, also known as CTG

82 Regulation of connective tissue growth factor (CCN2/CTGF) in gingival

83 pproach and demonstrated a broad affinity of connective tissue growth factor (CCN2/CTGF) to C-termina

84 ding fibronectin, alpha-smooth muscle actin, connective tissue growth factor, collagen I, and TGF-bet

85 d the expression of the ECM-associated genes connective tissue growth factor, collagen-alpha1[Iota],

86 Connective tissue growth factor (CTGF) and Cyr61 (cystei

87 cytosol, increase expression of YAP and TAZ connective tissue growth factor (CTGF) and Cyr61 target

88 The roles of connective tissue growth factor (CTGF) and transforming

89 Connective tissue growth factor (CTGF) and transforming

90 is study, we characterized the expression of connective tissue growth factor (CTGF) and transforming

91 Connective tissue growth factor (CTGF) and type I collag

92 acellular matrix (ECM) complex consisting of connective tissue growth factor (CTGF) and vascular endo

93 Connective tissue growth factor (CTGF) appears to play a

94 teine-rich angiogenic protein 61 (Cyr61) and connective tissue growth factor (CTGF) are structurally

95 Here, we have identified connective tissue growth factor (Ctgf) as a downstream t

96 We identified connective tissue growth factor (CTGF) as a novel target

97 Wnt3A and osteogenic BMPs, and we identified connective tissue growth factor (CTGF) as a potential ta

98 Here, we define connective tissue growth factor (CTGF) as a therapeutic

99 2 and AP4 is independent of the induction of connective tissue growth factor (CTGF) by TGFbeta.

100 Past studies have shown that connective tissue growth factor (CTGF) expression is ele

101 Connective tissue growth factor (CTGF) expression is reg

102 TGF-beta1 (TGFB1), Collagen1alpha1, and connective tissue growth factor (CTGF) gene expression w

103 thways controlling the TGF-beta induction of connective tissue growth factor (CTGF) gene expression.

104 The closely related mammalian genes connective tissue growth factor (CTGF) gene, nov, and cy

105 r, transforming growth factor (TGF)-beta and connective tissue growth factor (CTGF) genes are co-ordi

106 Connective tissue growth factor (CTGF) has been linked t

107 ssesses for the presence and localization of connective tissue growth factor (CTGF) in drug-induced g

108 the expression of collagen, fibronectin, and connective tissue growth factor (CTGF) in normal and SSc

109 wth factor (HGF) down-regulates collagen and connective tissue growth factor (CTGF) in scleroderma (s

110 In cardiomyocytes, aldosterone induced connective tissue growth factor (CTGF) in the absence bu

111 body of evidence suggests the involvement of connective tissue growth factor (CTGF) in the developmen

112 Delivery of connective tissue growth factor (CTGF) into full-transec

113 Connective tissue growth factor (CTGF) is a 36-to 38-kDa

114 Connective tissue growth factor (CTGF) is a cysteine-ric

115 Connective tissue growth factor (CTGF) is a cysteine-ric

116 Connective tissue growth factor (CTGF) is a downstream m

117 Connective tissue growth factor (CTGF) is a fibrogenic c

118 Since connective tissue growth factor (CTGF) is a key factor r

119 Connective tissue growth factor (CTGF) is a key mediator

120 Connective tissue growth factor (CTGF) is a major fibrog

121 Connective tissue growth factor (CTGF) is a matricellula

122 Connective tissue growth factor (CTGF) is a matricellula

123 Connective tissue growth factor (CTGF) is a multifunctio

124 Connective tissue growth factor (CTGF) is a novel fibrob

125 Connective tissue growth factor (CTGF) is a peptide secr

126 Since connective tissue growth factor (CTGF) is a potent mitog

127 Connective tissue growth factor (CTGF) is a secreted cyt

128 Connective tissue growth factor (CTGF) is a secreted mol

129 Connective tissue growth factor (CTGF) is a TGF-beta2 ta

130 Connective tissue growth factor (CTGF) is abundantly exp

131 Connective tissue growth factor (CTGF) is an important d

132 Connective tissue growth factor (CTGF) is an important m

133 In fibrotic liver, connective tissue growth factor (CTGF) is constantly exp

134 In mice, connective tissue growth factor (CTGF) is expressed in e

135 Connective tissue growth factor (CTGF) is highly express

136 Connective tissue growth factor (CTGF) is implicated as

137 Connective tissue growth factor (CTGF) is important for

138 We have reported that expression of connective tissue growth factor (CTGF) is increased in t

139 Connective tissue growth factor (CTGF) is induced by tra

140 Connective tissue growth factor (CTGF) is known to regul

141 In skin, the profibrotic protein connective tissue growth factor (CTGF) is not normally e

142 The matricellular secreted protein connective tissue growth factor (CTGF) is upregulated in

143 rowth factor/Cyr61/NOV (CCN) family members, connective tissue growth factor (CTGF) may be particular

