ライフサイエンスコーパス: consanguinity

1 n of Pakistani origin could be attributed to consanguinity.

2 ded if they had a family history of parental consanguinity.

3 sity in some individuals reflect substantial consanguinity.

4 and above that predicted by simple models of consanguinity.

5 f cognitive impairment, or family history of consanguinity.

6 om a large French-Canadian family with known consanguinity.

7 osomes suggested this finding was not due to consanguinity.

8 xtended Iranian families with high degree of consanguinity.

9 s demonstrated a marked increase of parental consanguinity (63%), compared with the general Iranian p

10 amilies enriched for inherited causes due to consanguinity and find familial ASD associated with bial

11 We investigate the effects of consanguinity and population substructure on genetic hea

12 nfirm and understand the association between consanguinity and serious cognitive disability.

13 The specific genetic diagnosis, consanguinity, and severe clinical course are associated

14 that in small populations with high rates of consanguinity, as compared with large outbred population

15 Along with the effects of gene drift and consanguinity, assortative mating also may have played a

16 SNP genotyping identified unknown ancestral consanguinity by detecting three autozygous regions.

17 s found in a large Lebanese family with high consanguinity, drastically inhibited this interaction by

18 with early-onset parkinsonism and confirmed consanguinity followed by data mining in the exomes of 1

19 kistani families with documented or probable consanguinity, from the city of Lahore and surrounding a

20 Our family studies show a high degree of consanguinity, highlighting the increased risk of iron o

21 Because of consanguinity in both families, we used whole-exome sequ

22 ited in 30%, and almost 60% had a history of consanguinity in both groups.

23 with a minimum of two affected offspring and consanguinity in most of the parental generation and map

24 regions in the genome may indicate levels of consanguinity in the individual's family lineage.

25 hy in a 16 year-old child with no history of consanguinity in the parents revealed a sickle S trait a

26 ations were homozygous recessive, reflecting consanguinity in these families.

27 he mutation profile attests to the impact of consanguinity in these families.

28 .9% of patients, reflecting the high rate of consanguinity in this cohort.

29 Consanguinity is a major risk factor for congenital anom

30 Consanguinity is a serious concern that leads to the hig

31 n in the Middle East and North Africa, where consanguinity is common often resulting in identical mut

32 developed countries, where the prevalence of consanguinity is high in many areas, and both genetic an

33 Parental consanguinity is present in three families.

34 that autozygosity (a genomic consequence of consanguinity) may be a factor in cancer predisposition.

35 Despite an absence of any history of consanguinity, microsatellite analysis showed shared gen

36 e results, however, were not consistent with consanguinity of the parents, who appear to have indepen

37 ssive (n=117, 81%), consistent with the high consanguinity of the study cohort, but also X-linked (n=

38 ents dealing with the deleterious effects of consanguinity on recessive disorders and consider how ot

39 In rural areas, consanguinity (OR = 15.13, 95% CI: 3.08, 74.30) and land

40 ms, had a familial history of the disease or consanguinity, or had a congenital onset were excluded.

41 lenecks) and recent ancestry events (such as consanguinity) play an important role in patterning vari

42 y descent as the result of processes such as consanguinity, population size reduction, and natural se

43 In Pakistan, consanguinity rates are notably high.

44 Measured consanguinity rates were an order of magnitude above tho

45 ly covered by public databases and have high consanguinity rates.

46 arious pedigree structures, with and without consanguinity relationship, and allows missing alleles t

47 iatric organ donor, factors such as parental consanguinity should prompt physicians to acknowledge th

48 Familial occurrence and consanguinity suggest autosomal recessive inheritance of

49 As parental consanguinity suggested an autosomal recessive mode of i

50 single sibships, as well as the presence of consanguinity, support an autosomal recessive mode of in

51 We found that despite the high levels of consanguinity that characterize UAE, this population is

52 prevalence in populations with high rates of consanguinity, then determining whether disease cases ar

53 n that among populations with a high rate of consanguinity, there is a significant increase in the pr

54 Several studies link consanguinity to higher rates of cancer, suggesting that

55 The tradition of consanguinity, variably practiced in the Persian Gulf re

56 Consanguinity was associated with a doubling of risk for

57 Empirically testing for ancestral consanguinity was effective in localizing the causative

58 searching for evidence of unknown ancestral consanguinity, we identified two autozygous intervals, c

59 icient severe combined immunodeficiency, and consanguinity were associated with worse outcome but tha

60 Four patients from families with parental consanguinity were subjected to homozygosity mapping tha

61 rt a patient of Indian descent with parental consanguinity, who developed 10 carcinomas and 35 adenom