ライフサイエンスコーパス: conserved region

1 level variability across the entire central conserved region.

2 the signal-peptide cleavage site in a poorly conserved region.

3 quires the intact ATPase activity and the CC conserved region.

4 h involves a VYGHF motif located within this conserved region.

5 in, but rather required a previously unknown conserved region.

6 esided within a 7 amino-acid, evolutionarily conserved region.

7 sed patterns/motifs tethered together by non-conserved regions.

8 rotein complexity and identifying functional conserved regions.

9 the interaction of pRb family proteins with conserved region 2 (CR2) of E1A is known to promote cell

10 Ca(2+)-dependent conserved-region 2 (C2) domains target their host signal

11 y islet transcription factors binding within conserved Region 3 (base pairs (bp) -8118/-7750) of MafA

12 We show that Par3 conserved region 3 (CR3) forms a tight inhibitory comple

13 ription, and we revealed that in addition to conserved region 3 (CR3) of FOXO3a, the C-terminal segme

14 conserved template/pseudoknot domain, and a conserved regions 4 and 5 (CR4/5) domain, all essential

15 e, structures of key elements from the core, conserved regions 4 and 5, and small Cajal body specific

16 ood gene expression: coding regions (4.47x), conserved regions (4.51x), and two histone marks (p < 3

17 expression included coding regions (11.41x), conserved regions (4.67x), and four histone marks (p < 5

18 nserved element was discovered (evolutionary conserved region 47) that functions as a transcriptional

19 -variant ADHD risk haplotype in evolutionary conserved region 47, formed by rs17226398, rs56038622, a

20 nclude a large enrichment of heritability in conserved regions across many traits, a very large immun

21 urther identify a glutamate residue within a conserved region adjacent to the last two putative TM do

22 and binding of RNA polymerase II within this conserved region, all of which are consistent with trans

23 We sequenced highly conserved regions along 22q from eight individuals with

24 This highly conserved region also makes contacts with residues on he

25 the identification and characterization of a conserved region, also known as H10, in intron IV of the

26 loop ((108)FQRFTPFTLGKEFKE(123)G), a highly conserved region among eAs that mediates binding to thei

27 The neck-linker is a structurally conserved region among most members of the kinesin super

28 mmon feature of MASPs is the presence of two conserved regions: an N-terminal region codifying for si

29 A reveals that plant-specific modules (plant-conserved region and class-specific region) fold into di

30 The conserved region and flanking sequences in an 85-bp intr

31 results support the importance of the plant-conserved region and/or class-specific region in CESA ol

32 s to C-rich single-stranded DNA within these conserved regions and also associates with double-strand

33 n of HIV-specific T-cell responses targeting conserved regions and induction of HIV-specific T-cell r

34 GNA finds large conserved regions and produces a one-to-one node mapping

35 ions link previously identified structurally conserved regions and reveal new motifs, which are beyon

36 indicating similar immunogenicities for the conserved regions and the outside regions.

37 emonstrate the immunogenicity of these small conserved regions and the potential for a vaccine to ste

38 says for C. watsonii abundances targeted the conserved regions and therefore could not differentiate

39 Two conserved regions are central for selective function: th

40 ncoding regulatory elements; however, extant conserved regions are enriched for novel noncoding RNAs

41 these findings demonstrate that the selected conserved regions are highly immunogenic and that anatom

42 helical bundle reveal critical roles for the conserved region as well as helix five.

43 : antibodies present in the antisera bind to conserved regions associated with cross-neutralization.

44 These data suggest that a conserved region at 20 kb upstream from the MMP-13 TSS i

45 , located in a non-coding but evolutionarily conserved region at 8q24.21, is strongly associated with

46 movirus L consisting of CR-VI and the poorly conserved region at its C terminus, the +domain.

47 A conserved region at the 3' end of the locus, containing

48 Additionally, an analysis of highly conserved regions at the family level revealed molecular

49 modes at recombination signal sequence (RSS)-conserved regions before nicking and synapsis.

50 protein interaction studies, we found that a conserved region between amino acids 34 and 52 of NleE,

51 ng and footprinting revealed that the highly conserved region between the branch point and 3'-splice

52 Network alignment aims to find conserved regions between different networks.

53 a1 N-terminal helix, which is among the most conserved regions between p22 and p32.

