ライフサイエンスコーパス: connexin 43

1 dependent internalization and degradation of connexin 43.

2 the dephosphorylation and internalization of connexin 43.

3 re associated with a significant increase of connexin 43.

4 and profound disturbances in connexin 40 and connexin 43.

5 f Wnt10B, SFRP1, cyclin D1, FzD2, WISP2, and connexin 43.

6 sperse with elongated macrophages expressing connexin 43.

7 t expressed a specific gap junction protein, connexin 43.

8 ted as label-retaining cells, do not express connexin 43.

9 n, vinculin, beta1-integrin, N-cadherin, and connexin 43.

10 conduction velocity due to downregulation of Connexin 43.

11 s on localization of desmosomal proteins and connexin 43.

12 ated with increased expression of myocardial connexin 43.

13 rated lowered expression of the gap junction connexin 43.

14 ponin I, troponin T, myosin heavy chain, and connexin-43.

15 in plakoglobin, and the gap-junction protein connexin-43.

16 a 53% reduction in the gap junction protein connexin-43.

17 n close association with both N-cadherin and connexin-43.

18 The expression of the 3 atrial connexins-connexins 43, 40, and 45-was analyzed at the mRNA and pr

19 ild inflammation and increased expression of connexin 43, a gap junction protein involved with labor.

20 Accordingly, we investigated whether connexin 43, a gap junction protein present in the basal

21 In contrast, connexin-43 abundance was higher (P<0.05) in cerebral co

22 torative effect and a stronger expression of connexin 43, alpha-sarcomeric actin, and major histocomp

23 Hearts were harvested for histology (connexin 43, alpha-sarcomeric actin, CD3, CD11c, major h

24 Connexin-43 also plays an essential role in facilitating

25 ibited hypertrophy and an increased level of connexin 43, an astroglial gap junction protein.

26 bFGF), NPCs express the gap junction protein connexin 43 and are dye-coupled.

27 ion also induced tyrosine phosphorylation of connexin 43 and association with c-Src, events linked to

28 Abundant connexin 43 and cadherin 11 in pellets demonstrated cell

29 This was accompanied by an increase in connexin 43 and connexin 40 expression levels, suggestin

30 diomyocytes >5-fold as reflected by elevated connexin 43 and consortin transcripts.

31 Upon withdrawal of bFGF, levels of connexin 43 and dye coupling decrease, and the cells cea

32 of A(L) cells that are dominant negative for connexin 43 and lack gap junction formation produced a c

33 Connexin 43 and N-cadherin were also present.

34 BMCs and myocytes express at their interface connexin 43 and N-cadherin, and this interaction may be

35 n adhesion molecules, the junctional protein connexin 43 and of alpha-smooth muscle actin.

36 Thus, gap junction channels comprised of connexin 43 and other connexins in airway cells provide

37 hese findings suggest that crosstalk between connexin 43 and purinergic signaling contributes to podo

38 e kinase, resulting in the downregulation of connexin 43 and subsequent electric abnormalities.

39 We showed previously that expression of connexin-43 and connexin-32 in an indolent prostate canc

40 pendent to -independent state, we introduced connexin-43 and connexin-32 into an invasive, androgen-i

41 icant decrease in the gap junction proteins, connexin-43 and connexin-40, was observed in N-cadherin-

42 ers of cellular injury and stress, including connexin-43 and kidney-injury-molecule-1 (Kim-1), were u

43 rogestin-sensitive genes (oxytocin receptor, connexin 43, and cyclooxygenase-2) and prolactins are do

44 cellular levels of E-cadherin, connexin 26, connexin 43, and gap junction.

45 Connexin 26, connexin 43, and gap-junction activity were also increas

46 esultant HCECs were immunostained with ZO-1, connexin 43, and Ki67.

47 ion, that IFN impairs migration by impairing connexin 43, and that impaired healing during NEC is ass

48 tion-associated genes, oxytocin receptor and connexin-43, and block oxytocin-induced contractility in

49 ssion and repressed E-cadherin, connexin-26, connexin-43, and gap junction levels in CRC cells.