144 receptor by des-Arg(10)-kallidin stabilized connective tissue growth factor (CTGF) mRNA, stimulated

145 The pro-fibrogenic cytokine connective tissue growth factor (CTGF) plays an importan

146 Khodosevich et al. show that connective tissue growth factor (CTGF) regulates a multi

147 e aim of this study was to determine whether connective tissue growth factor (CTGF) regulates the pro

148 TGF-beta-mediated connective tissue growth factor (CTGF) signaling is crit

149 ressed higher levels of mRNA and protein for connective tissue growth factor (CTGF) than OECs.

150 Connective tissue growth factor (CTGF) up-regulation ind

151 rential cDNA microarray analyses showed that connective tissue growth factor (CTGF) was expressed at

152 th-factor beta axis was enhanced in POH, and connective tissue growth factor (CTGF) was overexpressed

153 Connective tissue growth factor (CTGF), a direct target

154 The SMAD-mediated induction of connective tissue growth factor (CTGF), a fibroprolifera

155 genome-wide array technology, we found that connective tissue growth factor (CTGF), a gene product d

156 We identified connective tissue growth factor (CTGF), a matricellular

157 Arg(10)-kallidin stimulate the expression of connective tissue growth factor (CTGF), a matrix signali

158 Connective tissue growth factor (CTGF), a matrix-associa

159 Connective tissue growth factor (CTGF), a member of the

160 1-derived peptide sequence and its effect on connective tissue growth factor (CTGF), a protein involv

161 data about a structure function analysis of connective tissue growth factor (CTGF), a prototypic mem

162 ubular injury, fibrosis, collagen synthesis, connective tissue growth factor (CTGF), and alpha-smooth

163 cysteine-rich angiogenic inducer 61 (CYR61), connective tissue growth factor (CTGF), and ankyrin repe

164 on of alpha-smooth muscle actin (alpha-SMA), connective tissue growth factor (CTGF), and CCL2.

165 EGF), transforming growth factor (TGF)-beta, connective tissue growth factor (CTGF), and collagens IV

166 in-1, collagen I, alpha-smooth muscle actin, connective tissue growth factor (CTGF), and plasminogen

167 shown that expression of CCN2, also known as connective tissue growth factor (CTGF), correlates posit

168 thelial cells induced these cells to express connective tissue growth factor (CTGF), driving fibrobla

169 TGF-beta), TGF-beta receptor 1 (TGF-betaR1), connective tissue growth factor (CTGF), E-cadherin, SRY-

170 ownregulation of fibrosis markers, including connective tissue growth factor (CTGF), fibronectin, and

171 The matricellular protein, connective tissue growth factor (CTGF), has been shown t

172 transforming growth factor beta (TGF-beta), connective tissue growth factor (CTGF), IL-4, IL-13, MCP

173 n and stimulators of collagen synthesis, eg, connective tissue growth factor (CTGF), in patients with

174 The promoter of one of these genes, connective tissue growth factor (CTGF), is suppressed by

175 Cyr61 and connective tissue growth factor (CTGF), members of a new

176 ng this process, we investigated the role of connective tissue growth factor (CTGF), one of the candi

177 F-1), tumor growth factor beta1 (TGF-beta1), connective tissue growth factor (CTGF), procollagen I ca

178 Connective tissue growth factor (CTGF), type I collagen

179 ranscription and/or protein levels of SPARC, connective tissue growth factor (CTGF), type I collagen,

180 , some TGFbeta-regulated proteins, including connective tissue growth factor (CTGF), were basally upr

181 the profibrotic factors tenascin C (TNC) and connective tissue growth factor (CTGF), whereas forced e

182 wnstream effects of TGF-beta are mediated by connective tissue growth factor (CTGF), which is up-regu

183 es in human breast carcinomas, we quantified connective tissue growth factor (CTGF), WISP-1, CYR61, a

184 targeting cell cycle regulator cyclin A and connective tissue growth factor (CTGF).

185 aturation through the regulated secretion of connective tissue growth factor (CTGF).

186 y validation of the invasion candidate gene, connective tissue growth factor (CTGF).

187 ondin-1 (Tsp1) and related proteins, such as connective tissue growth factor (CTGF).

188 rix and is associated with the production of connective tissue growth factor (CTGF).

189 latelet-derived growth factor-B (PDGF-B) and connective tissue growth factor (CTGF).