54 Sequence alignment revealed several highly conserved regions between T-type and Na(v) channels that

55 Conserved region C (CR-C), a promoter proximal cis-regul

56 Loss of the ATPase region, but not other conserved regions, caused TBP to redistribute away from

57 active to an epitope proximal to the central conserved region (CCR) of RSV G protein (mAb 131-2G) sho

58 c analyses showed that eSTRs are enriched in conserved regions, colocalize with regulatory elements a

59 All members share a conserved region composed of five transmembrane regions.

60 SNPs in less conserved regions contributed more to occipital and dors

61 lso observe that SNPs in evolutionarily more conserved regions contributed significantly to the herit

62 nds on the specific MIRNA We show that these conserved regions correspond to structural determinants

63 uence analysis of HtaA and HtaB identified a conserved region (CR) of approximately 150 amino acids t

64 The coiled coil has two spatially distinct conserved regions: CRI and CRII.

65 orter construct driven by a component of the conserved region demonstrated an expression pattern simi

66 The poorly conserved region distal to the phosphorylation cluster i

67 insertional duplication of an evolutionarily conserved region (ECR) downstream of Hmx1 has recently b

68 y, we have identified several evolutionarily conserved regions (ECRs) that are shared between human,

69 sis, we have identified three evolutionarily conserved regions (ECRs), alpha, SINA, and DINA, that ac

70 nonneutralizing antibodies binding to a less conserved region encompassing residues 434 to 446.

71 igns two full genomes and annotates a set of conserved regions exhibiting reduced rates of insertion,

72 and biophysical analyses suggested that the conserved region forms a regular secondary structure ado

73 the periphery of the complex, and the plant-conserved region forms the base of the trimer.

74 n in-frame deletion mutation (DeltaE81) in a conserved region from the first ubiquitin interaction mo

75 Thus, FALCON@home first extracts conserved regions from each template and then aligns a q

76 nces; therefore, we selected four relatively conserved regions (Gag amino acids 148 to 214 and 250 to

77 ntifying rSNPs focus on sequence variants in conserved regions; however, it is unknown what fraction

78 to an adhesive conformation, and the highly conserved region I plays a critical role in this process

79 sent the structure of the N-terminal domain (conserved region I) of the L protein from a rhabdovirus,

80 high yielding soluble fragments encompassing conserved regions I and II (CRI and CRII) at the C-termi

81 Mutations in four GAAG repeats within the conserved region impaired generation of the same splice

82 It contains two conserved regions important for TBP interactions, anothe

83 Here we identify a conserved region in DRC4 critical for assembly of the N-

84 d (CA) HIV-1 DNA and RNA, targeting a highly conserved region in HIV-1pol, with sensitivities of 3 to

85 S349 and S351 are located in a conserved region in the C-terminal domain of YopJ family

86 minus of Rav1, V1 subunits E and C bind to a conserved region in the C-terminal half of Rav1, and the

87 ch indicated binding of miR-1247 to a highly conserved region in the coding sequence of SOX9 but not

88 TBR1 antibodies showed that TBR1 bound to a conserved region in the Fezf2 gene.

89 haracterized the function of the only highly conserved region in the H2B tail, the H2B repression (HB

90 A domain called the 'Conserved region in the middle' is responsible for targe

91 The TRP box, a conserved region in the N-end of the C terminus domain,

92 One of the tested MAbs, which binds to a conserved region in the NA of pH1N1 virus, inhibited NA

93 We identify a conserved region in the Ulp2 C terminus that mediates it

94 yces cerevisiae Upf2 and identified a highly conserved region in this domain that is essential for NM

95 entral part of HaNLP3 and corresponding to a conserved region in type 1 NLPs that induces ethylene pr

96 Mapping of conserved regions in a set of CagA sequences identified

97 targeted proteome areas outside the selected conserved regions in direct proportion to sequence lengt

98 The two conserved regions in HtaA, designated CR1 and CR2, were

99 The number of conserved regions in plant introns appeared to be hundre

100 We identify a NELF core subcomplex formed by conserved regions in subunits NELF-A and NELF-C, and res

101 We described conserved regions in the endoplasmic reticulum-facing lo

102 s9 system can specifically target and cleave conserved regions in the HBV genome, resulting in robust

