ライフサイエンスコーパス: conserve

1 the functional role of this splicing is also conserved.

2 -associated role of individual miRNAs is not conserved.

3 se of respiratory enzymes in leaves could be conserved.

4 the photons involved in the processes to be conserved.

5 sequence and function of Domain 2 are highly conserved.

6 g target recognition and cleavage are highly conserved.

7 n for NA in cell migration is evolutionarily conserved.

8 likely that the disulfide linkages are also conserved.

9 slowly translated codons and evolutionarily conserved.

10 membrane domain, and contains the absolutely conserved (679)LWYIK/R(683) sequence, proposed to embody

11 Canonical IN types conserved across distinct cortical regions have been def

12 BM25) is a putative splicing factor strongly conserved across eukaryotic lineages.

13 c processes were clearly site-specific, were conserved across species, and could be confirmed by diff

14 ired for the claustrum appears to be broadly conserved across species, despite various differences th

15 in a basophilic kinase motif that is highly conserved across species.

16 and kinetics of NTD self-assembly are highly conserved across spider species despite the different si

17 nct epigenetic methylation patterns that are conserved across tissues, rendering these CpGs novel epi

18 70%) revealed that the PNTs are both highly conserved across vertebrates and highly expressed across

19 Expression of a highly conserved, alkaline-regulated, sodium ATPase was toleran

20 uggest that pTRS1 inhibits PKR by binding to conserved amino acids in the PKR eIF2alpha binding site

21 nd we show that it is controlled by a set of conserved amino acids that couple RNA and ATP binding to

22 minus of Arabidopsis thaliana KNL2, which is conserved among a wide spectrum of eukaryotes.

23 Conserved among animal mRNAs, IRE-RNA structures are non

24 ed targets, and their CArG-boxes were widely conserved among Brassicaceae species.

25 strategies aimed at targets that are highly conserved among individual patients, treatment at the ge

26 requires a group of proteins that are highly conserved among poxviruses, including A6 and A11 of vacc

27 issense mutations changed essential residues conserved among Schizosaccharomyces species.

28 y-five percent of these eliminated genes are conserved among these nematodes, defining a core set of

29 the compact structure between ZFs 3 and 4 is conserved and enriched in other long poly-ZF proteins.

30 Mapping of conserved and nonconserved residues between K1-K10 and K

31 if near the N terminus as well as a strictly conserved arginine residue toward the C terminus of ORF5

32 r functions and autophagy are evolutionarily conserved arms of cell-autonomous immunity that restrict

33 -H...pi interaction between the ligand and a conserved aromatic residue in the ligand-binding pocket.

34 ciated with cyanobacterial blooms is largely conserved at the phylum level, with Proteobacteria (beta

35 nts show that the Ml proteins studied bind a conserved AT-rich site in the promoter region of the exo

36 Its development involves conserved basic mechanisms of induction and patterning,

37 Coat components are structurally conserved between COPI and clathrin/adaptor proteins.

38 protein homeostasis, and ClpP proteases are conserved between eubacteria and the organelles of eukar

39 Although some of the NMD machinery is conserved between kingdoms, little is known about its ev

40 Ube3a isoform 2 is conserved between mouse and human and known to play key

41 gion facilitates a dimerization mode that is conserved between PEAK1 and pragmin.

42 tude median response to Gagp24 regions, more conserved between prime and boost, compared to those of

43 b-type hemes through the histidine residues conserved between the MsrQ and NOX protein families.

44 ites revealed that acylsugar assembly is not conserved between tomato and petunia.

45 terooligomers coexist, and suggests that the conserved binding surface of Vpu TMD has been selected f

46 A conserved biochemical function of the CST complex is its

47 hydroxyketone rearrangement is potentially a conserved biosynthetic reaction in this molecular class.

48 iously reported for RBCs at 4 degrees C were conserved but accelerated with increasing temperature.

49 f m(6)A addition not only are evolutionarily conserved but also enhance virus replication.

50 omains 'locked' together is stabilized via a conserved C-terminal arm, which may interact with the po

51 In lipoxygenases, the topologically conserved C-terminal domain catalyzes the oxidation of p

52 The polymerase component, which contains a conserved C-terminal structural loop, preferentially bin

53 Ntn-hydrolase fold, a putative S1 pocket and conserved candidate catalytic residues Thr1, Asp17 and L

54 s that inhibit multiple HKs by targeting the conserved catalytic and ATP-binding (CA) domain.

