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2 onal disorder due to protein misfolding with consequent aberrant intermolecular protein aggregation.
3 design and assessment are possible, and the consequent ability to precisely abrogate specific MMP ac
4 severe defects in stress fiber assembly and consequent abnormalities in cell morphogenesis, polarity
5 we show that KLLN interacts with DBC1, with consequent abrogation of DBC1 inhibition of SUV39H1, a H
6 ) signaling causing hyperphosphorylation and consequent accumulation of 4E-BP1, along with greater ce
7 on of the pVHL tumour suppressor protein and consequent accumulation of the HIF-2alpha transcription
8 ts associated focal adhesion complex and the consequent acquisition of adhesive properties by the cel
9 ed for promoting invadopodium maturation and consequent actin polymerization, matrix degradation, and
10 induction of E2F1 mRNA translation with the consequent activation of c-Myc and cell proliferation.
11 de stimulation of striatopallidal axons with consequent activation of inhibitory collaterals and redu
12 ces a constitutive lysosomal association and consequent activation of mTORC1 in chondrocytes, the cel
13 ohort of sensory neurons via ATP release and consequent activation of P2X2 and/or P2X3 purinergic rec
14 ous thrombosis (VT) due to slow flow and the consequent activation of the endothelial cells (ECs) lin
16 ed neural stem cell (NSC) self-renewal, with consequent age-dependent depletion, neurogenesis defects
17 nd use, they have focused on the masking and consequent alteration of acoustic signals and cues; so-c
24 ur of the paediatric RCC in our case and the consequent atypical imaging findings are distinctly unus
28 suggest that widespread increases in DOM and consequent browning of surface waters reduce the potenti
32 induce intracellular Na and Ca overload with consequent CaMKII activation enhancing late INa and the
33 1 and HLA-B calibrate NK education and their consequent capacity to eliminate HIV-infected cells.
36 evolution is necessarily constrained by the consequent challenge to protein folding and function.
37 global change on ecosystem C fluxes and the consequent changes in C storage, we have conducted a fie
38 mutants for specific polarity proteins, with consequent changes in protrusion form and position and a
40 sharply during the latest Katian time, with consequent changes in the extent of the oxygen minimum z
41 C)n trinucleotide repeats (n = 1, 4) and the consequent changes in the overall structure of the RNA a
42 cer cells, leading to mitotic DNA damage and consequent chromatin bridges and lagging chromosomes in
43 ulation of pericentric heterochromatin, with consequent chromosomal instability manifested by increas
44 the brain, progressive neurodegeneration and consequent cognitive and behavioral deficits that typify
48 NBDs in a two-stroke cycle and elucidate the consequent conformational motion that reconfigures the T
49 such as anomalous seawater temperatures and consequent coral bleaching and mortality influence these
51 nterpretation of these lithium gradients and consequent crystal thermal histories that raise concerns
53 ween cell types can significantly impact the consequent cytokine environment, emphasizing the value o
54 und-guided fine needle aspiration biopsy and consequent cytopathological examination that included im
57 ifically hydrolyzed its cleavage sequence, a consequent decrease in the fluorescence intensity of the
58 austion of late cortical progenitors and the consequent decrease of neurogenesis together with the im
61 tive pathway activation of macrophages, with consequent decreased NO expression and/or by poor granul
64 causes endocytosis, lysosomal targeting and consequent degradation of GluA2- and GluA3-containing AM
65 in oxygen and glucose deprivation (OGD) and consequent delayed cell death of vulnerable neurons, wit
66 ponse to the photoreceptor loss and in their consequent dendritic restructuring.SIGNIFICANCE STATEMEN
67 undergone considerable genome reduction with consequent dependence on host biosynthetic pathways, met
68 In addition, hepatocyte ATX ablation and the consequent deregulation of lipid homeostasis was also sh
69 ifies aberrant R-spondin/LGR4 signaling with consequent deregulation of Wnt (co)receptor turnover as
70 binding transcriptional repressor, RBPJ, and consequent derepression or activation of associated gene
71 f noninvasive tests must take in account the consequent diagnostic testing, invasive procedures, clin
72 ncrease in alkalinity of the seawater with a consequent DIC increase due to CO2 invasion, thus confir
75 tin assembly around the myocardial cells and consequent disorganization of the myocardial epithelium.
