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1 to a missense mutation in an evolutionarily conserved amino acid.
2 tion, and (4) one allele has a mutation in a conserved amino acid.
3 All three variants change evolutionarily conserved amino acids.
4 and nearly monoclonal CDR3 containing novel conserved amino acids.
5 family-specific missense mutations at highly conserved amino acids.
6 yme is inactivated by mutation of two highly conserved amino acids.
7 Both mutations affect highly conserved amino acids.
8 domain of TGBp2, which contains a stretch of conserved amino acids.
9 l roles are assigned to this latter class of conserved amino acids.
10 xon 11 that results in deletion of 30 highly conserved amino acids.
11 ed mutations and/or (for coding DNA) encoded conserved amino acids.
12 inant viruses containing HA with exchange of conserved amino acids adjacent to acylation sites or wit
13 rchanging the first four coding exons or the conserved amino acids adjacent to the RGD of DMP1 with c
15 eteen missense mutations occur in absolutely conserved amino acids among the vertebrate homologs.
16 tution, arginine 321 to histidine, at a well-conserved amino acid and behaves genetically as a domina
19 OL4A1(R538G)) found only in patients changed conserved amino acids and impaired COL4A1 secretion much
20 inase domain contains several alterations in conserved amino acids and is catalytically inactive.
23 The C-terminal subdomain displays a patch of conserved amino acids and we show that this patch define
24 the phenotype in these families, affect well-conserved amino acids, and are predicted to be damaging
25 The replication-defective mutations affected conserved amino acids, and similar phenotypes were obser
28 though mutational analyses demonstrated that conserved amino acids are essential for the function of
29 s support the concept that SNPs altering the conserved amino acids are more likely to be associated w
30 inding domains (motif III) demonstrated that conserved amino acids are often not essential for functi
35 e-structural relationships; (iv) identifying conserved amino acids as fingerprints of the Dbl and Rho
38 n in cardiac troponin T (cTnT) of two highly conserved amino acids (Asn-100 and Glu-101) was found in
40 of the CENPC-k motif and by mutating single conserved amino acids, but can be restored by insertion
42 he resulting EF-Tu variants contained highly conserved amino acid changes within members of the libra
43 ntified two natural variant toxins with four conserved amino acid changes, including a switch of E to
48 or enhanced DSP-PP(240) cleavage; 2) certain conserved amino acids distant from the cleavage site wer
50 Yip1A was blocked by alteration of a single conserved amino acid (E95K) in its N-terminal cytoplasmi
51 ed a predicted missense mutation in a highly conserved amino acid encoded by thiamine biosynthesis2 (
52 in the CHRNA5 gene (D398N), which changes a conserved amino acid from aspartic acid to asparagine.
54 wer this question, we mutated evolutionarily conserved amino acids, generated eight mutants in the HE
57 mutation in the PUS1 gene affecting a highly conserved amino acid has been associated with mitochondr
60 rrga1-d) that is caused by substitution of a conserved amino acid in the C-terminal domain of a DELLA
62 ning reveals a missense mutation of a highly conserved amino acid in the low density lipoprotein rece
64 sidues Arg283, Arg285, and Ile287 are highly conserved amino acids in bovine viral diarrhea virus RNA
68 volves pattern matching to a small number of conserved amino acids in precursor proteins, and thus al
73 cofactor suggested a possible role for three conserved amino acids in substrate binding or catalysis:
76 Our studies are the first to identify key conserved amino acids in the C terminus of alpha-catenin
81 common rearrangement in the packing of three conserved amino acids in the core of the muOR, and molec
82 splice-site, and three missense variants at conserved amino acids in the CUL4B gene on Xq24 in 8 of
88 uggest that pTRS1 inhibits PKR by binding to conserved amino acids in the PKR eIF2alpha binding site
89 ing revealed substitutions of several highly conserved amino acids in the PtD14b protein including a
90 ver, we found that changing three of the six conserved amino acids in the signature, one of which was
95 rable or interdependent by substituting many conserved amino acids in this region with alanine to ide