50 n cardiac endothelial nitric oxide synthase, connexin-43, and markers of hypertrophy and fibrosis, in

51 unostaining for myosin heavy chain, actinin, connexin-43, and von Willebrand factor VIII showed exten

52 er ID proteins like N-cadherin, desmoplakin, connexin-43, and ZO-1 was significantly perturbed upon p

53 immunohistochemically undetectable levels of connexin 43 are found in the epidermal basal layer of ne

54 Connexin-32 and connexin-43 are among the most abundant connexins in bra

55 N-cadherin and connexin-43 associate with Nav1.5 in heart membranes as

56 ESCs expressed connexin 43 at intercellular contact sites.

57 cta, and a larger fraction of phosphorylated connexin 43 at serine 368.

58 ibodies to detect total and dephosphorylated connexin-43 at various time points.

59 selective hemichannel blocker) and selective connexin-43 blockers (connexin-43 mimetic peptides (43)G

60 actor (NF)-kappaBeta and upregulated that of connexin 43, both of which sensitized cancer cells to Ta

61 YO5B in the surface trafficking of Kv1.5 and connexin-43 but not potassium voltage-gated channel, sub

62 sal epithelium was negative to keratin 3 and connexin 43, but was scatter positive for p63.

63 beta receptor types I and II, cadherins, and connexin 43 by immunocytochemistry, Western blot analysi

64 tokeratin-19, OV-1 antigen, a6 integrin, and connexin 43), cell surface markers recently identified b

65 d PKCgamma was targeted into caveolin-1- and connexin 43-containing lipid rafts, and the PKCgamma pho

66 to spontaneously beating cardiomyocytes via connexin-43-containing gap junctions, cardiac macrophage

67 protein expression of CMC-specific markers, Connexin-43, CTI, CTT, Mef2c, Tbx5, Nkx2.5, GATA-4, and

68 ctional intracellular communication molecule connexin 43 (Cx-43), known to be involved in tumor cell

69 We report that elevated connexin-43 (Cx-43) in stem cells preconditioned with in

70 Gap junctions (connexin-43 [CX-43]) were formed between BCCs and BM str

71 A library clone with disrupted expression of connexin 43 (Cx43) (also known as gap junction protein a

72 e coupled via gap junctions (GJs) comprising connexin 43 (Cx43) (Gja1) and Cx30 (Gjb6), which facilit

73 Here we engineered a Cys-less version of connexin 43 (Cx43) and assessed its function using a Xen

74 GJ proteins, connexin 43 (Cx43) and connexin 47 (Cx47), play a crucia

75 Using short hairpin RNA knockdown of Connexin 43 (Cx43) and Cx26 together with rescue experim

76 f cells with dominant-negative constructs of connexin 43 (Cx43) and Cx43-specific antisense oligodeox

77 ecent study showed that gap junction protein connexin 43 (Cx43) and desmosome protein plakophilin-2 a

78 olar again, is associated with expression of connexin 43 (Cx43) and, that knockdown of Cx43 retards,

79 gap junction subunits connexin 26 (Cx26) and connexin 43 (Cx43) are expressed at the contact points b

80 Phosphorylation of connexin 43 (Cx43) by PKC abolishes the permeability of

81 We show that connexin 43 (Cx43) colocalizes, cofractionates, and coim

82 Connexin 43 (Cx43) downregulation is associated with nor

83 Conduction slowing was likely due to connexin 43 (Cx43) downregulation, decreased colocalizat

84 nd control uninfected individuals to examine connexin 43 (Cx43) expression and distribution and HIV-a

85 e whether high glucose-induced inhibition of connexin 43 (Cx43) expression and reduced gap junction i

86 stigated and the model displayed predominant connexin 43 (Cx43) expression in basal proliferating cel

87 manner to regulate gap junction function and connexin 43 (Cx43) expression.