103 most active shRNA molecules against the most conserved regions in the HCV genome, which were then use

104 We show that Aiolos binds conserved regions in the IL10 locus in IL-17+ CD4+ T cel

105 We propose cholesterol interacts with the conserved regions in the LAT1 transporter that have been

106 othalamus is among the most phylogenetically conserved regions in the vertebrate brain, reflecting it

107 To better understand if conserved regions in VAR2CSA can be targeted by antibodi

108 ersity and primer localization in relatively conserved regions, in addition to recognized constraints

109 r restricts access to the active site as its conserved-region-in-the-middle (CRIM) domain is position

110 Conserved regions include the IR1 latency promoter (Wp)

111 etratricopepide repeat region and the TRIP8b conserved region--interact with two different regions of

112 for remote homologous proteins, consists of conserved regions interweaved with highly variable regio

113 The results indicate each conserved region is required for a different subset of a

114 bodies specific for region III or the highly conserved regions IV-V predict strong protection from cl

115 mentation between the zinc finger domain and conserved region IX.

116 SH2) domain of p85 through an evolutionarily conserved region located at the C terminus of BRD7.

117 uence flanking to the K1 segment and a novel conserved region located between the S and K1 segments [

118 ist(INV), designed to test the function of a conserved region located in exon 1 of Xist RNA during X

119 Both mutations occur in a conserved region located outside of the C2-C2 zinc finge

120 ccine-elicited immune responses or targeting conserved regions may improve coverage of circulating st

121 h CD8+ T cell epitope escape in these highly conserved regions may lead to variable levels of viral f

122 multiple sites in such a multidimensionally conserved region might render the virus particularly vul

123 ellow fever, and West Nile virus, identifies conserved regions modified by m(6)A.

124 that noroviruses often recombine in a highly conserved region near the junction of the viral polyprot

125 Mutations within this conserved region not only inactivate NMD but also disrup

126 omologue of NSUN5, methylates C2278 within a conserved region of 25S rRNA.

127 Alignment of amino acid sequences revealed a conserved region of 52 amino acids, referred herein as W

128 polymorphisms, one of which was in a highly conserved region of a gene encoding a sensor kinase, lia

129 neutralizing antibodies (bNAb) that target a conserved region of a viral antigen hold significant the

130 Importantly, we show that Lys(91) in the conserved region of Ad2 E3-19K targets the C terminus of

131 22, a 22-amino acid peptide derived from the conserved region of bacterial flagellin proteins.

132 multiple sites near the D1 domain, a highly conserved region of bacterial flagellins that interact w

133 n the 'RNR' region, which represent the most conserved region of bacterial RNase P proteins, exhibit

134 A conserved region of E2 encompassing amino acids 412 to 4

135 s work, we examined the role of PNLGs in the conserved region of HIV-1 Env, particularly the role of

136 Herein we demonstrate that a conserved region of human and mouse SYN1 promoters conta

137 ing qRT-PCR primers and a probe for a highly conserved region of integrase in the HIV-1 pol gene (the

138 tion resulted in alternative splicing in the conserved region of intron 34, which strongly decreased

139 identified an A896T substitution in a highly conserved region of KCNJ2 that resulted in a de novo mut

140 closely related to mule deer CrERVgamma in a conserved region of pol; more distantly related sequence

141 In this study, we show that a highly conserved region of Rabin8 is pivotal for its activation

142 a putative catalytic residue within a highly conserved region of RbgA, His9, which is contained withi

143 divergent open reading frames (ORFs) in the conserved region of rpoA, the gene encoding the PEP alph

144 We also discovered a highly conserved region of She3p upstream of its hook region.

145 hat the CP2 motif is in close proximity to a conserved region of TER known as the template boundary e

146 erase essential N-terminal (TEN) domain is a conserved region of TERT proposed to mediate DNA substra

147 ), and a CD4 or CD8 molecule that binds to a conserved region of that same MHC gene product (class II

148 ptase quantitative PCR (RT-qPCR) targeting a conserved region of the 5' untranslated region (5'-UTR).

149 ation is located in an evolutionarily highly conserved region of the alpha-helical rod of the lamin B

150 Bfuxs1 is located in a conserved region of the B. fragilis genome, whereas Bfux

151 ibitors FK506 and rapamycin bind to the most conserved region of the binding site.

