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1 oskeletal GTPase Septin7, at an evolutionary conserved residue.
2 tion on lysine 403 (K403), an evolutionarily conserved residue.
3 ion in xanthophores, phosphorylates Plin6 on conserved residues.
4 ds the top face or to be at buried or highly conserved residues.
5 She2p binding pocket are composed of highly conserved residues.
6 ubules by using small groups of evolutionary conserved residues.
7 two families displaying MFSD2A mutations in conserved residues.
8 ally interacts with COQ7 through a series of conserved residues.
9 ysis reveals that prolines constitute 17% of conserved residues.
10 tinguish regulatory sites from nonfunctional conserved residues.
11 to a wide range of mutations, even in highly conserved residues.
12 e containing a Mn(2+) cluster coordinated by conserved residues.
13 sents a previously unknown key role of these conserved residues.
14 nt posttranslational modifications at highly conserved residues.
15 d specific interaction involving several Sox conserved residues.
16 fibronectin (FN1) variants affecting highly conserved residues.
17 trinuclear zinc center, coordinated by nine conserved residues.
18 bridges, or hydrophobic interactions between conserved residues.
20 of hydrogen bond interactions between highly conserved residues across the RNase dimer interface that
21 the oxyanion hole, are among the most highly conserved residues across the YCII superfamily members.
25 erefore, K8 acetylation at Lys-207, a highly conserved residue among type II keratins and other IFs,
28 ine functional roles for each of these eight conserved residues and allow us to propose a sequential,
29 : NM_001273.3), affect evolutionarily highly conserved residues and are predicted to be deleterious.
30 in binding produce different arrangements of conserved residues and customized interfaces on the hydr
31 ar head of H3 HA that is comprised of highly conserved residues and is distinct from the receptor bin
32 we have identified a surface patch of highly conserved residues and shown that those residues are ess
34 up the recombinant protein when four highly conserved residues and the 70-amino acid small alpha+bet
36 amino acid residues of the active quintet of conserved residues, and of surface-exposed residues for
38 We hypothesize that deleterious variants at conserved residues are enriched in severely affected pat
43 rent de novo mutations, affecting the highly conserved residue Arg138 of P5CS, cause an autosomal-dom
47 nsport cycle were examined, and the roles of conserved residues Asp(196), Glu(198), Lys(873), and Asn
48 ange is stabilized by the interaction of the conserved residues Asp(590) and Tyr(628) and results in
49 Site-directed mutagenesis of these highly conserved residues (Asp-192, Arg-258, Phe-272, Glu-295,
50 rvation of another LBHB (2.47 A) between two conserved residues, Asp233 and Asp246, suggests that LBH
52 HA subtypes, including substitution of other conserved residues associated with receptor binding.
53 (-) and mutations of the proton glutamate, a conserved residue at the internal side of the protein.
55 nine substitutions introduced to four highly conserved residues at the C terminus and one at the N te
56 that cdG binds to FliI in a pocket of highly conserved residues at the interface between two FliI sub
58 We hypothesized that the myristate and the conserved residues at the N terminus of L1 are critical
59 and found that they contained nearly all the conserved residues characteristic of SPaseII family memb
61 expected under the assumption that the most conserved residue confers the highest fitness, there was
62 to identify signatures involving the role of conserved residues, conserved contacts, and downstream s
66 ore sequences, we were able to highlight key conserved residues driving essential elements of TCR rec
68 The five missense mutations affect highly conserved residues either in the sixth repeat of the RCC
69 ialized active site consisting of two highly conserved residues equivalent to SOD5 Glu-110 and Asp-11
71 of these mutations were localized near or at conserved residues essential for diiron ion coordination
72 ltimate interaction we detected involves the conserved residue F402, which has hydrophobic contacts w
73 st, most missense mutations affecting highly conserved residues failed to eliminate ACC2 function.
74 stitution (p.Arg970Pro) at amino-acid 970, a conserved residue for the catalytic activity of AGTPBP1.