77 f a Nox2 dependent Src/PI3K/Akt axis, with a consequent disruption of a Beclin1-VPS34 interaction tha
78 te discrete sites for Ca(2+) interaction and consequent disruption of salt bridges in the open hemich
79 impairs inhibitory synapse development with consequent disruptions in hippocampal network activity a
80 esized to facilitate parasite egress and the consequent dissemination of released merozoites througho
81 ion and reduced cellular glucose uptake with consequent diversion of acetyl-CoA into ketogenesis.
82 ts in its nuclear export for degradation and consequent down-regulation of FOXO3a-target autophagy-re
86 des litter particle size and shape and their consequent effect on fuel bed structure, ventilation and
88 es of the nascent RNA binding properties and consequent effects on the Rho-dependent termination func
94 e selective elimination of mutant mtDNA, and consequent enrichment of wild-type mtDNA, can rescue pat
95 ation of NKA into a lipidic cubic phase with consequent enzyme functionality and stability evaluation
96 ion of the intestinal epithelial barrier and consequent escape of microbial products may be one of th
97 y devoted to encode external threats and the consequent escape; a process that, if disrupted, may com
98 calized chromatin reconfiguration by HSI and consequent establishment of an adjacent domain of noncod
100 an trigger endoplasmic reticulum stress with consequent exposure of the "eat-me" signal calreticulin
105 ation of CD8(+) T cells in the pancreas, and consequent glucose intolerance observed in the context o
107 taxel more efficiently into tumor cells with consequent greater antitumor efficacy and less systemic
108 ocean salinity for exoplanetary climate and consequent habitability and the need for its considerati
109 of imaging, thus increasing misdiagnoses and consequent harm while offering no compensating benefits.
110 w that NKG2D contributes to liver damage and consequent hepatocyte proliferation known to favour tumo
111 des a new model of acute protoporphyria with consequent hepatocyte protein aggregation and proteotoxi
112 the glass transition, and that there may be consequent heterogeneities in the resulting glasses.
113 findings establish primary ciliogenesis and consequent Hh signaling as a key mechanism by which MaSC
116 ormal fluid flow intensity and pattern, with consequent impact on dand5 expression pattern and left-r
119 s, in addition to the acute brain injury and consequent impairment, ischemic stroke may also be assoc
120 emostasis or to augment thrombosis risk with consequent implications for myosin's possible contributi
121 ual differences in food availability and the consequent importance of information transfer, and/or th
123 ise in astrocytic Na(+) concentrations and a consequent increase in astrocytic Ca(2+) through Na(+)/C
125 es the dissociation of Ago2 from PICK1 and a consequent increase in dendritic miRNA-mediated gene sil
129 nduced mitochondrial hyperpolarization and a consequent increase in mitochondrial calcium (Ca(2+)) ac
130 ctivation from excess lysine acetylation and consequent increase in negative DNA supercoiling is an i
133 e of D2R on cholinergic interneurons and the consequent increase of acetylcholine signaling on striat
135 t of differential SLCO2B1 expression and the consequent increased uptake of DHEAS and subsequent resi
137 growing season with higher temperatures, and consequent increases in terrestrial C sink strength, may
138 Rtp801 triggers nuclear factor kappaB and consequent inducible NOS (iNOS)-mediated overproduction
139 cellular carcinoma, SIRT6 downregulation and consequent induction of ANXA2 were critical for UBE3A-me
140 ation of the transcription factor DMRT1, and consequent induction of Stra8 expression, is required fo
141 from a specific sigma(28)-RNAP promoter and consequent induction of the hummingbird phenotype in the
142 polyubiquitination and degradation, and the consequent inefficient assembly of the FA core complex,
143 arance of mucus from the lungs and treat the consequent infection, in combination with correction of
145 Parasitized erythrocyte sequestration and consequent inflammation in the placenta are common attri
148 rotein kinase C-epsilon (PKCepsilon) and the consequent inhibition of insulin receptor (INSR) kinase