55 n, the alphaC fragment is unable to form the conserved catalytic interface that was thought to be ess

56 lasmic reticulum stress is an evolutionarily conserved cell stress response associated with numerous

57 for mTORC1 activation by cholesterol through conserved cholesterol-responsive motifs.

58 hromatin protein 1 (HP1) family proteins are conserved chromatin binding proteins involved in gene si

59 godendrocyte-restricted lncRNAs, including a conserved chromatin-associated lncOL1.

60 g of cilia from diverse eukaryotes defines a conserved ciliary proteome, reveals ancient connections

61 The conserved COE-type terminal selector UNC-3 not only cont

62 nding protein 1]) and dynamic recruitment of conserved combinatorial associations of additional regul

63 extended 150-loop of the H15 HA retains the conserved conformation as in H7 and H10 HAs.

64 studies definitively rule out a role for all conserved consensus PKA phosphorylation sites in alpha1C

65 try into epithelial cells is mediated by the conserved core fusion machinery, composed of the fusogen

66 th these effects, we also found that several conserved (core) baculovirus proteins closely associate

67 with the R domain of FisR through the three conserved cysteine residues (C53, C64 and C71), FisR act

68 hionine methyltransferase requiring only two conserved cysteine residues.

69 tinct boundary between them, focusing on the conserved cytokinesis midzone proteins Prc1 and Kif4A.

70 ted mutations revealed the importance of the conserved DDE motif and a W residue.

71 Our analyses reveal that a conserved diacidic motif (Asp-Glu) in these proteins is

72 of Tim10 is accelerated by the disruption of conserved disulfide bonds within the substrate.

73 functional significance of this evolutionary conserved diversity remains poorly understood.

74 and p.R213P) predicted to affect the highly conserved DNA binding domain.

75 CMTs are evolutionary conserved DNA methyltransferases in Viridiplantae.

76 n assay was developed to show that a unique, conserved domain at the C-terminus of Swc5, called Bucen

77 findings shed light on a novel role for this conserved domain in providing the necessary stability to

78 targets, show that relatives exhibit highly conserved drug binding sites.

79 is-PTs) constitute a large family of enzymes conserved during evolution and present in all domains of

80 and their binding sites in target genes are conserved during evolution.

81 or positions can distinguish homologs with a conserved dynamic pattern and optimal catalytic activity

82 ta, and found that, except for few mammalian conserved editing sites, editing is significantly higher

83 The results also highlight unique as well as conserved elements in the PAR-binding pocket that can se

84 o, the interplay of structurally differently conserved elements in this protein likely reflects an in

85 This functionally conserved epitope is a potential target for vaccines aga

86 nsgenic approaches demonstrate that a highly conserved ERG-bound enhancer located upstream of HLX (wh

87 The chromosomal passenger complex (CPC) is a conserved, essential regulator of cell division.

88 Muniscins are a conserved family of endocytic adaptors, including Syp1 i

89 atterning of membrane proteins is a commonly conserved feature across diverse protein families (revie

90 channel structure by substituting the highly conserved first arginine residue in transmembrane segmen

91 We found that LFY and AP1 are conserved floral regulators that act nonredundantly in C

92 despite the apparent surface uniformity and conserved fold of SH3 domains, they display different bi

93 The translocation mechanism is likely conserved for other AAA+ ATPases.

94 d for ubiquitous profiles, and may be mildly conserved for the neuronal profiles.

95 However, the genetic interactions were not conserved for ubiquitous profiles, and may be mildly con

96 last residue of post-M4 and Phe(170) of the conserved FPF sequence of the Cys loop, and that these i

97 omologous recombination (HR) protein that is conserved from bacteriophage to humans.

98 a Y/F-x-x-Y/L/F-x-Y/F motif, evolutionarily conserved from the first tetrapods to man, that is cruci

99 activated protein kinase (MAPK) pathways are conserved from yeast to man and regulate a variety of ce

100 all non-coding RNAs that have evolutionarily conserved function in mobile genetic element (transposon

101 , suggesting that bactericidal activity is a conserved function of the RELM family.

102 f rRNA and tRNA genes, and the occurrence of conserved functional domains.