75 del in which backbone strain co-evolved with conserved residues for allosteric control of catalytic a
77 ng of all members of the genus also revealed conserved residues forming the structural basis of the E
78 ar beta-helical (solenoid) conformation with conserved residues forming the tightly packed core and p
80 SB complex formation requires evolutionarily conserved residues from both proteins, including a pair
82 croscopic analyses to demonstrate that these conserved residues function after assembling HIV-1 Gag h
83 n this study, we demonstrate that the highly conserved residue G33, located within domain 1 of the co
87 individual BTHS mutations at evolutionarily conserved residues has identified seven distinct loss-of
89 ular N-terminal core, a flexible linker, 8-9 conserved residues implicated in interactions with modul
90 on other NAOX-nucleic acid complexes reveals conserved residues important for recognition and demethy
95 uenced by Polo-mediated phosphorylation of a conserved residue in Miro, which positively regulates Mi
97 mical mechanism: direct phosphorylation of a conserved residue in the activation loop (Cdr2-T166 and
98 l analyses reveal that a single, differently conserved residue in the cap domain of either AUM or chr
99 .Thr270Ala missense variant affects a highly conserved residue in the DBL homology domain, which is r
101 utagenic screen we identified K165, a highly conserved residue in the extracellular vestibule of the
104 Finally, we show that an evolutionarily conserved residue in the PLL domain is critical for olig
105 This A178D missense mutation, affecting a conserved residue in the second immunoglobulin-like doma
107 phosphorylates a subset of Rab GTPases on a conserved residue in their switch-II domains (PMID: 2682
108 y an arginine-to-cysteine change at a highly conserved residue in tyrosinase-related protein 1 (TYRP1
109 y more new damaging and missense variants at conserved residues in cases than in controls (P = 1.6 x
110 Interestingly, there are six differentially conserved residues in DPs affording either the (+)- or (
114 BL patients, are either truncating or affect conserved residues in functional domains, thus supportin
115 en in the presence of extensive mutations to conserved residues in HA's receptor-binding pocket.
116 functional differences between positionally conserved residues in how they influence recombinase-tar
117 We show that ERK phosphorylates Dicer on two conserved residues in its RNase IIIb and double-stranded
118 ys, we performed an in vivo analysis of well-conserved residues in Msh3 that are hypothesized to be r
123 unctional significance of two evolutionarily conserved residues in SETD2 that are recurrently mutated
124 s O-linked mannose (O-Man) glycans at highly conserved residues in specific extracellular cadherin do
125 s) holds that there are several evolutionary conserved residues in TCR variable regions that contact
129 erpesviruses revealed the presence of highly conserved residues in the central portion of the UL37 pr
130 We report that mutation of three strongly conserved residues in the ectodomain has no effect on ta
133 Previous studies have shown that highly conserved residues in the inner domain of gp120 are requ
134 NCT variants that harbor mutations at highly conserved residues in the lid region inNCT-deficient cel
139 mmunoelectron microscopy to demonstrate that conserved residues in the MHR are required after assembl
140 Using yeast coa6Delta cells, we show that conserved residues in the motif, including the residue m
142 These amino acid substitutions affect well-conserved residues in the prodomain and in the peptidase
143 esis-based approach, we demonstrate that the conserved residues in the putative cyclin-binding motif
144 rus reveals that the antibody targets highly conserved residues in the receptor binding site and cont
145 that the intermolecular interactions between conserved residues in the RNase domain are required for
147 the mechanism of Erv14 function, we identify conserved residues in the second transmembrane domain of
149 Accordingly, single mutation of specific conserved residues in these motifs, whilst irrelevant in
152 formation by demonstrating that defined non-conserved residues in TM3 and ECL2 of classic claudins c
162 2.Pi state, in which D714 interacts with the conserved residue K693, which possibly stimulates Zn(2+)
164 n amino acid structurally different from the conserved residue leads to the degradation of RT and, in
165 tion of these interaction sites and of other conserved residues leads to decreased DnaB helicase load
169 le PASTA domain or by mutation of individual conserved residues lining the putative ligand-binding su
171 able LQTS-susceptibility gene and involves a conserved residue localizing to the proline, gltamic aci
174 t PKD1 phosphorylation at Ser(203), a highly conserved residue located within the PKD1 N-terminal dom
175 type specificity because they bind to highly conserved residues located in the channel's central cavi
180 lower magnitude compared with CNIH-3, these conserved residues mediate a direct interaction between
184 genomics and substituted with evolutionarily conserved residues (N251D, A263S, I299L, F387L, I476V, a
190 13 that are all phosphorylated at the highly conserved residue of serine 111 (Ser(111)) in response t
193 el with an RNase H2 AGS mutation in a highly conserved residue of the catalytic subunit, Rnaseh2a(G37
196 introduced mutations in noncanonical and in conserved residues of either of the two nucleotide bindi
198 missense mutations were identified at highly conserved residues of lysyl-tRNA synthetase (KARS): the
201 milar studies of mutagenesis of structurally conserved residues of other tryptophylquinone enzymes.