149 ar IkappaBalpha (also known as NFKBIA), with consequent inhibition of NFkappaB transcription factor a
150 s well as activation of pulmonary Rtp801 and consequent iNOS/NO-induced nitration of lung proteins, t
152 tact with the basal extracellular matrix and consequent integrin-Src signalling is a key determinant
153 nce of rHSA facilitated duplex annealing and consequent interaction that allowed in vivo studies usin
154 vascular disease in rice, on rice plants and consequent interactions with a rice herbivore, brown ric
156 tracellularly via electron shuttles, and the consequent ion migration led to high anode salinities an
160 and volume of the developing brain, and the consequent lack of suitable algorithms for fetal brain i
161 teristic feature of a 2D system undergoing N consequent Lifshitz topological transitions is the occur
164 om endothelial-to-mesenchymal transition and consequent liver fibrosis in mice via a SMAD3-dependent
165 factors to cognate sites in the genome, with consequent local acquisition of DNA methylation, and the
166 nsumption, freshwater eutrophication and the consequent local and global biodiversity impacts with Sw
167 otic-mediated microbiota destruction and the consequent loss of colonization resistance can result in
168 despread crisis in neuroimaging research and consequent loss of credibility in the public eye, we nee
171 lipase C that cleaves and releases uPAR with consequent loss of function, whereas its homologue GDE2
175 d of the second dimension separation and the consequent loss of peak capacity due to under sampling o
179 e spatially localized, long-range forces and consequent matrix alignment to navigate through the ECM.
184 t deficiency in mitochondrial biogenesis and consequent mitochondrial bioenergetic defect could contr
185 ganization of the actin filament network and consequent mitochondrial dysfunction through altered Drp
186 e speed of pCPI-17 dephosphorylation and the consequent MLCP activation during muscle relaxation.
187 RAGE ligand-mediated signal transduction and consequent modulation of gene expression and cellular pr
188 y tunes the GPCR-G protein interaction, with consequent modulation of second messenger signaling for
194 omised by short half-lives of drugs with the consequent need for multiple daily injections that reduc
195 been identified before clinical trials, with consequent negative effects on the fate of new potential
198 ide groove obscuring tryptophan residue, and consequent opening up of the binding site for interactio
199 nd heterogeneous BBS clinical phenotypes and consequent oral comorbidities confound oral health manag
200 ssue-specific chromatin loop formation, with consequent organ-specific deficiency of PMM2 leading to
201 dentified that aberrant NOTCH2 signaling and consequent osteoclast hyperactivity are closely associat
202 least 28 plant species and that there was a consequent overall reduction in pollen transport at lit
204 fluenced chloroplast electron transport with consequent overreduction of plastoquinone and donor-side
205 We also identified a role of CYP450 and consequent oxidative ER stress signaling in these effect
206 te bone formation on their surface and their consequent perfect integration with the surrounding tiss
207 e-specific system followed by observation of consequent phenotypic changes and visualization of linke
208 significantly contributes to activating the consequent phosphoinositide 3-kinase (PI3K)/Akt signalin
210 ed miR-223 suppressed RhoB and inhibited the consequent phosphorylation of myosin phosphatase target
211 bending of the S6 transmembrane segment and consequent pore dilation, displacement, and deformation
217 with distinct electronic configurations and consequent prediction of unique reactivity and magnetic
219 us, the splicing history of an mRNA, and the consequent presence or absence of EJCs, affects its leve
222 , we showed that the methylation of H3K4 and consequent promoter nucleosome deacetylation repress ste
224 otein termini allow rapid bioconjugation and consequent purification through complexation with immobi
226 oxyhydroxide surface layer is observed, with consequent pyrite dissolution rates reduced by more than