103 As a result, such conserved functional modules can be identified through c

104 (2) They, predictably, tend to avoid conserved functional regions, such as exons, but, somewh

105 indicating that immune responses to the more conserved fusion protein contribute to protection agains

106 Here we report that conserved GA repeat cis elements within the bidirectiona

107 An evolutionarily conserved Galpha-GPR-1/2(Pins/LGN)-LIN-5(Mud/NuMA) corti

108 lls, spindle orientation is regulated by the conserved Galphai-LGN-NuMA complex, which targets the fo

109 significantly associated with evolutionarily conserved genes suggesting selection of specific alleles

110 linkage between traits within species and a conserved genetic basis across species.

111 By manipulating the highly conserved -GH- residues in the CGHC active site of PDI,

112 The conserved Glu residue at position 5 (E5) of mature (pseu

113 We have now identified a highly conserved glutamate residue in the transmembrane region

114 eriplasm of bacteria is mediated by a highly conserved heterotrimeric membrane protein complex denote

115 Unlike other GMC enzymes, the conserved His447 is not the catalytic base that deproton

116 ysis, we demonstrate that the evolutionarily conserved human CDC73 N-terminal 111 residues form a glo

117 x, showing IncE bound to a unique and highly conserved hydrophobic groove on SNX5.

118 Several MIPs are conserved hypothetical proteins and may be involved in r

119 dent activation of lung macrophages toward a conserved hypoxia program, with the development of compa

120 fibrinogen, into a polymeric fibrin clot, is conserved in all vertebrates.

121 named conoid protein hub 1 (CPH1), which is conserved in apicomplexan parasites.

122 ain of CaV1 LTCC alpha1 subunits that is not conserved in CaV2 or CaV3 voltage-gated Ca(2+) channel s

123 We have cloned both; while highly conserved in domain organization they display just 31% a

124 Vps13 proteins are conserved in eukaryotes, but their molecular function re

125 ause the heme biosynthesis pathway is highly conserved in eukaryotes, this finding, as we show in our

126 receptors on T cells, and this regulation is conserved in human T cells.

127 It is highly conserved in many non-vertebrate taxa and may protect ce

128 The homeotic (Hox) genes are highly conserved in metazoans, where they are required for vari

129 Since the ten Cys residues are highly conserved in Meteorin and Cometin, it is likely that the

130 on in the stalk domain, where 66Y was highly conserved in N1 NAs.

131 stem cell-mediated regeneration that may be conserved in other adult stem cell niches.

132 ons in Kir1.1 suggest that this mechanism is conserved in other Kir channels.

133 sis revealed that SDH3 and SDH4 lack helices conserved in other organisms.

134 on in the maturation of FeS proteins that is conserved in plants, and is closely allied to the functi

135 n the promoters of both these gene sets, and conserved in SARD1 orthologs within the Brassicaceae.

136 get sites fall within two domains, which are conserved in sequence/structure indicating their importa

137 It is conserved in the alphabaculoviruses and expressed at hig

138 Genome packaging is strongly conserved in the complex double-stranded DNA viruses, in

139 terns and RFRP-3/GnRH cross-talk are largely conserved in the NMR brain, with the exception of the un

140 protein that we term BciE, encoded by a gene conserved in these organisms.

141 TD Ser2 residues at 5' ends of genes that is conserved in yeast.

142 Our study underscores an evolutionarily conserved interaction between lentiviruses and primate i

143 licits potent T cell responses toward highly conserved internal Ags while simultaneously inducing hig

144 Autophagy is a conserved intracellular degradation pathway and has emer

145 Autophagy is an evolutionarily conserved intracellular degradation/recycling system tha

146 Bimodal exons are flanked by more conserved intronic sequences harboring distinct cis-regu

147 y of sodium channels, and while it is highly conserved, it is not known whether the functional role o

148 zing CRISPR-induced allelic variation in the conserved kinase domain of MPK6.