88 that direct cell-cell communication through connexin 43 (Cx43) gap junction channels also plays a ma

89 t evidence suggests that the permeability of connexin 43 (Cx43) gap-junctional channels (connexons) t

90 The pore-forming gap junctional protein connexin 43 (Cx43) has a short (1-3 h) half-life in cell

91 (MAPK) phosphorylation of proteins including connexin 43 (Cx43) has been associated with VSMC prolife

92 The connexin 43 (Cx43) hemichannel (HC) in the mechanosensor

93 Previous studies have implicated connexin 43 (Cx43) in ATP release, but definitive proof

94 (+) (mitoK(ATP)) channels, and mitochondrial connexin 43 (Cx43) in cytoprotection, it is not clear ho

95 We investigated the role of connexin 43 (Cx43) in maintaining the integrity of mitoc

96 ia on the expression and channel activity of connexin 43 (Cx43) in melanoma cells and its impact on t

97 Connexin 43 (Cx43) is a gap junction (GJ) protein widely

98 Connexin 43 (Cx43) is a protein expressed in a variety o

99 The gap junction protein connexin 43 (Cx43) is absent in the limbal basal epithel

100 Connexin 43 (Cx43) is expressed in the embryonic heart,

101 The phosphoprotein connexin 43 (Cx43) is the major constituent of gap junct

102 Connexin 43 (Cx43) is the major protein component of gap

103 In mammalian tissues, connexin 43 (Cx43) is the most prominent member of the c

104 Connexin 43 (Cx43) is the most ubiquitous connexin in va

105 we measured accumulation of dephosphorylated Connexin 43 (Cx43) isoform P0 and AMP kinase activation

106 al pharmacological inhibitors, including the connexin 43 (Cx43) mimetic peptide Gap26, carbenoxolone,

107 eceptor agonist; EC50 0.1 microM) stimulated connexin 43 (Cx43) mRNA and protein expression within 1-

108 2) (PGE(2)) had a stimulatory effect on both connexin 43 (Cx43) mRNA and protein expression.

109 tein alpha1 gene (Gja1), resulting in a G60S connexin 43 (Cx43) mutant protein that is dominant negat

110 Connexin 43 (Cx43) nonjunctional or "unapposed" hemichan

111 tion of the ventricular gap junction protein connexin 43 (Cx43) occurs in epicardial border zone myoc

112 Here we show that connexin 43 (Cx43) plays a key role in protection afford

113 udies indicate that the gap junction protein connexin 43 (Cx43) renders GBM cells resistant to TMZ th

114 Previously, we demonstrated that connexin 43 (cx43) suppressed the growth of human gliobl

115 from green fluorescent protein (GFP)-tagged connexin 43 (Cx43) to the PM and GJs in living cells.

116 Overexpression of connexin 43 (Cx43) via transduction of BMSCs with a lent

117 These genes include GJA1 (encoding connexin 43 (Cx43)) and TWIST1, which are highly upregul

118 Herein, we demonstrate that connexin 43 (Cx43), a gap junction integral membrane pro

119 rate that one of these regulating factors is Connexin 43 (Cx43), a gap junction protein highly expres

120 Here, we report that the expression of connexin 43 (Cx43), a major gap junction protein, is mar

121 ytic tumors express the gap junction protein connexin 43 (Cx43), and we show here that Cx43 expressio

122 munoblotting to ZO-1, cytokeratin K12 (K12), connexin 43 (Cx43), cytokeratin K10 (K10), and involucri

123 We have found that connexin 43 (Cx43), expressed by thymic T(R) cells proge

124 s evident in mouse lungs lacking endothelial connexin 43 (Cx43), or in rat lungs in which we pretreat

125 monstrate here that the forced expression of connexin 43 (Cx43), the main constituent of astrocytic g

126 Using human and mouse models, we show that connexin 43 (Cx43), the main GJ protein in the immune sy

127 Previously, we showed that connexin 43 (Cx43), the main GJ protein in the immune sy

128 GJA1 encodes connexin 43 (Cx43), the most widely expressed gap juncti

129 the abundance of the gap junctional protein, connexin 43 (CX43), which is highly expressed in astrocy

130 ntrol mice, Abeta25-35 peptide promoted both connexin 43 (Cx43)- and Panx1 HC-dependent MC dye uptake

131 studies have illustrated the significance of connexin 43 (Cx43)-based gap junction in maintaining the

132 et of AMs attached to the alveolar wall form connexin 43 (Cx43)-containing gap junction channels with

133 ical studies revealed that the mBMSCs formed connexin 43 (Cx43)-containing gap junctional channels (G

134 nexins, of which the best-studied isoform is connexin 43 (Cx43).