229 nscriptional suppressor CREM by IFN-beta and consequent recruitment of histone deacetylases to the IL
230 ncrease in glomerular heparanase expression, consequent reduction in heparan sulfate expression and e
232 t problems without high-level evidence for a consequent reduction in the incidence of subsequent hear
234 ting in further accumulation of ceramide and consequent reduction of surface sphingosine, a lipid tha
235 that this effect upon neutrophils results in consequent reductions in inflammatory monocyte expressio
237 at this effect, at least in part, results in consequent reductions in the inflammatory status of athe
238 ficits lead to sharply reduced JH levels and consequent reductions of ovary size, egg production, and
242 ver, thiazide-mediated inhibition of NCC and consequent restoration of sodium excretion did not immed
244 pends on the firing of action potentials and consequent rises of intracellular calcium activity ([Ca(
245 gly incorporated in various food items, with consequent risk of hypersensitivity reactions that are o
247 ntail subsequent desalting methodologies and consequent sample losses and are incompatible with ortho
252 been associated with barrier impairment and consequent skin disorders, and it is therefore important
255 g the like-charged soluble macroions and the consequent spontaneous, reversible formation of blackber
256 for reduced H3R2me2a binding, and found that consequent Srcin1 induction in the NAc decreases Src sig
257 ld promote the degradation of tankyrases and consequent stabilization of Axin to antagonize Wnt signa
259 d the premature expression of Cdkn2a and the consequent stabilization of p53, an effector of the pre-
261 ess whether B-Raf/MEK/ERK inhibition and the consequent suppression of DR5 expression impede cancer c
262 isrupts activity-dependent signaling and the consequent synapse development, maturation, and refineme
263 tream target of mTORC1 whose translation and consequent synaptic protein expression are increased in
264 eral, nonspecific change in space perception consequent the illusion, we also assessed peripersonal s
266 ic 17 and T-follicular helper paradigms with consequent thymic damage and impaired donor antigen pres
267 stent elevation of microglial reactivity and consequent TNFalpha secretion induces mitochondrial stre
268 arcinogenesis in a subset of colon cancer is consequent to a molecular mechanism driven by fucosylati
269 psilateral to TN, and (2) this asymmetry was consequent to an increased estimated potential of sensor
270 rding means of monitoring CDK4 hyperactivity consequent to cancer-associated molecular alterations in
273 e Na(+) channel alpha subunit, can be partly consequent to disrupted intracellular Ca(2+) homeostasis
274 e Na(+) channel alpha subunit, can be partly consequent to disrupted intracellular Ca(2+) homeostasis
275 is study investigates epigenetic alterations consequent to experimental murine colitis induced by dex
277 tric oxide deficiency state and vasculopathy consequent to intravascular hemolysis, (2) chronic pulmo
279 investigated whether a lack of fucosylation consequent to loss of GDP-fucose synthesis contributes t
281 phin-1-treated mesenchymal stromal cells was consequent to signal transducer and activator of transcr
282 igid, probably through osmotic dysregulation consequent to the disruption of the parasite's sodium ef
287 of calcineurin/NFATc4 signaling pathway and consequent TRPC6 up-regulation in PASMCs, while these in
289 t with, and induce rapid phosphorylation and consequent ubiquitin-mediated degradation of, transcript
290 derestimation of infectious disease risk and consequent underinvestment in preparedness and response
292 s against ER luminal protein aggregation and consequent unfolded protein response hyperactivation and
294 nalyses revealed that LATS1 inactivation and consequent up-regulation of its reciprocal effector Yes-
295 1-a master transcription factor for ICCs-and consequent up-regulation of v-kit Hardy-Zuckerman 4 feli
297 shown that chronic GPCR stimulation and the consequent upregulated interaction between the G-protein
299 s obviates the need for hapten labelling and consequent use of capture and reporter antibodies, whils
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