149 lation of the Ctf19 kinetochore protein by a conserved kinase, DDK, provides a binding site for the S

150 generated recombinant versions of two highly conserved Leishmania proteins, Leishmania (Viannia) braz

151 PI(3,5)P2 is generated from PI3P by the conserved lipid kinase Fab1/PIKfyve.

152 iacylglyceryl transferase (Lgt) recognizes a conserved lipobox motif within the prolipoprotein signal

153 investigated the expression patterns of the conserved lncRNAs at different time points during rat br

154 We find that TOP2A cleavage has functionally conserved local sequence preferences, occurs in cleavage

155 e amino acid substitutions lie in two highly conserved loop regions of uS12 with known roles in maint

156 UBE3A ubiquitylated the highly conserved Lys160 residue on SIRT6.

157 Here, we report that the conserved lysine residue 714 in the ErbB4 ICD undergoes

158 We investigated how Sirtuin 1 (SIRT1), a conserved mammalian NAD(+)-dependent protein deacetylase

159 Ultimately, conserving many of these species necessitates a paradigm

160 AMPK is a highly conserved master regulator of metabolism, which restores

161 unctions and may represent an evolutionarily conserved means to ensure proper programming of CD8(+) a

162 Mismatch repair (MMR) is a conserved mechanism exploited by cells to correct DNA re

163 l, our study describes a hitherto unreported conserved mechanism of transcription of genes with methy

164 pecific control of MT glutamylation may be a conserved mechanism to specialize the form and function

165 , Mlh1-Mlh2, specifically interacts with the conserved meiotic Mer3 helicase, which recruits it to re

166 ed by criss-crossing of the S6 segments at a conserved Met.

167 Among these, the conserved metabolic and developmental regulator ESRRA wa

168 Animal lifespan is regulated by conserved metabolic signalling pathways and specific tra

169 Functional knowledge has been gained for its conserved methylated DNA binding N-terminal ZF region; h

170 This premature stabilization requires the conserved microtubule-binding Ska complex, which enriche

171 Furthermore, we identified conserved miRNA-targets regulations in the control of do

172 ondrial targeting of Vms1 is mediated by its conserved mitochondrial targeting domain (MTD), which, i

173 The conserved modification N(6)-methyladenosine (m(6)A) modu

174 a (Hsp70s), a class of ubiquitous and highly conserved molecular chaperone.

175 cretion and have uncovered an evolutionarily conserved molecular link between intracellular Ca(2+) le

176 and fission yeast systems illuminates highly conserved molecular mechanisms of how cohesin and conden

177 receptor families essential for recognizing conserved molecular motifs characteristic of pathogenic

178 Axons in BMMC-treated rats exhibited a more conserved morphological appearance than those in nontrea

179 terize genome-wide methylation and highlight conserved motifs across three Trichodesmium isolates and

180 n analysis of the exon-intron structures and conserved motifs provided further insight into the evolu

181 he beta-barrel assembly machinery (BAM) is a conserved multicomponent protein complex responsible for

182 It is an evolutionary conserved multifunctional protein localized primarily in

183 ound partner proteins, suggesting the highly conserved nature of 14-3-3 affects the structures of man

184 , membrane-associated proteins including the conserved Ndc1 encircle the SPB and retain it within the

185 Biogenic amines, such as like serotonin, are conserved neurotransmitters that regulate behavior and m

186 Here, we identified the conserved NK-2 homeobox gene ceh-24 to be crucially requ

187 ion suggested a cis-regulatory mechanism via conserved noncoding elements or enhancers.

188 Catalytic activity is imparted by a conserved novel E3 ligase (NEL) domain that is unique to

189 mium metagenomes, thereby identifying highly conserved, novel genomic signatures of potential gene re

190 l contributing mechanisms are evolutionarily conserved offering new insight into the etiology of huma

191 The primary cilium is a highly conserved organelle housing specialized molecules respon

192 within Gagp15 (not primed) and Gagp17 (less conserved; P < 0.0001 for both).

193 ults suggest the existence of evolutionarily conserved pathways used by S100A4 to promote metastatic

194 This species-conserved peak was delayed in females and marked a reorg

195 ed C-terminal linker (CTL), and a C-terminal conserved peptide (CTC).

196 Plants utilize this conserved phospho-regulatory feedback mechanism to optim

197 that Stx3 undergoes monoubiquitination in a conserved polybasic domain.

198 iperin putative active site contains several conserved positively charged residues, and a portion of

199 ein glycosylation is an essential and highly conserved post-translational modification in eukaryotes.

200 Eukaryotic genes are marked by conserved post-translational modifications on the RNA po

201 Each of these proteins has a highly conserved primary activity; however, numerous additional

202 generate primers or targeting amplicons with conserved priming sites.