152 Domain analysis of atlastin shows that a conserved region of the C-terminal cytoplasmic tail is a

153 ucture of the heterodimer of the multidomain conserved region of the DBHS proteins, PSPC1 and NONO.

154 nteracting with amino acid residues within a conserved region of the DNA binding domain.

155 ecently solved crystal structure of a highly conserved region of the Drosophila orthologue of BICD2 t

156 on of a single tyrosine (p*Y504) in a highly conserved region of the fibronectin type III (FN3) domai

157 OCHROME C (HvPHYC), carrying a mutation in a conserved region of the GAF domain, is a candidate under

158 This variant is in exon 2, a highly conserved region of the gene.

159 OMA-1 binds with high affinity to a conserved region of the glp-1 3'-UTR previously shown to

160 The most conserved region of the HIV type 1 (HIV-1) genome, the a

161 orthogonal methods, alters an evolutionarily conserved region of the HMGB3 protein from a negatively

162 We also show that four genes within the more conserved region of the KSHV genome contained polymorphi

163 sociation is mediated through the N-terminus conserved region of the LFY protein.

164 A synthetic peptide vaccine (J8-DT) from the conserved region of the M protein has shown efficacy aga

165 YBR Green chemistry with primers targeting a conserved region of the M1 gene of influenza A viruses).

166 The most conserved region of the Notch intracellular domain is an

167 e identification of pathogenic variants in a conserved region of the OVOL2 proximal promoter sequence

168 S690 is in a conserved region of the p85 cSH2 domain, and IKK-mediate

169 ssion and miR-423-5p, which targets a highly conserved region of the PR promoter, was chosen for deta

170 Although this domain of AF10 is the most conserved region of the protein, its biological signific

171 , and we determined association of ELF3 to a conserved region of the PRR9 promoter.

172 ther, complicating the events at this highly conserved region of the receptor.

173 ovel missense mutation (p.I141V) in a highly conserved region of the SCN5A gene, encoding the Nav1.5

174 ural progenitor cells of the hypothalamus, a conserved region of the vertebrate brain that centrally

175 The epithalamus is a highly conserved region of the vertebrate brain that differenti

176 , Vgamma10, and Vgamma11 genes represent the conserved region of the Vgamma gene locus whereas the re

177 A therapeutic agent that targets a highly conserved region of the virus could bypass resistance an

178 interference construct, designed to a highly conserved region of these genes, was used to transform c

179 contain multiple amino acid changes within a conserved region of VHS.

180 novel frame-shift insertion discovered in a conserved region of WNT16a, and it is proposed that this

181 enly map to reference genomes, especially to conserved regions of common housekeeping genes, such as

182 results lend support for the development of conserved regions of EBA-175 as components in a combinat

183 bsence of glycosylation sites encoded in the conserved regions of env, further reduced in transmitted

184 Because eCD4-Ig binds only conserved regions of Env, it is also much broader than a

185 cted subjects that target other structurally conserved regions of Env.

186 This effect was independent of the conserved regions of flagellin and occurred in response

187 Six distinct NAIP5 domains contact multiple conserved regions of flagellin, prying NAIP5 into an ope

188 LIPs, and that subtle differences within the conserved regions of FLIPs possess distinct molecular an

189 s) can greatly assist others in highlighting conserved regions of hemagglutinin.

190 e HIV-1 isolates and if other glycans in the conserved regions of HIV-1 Env display similar functions

191 However, the role of specific glycans in the conserved regions of HIV-1 Env in modulating epitope rec

192 reverse transcriptase (RT)-PCR detection of conserved regions of HIV-1 RNA and can be limited by det

193 that vaccine immunogens should contain only conserved regions of HIV-1.

194 ADCC-mediating Abs can target more conserved regions of influenza virus proteins and recogn

195 ines against influenza virus, elucidation of conserved regions of influenza viruses is crucial.

196 t-binding site(s) on RD3, short evolutionary conserved regions of its primary structure were scramble

197 polymerase chain reaction (PCR) assay using conserved regions of mitochondrial DNA (cytochrome b gen

198 ment assay using deletion derivatives in the conserved regions of Mot1 to investigate their contribut

199 o methionine substitution (I4790M) in highly conserved regions of RyR.