135 ncides with the reduced expression levels of connexin 43 (Cx43).

136 ll to cell through gap junctions composed of connexin 43 (Cx43).

137 ct with the C-terminal cytoplasmic region of connexin 43 (Cx43).

138 of keratin-3 (K3) and a lower expression of connexin 43 (Cx43).

139 ated discs and binds to gap junction protein connexin 43 (Cx43).

140 arcinoma-astrocyte gap junctions composed of connexin 43 (Cx43).

141 rescent dye calcein; (ii) immunostaining for connexin 43 (Cx43); and (iii) measurement of intracellul

142 c kidney 293 (HEK293) cell expressing either connexin-43 (Cx43 HEK) or inward rectifier potassium cha

143 lia-specific disruption of the gene encoding connexin-43 (Cx43) (hGFAP::CreER(T2+/-)/Cx43(f/f) mice).

144 lated with decreased protein accumulation of connexin-43 (Cx43) and N-cadherin, whereas at later stag

145 Mutations in the gene encoding connexin-43 (Cx43) cause the human development disorder

146 xamined the role of casein kinase 1 (CK1) in connexin-43 (Cx43) gap junction assembly.

147 test whether c-Src tyrosine kinase mediates connexin-43 (Cx43) reduction and sudden cardiac death in

148 Connexin-43 (Cx43), a connexin constituent of gap juncti

149 Connexin-43 (Cx43), a gap junction protein involved in c

150 Coupling correlated with levels of connexin-43 (Cx43), a protein previously linked to late-

151 molecules, such as the gap junction protein connexin-43 (Cx43), also influence proliferation.

152 e (P4) is known to inhibit the expression of connexin-43 (Cx43, major component of GJs) and GJ format

153 Connexin 43 (Cx43alpha1) gap junction has been shown to

154 cs, and integral gap junction proteins Cx43 (connexin 43), Cx45 (connexin 45), and ZO-1 (zonula occlu

155 phosphorylation of the gap junction protein connexin 43, decreases gap junction communication, and i

156 urance-trained R735X-infected mice displayed connexin 43 delocalization at intercardiomyocyte gap jun

157 The connexin 43 density was significantly increased in the m

158 During early reperfusion, slow recovery from connexin-43 dephosphorylation leads to persistent CV slo

159 CV slowing was accompanied by connexin-43 dephosphorylation.

160 Direct binding of MMP-7 to connexin-43, determined by surface plasmon resonance tec

161 ibrosis, and conduction defects with altered connexin 43 distribution.

162 tomorphometry of myocardial architecture and connexin 43 distribution.

163 portantly, the activities of stromal AE2 and connexin-43 do not place an energetic burden on cancer c

164 To examine whether diabetes-induced connexin 43 downregulation promotes retinal vascular les

165 Pharmacological inhibition of cSrc mitigates connexin 43 downregulation, slowed conduction, and arrhy

166 Connexin 43/ERK-mediated anti-apoptosis induced by bisph

167 ique pattern of change with development, (3) connexin-43 exhibited ontogenic increases in protein abu

168 the development of NEC, and showed restored connexin 43 expression and intestinal restitution.

169 es a strong correlation between the sites of connexin 43 expression and the clinical phenotype displa

170 d enhanced sarcomere alignment and increased connexin 43 expression at 220 days after transplantation

171 Connexin 43 expression, trafficking, and localization we

172 ated with IFN release and loss of enterocyte connexin 43 expression.

173 d synchronized contraction of CMs as well as connexin 43 expression.

174 lls can be identified and separated based on connexin 43 expression.