203 s during virus replication and highlight the conserved properties of the NoV NS3 proteins among the s

204 e eukaryotic RNA exosome is an essential and conserved protein complex that can degrade or process RN

205 Macrodomain is a conserved protein fold found in several plus-strand RNA

206 ts and growth factor stimuli converge on the conserved protein kinase mechanistic target of rapamycin

207 In the course of this analysis, highly conserved protein motifs and domains within each of the

208 tonemal complex (SC) is an ultrastructurally conserved proteinaceous structure that holds homologous

209 on macromolecular assemblies composed of 15 conserved proteins in model gram-negative species.

210 excitatory synapses comprises 1,000 highly conserved proteins that control the behavioral repertoir

211 tins (PLS1, PLS2, and PLS3) are evolutionary conserved proteins that non-covalently crosslink actin f

212 ng traditional phylogenetic methods based on conserved proteins.

213 The broadly conserved Rad51/RecA family of recombinases catalyzes th

214 While proteins with conserved rare codon clusters are structurally and funct

215 This protein constellation consists of many conserved RBPs, some of which are potential stage-specif

216 We identify a conserved region in the Ulp2 C terminus that mediates it

217 lationships and highlights the importance of conserving regional species pools to help buffer ecosyst

218 We propose cholesterol interacts with the conserved regions in the LAT1 transporter that have been

219 Truncation analyses of the non-conserved regions showed that they are not essential for

220 human Chanarin-Dorfman syndrome, is a highly conserved regulator of adipose triglyceride lipase (ATGL

221 Previous work established that Lis1, a conserved regulator of dynein, binds to its motor domain

222 ave been proposed to stem from disruption of conserved regulatory mechanisms evolved during the trans

223 gh the overall fold and catalytic center are conserved relative to other NPPs, alk-SMase recognizes t

224 Here we show a conserved requirement for Jagged1-Notch2 signaling in pa

225 Here, we identified two conserved residues (R151, I155) in the syntaxin-1 linker

226 ore sequences, we were able to highlight key conserved residues driving essential elements of TCR rec

227 of these mutations were localized near or at conserved residues essential for diiron ion coordination

228 nt in soybeans with deleterious mutations at conserved residues of GmSACPD-C.

229 nel of the 40S subunit and contacts mRNA via conserved residues whose functional importance was unkno

230 Site-specific mutational analyses of the conserved residues within WRDPLVDID indicated that Trp-6

231 Both mutations affected conserved residues, and R291Q is orthologous to R294, wh

232 homologous protein models identified highly conserved residues, particularly at the azole binding si

233 ion in xanthophores, phosphorylates Plin6 on conserved residues.

234 trinuclear zinc center, coordinated by nine conserved residues.

235 tency-associated nuclear antigen (LANA) is a conserved Rhadinovirus protein that is necessary for lon

236 The highly conserved Rho-GTPase Cdc42p promotes yeast fusion throug

237 Here, we identify the conserved RNA helicase Aquarius/EMB-4 as a direct and es

238 Neuronal protein 3.1 (P311), a conserved RNA-binding protein, represents the first docu

239 Consistent with a conserved role for SLC25A3 in copper transport, its hete

240 l differentiation of P19 cells, suggesting a conserved role of this kinase in the epigenic activation

241 essions of this species, indicating a highly conserved role of this protein in controlling organ size

242 but to what degree these known NS genes play conserved roles in nephrocytes remains unknown.

243 how phosphorylation destabilizes this highly conserved salt-bridge in temporal and physical space.

244 Here, we have examined the contributions of conserved salt-bridging residues in stabilizing the dime

245 NUSAP1 contains a conserved SAP domain (SAF-A/B, Acinus, and PIAS).

246 ies reveal that all the five residues in the conserved sequence are required for binding to Nedd8.

247 RGLU1 contains a long, highly evolutionarily conserved sequence known as an Ultraconserved Element (U

248 ns involved in pathway interactions revealed conserved sequence patterns that enabled us to unambiguo

249 This is the report where conserved sequences present in all the serotypes of Deng

250 ased experiments have identified 5'-flanking conserved sequences that control pancreatic and beta-cel

251 with physiological outcomes usually rely on conserved sequences within the RNA element.