97 d a homozygous missense mutation, changing a conserved amino acid, in ATG5 in two siblings with conge
99 plants and RNA editing events, which restore conserved amino acids, indicates that matR encodes a fun
100 t points (such as amino acids 4 and 29), and conserved amino acids interacting with other proteins su
101 recognition domains, each displaying 6 of 8 conserved amino acids involved in galactoside-binding ac
102 -specific recognition of the flanking DNA by conserved amino acids is revealed, defining a new role f
104 of these 10 amino acids or mutation of three conserved amino acids (L(385), F(389), and T(390)) in th
107 h ATP, and x-ray structures, show a triad of conserved amino acids lining the nucleotide site that fo
111 patients harbored COI mutations that altered conserved amino acids (mean conservation index=83%), whe
112 from covalently linked side chains of three conserved amino acids (Met-255, Tyr-229, and Trp-107, My
113 ne expression requires box B, a short highly conserved amino acid motif characteristic of BTG2/TOB fa
118 ecognizing stop codons on the mRNA via their conserved amino acid motifs (NIKS in eRF1 and SPF in RF2
120 tein, and their binding sites are defined by conserved amino acid motifs, forming the structural basi
122 l coupling analysis approach to characterize conserved amino acid networks important for biochemical
123 le through public databases, which changes a conserved amino acid of cadherin 2 protein and is suppor
124 quencing to identify a mutation (A280V) in a conserved amino acid of the glycerol-3-phosphate dehydro
125 tivity, an alanine substitution (P365A) in a conserved amino acid of the GP(Y/F) domain did not signi
129 o structure-function studies to identify the conserved amino acids of the C2 domain that regulate the
131 alleles all contain transversions in highly conserved amino acids of the extracellular domains, sugg
132 vity was not reduced by substitutions in two conserved amino acids of the GP(Y/F) domain, G364A and P
137 A22 c.G328C, results in a change of a highly conserved amino acid (p.G110R) and was not present in co
139 gous variant c.3562C > T located at a highly conserved amino acid position (p.R1188W) in the low dens
140 5 transposases (Tnp's) with mutations at the conserved amino acid position W450, which was structural
141 translocated across membranes facilitated by conserved amino acids positioned on the exoplasmic, cyto
142 ous OPA1 missense mutations affecting highly conserved amino acid positions (p.G488R, p.A495V) in the
143 ve a very strong tendency to occur at highly conserved amino acid positions in proteins, suggesting t
144 Finally we have identified conserved and non-conserved amino acid positions within the rim loops that
145 describing the clearly observable and highly conserved amino acid preferences at individual sites is
147 ropeptide Y type 2 receptors that the highly conserved amino acids, proline and alanine, naturally oc
150 rithms to identify oligonucleotide probes in conserved amino acid regions and untranslated sequences.
153 oss a shallow intersubunit channel formed by conserved amino acids required for RNA-stimulated ATP hy
154 ng mutation, c.567 G > A, affecting a highly conserved amino acid residue (p.Gly189Arg) of the MRM2 p
155 4C sequence change affects an evolutionarily conserved amino acid residue and was not detected in una
156 he transcript, including bases that encode a conserved amino acid residue considered critical for ACC
159 R-1 is linked to the replacement of a highly conserved amino acid residue in the activation loop.
161 The identified mutation affects a highly conserved amino acid residue in the zinc finger domain o
163 ation of AMPAR can also be modified by a non-conserved amino acid residue substitution within the spl
164 ward genetic screen in planta, we identify a conserved amino acid residue that determines product spe
165 e disease in the pedigree, affected a highly conserved amino acid residue, and was predicted to be de
166 transporter to study the impact of a highly conserved amino acid residue, Thr(101), in transmembrane
170 cess, we substituted alanines for each of 19 conserved amino acid residues and assessed the in vivo r
171 responsible for substrate specificity, while conserved amino acid residues and divalent cations are r
173 racterize eight BRCA2 VUS that affect highly conserved amino acid residues and map to the N-terminal