175 TNF-alpha also increased connexin-43 expression and hemichannel activity, but not

176 munoblot was used to measure connexin-32 and connexin-43 expression in cerebral cortices of fetuses a

177 tenin Tyr142-phosphorylation was mediated by connexin 43/Fer and that the beta-catenin Ser45/Thr41-ph

178 expressing wild-type connexin 45 (Cx45) and connexin 43 fused with enhanced green fluorescent protei

179 This resulted in disassembly of connexin 43 gap junction plaques and decreased gap junct

180 function and increased strong expressions of connexin 43 gap junction protein in heart and lung speci

181 d rafts, and the PKCgamma phosphorylated the connexin 43 gap junction proteins on Ser-368.

182 Inhibiting connexin 43 gap junctions abolished network activity, su

183 Connexin 43 (gap junction protein) is expressed in pigme

184 um, mice with a heterozygous deletion of the connexin 43 gene (connexin 43+/-) had proteinuria, BUN,

185 The human connexin 43 gene, or GJA1, is located at human chromosom

186 was identified that included Nanog, GTCM-1, connexin 43 (GJA1), oct-4, and TDGF1 (cripto).

187 (endothelial nitric oxide synthase), glial (connexin-43, glial fibrillary acidic protein, CD11b), an

188 terozygous deletion of the connexin 43 gene (connexin 43+/-) had proteinuria, BUN, and serum creatini

189 ls such as mitochondrial K(ATP) channels and connexin-43 have now been implicated as critical regulat

190 Our results show that in the olfactory bulb, connexin 43 hemichannel function is promoted by neuronal

191 he osteocyte's response was observed through connexin 43 hemichannel opening.

192 that release further ATP; by 7 h treatment, connexin 43 hemichannels (Cx43 HCs) are also opened.

193 We infused a mimetic peptide that blocks connexin 43 hemichannels into the lateral ventricle of c

194 s, we showed that the activity of astroglial connexin 43 hemichannels, opened in an activity-dependen

195 P is released by efflux through gap junction connexin 43 hemichannels, the opening of which is evoked

196 n receptor, bisphosphonates do so by opening connexin 43 hemichannels.

197 ith the observation that ATP is released via connexin 43 hemichannels.

198 e purity of the SAN protein was confirmed by Connexin 43 immunoblot.

199 Intercalated disk morphology and connexin 43 immunolabelling were not different in hypert

200 ow that knockout of the gap junction subunit connexin 43 in astrocytes throughout the brain causes ex

201 g Wnt10B, SFRP1, cyclin D1, FzD2, WISP2, and connexin 43 in both genotypes; however, there was a furt

202 mmunoreactive cells and gap junction protein connexin 43 in both small intestine and colon.

203 mmunostaining revealed de novo expression of connexin 43 in damaged glomeruli in patients with glomer

204 studies, ZO-1 colocalized with cadherins and connexin 43 in intercellular junctions.

205 conduction, whereas conditional deletion of connexin 43 in macrophages and congenital lack of macrop

206 ic glia, either reducing glial expression of connexin 43 in Sox10::CreER(T2+/-) /Cx43(f/f) mice or ac

207 ori the transcription factors GATA4 and SRF, connexin 43 in the cell membrane, and myoinositol 1,4,5-

208 cardiac output and decreased expressions of connexin 43 in the heart and lungs.

209 fect localization of desmosomal proteins and connexin 43 in the skin, and result in desmosome aggrega

210 Enterocytes expressed connexin 43 in vitro and in vivo, and exchanged fluoresc

211 expressed primarily in oligodendrocytes and connexin-43 in astrocytes in adult brain.

212 an inward-rectifying potassium channel, and connexin-43 in primary human fibroblasts from the heart,

213 injury elicited a persistent upregulation of connexin-43 in spinal astrocytes for >3 weeks.

214 olangiocyte differentiation (cytokeratin 19, connexin 43, integrin beta4, and gamma-glutamyltranspept

215 ted upregulation of contractile proteins and connexin 43 is a critical step in myometrial activation,

216 ted upregulation of contractile proteins and connexin 43 is a critical step in myometrial activation,

217 n post-MI remodeling and to demonstrate that connexin-43 is a novel MMP-7 substrate.