252 of at least one Thr (Thr(304)), adjacent to conserved Ser, comes close to the HMBPP diphosphate, whe

253 its autophosphorylation at an evolutionarily conserved serine residue near the carboxyl terminus (Ser

254 AR) and AR variants, such as AR-V7, at their conserved SET/NAP domain, and exacerbate and repress the

255 Here, we focus on the conserved sex-determination gene doublesex (dsx) and the

256 associated SIRT2 mutations at evolutionarily conserved sites disrupt its deacetylation of DNA-damage

257 ds, with tens of thousands of evolutionarily conserved sites.

258 miRNAs are evolutionarily conserved small noncoding RNAs that display important ph

259 Mutational analyses of the positionally conserved sORF of TAS3a linked its translation with tasi

260 M-Prts have shown that they contain a highly conserved sortase A-dependent cell wall-anchored C termi

261 Across subjects, we found conserved spectral patterns among the canonical frequenc

262 and host factors that alter these relatively conserved splicing patterns.

263 , although some differentiated cells utilize conserved strategies to remodel microtubules, there is c

264 Collectively, our study sheds light on a conserved strategy by the viral proteins Vpx and Vpr to

265 ugh alternative splicing is phylogenetically conserved; strongly suggesting it is biologically signif

266 This finding implicates conserved structural organization, not a precise array o

267 networks (PPINs) are known to share a highly conserved structure across all organisms.

268 ructed IINs from yeast and humans and find a conserved structure of these networks with a unique topo

269 In addition, disruption of a conserved structure proximal to A1 caused a 10-fold redu

270 oupled repair (TCR) is an important and well-conserved sub-pathway of nucleotide excision repair that

271 We found that conserved subdomains generally are critical for channel

272 ies use germline residues to interact with a conserved surface on F protein that could guide the emer

273 d 50 years or older who had undergone breast-conserving surgery for unifocal invasive ductal adenocar

274 treated with radiotherapy (RT) after breast-conserving surgery.

275 Preferential binding of G-quadruplex RNA is conserved, surprisingly using different protein elements

276 Finally, we identify and analyze the conserved syntenic blocks among reconstructed ancestral

277 time genes were highly overrepresented among conserved targets, and their CArG-boxes were widely cons

278 rystal structure of the N-terminal half of a conserved tegument protein, UL37, from HSV-1.

279 Although the sequence of RAM is poorly conserved, the linear patterning of oppositely charged r

280 ordinary autosomes, and X-chromosomes mostly conserve their ancestral genes.

281 Of 1697 patients, breast conserving therapy was performed in 656 (39%), mastectom

282 When compared with breast-conserving therapy, we found no significant improvement

283 regulation of mitotic entry by Cdc25 is well conserved, this mechanism may provide a widespread solut

284 Most of these subfamilies are conserved throughout echinoderms.

285 at perform many cellular functions-is highly conserved throughout natural life.

286 etabolism can be measured by the universally conserved TOR (Target of Rapamycin) pathway to balance g

287 tivity-inducing factor (DSIF or Spt4/5) is a conserved transcription elongation factor that both inhi

288 t RNA sequences, DNA template sequences, and conserved transcription factors.

289 e Notch receptor is an evolutionarily highly conserved transmembrane protein that is essential to a w

290 a large extended connector loop containing a conserved trio of aromatic residues.

291 d to be taken into account when studying and conserving tropical forest ecosystems today.

292 ng analyses indicated that an evolutionarily conserved, truncated leucine zipper motif near the N ter

293 gand-induced conformational transitions of a conserved tryptophan side chain in the LBD that trigger

294 horylation of human Hsp90alpha at the highly conserved tyrosine 627 has previously been reported to r

295 of autism, results from the loss of FMR1, a conserved, ubiquitously expressed RNA-binding protein.

296 oxic to humans and other vertebrates, target conserved voltage-gated sodium channels (NaV) of nerve a

297 iality of a Pol I-transcribed ES, as well as conserved VSG 3'UTR 16-mer sequences for the generation

298 ysis; (iii) the location of this arginine is conserved with the HerA/FtsK ATPase superfamily; (iv) a

299 ovel transcriptional lupus signature that is conserved within the gene expression profiles from whole

300 26 in RF1 and Asp-143 in RF2, which are also conserved within their respective groups.