176 CD4 suggested a critical role of the highly conserved amino acid residues at positions 423 and 432.
177 eruginosa indicate that these proteins share conserved amino acid residues at positions known to be i
178 introduced a single or a double mutation in conserved amino acid residues contained within this doma
179 n that resembles a Cu-Zn SOD with all of the conserved amino acid residues for binding copper and zin
181 ate shuffling to introduce 62 differentially conserved amino acid residues from type I SUTs into OsSU
183 binding interface utilizes many of the same conserved amino acid residues implicated in the binding
184 that these plant-specific proteins lack key conserved amino acid residues important for GTP binding
185 ference in interaction between antimycin and conserved amino acid residues in bovine and bacterial bc
187 the mechanisms of this coupling, we mutated conserved amino acid residues in membrane helices H and
190 in an ordered series of motifs that included conserved amino acid residues in the cytoplasmic domain
192 e G(-2)A(-1) cleavage site and several other conserved amino acid residues in the leader peptide were
195 kappaM-, and psi-conotoxins revealed highly conserved amino acid residues in the precursor sequences
198 that IrvR is a "LexA-like" protein with four conserved amino acid residues likely required for IrvR a
203 s of the cysteine residues of Tvc as well as conserved amino acid residues of the IgV Tvc domain comp
205 Furthermore, we identified additional highly conserved amino acid residues or motifs within the DDE/D
206 Based on this structural similarity several conserved amino acid residues present in all velvet doma
207 ition, we have examined the roles of several conserved amino acid residues surrounding the phosphoryl
208 e electrostatic effects of non-conserved and conserved amino acid residues surrounding the rhodopsin
209 proteins containing substitutions of highly conserved amino acid residues that contact the triphosph
210 the DeoR/GlpR family have identified highly conserved amino acid residues that function in DNA-bindi
212 ve site of myosin contains a group of highly conserved amino acid residues whose roles in nucleotide
215 m, we and others recently identified several conserved amino acid residues within L protein domain VI
216 entified distinct mutations affecting highly conserved amino acid residues within NS4B, which mediate
218 in the public databases, both affect highly conserved amino acid residues, and both are predicted to
219 and c.772C>T (p.Arg258Trp) mutations involve conserved amino acid residues, are located within the co
220 ps (kappa, lambda, and sigma isotypes) using conserved amino acid residues, recombination signal sequ
221 led that both of the mutations affect highly conserved amino acid residues, which are predicted to be
232 utilizing Block Maker identified a region of conserved amino acid sequence in a large domain between
233 uires that biochemical functions, defined by conserved amino acid sequence motifs, be embedded into a
235 ow that Spa40 is cleaved within the strictly conserved amino acid sequence NPTH and substitution of t
239 HIV-1 Vif proteins, we identified two highly conserved amino acid sequences, (81)LGxGxSIEW(89) and (1
240 rther insights into their genetic diversity, conserved amino acid sequences, and plausible catalytic
241 ly the interspersed segments of variable and conserved amino acid sequences, generate recurring patte
244 airs were first designed based on the highly conserved amino-acid sequences of several selected yeast
247 rve ciliate-specific modifications of widely conserved amino acid sites in DNA polymerases as one pot
249 4%, respectively), while HPV45 E1 was highly conserved (amino acid substitution rate was 0.77%).
250 n MCLs and ICLs could be attributed to three conserved amino acid substitutions in the active site, s
251 n, tissue culture-adapted (TC) PoSaV has two conserved amino acid substitutions in the RNA-dependent
254 are distinguishable from eIF4E1a by a set of conserved amino acid substitutions, several of which are
256 s of homologous proteins are relatively well conserved, amino acid substitutions lead to significant
258 We identified 66Y (N1 numbering), a highly conserved amino acid that was critical for the stability
259 gating of iGluRs is crucially dependent on a conserved amino acid that was first identified in the 'l
260 ne the following: (i) identified a number of conserved amino acids that are crucial for GerBC functio
261 s in all ref4 alleles cause substitutions in conserved amino acids that are located adjacent to predi
263 nd we show that it is controlled by a set of conserved amino acids that couple RNA and ATP binding to
264 e-rich region of each family member contains conserved amino acids that include a PPGY consensus bind
265 TnDOT (IntDOT) carries the C-terminal set of conserved amino acids that is characteristic of the tyro
268 proteins are an effective way of identifying conserved amino acids that provide clues to functional r
269 ic strain Beaudette C (BC), we mutated three conserved amino acids thought to be part of the binding/
270 e function of the SBP2-ribosome interaction, conserved amino acids throughout the SBP2 L7Ae RNA bindi
271 tal structure data and the information about conserved amino acids to perform semiempirical PM3 calcu
273 ive site of CYP72C1 does not contain several conserved amino acids typically needed for substrate hyd
275 d, surprisingly, that pre-phosphorylation or conserved amino acid variation at the 7-position in the
276 of the chromodomain or point mutation of the conserved amino acids, W64A or W67A, of SUV39H1 impaired
281 x and as they replaced evolutionarily highly conserved amino acids with a SIFT score < 0.005, they ar
282 ins shares a common geometry and identity of conserved amino acids with the active site of response r
284 lts in the substitution of an evolutionarily conserved amino acid within the beta-propeller domain, w
285 The R658C mutation in PPP1R15B affects a conserved amino acid within the domain important for pro
287 site of interaction on FBF-2, we identified conserved amino acids within C. elegans PUF proteins.
290 within its domain III, which contains highly conserved amino acids within motifs designated A and C.
291 of deleterious mutations that disrupt highly conserved amino acids within protein-coding sequences, w
292 ctroscopic methods, we examined the roles of conserved amino acids within the bilin-binding domain of
294 g revealed that the 3 variants affect highly conserved amino acids within the GTPase domain of the pr
295 ct missense mutations affecting three highly conserved amino acids within the HCFC1 kelch domain.
297 he MEEVD domain of Hsp90, as well as several conserved amino acids within the tetratricopeptide repea
298 f the putative UL28 metal-binding domain and conserved amino acids within the UL15 nuclease domain ar
299 itro and in planta mutagenesis revealed that conserved amino acids within this domain can be altered
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