218 educed gap junctional coupling in areas with Connexin 43 isoform P0 accumulation.

219 ps at baseline, but regional accumulation of Connexin 43 isoform P0 occurred within minutes in all Ca

220 Connexin 43 knockout (Cx43 KO) mice exhibit conotruncal

221 Connexin 43 knockout (Cx43alpha1KO) mice exhibit germ ce

222 Connexin 43 knockout (Cx43alpha1KO) mice have conotrunca

223 -cell impulse transmission (24% reduction in Connexin-43 levels).

224 h loss of membrane and increased cytoplasmic connexin 43 localization.

225 Connexin 43 loss may provide insights into the developme

226 ced in individuals with glomerular diseases, connexin 43 may be a novel target for therapeutic treatm

227 These findings suggest that connexin 43-mediated communication between the retina an

228 ay require interenterocyte communication via connexin 43-mediated gap junctions.

229 Additionally, the connexin 43+/- mice showed less crescent formation, tubu

230 blocker) and selective connexin-43 blockers (connexin-43 mimetic peptides (43)Gap26 and (37,43)Gap27)

231 acted hypertrophic cardiomyocyte growth, and connexin 43 mislocalization caused by cnNfat3 expression

232 degrees C), followed by analysis of CE cell connexin-43 mRNA and protein by semiquantitative RT-PCR

233 Oxytocin receptor and connexin-43 mRNA expression were reduced in the myometri

234 CE cell connexin-43 mRNA levels in CNTF-treated and (rhCNTFRalph

235 of VIP protein and mRNA, N-cadherin (but not connexin-43) mRNA and protein, and the antiapoptotic Bcl

236 robust expression of cardiac alpha-actinin, connexin 43, myosin light chain 2a, alpha/beta-myosin he

237 We found that pYbeta1 colocalized with connexin-43, N-cadherin, and Nav1.5 at intercalated disk

238 About 10% of the basal keratinocytes are connexin 43 negative, as determined by flow cytometry.

239 ic compact region around the SAN artery with Connexin 43-negative pacemaker cardiomyocytes visualized

240 Astrocytic connexin-43 (now known as GJ1) has been implicated in ga

241 epithelial junction proteins (ss-catenin and connexin 43), of stromal keratocytes (CD34), of apoptosi

242 the MAP kinase-dependent phosphorylation of connexin 43 on serines 255, 262 and 279/282.

243 lloproteinase-9, collagen I/III, and reduced connexin 43 phosphorylation (P<0.05 versus WKY).

244 As connexin-43 phosphorylation recovered in the reperfused

245 ns of reports indicate that dysregulation of connexin 43 plays an important role in bladder overactiv

246 ssion of the MMP-7, CCND1 (Cyclin D1), CX43 (Connexin 43), PPAR-delta, and ITF2 genes in OEAs with de

247 Our findings indicate cyclin D1, MMP-7, connexin 43, PPAR-delta, and ITF-2, likely play importan

248 Connexin-43 processing by MMP-7 was confirmed by in sili

249 ation or cell death, while overexpression of connexin 43 promotes NPC self-renewal in the absence of

250 that JNK activation led to specific loss of connexin 43 protein and gap junctions without affecting

251 d the effects of ontogeny on connexin-32 and connexin-43 protein abundance in cerebral cortices of sh

252 We conclude that (1) connexin-32 and connexin-43 protein are expressed early in fetal life an

253 ocalization of E-cadherin, beta-catenin, and connexin-43, proteins necessary for the establishment of

254 t at E15.5 albino RPE cells have fewer small connexin 43 puncta, and a larger fraction of phosphoryla

255 markers for astrocytic cells and fibers and connexin 43 puncta.

256 Connexin 43 reboots meiosis and reseals blood-testis bar

257 ion at Cys(156), leading to cSrc activation, connexin 43 reduction, impaired gap junction function, a

258 In addition, while levels of connexin 43 remained unchanged, its relocalization from

259 hort hairpin RNA-mediated knockdown of Cx43 (connexin 43) retards the apically directed interkinetic

260 y also express cardiac gap-junction protein, connexin-43, similar to CMs and synchronized spontaneous

261 essed using live microscopy with oleamide or connexin 43 siRNA.