200 ty by RbpA, showing that RbpA interacts with conserved regions of sigma(A) as well as the nonconserve

201 We examined the functional significance of conserved regions of SmpB and tmRNA to the trans-transla

202 (Trp-501) region of DdMII demonstrate these conserved regions of the active site are sensitive to Mg

203 domains that roughly correspond to the three conserved regions of the CTD: an alpha helix, needed for

204 ertype-restricted immune responses to highly conserved regions of the dengue proteome may protect aga

205 As N-linked glycans are thought to shield conserved regions of the EBOV GP receptor-binding domain

206 Skewing away from these conserved regions of the epitopes recognized by current

207 possible, though there are no suitable 100% conserved regions of the gene, leading to bias.

208 moval of the heavy glycan shield surrounding conserved regions of the glycoprotein does not enhance v

209 n mice to boost the humoral response against conserved regions of the hemagglutinin (HA) glycoprotein

210 e monoclonal antibody designed to target the conserved regions of the hemagglutinin of influenza A H1

211 ation-scale boost in antibodies specific for conserved regions of the hemagglutinin stalk and the vir

212 t advantage to simultaneously targeting both conserved regions of the HIV-1 envelope glycoprotein.

213 induction of neutralizing antibodies against conserved regions of the human immunodeficiency virus ty

214 ivating CD8+ and CD4+ T cells against highly conserved regions of the influenza genome.

215 la patens and identified mutations in highly conserved regions of the moss ortholog of tomato DGT.

216 tasks are likely subserved by evolutionarily conserved regions of the nervous system.

217 s a series of basic residues residing on two conserved regions of the primary structure.

218 his extensive glycosylation not only shields conserved regions of the protein from the immune system

219 ocated near catalytic sites or within highly conserved regions of the protein.

220 ingle mutations localize within three highly conserved regions of the telomerase thumb domain referre

221 Several of these mutations are located in conserved regions of the transmembrane domain associated

222 In order to assess the importance of conserved regions of the UL15 and UL28 proteins, recombi

223 iscover de novo functional motifs located in conserved regions of the viral genome.

224 earch has focused on the potential of highly conserved regions of the viral hemagglutinin (HA) as tar

225 T-PCR) with degenerate primer sets targeting conserved regions of the viral L genome segment.

226 Allosteric ligands may bind to less-conserved regions of these receptors and therefore are m

227 Antisense reagents targeting conserved regions of two zebrafish lincRNAs caused devel

228 ither deletions or substitutions in the most conserved regions of UL33 using a bacterial artificial c

229 dence suggests that HLAs preferentially bind conserved regions of viral proteins, a concept we term "

230 This work identifies a conserved region on the C terminus of Zip1 (called Zip1

231 potent inhibiting antibodies specific for a conserved region on the globular head of the pandemic H2

232 utoreactive bNAbs, 2F5 and 4E10, recognize a conserved region on the HIV-1 envelope glycoprotein gp41

233 tructural and biochemical studies identify a conserved region on TREX-2, which directly binds the Med

234 is mediated by antibodies targeting several conserved regions on the HIV-1 envelope glycoprotein.

235 spectrum of viruses by targeting relatively conserved regions on the surface HIV envelope trimer spi

236 arise during natural HIV-1 infection bind to conserved regions on the virus envelope glycoprotein and

237 y purifying selection and that contains four conserved regions, one of which is responsible for immob

238 Finally, we identified two conserved regions-one the previously noted post II regio

239 emplate and then aligns a query protein with conserved regions only rather than the full-length templ

240 h of cellular immune responses compared with conserved-region-only HIV-1 immunogens, including greate

241 fic T lymphocyte responses compared with the conserved-region-only immunogens (P = 0.007).

242 st conserved HIV-1 regions compared with the conserved-region-only immunogens.

243 Inactivating mutations in this conserved region or in p10 can inhibit activation of the

244 roup (HMG) box DNA-binding domain and poorly conserved regions outside the HMG box.

245 ation of PsbZIP1 was determined by a central conserved region overlapping the DNA binding domain.