190 l fibrosis, particularly CCN2 [also known as connective tissue growth factor (CTGF)], markers of epit

191 Cysteine-rich 61 (Cyr61, CCN1) and connective tissue growth factor (CTGF, CCN2) are growth

192 Connective tissue growth factor (CTGF, CCN2) is a secret

193 transforming growth factor-beta (TGF-beta), connective tissue growth factor (CTGF, CCN2), and ED-A f

194 ed in mediating the differential response of connective tissue growth factor (CTGF, CCN2).

195 ere statistically significant in four genes: connective tissue growth factor (Ctgf, P = 0.04), tenasc

196 d that there was a 7.5-fold up-regulation of connective tissue growth factor (CTGF/CCN2) expression i

197 ERK1/2 acts on connective tissue growth factor (CTGF/CCN2) expression t

198 The role of connective tissue growth factor (CTGF/CCN2) in pathologi

199 Connective tissue growth factor (CTGF/CCN2) is a fibrosi

200 Connective tissue growth factor (CTGF/CCN2) is an immedi

201 Connective tissue growth factor (CTGF/CCN2) is an induci

202 Myocardial connective tissue growth factor (CTGF/CCN2) is induced i

203 Several lines of evidence indicate that connective tissue growth factor (CTGF/CCN2) stimulates c

204 Connective tissue growth factor (CTGF/CCN2), a downstrea

205 .CT signaling that induces the expression of connective tissue growth factor (CTGF/CCN2), a potent me

206 Connective tissue growth factor (CTGF/CCN2), associated

207 diomyocyte-TrkA recognition by matricellular connective tissue growth factor (CTGF/CCN2).

208 pleiotropic matricellular signaling protein connective tissue growth factor (CTGF/CCN2).

209 Here, we show that connective tissue growth factor (CTGF; also known as CCN

210 Connective tissue growth factor (CTGF; CCN2) is overexpr

211 Connective-tissue growth factor (CTGF) is a member of th

212 xpression of the classical Hippo target CCN2/connective-tissue growth factor (CTGF), as well as ancho

213 overexpressed gene) is a member of the CCN (connective tissue growth factor [CTGF], Cyr61/Cef10, NOV

214 CCN1 and the homologous family members CCN2 (connective tissue growth factor, CTGF) or CCN3 (NOV) but

215 d protein 1 (WISP-1) is a member of the CCN (connective tissue growth factor, Cyr61, NOV) family of g

216 d protein 1 (WISP-1) is a member of the CCN (connective tissue growth factor, Cyr61, NOV) family of g

217 regulator family called CCN, which includes connective-tissue growth factor, CYR61, CEF10 (v-src ind

218 ta on fibroblast properties induction of the connective tissue growth factor/Cyr61/NOV (CCN) family m

219 fibrosis as assessed by decreased levels of connective tissue growth factor, cysteine-rich 61, colla

220 secreted protein 3) is a member of the CCN (connective tissue growth factor, cysteine-rich 61, nephr

221 ain, secreted protein, whose paralogous CCN (connective tissue growth factor/cysteine-rich protein 61

222 rogenitor cells were selectively enriched by connective tissue growth factor delivery (CTGF delivery)

223 tically decreased (by more than 2-fold) were connective tissue growth factor, endothelin-1, monocyte

224 Connective tissue growth factor expression has not been

225 Ultraviolet reduction of connective tissue growth factor expression may contribut

226 vels, which coincided with (1) a decrease in connective tissue growth factor expression, (2) a reduct

227 te fibroblasts, leading to contractility and connective tissue growth factor expression.

228 -3, these proteins define a subfamily of the connective tissue growth factor family.

229 rs such as platelet-derived growth factor-c, connective tissue growth factor, fibroblast growth facto

230 f fibrosis (transforming growth factor-beta, connective tissue growth factor, fibronectin, collagen-1

231 , HSPA8, HSPE1 and AXIN1, BRCA1, CD14, CTGF (connective tissue growth factor), GABRE (gamma-aminobuty

232 /endothelial cell adhesion gene (Thbs4), the connective tissue growth factor gene (Ctgf), and the sel

233 tor beta/Smad responsiveness elements in the connective tissue growth factor gene promoter, in human

234 transcriptional responses of the endogenous connective tissue growth factor gene to different physio

235 Connective tissue growth factor had a similar time and t

236 endothelial growth factor, thrombospondin 1, connective tissue growth factor, hepatocyte growth facto

237 Connective tissue growth factor, however, is constitutiv

238 phosphorylation and reduced transcription of connective tissue growth factor in an AIP4-dependent man

239 Constitutive expression of connective tissue growth factor in normal human skin sug

240 ncluding transforming growth factor-beta and connective tissue growth factor, in muscles of periodate