262 agonist, and pretreatment of astrocytes with connexin-43 small interfering RNA.

263 s blocked by carbenoxolone, Gap26/Gap27, and connexin-43 small interfering RNA.

264 nally, therapeutic treatment of GN mice with connexin 43-specific antisense oligodeoxynucleotide impr

265 Treatment of cultured podocytes with connexin 43-specific blocking peptides attenuated TGF-be

266 at was highly enriched in N-RAP, N-cadherin, connexin 43, talin, desmin, and alpha-actinin.

267 undergone by the fraction of plasma membrane connexin 43 targeted for macroautophagy and the sequence

268 RATIONALE: Downregulation of Cx43 (connexin 43), the major cardiac gap junction protein, is

269 lated disks, identified by immunostaining of connexin 43, the major protein of cardiac gap junctions.

270 actile proteins and the gap junction protein connexin 43 through cAMP/PKA signaling in human myometri

271 actile proteins and the gap junction protein connexin 43 through cAMP/PKA signaling in human myometri

272 demonstrate a novel mechanism of astrocytic connexin-43 to enhance spinal cord synaptic transmission

273 trol subjects and revealed redistribution of connexin-43 to lateral membranes in sepsis (P < 0.020).

274 igated whether nerve injury could upregulate connexin-43 to sustain late-phase neuropathic pain by re

275 RATIONALE: Delivery of Cx43 (connexin 43) to the intercalated disc is a continuous an

276 were subjected to immunostaining with ZO-1, connexin 43, type IV collagen, laminin-5, and perlecan,

277 GJA1, which encodes the gap junction protein connexin 43, underlie oculodentodigital syndrome.

278 Ralpha) and CNTF (0.83 nM) responsiveness in connexin 43 upregulation were monitored (Western blot an

279 on, or in cells carrying a dominant negative connexin 43 vector.

280 n be counteracted by forced up-regulation of connexin 43, via either gene transfer or proteasome inhi

281 the presence of c-Kit, CD34, Ano1, NTPDase2, connexin 43, vimentin, desmin, PDGFbeta receptor and mer

282 n analyses performed at 24, 72, and 144 hpi, connexin 43 was efficiently downregulated during HCMV in

283 Connexin 43 was expressed at this site from E15 onward,

284 n were reduced, and the gap junction protein connexin 43 was mislocalized to the lateral myocyte bord

285 increased atrial interstitial fibrosis, but connexin 43 was not affected.

286 The transmural distribution of connexin 43 was quantified with immunohistochemistry.

287 F stimulation leading to the upregulation of connexin-43 was demonstrated, and the effectiveness of r

288 ctural remodeling was prominent at 10 weeks: connexin-43 was downregulated and redistributed to later

289 redox-sensitive gap junctional protein Cx43 (Connexin 43) was reduced in the peri-infarct area of wil

290 ficant decrease in the gap junction protein, connexin 43, was observed in the N-cadherin-depleted hea

291 ripts, neural cellular adhesion molecule and connexin-43, was confirmed at the protein level, suggest

292 ern and function of the gap junction protein connexin 43 were examined in vivo in the rat at the inte

293 nd the gap junction proteins connexin 40 and connexin 43 were misexpressed and/or mislocalized in Lmn

294 Expression and distribution of connexin 43 were unaffected, but CAR(+)/(-) hearts displ

295 unction of the beta-catenin signaling target connexin-43 were down-regulated by FH535, and functional

296 eta-catenin and its effectors, cyclin D1 and connexin 43, were up-regulated in TSC-related angiomyoli

297 d in cardiac tissue sections by staining for connexin 43 (which is expressed in atrial tissue but not

298 lated expression of the gap junction protein connexin 43, which has been observed in the progression

299 y, they show convincing co-localization with connexin 43, which was not present in smooth muscle.

300 by gap junctions formed by proteins such as connexin-43, which allows the absorbed acid load to be t