246 a sativa) cellulose synthase, OsCesA8, plant-conserved region (P-CR), one of two unique domains in th

247 raction of the genome than do evolutionarily conserved regions, raising the question of whether nonco

248 Although the conserved regions ranged from 43 to 86 amino acids and c

249 homologs but also identified a novel, highly conserved region (region IX) essential for terminase fun

250 putative zinc finger motif (30-ZF3A) or in a conserved region (region IX) with predicted structural s

251 s an 8-amino acid deletion at the C-terminal conserved region) resulted in not only respiratory defic

252 monstrated by the prevalence of structurally conserved regions (SCRs) even in highly divergent protei

253 The structure reveals that two highly conserved regions, separated by an unconserved linker, f

254 ne design, antigenic epitopes in some highly conserved regions shared by numerous ESAT-6 proteins wer

255 Truncation analyses of the non-conserved regions showed that they are not essential for

256 Baseline enhancer activity of the conserved region specifically on the MYC promoter and it

257 ' untranslated region containing five highly conserved regions suggesting miRNA regulation of its exp

258 to variable antigenic sites or structurally conserved regions, suggesting a combination of evolution

259 combined with frame-disrupting mutations in conserved regions, suggests that evolutionary pressure p

260 Vaccination with J8, a conserved region synthetic peptide derived from the M-pr

261 The CRV yielded a conserved-region targeting density that was approximatel

262 ions important for TBP interactions, another conserved region that hydrolyzes ATP to remove TBP from

263 The survivin protein forms dimers through a conserved region that is critical for subcellular locali

264 ions were missense and presented in a highly conserved region that is implicated in ATP catalysis.

265 We find that Vms1 contains a highly conserved region that is necessary and sufficient for mi

266 nal transmembrane domain of CHS1 in a highly conserved region that may serve a noncatalytic but essen

267 terminal to the ankyrin repeats, in a highly conserved region that we identify here as a novel domain

268 vaccine serotypes to locate primer pairs in conserved regions that border variable regions and could

269 dopamine neuron function, but failed to find conserved regions that functioned as enhancers.

270 n-mediated endocytic receptors contain short conserved regions that recognize tyrosine or dileucine s

271 We show that one of these conserved regions, the p62/Tfb1 Anchor region, directly

272 ha-helix that potentiates the ability of the conserved region to self-assemble.

273 nteracts with Ldb as well as Awh through the conserved regions to mediate transcriptional activation

274 An upstream conserved region (UCR) localizes Sec16 to tER sites.

275 in which each subunit contains two upstream conserved regions (UCR), UCR1 and -2, which precede the

276 A new method that can identify uniquely conserved regions (UCRs) as candidate diagnostic targets

277 CD8+ T cell-driven variations in conserved regions under functional constraints result in

278 of 140 sequences of PIB-1-ATPases revealed a conserved region unusually rich in histidine and cystein

279 impact on activation efficiency, whereas the conserved region up to the first HXH motif is highly ben

280 A conserved-region vaccine (CRV) delivering genes for thes

281 The conserved region VI (CR VI) of the large (L) polymerase

282 The conserved region VI (CR VI) of the large (L) polymerase

283 While targeting of conserved regions was similar in the two groups (P = 0.4

284 3, Arg74, Lys79 and Arg81) in the downstream conserved regions were required for binding of WhiB1 DNA

285 One highly conserved region, which contained a myocyte enhancer fac

286 Its non-conserved regions, which are located between the conserv

287 Notably, we identified a novel conserved region with the consensus sequence WWxxRxxLD p

288 zes ATP to remove TBP from DNA, and a fourth conserved region with unknown function.

289 Our results suggest that targeting conserved regions with less plasticity and more structur

290 ri, which share 97% nucleotide identity over conserved regions with SPI-7 and with each other.

291 bp downstream of the termination codon, in a conserved region, with the A-allele ancestral in primate

292 s recently been identified to sense a highly conserved region within bacterial 23S rRNA.

293 These differences are mediated by a conserved region within the carboxy terminus of perilipi

294 the hMPV N protein that was the most highly conserved region within the hRSV N protein.

295 we determined that androgen receptor binds a conserved region within the phosphatase, Ptpn1, and cons

296 the ability to strongly select mutations in conserved regions within HIV's structural and functional

297 Comparative phylogenetic analysis of highly conserved regions within Pezizomycotina TERs revealed tw

298 udy was to determine the contribution of two conserved regions within TbpB to the function of this pr

299 We examine 15 evolutionary conserved regions within the Jagged1 genomic locus and i

300 In addition, less conserved regions within the N terminus of Ets1 play an