ライフサイエンスコーパス: conopeptide

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1 n the genus Conus (known as "conotoxins" or "conopeptides").

2 which together define a new P-superfamily of conopeptides.

3 notably different from other Gla-containing conopeptides.

4 onses to hydroxylated versus nonhydroxylated conopeptides and the relative susceptibility of proteins

5 Conopeptides are encoded by a few gene superfamilies; he

6 roteins, mainly ion channels, the targets of conopeptides are less well known.

7 (V)1.2 and that further engineering of micro-conopeptides belonging to the KIIIA group may provide su

8 The four major A-conopeptide clades defined are consistent with the curre

9 A new 23AA conopeptide, conolysin-Mt has potent hemolytic activity

10 Here, we examined a panel of 11 mu-conopeptides for their ability to block rodent Na(V)1.1

11 ed a surprisingly diverse origin of alpha4/4 conopeptides from a single species, Conus bullatus.

12 By analysing several A-conopeptides from other Conus species recorded in GenBan

13 somally expressed polypeptide chains of four conopeptides from the venoms of Conus gladiator and Conu

14 v(O-TBDMS) was used for the synthesis of the conopeptide gld-V* from Conus gladiator.

15 We have also isolated analogous conopeptides (gld-V and mus-V) containing d-Val instead

16 because (i) they are not constrained as most conopeptides, (ii) they are extremely short in length, (

17 he first example of the new mini-M branch of conopeptides in the M superfamily.

18 at are functionally linked to the targets of conopeptides) is another determinant of the elicited beh

19 Opioid receptor screening of a conopeptide library led to a novel selective kappa-opioi

20 This conopeptide, like a previously characterized peptide in

21 selection; the magnitude depends on which A-conopeptide lineage and amino-acid locus is analyzed.

22 ustelinus, conolysin-Mt, we expand the known conopeptide mechanisms to include association with and d

23 inding site for the N-channel-specific omega-conopeptide MVIIA, but also a distinct high-affinity sit

24 istinct high-affinity site for another omega-conopeptide (MVIIC), which affects both N- and P/Q-chann

25 We identified a small conopeptide of only four amino acids from the venom of C

26 Conopeptides possessing the Ser-d-Hyv-Trp motif have bee

27 o-conotoxin KIIIA is representative of micro-conopeptides previously characterized as inhibitors of t

28 nderstanding of the mechanisms by which four conopeptides produce different behaviors in mice.

29 The 19-amino acid conopeptide (rho-TIA) was shown previously to antagonize

30 The ability to manipulate a mu-conopeptide's affinity and efficacy, as well as its capa

31 More than 90 conopeptide sequences from 11 different Conus species we

32 The panel of mu-conopeptides should be useful in identifying the functio

33 he venom of Conus purpurascens, is the first conopeptide shown to inhibit the Shaker K(+) channel.

34 C-PrXA is strikingly different from the many conopeptides shown to be nicotinic antagonists; it is mo

35 In summary, we identified a conopeptide that targets the nociceptor-specific ion cha

36 s might help improve the design of analgesic conopeptides that selectively "avoid" nAChR receptors wh

37 and Conus ferrugineus, define a new class of conopeptides, the conopeptide Y (CPY) family.

38 to help identify the allosteric site for rho-conopeptide TIA, an inverse agonist at this receptor.

39 n and alkylation enables cysteine-containing conopeptides to be ascertained.

40 Four conopeptides were initially isolated, gld-V/gld-V'from t

41 ypeptides stabilized by disulfide bonds, and conopeptides, which have no or only one disulfide bond.

42 eptides provides a guidepost for identifying conopeptides with potentially novel functions.

43 eus, define a new class of conopeptides, the conopeptide Y (CPY) family.

44 rmatic tools, we found the highest number of conopeptides yet discovered in a single Conus specimen,

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