241 bulin, vascular endothelial growth factor A, connective tissue growth factor, insulin-like growth fac

242 Connective tissue growth factor is expressed in fibrotic

243 CCN2/connective tissue growth factor is highly expressed in h

244 Connective tissue growth factor is not normally expresse

245 The connective tissue growth factor known as CCN2 is an indu

246 We have identified and cloned a novel connective tissue growth factor-like (CTGF-L) cDNA from

247 ransforming growth factor-beta1 (TGF-beta1), connective tissue growth factor, matrix metalloproteinas

248 sing scleroderma as a model system, the part connective tissue growth factor might play in fibrotic d

249 Connective tissue growth factor mRNA and protein were al

250 inimal erythema dose, UVB/A2 source) reduced connective tissue growth factor mRNA expression througho

251 At 24 h post ultraviolet, connective tissue growth factor mRNA expression was redu

252 s resulted in a time-dependent inhibition of connective tissue growth factor mRNA expression.

253 se chain reaction revealed that the level of connective tissue growth factor mRNA in the epidermis an

254 Previous irradiation-enhanced induction of connective tissue growth factor mRNA in wild-type, but n

255 We report here that connective tissue growth factor mRNA is constitutively e

256 sforming growth factor beta1 rapidly induced connective tissue growth factor mRNA levels (5-fold with

257 accompanied by significant up-regulation of connective tissue growth factor mRNA levels.

258 In situ hybridization demonstrated that connective tissue growth factor mRNA was expressed in ke

259 Connective tissue growth factor mRNA was reduced (30%) w

260 xpression of fibronectin, procollagen I, and connective tissue growth factor mRNA, MMP-2 activity, an

261 the upregulation of cutaneous TGF-beta1 and connective tissue growth factor mRNAs and type I collage

262 that cysteine-rich protein 61 (CYR61)/CYR61 connective tissue growth factor nephroblastoma overexpre

263 ed family of secreted proteins that includes connective tissue growth factor, nephroblastoma overexpr

264 his gene is a member of the cysteine-rich 61/connective tissue growth factor/nephroblastoma-overexpre

265 overexpressed (Nov), a member of the Cyr 61, connective tissue growth factor, Nov (CCN) family of pro

266 otein of the CCN family, which also includes connective tissue growth factor, Nov, WISP-1, WISP-2, an

267 uid from patients with ALI/ARDS induced more connective tissue growth factor (p < 0.05), collagen 1 (

268 with senescence and/or apoptosis (TGF-beta1, connective tissue growth factor, p53, alpha-synuclein, a

269 icted primary translation product of porcine connective tissue growth factor (pCTGF).

270 The overexpression of connective tissue growth factor present in fibrotic lesi

271 uppressed the TGF beta-mediated induction of connective tissue growth factor promoter activity.

272 on of reporter genes for the p21, cdc25, and connective tissue growth factor promoters and of a repor

273 utes to the phenotype of scleroderma in that connective tissue growth factor promotes matrix depositi

274 ncreased the expression of collagens and the connective tissue growth factor protein.

275 agonists of transforming growth factor-beta, connective tissue growth factor, several tyrosine kinase

276 including plasminogen activator inhibitor-1, connective tissue growth factor, Smad3, Smad4, and Smad7

277 Connective tissue growth factor stimulation enhanced ext

278 release of cytokines and growth factors like connective tissue growth factor that induce an active an

279 down-regulation of the steady-state level of connective tissue growth factor that induces collagen ty

280 -regulated the expression of Cyr61 and CTGF (connective tissue growth factor), the genes that encode

281 nd fibrogenic cytokines such as TGFbeta2 and connective tissue growth factor.This inhibitory effect o

282 The most potent inducer of connective tissue growth factor thus far identified is t

283 ents targeting specific cytokines, including connective tissue growth factor, transforming growth fac

284 tissue inhibitor of metalloproteinase 1, and connective tissue growth factor was also noted.

285 Interestingly, profibrogenic connective tissue growth factor was induced significantl

286 ondin, plasminogen activator inhibitor 1, or connective tissue growth factor was unaffected.

287 gulation of bone morphogenetic protein 2 and connective tissue growth factor was validated.

288 broblasts, whereas its human ortholog, CTGF (connective tissue growth factor), was identified as a mi

289 decorin, important for the interaction with connective tissue growth factor, was detected predominan

290 ogen activator inhibitor-1, fibronectin, and connective tissue growth factor, was suppressed by metfo

291 Hif-1alpha and its downstream target connective tissue growth factor were necessary for the d

292 Connective tissue growth factor, which is induced by tra