204 fferent de novo missense mutations involving conserved residues of the four GSK3 phosphorylation moti
205 to the identification of coding mutations in conserved residues of the melanocortin 4 receptor (MC4R)
207 interface of the Rev1-BRCT domain comprises conserved residues of the outer surface of the alpha1-he
208 dorferi clones containing point mutations in conserved residues of the putative TPR motif of BB0238 d
210 fied in these individuals localize to highly conserved residues of this WD-40-repeat-containing prote
211 chymotrypsin homologs that lack one or more conserved residues of typical trypsins and chymotrypsins
213 To accomplish this, we have identified a non-conserved residue on the small subunit of all caspases t
214 eraction interface maps to a patch of highly conserved residues on B', which when mutated render B' i
215 imer with internal symmetry, and we identify conserved residues on the surface and within the dimeriz
216 Binding and actin-assembly assays show that conserved residues on the surface of this domain mediate
221 ified a missense mutation affecting a highly conserved residue (p.F90L) in the CALM1 gene encoding ca
222 trans in the S state but that two absolutely conserved residues (P14 and P101) become cis in the D st
223 tural analysis reveals key interactions with conserved residues P95 and W229 of importance for design
224 homologous protein models identified highly conserved residues, particularly at the azole binding si
226 long to the Ig-fold superfamily, the sets of conserved residue positions and identities differ betwee
227 posttranslational hydroxylation of a highly conserved residue (Pro-62) in the small ribosomal protei
231 her with biochemical data, indicate that the conserved residue Q146 in the flexible loop of HIV-1 int
235 Biochemical and structural studies identify conserved residues required for this interaction and tra
236 odel that exploits knowledge of structurally conserved residue-residue interactions in the coiled-coi
237 ite-directed mutagenesis of gammaherpesvirus conserved residues revealed functional domains of these
238 hosphorylation by CSNK1A1 on a set of highly conserved residues (S824-S834), followed by rapid dephos
241 Soybeans carrying Gmsacpd-c mutations at conserved residues showed the highest stearic acid conte
242 ies of the autotransporter Pet show that the conserved residues significantly quicken completion of t
244 cade of interactions predominantly involving conserved residues such as V139, D148, R167 and K155.
246 uence alignments and the locations of highly conserved residues suggest the presence of a dynamic lat
248 ss-of-function ESR1 mutation in a completely conserved residue that interferes with estrogen signalin
249 missense mutation (p.Arg2024Gln) in a highly conserved residue that is essential for carbamoyl-phosph
250 enzyme is compared with mutants at Tyr68, a conserved residue that is located behind the reactive su
252 We conducted mutagenesis studies on several conserved residues that are considered critical for chlo
253 tures of NavAb, with helix bending involving conserved residues that are critical for slow inactivati
254 he binding affinity of ACK relies on several conserved residues that are critical for stabilizing the
255 We performed site-directed mutagenesis of conserved residues that are located in exposed regions o
256 shots have revealed several different highly conserved residues that are prominently inserted into th
259 ere used to define the functions of the five conserved residues that define the FakB protein family (
260 ded through the channel by interplay between conserved residues that determine proton rejection and s
261 ngs, is facilitated by an insertion loop and conserved residues that hold the 3' primer terminus, and
263 e superfamily, members of which use a set of conserved residues to catalyze a wide variety of reactio
264 This study investigates the role of a highly conserved residue, tryptophan residue 420, of the viral
266 phosphate additionally required active site conserved residues Tyr(40), Asp(181), and Arg(100)and a
267 transmembrane domains are composed of highly conserved residues, underlining their functional relevan
268 rm10 and variants with alterations in highly conserved residues, using crystal structures solved in t
270 f apelin-36 variants in which evolutionarily conserved residues were mutated, and evaluated their abi
271 erm lineage provided evidence that W324 is a conserved residue, whereas the position equivalent to H5
272 onsible encodes the substitution of a highly conserved residue, which lies outside the benzamide-bind
274 nel of the 40S subunit and contacts mRNA via conserved residues whose functional importance was unkno
275 orters and from the analysis of mutations of conserved residues will improve the understanding of the
276 findings identify a discrete pair of highly conserved residues with an essential role for controllin
278 p.Val404Met is novel and occurs at a highly conserved residue within the C-terminal end of the trans
283 omatic NEK9 mutations, each affecting highly conserved residues within its kinase or RCC1 domains, in
286 ids from the carboxyl tail, including highly conserved residues within the catalytic domain, plus a c
288 in sequences preceding the first C of highly conserved residues within the CX5C or CX3H regions or wi
289 al of the C-tail alone or mutation of highly conserved residues within the domain still allows signif
291 after the SP (HRASP), glycosylation and the conserved residues within the N-terminus in GLP-1R traff
292 hermore, site-directed mutagenesis of highly conserved residues within the PepSY domains resulted in
294 the effects of alanine substitutions at many conserved residues within the SSP on viral replication i
297 We conclude that, although the majority of conserved residues within the TZF domain of TTP are requ
298 lographic and mutational studies reveal that conserved residues within the UBN1-HRD and H3.3 G90 as k
299 hysiological characterization shows that the conserved residues within transmembrane segments 2 and 7
300 Site-specific mutational analyses of the conserved residues within WRDPLVDID indicated that Trp-6
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